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Abstract Bovine respiratory disease (BRD) is one of the most frequent clinical concerns inweaned calves after their arrival at the feedlot. This work reports the first local isolation ofMycoplasma bovis from feedlot calves with pneumonia and polyarthritis in Argentina. Twentyfour out of 545 calves showed progressive, subacute to chronic respiratory distress, coughing,and fever. Thirty percent of the affected calves also showed lameness and swelling of elbowor carpal, and knee or tarsal joints. Five necropsies were performed and severe multifocal tocoalescent pulmonary nodules, containing white-yellowish caseous exudate encircled by fibroustissue, and fibrinonecrotic arthritis and tenosynovitis were detected. Mycoplasma was isolatedfrom lung and joint samples. The 16S-23S rRNA ITS consensus sequence obtained from theseisolates showed 100% similarity with the same region of M. bovis strains. Since there are no com-mercially available vaccines in the region for the prevention and control of M. bovis pneumoniaand arthritis, surveillance is a priority to reduce the source of disease to naïve animals.

Resumen La enfermedad respiratoria bovina es uno de los problemas sanitarios más fre-cuentes en terneros recién destetados luego de su arribo a los corrales de encierre (feedlots).Este trabajo describe el primer aislamiento local de Mycoplasma bovis de terneros de feedlotcon neumonía y poliartritis en Argentina. Se vieron afectados 24 de 545 terneros; mostraron enfermedad respiratoria progresiva, subaguda a crónica, tos y fiebre. De los terneros afecta-dos, el 30% presentó, además, problemas en articulaciones carpales o tarsales. Se realizaron5 necropsias de terneros afectados y se observaron nódulos pulmonares multifocales a coa-lescentes, que contenían un exudado caseoso blanco-amarillento, rodeados de tejido fibroso,artritis y tenosinovitis fibrinonecrótica. Se aisló Mycoplasma de muestras de pulmón y artic-ulación. La secuencia consenso del gen codificante del ARNr 16S-23S rRNA obtenido de estosaislamientos mostró un 100% de similitud con la misma región de cepas de M. bovis. Teniendoen cuenta que no hay vacunas disponibles comercialmente en la región para la prevencióny el control de neumonías y poliartritis por M. bovis, es importante realizar una vigilanciaepidemiológica a fin de reducir las fuentes de infección para animales susceptibles.

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BACKGROUND: Polyarthritis has been associated with canine visceral leishmaniasis (CanVL), and co-infection with Ehrlichia canis is common and may alter clinical manifestations. METHODS: A total of 89 dogs presenting CanVL were subdivided into two groups: (1) G1, consisting of 46 dogs seronegative to Ehrlichia spp., and (ii) G2, consisting of 43 dogs seropositive to Ehrlichia spp. Eight joints (carpal, tarsal, stifles and elbows) from each dog were evaluated by radiography and synovial fluid (SF) cytologic analysis. RESULTS: Overall, 74 of the 89 (83.1%) dogs presented joint abnormalities suggestive of osteoarthritis by radiography (G1: 40/46 [86.9%]; G2: 34/43 [79.0%]), with no statistically significant between-group difference. All dogs with abnormal joint X-ray images presented radiographic lesions bilaterally, independent of the characteristics of the lesion. Soft tissue swelling around the joint and joint space narrowing were more commonly observed in G1 than in G2 dogs. There was no significant between-group difference in terms of other radiographic abnormalities suggestive of osteoarthritis (evident trabecular pattern, subchondral bone sclerosis, osteolysis, osteolytic-proliferative lesions or bone proliferation). SF from 174/315 (55.2%) and 152/307 (49.5%) joints from G1 and G2 dogs, respectively, presented an inflammatory infiltrate, but there was no significant association between the presence of inflammatory infiltrate and group. There was also no statistical difference between groups in either of the evaluated joints in terms of the percentage of neutrophils or mononuclear cells. Leishmania spp. amastigotes were found in 69/315 (21.9%) joints from G1 dogs and in 100/307 (32.5%) joints from G2 dogs (Fisher's exact test, P = 0.002, odds ratio = 0.5, 95% confidence interval = 0.4-0.8). The neutrophilic infiltrate was significantly higher in joints with amastigote forms in both G1 (Mann-Whitney U-test, U(18) = 817, Z = -3.76, P = 0.0001) and G2 dogs (Mann-Whitney U-test, U(18) = 6543, Z = - 5.06, P < 0.0001). CONCLUSIONS: A high prevalence of arthritis in dogs with CanVL was found, and all dogs presented involvement in multiple joints. Although no difference was observed between groups in terms of the number of dogs with polyarthritis and the presence of an inflammatory infiltrate in SF, Leishmania spp. amastigotes were found more frequently in joints from G2 dogs. Further studies evaluating SF in dogs co-infected with L. infantum and E. canis should be performed to evaluate this finding.

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Objetivo: Identificar e analisar os anti-inflamatórios não esteroides tópicos para o alívio da dor artrítica, benefícios para idosos. Métodos: Trata-se de uma revisão integrativa realizada nas bases de dados no mês de maio de 2020, mediante consulta às bases de dados MEDLINE/PubMed, CINAHL, EMBASE, Web of Science, SCOPUS e índice bibliométrico LILACS, acessados por meio do Portal Periódicos da Comissão de Aperfeiçoamento de Pessoal de Ensino Superior, utilizando os descritores: idoso (Aged/elderly), anti-inflamatório não esteroide (Anti-Inflammatory Agents, Non-Steroidal) artrite (Arthritides/Polyarthritis). No qual foram selecionados 13 artigos sem limitador para tempo e idioma. Resultados: Detectou se que as variáveis mais evidenciadas foram: inglês (100%); artigos indexados na MEDLINE/PubMed (69,2%); pais com mais publicações Inglaterra (46%). Destaca-se que 69,3% dos artigos foram ensaios clínicos randomizados controlados; anti-inflamatório tópico mais usado diclofenaco sódico (61,5% seguido do cetoprofeno (38,7%). Conclusão: Concluiu se o diclofenaco e o cetoprofeno apresentam eficácia e segurança no alívio da dor artrítica, e baixa toxicidade cutânea local. (AU)

Objective To identify and analyze topical non-steroidal anti-inflammatory drugs for the relief of arthritic pain, benefits for the elderly. Methods: This is an integrative review carried out on the databases in May 2020, by consulting the MEDLINE / PubMed, CINAHL, EMBASE, Web of Science, SCOPUS and LILACS bibliometric index databases, accessed through the Portal Journals of the Higher Education Personnel Improvement Commission, using the descriptors: elderly (Aged / elderly), non-steroidal anti-inflammatory (Anti-Inflammatory Agents, Non Steroidal) arthritis (Arthritides / Polyarthritis). In which 13 articles were selected without time and language limitations. Results: It was found that the most evident variables were: English (100%); articles indexed in MEDLINE / PubMed (69.2%); parents with the most publications in England (46%). It is noteworthy that 69.3% of the articles were randomized controlled clinical trials; most commonly used topical anti-inflammatory diclofenac sodium (61.5% followed by ketoprofen (38.7%). Conclusion: Diclofenac and ketoprofen were concluded to be effective and safe in relieving arthritic pain and low local skin toxicity. (AU)

Objetivo: Identificar y analizar medicamentos antiinflamatorios no esteroideos tópicos para el alivio del dolor artrítico, beneficios para los ancianos. Métodos: Esta es una revisión integradora realizada en las bases de datos en mayo de 2020, consultando las bases de datos del índice bibliométrico MEDLINE / PubMed, CINAHL, EMBASE, Web of Science, SCOPUS y LILACS, a las que se accede a través del Portal Revistas de la Comisión de Mejoramiento del Personal de Educación Superior, utilizando los descriptores: artritis de edad avanzada (Ancianos / ancianos), antiinflamatorios no esteroideos (agentes antiinflamatorios, no esteroideos) (artritis / poliartritis). En el que se seleccionaron 13 artículos sin limitaciones de tiempo e idioma. Resultados: se encontró que las variables más evidentes fueron: inglés (100%); artículos indexados en MEDLINE / PubMed (69,2%); padres con más publicaciones en Inglaterra (46%). Es de destacar que el 69,3% de los artículos fueron ensayos clínicos controlados aleatorios; diclofenaco sódico antiinflamatorio tópico más utilizado (61.5% seguido de ketoprofeno (38.7%). Conclusión: Se concluyó que el diclofenaco y el ketoprofeno son efectivos y seguros para aliviar el dolor artrítico y la baja toxicidad local de la piel. (AU)

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Bovine respiratory disease (BRD) is one of the most frequent clinical concerns in weaned calves after their arrival at the feedlot. This work reports the first local isolation of Mycoplasma bovis from feedlot calves with pneumonia and polyarthritis in Argentina. Twenty four out of 545 calves showed progressive, subacute to chronic respiratory distress, coughing, and fever. Thirty percent of the affected calves also showed lameness and swelling of elbow or carpal, and knee or tarsal joints. Five necropsies were performed and severe multifocal to coalescent pulmonary nodules, containing white-yellowish caseous exudate encircled by fibrous tissue, and fibrinonecrotic arthritis and tenosynovitis were detected. Mycoplasma was isolated from lung and joint samples. The 16S-23S rRNA ITS consensus sequence obtained from these isolates showed 100% similarity with the same region of M. bovis strains. Since there are no commercially available vaccines in the region for the prevention and control of M. bovis pneumonia and arthritis, surveillance is a priority to reduce the source of disease to naïve animals.

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Resumen Objetivo: Revisar las características demográficas, clínicas y ecocardiográficas, así como el abordaje quirúrgico de pacientes con fiebre reumática menores de 18 años, durante un periodo de diez años. Materiales y métodos: Estudio descriptivo, retrospectivo, en el cual se incluyeron pacientes menores de 18 años, con diagnóstico de fiebre reumática entre los años 2006 a 2016. Resultados: Se incluyeron 22 niños con edades entre los 10 a los 14 años, de los cuales 59% (13/22) eran mujeres; 13,6% (3/22) provenían de Arauca y el 18,1% (4/22) eran indígenas. Se diagnosticó carditis en el 63,6% (14/22) seguido de poliartralgia y fiebre en un 59% (13/22) y 54% (12/22) respectivamente; así mismo, se detectó corea de Sydenham y eritema marginado 4,5% (1/22). Se determinó compromiso severo de válvula mitral en el 72,7% (16/22). 15 pacientes fueron llevados a cirugía; se realizó reemplazo valvular mitral en 13,3% (2/15), plastia mitral y tricúspide en el 40% (6/15), plastia mitral, tricúspide y aórtica en el 6,66%(1/15) y reemplazo aórtico en el 5,2% (1/15). Un paciente requirió oxigenación por membrana extracorpórea. La mortalidad fue del 0% (0/22). Conclusiones: Se observó que la fiebre reumática ocasionó grave compromiso cardiaco, que requirió un alto grado de intervención quirúrgica. Las poblaciones rurales e indígenas se beneficiarían notablemente de una prevención primordial, primaria y secundaria, al igual que de un diagnóstico y tratamiento oportunos.

Abstract Objective: The aim of this study is to review the demographic, clinical, and cardiac ultrasound characteristics, as well as the surgical approach, of patients less than 18 years-old with rheumatic fever. Materials and methods: A descriptive, retrospective study was conducted that included patients less than 18 years-old diagnosed with rheumatic fever between the years 2006 to 2016. Results: The study included a total of 22 children with ages between 10 and 14 years, of whom 59% were female. It was recorded that 13.6% (3/22) were from Arauca Department (Colombia), and 18.1% (4/22) were indigenous. Carditis was diagnosed in 63.6% (14/22), followed by polyarthralgia and fever in 59% (13/22) and 54% (12/22), respectively. Sydenham's chorea and marginal erythema was also detected in 4.5% (1/22). The severity of mitral valve involvement was determined in 72.7% (16/22). Of the 15 patients that had surgery, 13.3% (2/15) had a mitral valve replacement, mitral and tricuspid repair in 40% (6/15), mitral, tricuspid, and aortic repair in 6.66%, respectively (1/15), and aortic replacement in 5.2% (1/15). One patient required extracorporeal membrane oxygenation. There was no mortality. Conclusions: It was observed that rheumatic fever led to serious cardiac compromise that required a high rate of surgical interventions. Rural and indigenous population would notably benefit from basic, primary, and secondary prevention, as well as a timely diagnosis and treatment.

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This study investigated the effects of systemic treatment with a new formulation of resveratrol (RSV) vehicled in rice oil (RSVO) in experimental rat models of inflammation. Male Wistar rats were evaluated in the following in vivo models: carrageenan-induced acute edema, complete Freund's adjuvant (CFA)-evoked sub-chronic edema, and CFA-induced polyarthritis. The animals were treated orally with RSVO (10-15 mg/kg) or RSV (100-200 mg/kg), depending on the experimental protocol. RSV was more effective than RSVO in carrageenan-elicited acute edema when dosed in either prophylactic or therapeutic schemes of administration. However, the repeated RSVO administration, at 10-fold lower doses, exhibited superior anti-inflammatory actions in either the sub-chronic edema or the chronic polyarthritis model elicited by CFA, when compared with RSV. The novel formulation RSVO displayed a lower plasma biotransformation when compared with the RSV-treated group-46% versus 88% of metabolites, respectively. RSVO also prevented polyarthritis-related cartilage destruction, an effect that might rely on the inhibition of the pro-inflammatory cytokine interleukin-6 (IL-6), associated with an increase of the anti-inflammatory cytokine interleukin-10 (IL-10). Noteworthy, the long-term administration of RSVO did not elicit any gastrointestinal harm. Our study revealed that RSVO was notably effective in the long-term inflammatory and degenerative responses triggered by CFA. This innovative formulation might well represent a promising alternative for treating chronic inflammatory diseases, such as arthritis.

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La leucemia linfoblástica aguda es la enfermedad oncohematológica más frecuente en la edad pediátrica. El debut con manifestaciones osteoarticulares obliga a realizar el diagnóstico diferencial con artritis idiopática juvenil. El tratamiento con corticoides ante una sospecha de enfermedad reumatológica puede retrasar el diagnóstico y demorar la instauración de un tratamiento adecuado. Describimos el caso clínico de una niña de 8 años con poliartritis migratriz como forma de presentación atípica de leucemia

Acute lymphoblastic leukemia is the most common oncohematological disease in childhood. The onset of the disease with osteoarticular manifestations requires a differential diagnosis with juvenile idiopathic arthritis. Treatment with corticosteroids in case of suspected rheumatic disease can delay the correct diagnosis of leukemia and therefore postpone adequate treatment. We describe the clinical case of an 8-year-old girl with migratory polyarthritis as a form of atypical presentation of leukemia

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O Vírus da leucemia felina é um agente que acomete felinos domésticos com distribuição mundial. Ela induz alterações imunológicas no animal que podem comprometer a saúde do mesmo. Os sinais clínicos são variáveis e inespecíficos. Objetivou-se relatar um caso de poliartrite em um felino com FeLV, condição rara. Foi atendido em uma clínica veterinária um felino, com 3 anos de idade, com histórico de claudicação em membros posteriores e anteriores.Ao exame clínico, verificou-se dor e edema em articulações rádio-cárpicas e tíbio-társicas direito e esquerdas, linfadenomegalia de poplíteos. Foram solicitados exames complementares. O teste rápido para FeLV mostrou-se positivo. O hemograma apresentou neutrofilia. Na radiografia verificou-se a presença de alterações sugestivas para poliartrite. O resultado da citologia mostrou a presença de infiltrado de neutrófilos e linfócitos, sem a presença agentes infecciosos. O histopatológico dos fragmentos ósseos do calcâneo mostrou osteomielite e osteonecrose. Conclui-se que o vírus da leucemia felina induziu um quadro de poliartrite crônica, condição rara, que levou a diversas alterações articulares e ósseas no animal.

The feline leukemia virus is an agent that affects domestic cats with a worldwide distribution. It induces immune changes in the animal that can compromise the health of the animal. The clinical signs are variable and non-specific. The objective of this study was to report a case of polyarthritis in a feline with FeLV, a rare condition. A feline, 3-year-old, with a history of lameness in hind and anterior limbs was seen in a veterinary clinic. Clinical examination revealed pain and edema in the right and left tibial-tarsal radiculopathy and joints, and popliteal lymphadenomegaly. Further examinations were requested. The rapid test for FeLV was positive. The hemogram showed neutrophilia. The presence of suggestive alterations for polyarthritis was observed in the radiograph. The cytology result showed the presence of neutrophil and lymphocyte infiltration, without the presence of infectious agents. The histopathological examination of the bone fragments of the calcaneus showed osteomyelitis and osteonecrosis. It is concluded that the feline leukemia virus induced a chronic condition of polyarthritis, a rare condition that led to several joint and bone changes in the animal.

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O Vírus da leucemia felina é um agente que acomete felinos domésticos com distribuição mundial. Ela induz alterações imunológicas no animal que podem comprometer a saúde do mesmo. Os sinais clínicos são variáveis e inespecíficos. Objetivou-se relatar um caso de poliartrite em um felino com FeLV, condição rara. Foi atendido em uma clínica veterinária um felino, com 3 anos de idade, com histórico de claudicação em membros posteriores e anteriores.Ao exame clínico, verificou-se dor e edema em articulações rádio-cárpicas e tíbio-társicas direito e esquerdas, linfadenomegalia de poplíteos. Foram solicitados exames complementares. O teste rápido para FeLV mostrou-se positivo. O hemograma apresentou neutrofilia. Na radiografia verificou-se a presença de alterações sugestivas para poliartrite. O resultado da citologia mostrou a presença de infiltrado de neutrófilos e linfócitos, sem a presença agentes infecciosos. O histopatológico dos fragmentos ósseos do calcâneo mostrou osteomielite e osteonecrose. Conclui-se que o vírus da leucemia felina induziu um quadro de poliartrite crônica, condição rara, que levou a diversas alterações articulares e ósseas no animal.(AU)

The feline leukemia virus is an agent that affects domestic cats with a worldwide distribution. It induces immune changes in the animal that can compromise the health of the animal. The clinical signs are variable and non-specific. The objective of this study was to report a case of polyarthritis in a feline with FeLV, a rare condition. A feline, 3-year-old, with a history of lameness in hind and anterior limbs was seen in a veterinary clinic. Clinical examination revealed pain and edema in the right and left tibial-tarsal radiculopathy and joints, and popliteal lymphadenomegaly. Further examinations were requested. The rapid test for FeLV was positive. The hemogram showed neutrophilia. The presence of suggestive alterations for polyarthritis was observed in the radiograph. The cytology result showed the presence of neutrophil and lymphocyte infiltration, without the presence of infectious agents. The histopathological examination of the bone fragments of the calcaneus showed osteomyelitis and osteonecrosis. It is concluded that the feline leukemia virus induced a chronic condition of polyarthritis, a rare condition that led to several joint and bone changes in the animal.(AU)

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Background: Endocarditis is one of the most important heart diseases in cattle and a rare disease in sheep. This illness could be caused by any bacteria when related to bacteremia, being Staphylococcus aureus one uncommon cause for this disorder in ruminants. The clinical sings at the early stages are unspecific and many cases are only diagnosed just at the final stages of the disease, resulting in heart insufficiency with bad prognosis. The aim of this study is to report two cases of endocarditis caused by Staphylococcus spp. leading to sepsis in a sheep and osteoarthritis in a cow, showing the importance of this bacteria in the pathogenesis of this disease.Cases: Case 1. A 8-month-old sheep, female, Texel showed lameness in the left thoracic limb, and even treated with nonsteroidal anti-inflammatory drug had anorexia, locomotion difficulty and on the day before of death showed neurological sings, with less than one week of total clinical course. At necropsy, in the heart was observed thrombus in the tricuspid, mitral and aortic valves and pale areas in the myocardium. Multiples abscesses were observed in the lungs, liver and kidneys and infarcts in kidneys, spleen and brain. At the histopathology exam was observed in the tricuspid, mitral and aortic valves subacute endocarditis with intralesional coccoids bacteria Gram positives. There were multifocal fibrinonecrotic myocarditis, abscess in lung, liver and kidney with intralesional bacterial myriads. In kidneys, spleen and brain was observed thrombosis associated to multiple infarct areas. Samples of cardiac thrombus, heart, spleen, kidney and meningeal swabs were submitted for bacterial cultivation and was isolated Staphylococcus aureus in all samples, in pure culture. Case 2. A 2-year-old cow, female, mixed breed Angus and Charolais showed a wound in the distal part of the thoracic limb that was done topical treatment.[...](AU)

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Background: Endocarditis is one of the most important heart diseases in cattle and a rare disease in sheep. This illness could be caused by any bacteria when related to bacteremia, being Staphylococcus aureus one uncommon cause for this disorder in ruminants. The clinical sings at the early stages are unspecific and many cases are only diagnosed just at the final stages of the disease, resulting in heart insufficiency with bad prognosis. The aim of this study is to report two cases of endocarditis caused by Staphylococcus spp. leading to sepsis in a sheep and osteoarthritis in a cow, showing the importance of this bacteria in the pathogenesis of this disease.Cases: Case 1. A 8-month-old sheep, female, Texel showed lameness in the left thoracic limb, and even treated with nonsteroidal anti-inflammatory drug had anorexia, locomotion difficulty and on the day before of death showed neurological sings, with less than one week of total clinical course. At necropsy, in the heart was observed thrombus in the tricuspid, mitral and aortic valves and pale areas in the myocardium. Multiples abscesses were observed in the lungs, liver and kidneys and infarcts in kidneys, spleen and brain. At the histopathology exam was observed in the tricuspid, mitral and aortic valves subacute endocarditis with intralesional coccoids bacteria Gram positives. There were multifocal fibrinonecrotic myocarditis, abscess in lung, liver and kidney with intralesional bacterial myriads. In kidneys, spleen and brain was observed thrombosis associated to multiple infarct areas. Samples of cardiac thrombus, heart, spleen, kidney and meningeal swabs were submitted for bacterial cultivation and was isolated Staphylococcus aureus in all samples, in pure culture. Case 2. A 2-year-old cow, female, mixed breed Angus and Charolais showed a wound in the distal part of the thoracic limb that was done topical treatment.[...]

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Las poliartritis agudas son cuadros de menos seis semanas de duración, cuyas causas pueden o no ser infecciosas. Entre las primeras, destacan las virales, con gran varie-dad de agentes causales. Entre ellos se distinguen por su frecuencia: virus hepatitis B,virus hepatitis C, parvovirus B19, virus rubéola y la fiebre Chicungunya. Tienen elementos comunes, como su expresión poliarticular, generalmente simétrica, con predilección por las pequeñas articulaciones de las manos, siendo habitualmente autolimitadas. A su vez, poseen elementos propios, clínicos y de laboratorio, que permiten diferenciarlos, teniendo algunos una evolución más agresiva con morbilidad más significativa. A su vez, por sus características clínicas y de laboratorio, plantean el diagnóstico diferencial con enfermedades inmunoreumatológicas, como la artritis reumatoidea y el lupus eritematoso sistémico, entre otras.Se realiza una revisión del cuadro clínico y de laboratorio de las poliartritis causadas por los virus señalados, su diagnóstico diferencial y posibilidades terapéuticas.

The acute polyarthritis are pictures of less six weeks duration, whose causes can be or not to be infectious. Among the first, the viral ones stand out with a variety of causal agents. Among there distinguished by their frequency: virus hepatitis B, hepatitis C virus, parvovirus B19, rubella virus and the fever Chicungunya. They have common elements, such as his expression polyarticular, usually symmetrical, with a predilection for the small joints of the hands, being usually self-limiting. At the same time, they have own laboratory and clinical elements that allow differentiation, some having a more aggressive evolution with more significant morbidity. At the same time, for its clinical and laboratory characteristics, raise the differential diagnosis of immunohematological diseases, such as arthritis rheumatoid and systemic lupus erythematosus among others.Is done a review of clinical and laboratory of the polyarthritis caused by the mentioned viruses, differential diagnosis and therapeutic possibilities.

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A neutered male Mexican Hairless dog was presented for generalized weight loss and weakness. Initial laboratory testing and diagnostic imaging revealed thrombocytopenia and an interstitial to miliary lung pattern affecting all lung fields. Mild joint effusion was found on physical examination affecting the stifle, tarsal, carpal, and elbow joints. Examination of synovial fluid demonstrated an inflammatory polyarthropathy in 3 joints. Cytocentrifuged and direct preparations of the bronchoalveolar lavage (BAL) fluid sample were made and cells consistent with lupus erythematosus (LE) cells and ragocytes were found. Based on these findings, the anti-nuclear antibody (ANA) titer was determined as 1:640. A clinical diagnosis of systemic LE was made based on the satisfaction of 2 major criteria (thrombocytopenia and inflammatory polyarthritis), 4 minor criteria (central nervous system signs, lymphadenopathy, fever of unknown origin, and pleuritis), positive ANA titer, and the identification of presumed LE cells in BAL fluid. This case report highlights a novel finding of LE cells in respiratory secretions and provides a review of diagnostic criteria of systemic LE.

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La policondritis recidivante, es una infrecuente enfermedad inflamatoria del tejido conjuntivo, de etiología desconocida. Se caracteriza por inflamación episódica y progresiva de tejido cartilaginoso, principalmente del pabellón auricular, nariz y árbol traqueo-bronquial. Se presenta el caso de una paciente femenina de 58 años, que consulta por enrojecimiento y dolor en pabellón auricular derecho, con episodios previos similares en ambos oídos y nariz, además de estudio por poliartritis simétrica. Al examen físico destaca: eritema, edema y dolor local en pabellón auricular, respetando lóbulo. Con exámenes complementarios normales y presencia de tres criterios característicos de McAdam, se diagnostica policondritis recividante, iniciando prednisona oral, con respuesta favorable. Pese a ser una enfermedad poco frecuente, es importante considerarla en casos recurrentes de eritema y dolor local en regiones cartilaginosas, principalmente en pabellón auricular y nariz, de tal forma de lograr un diagnóstico precoz, para suprimir las crisis y mejorar el pronóstico de estos pacientes.

Relapsing Polychondritis (RP) is a rare inflammatory connective tissue disease of unknown etiology. It is characterized by episodic and progressive inflammation of cartilage tissue, especially ear, nose and tracheobronchial tree. We report the case of 58 year old Chilean female patient, who consulted for redness and pain in the right ear, with similar previous episodes in both ears and nose; along with symmetric polyarthritis study it is presented. Physical examination highlighted erythema, edema and local pain in ear, respecting lobe. With normal complementary examinations and presence of three diagnostic criteria of McAdam y col. relapsing polychondritis diagnosed, initiating oral prednisone, with favorable response. Despite being a rare disease, it is important to consider in recurrent cases of erythema and local pain in cartilaginous regions, mainly in ear and nose, so to achieve early diagnosis, to suppress the crisis and improve the prognosis of these patients.

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The article presents a review of the main clinical and epidemiological characteristics and contagious agalactia control measures. The disease is characterized by agalactia, mastitis, polyarthritis and keratoconjunctivitis and has been diagnosed in small ruminants from States of Northeast and Southeast of the Brazil. The use of homeopathic medicine presents good clinical results although not fully resolve joint damage. Prevention of the disease can be achieved by induction of birth, followed by immediate separation of kids to new group formation, vaccination of young animals and animal input control in the herd.(AU)

O artigo apresenta uma revisão das características clínico-epidemiológicas e medidas de controle da agalaxia contagiosa. A doença se caracteriza por mastite seguida de agalaxia, poliartrite e ceratoconjuntivite e tem sido diagnosticada em rebanhos dos estados do Nordeste e Sudeste brasileiro. O uso de medicamento homeopático apresenta bons resultados clínicos, embora não resolvam totalmente as lesões articulares. A prevenção da enfermidade pode ser obtida pela indução do parto, seguida de separação imediata das crias com formação de novo plantel, vacinação dos animais jovens e controle de entrada de animais no plantel.(AU)

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The article presents a review of the main clinical and epidemiological characteristics and contagious agalactia control measures. The disease is characterized by agalactia, mastitis, polyarthritis and keratoconjunctivitis and has been diagnosed in small ruminants from States of Northeast and Southeast of the Brazil. The use of homeopathic medicine presents good clinical results although not fully resolve joint damage. Prevention of the disease can be achieved by induction of birth, followed by immediate separation of kids to new group formation, vaccination of young animals and animal input control in the herd.

O artigo apresenta uma revisão das características clínico-epidemiológicas e medidas de controle da agalaxia contagiosa. A doença se caracteriza por mastite seguida de agalaxia, poliartrite e ceratoconjuntivite e tem sido diagnosticada em rebanhos dos estados do Nordeste e Sudeste brasileiro. O uso de medicamento homeopático apresenta bons resultados clínicos, embora não resolvam totalmente as lesões articulares. A prevenção da enfermidade pode ser obtida pela indução do parto, seguida de separação imediata das crias com formação de novo plantel, vacinação dos animais jovens e controle de entrada de animais no plantel.

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RESUMO

La reticulohistiocitosis multicéntrica (RHM) es una patología sistémica, de baja prevalencia, considerada dentro delgrupo de las histiocitosis no Langerhans. Clínicamente se caracteriza por el compromiso de la piel y las articulaciones.Se describe el caso de un paciente masculino con antecedente de diagnóstico de artritis reumatoidea (AR) de 10 años de evolución, que en 2008 se presenta a la consulta por un cuadro de poliartritis asociado a prurito cutáneo,hiperpigmentación facial y presencia de múltiples lesiones nodulares rojovioláceas en codos y manos. Mediante biopsia de las lesiones cutáneas se confirma el diagnóstico de RHM. Cabe destacar que se ha descripto hasta un 30% de asociación de la entidad con patologías neoplásicas; en nuestro paciente el tamizaje fue negativo. En cuanto al tratamiento no existen protocolos avalados científicamente dada la baja incidencia de la enfermedad, por lo que sigue siendo experimental. En nuestro paciente se realizó tratamiento exitoso con metotrexate.(AU)

Multicentric reticulohistiocytosis (MRH) is a systemic pathology of low prevalence within the group of histiocytosis no-Langerhans. It is clinically characterized by the involvement of skin and joints. The present article describes the case of a male subject with a diagnosis of rheumatoid arthritis of 10 yearsÆ duration. In 2008 he was seen in our service with multiple nodular, red skin lesions in his hands and elbows. A biopsy of the cutaneous lesions confirmed the diagnosis of MRH. An association with neoplasic disease has been described in 30% of the cases; however, in our patient cancer screening was negative. With regard to the treatment, scientifically proven protocols do not exist. This is due to the low incidence of the disease. Our patient responded well to methotrexate.(AU)

Assuntos

RESUMO

La reticulohistiocitosis multicéntrica (RHM) es una patología sistémica, de baja prevalencia, considerada dentro delgrupo de las histiocitosis no Langerhans. Clínicamente se caracteriza por el compromiso de la piel y las articulaciones.Se describe el caso de un paciente masculino con antecedente de diagnóstico de artritis reumatoidea (AR) de 10 años de evolución, que en 2008 se presenta a la consulta por un cuadro de poliartritis asociado a prurito cutáneo,hiperpigmentación facial y presencia de múltiples lesiones nodulares rojovioláceas en codos y manos. Mediante biopsia de las lesiones cutáneas se confirma el diagnóstico de RHM. Cabe destacar que se ha descripto hasta un 30% de asociación de la entidad con patologías neoplásicas; en nuestro paciente el tamizaje fue negativo. En cuanto al tratamiento no existen protocolos avalados científicamente dada la baja incidencia de la enfermedad, por lo que sigue siendo experimental. En nuestro paciente se realizó tratamiento exitoso con metotrexate.

Multicentric reticulohistiocytosis (MRH) is a systemic pathology of low prevalence within the group of histiocytosis no-Langerhans. It is clinically characterized by the involvement of skin and joints. The present article describes the case of a male subject with a diagnosis of rheumatoid arthritis of 10 years’ duration. In 2008 he was seen in our service with multiple nodular, red skin lesions in his hands and elbows. A biopsy of the cutaneous lesions confirmed the diagnosis of MRH. An association with neoplasic disease has been described in 30% of the cases; however, in our patient cancer screening was negative. With regard to the treatment, scientifically proven protocols do not exist. This is due to the low incidence of the disease. Our patient responded well to methotrexate.

Assuntos