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Fragile X Syndrome (FXS) is a neurodevelopmental disorder and the leading monogenic cause of autism and intellectual disability. For years, several efforts have been made to develop an effective therapeutic approach to phenotypically rescue patients from the disorder, with some even advancing to late phases of clinical trials. Unfortunately, none of these attempts have completely succeeded, bringing urgency to further expand and refocus research on FXS therapeutics. FXS arises at early stages of postnatal development due to the mutation and transcriptional silencing of the Fragile X Messenger Ribonucleoprotein 1 gene (FMR1) and consequent loss of the Fragile X Messenger Ribonucleoprotein (FMRP) expression. Importantly, FMRP expression is critical for the normal adult nervous system function, particularly during specific windows of embryogenic and early postnatal development. Cellular proliferation, migration, morphology, axonal guidance, synapse formation, and in general, neuronal network establishment and maturation are abnormally regulated in FXS, underlying the cognitive and behavioral phenotypes of the disorder. In this review, we highlight the relevance of therapeutically intervening during critical time points of development, such as early postnatal periods in infants and young children and discuss past and current clinical trials in FXS and their potential to specifically target those periods. We also discuss potential benefits, limitations, and disadvantages of these pharmacological tools based on preclinical and clinical research.

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Brazil has been severely affected by the COVID-19 pandemic. Temperature and humidity have been purported as drivers of SARS-CoV-2 transmission, but no consensus has been reached in the literature regarding the relative roles of meteorology, governmental policy, and mobility on transmission in Brazil. We compiled data on meteorology, governmental policy, and mobility in Brazil's 26 states and one federal district from June 2020 to August 2021. Associations between these variables and the time-varying reproductive number (R t ) of SARS-CoV-2 were examined using generalized additive models fit to data from the entire 15-month period and several shorter, 3-month periods. Accumulated local effects and variable importance metrics were calculated to analyze the relationship between input variables and R t . We found that transmission is strongly influenced by unmeasured sources of between-state heterogeneity and the near-recent trajectory of the pandemic. Increased temperature generally was associated with decreased transmission and increased specific humidity with increased transmission. However, the impacts of meteorology, policy, and mobility on R t varied in direction, magnitude, and significance across our study period. This time variance could explain inconsistencies in the published literature to date. While meteorology weakly modulates SARS-CoV-2 transmission, daily or seasonal weather variations alone will not stave off future surges in COVID-19 cases in Brazil. Investigating how the roles of environmental factors and disease control interventions may vary with time should be a deliberate consideration of future research on the drivers of SARS-CoV-2 transmission.

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BACKGROUND: Supporting therapies that provide stress and pain control of preterm and term newborns infants contribute positively to the neuropsychomotor development. Non-pharmacological interventions that involve manual techniques are described, considering protocols that can be reproduced by physical therapists, with positive and negative outcomes reports. DATA SOURCES: Systematic review follows PRISMA 2020 statements guidelines. Primary and specific health sciences databases (Science Direct, Pubmed, Scielo, Embase and Scopus) were consulted between October 2021 and May 2022. Articles considered were clinical trials, randomized or not, that included descriptions of the type of intervention as non-pharmacological and that studied the following outcomes: "pain" and "stress". RESULTS: Fifteen articles were selected for analysis, reaching a methodological quality of at least 3 on the Jadad Scale for the Quality of Researched Sources. The non-pharmacological therapies most applied in isolation were massage, swaddling or wrapping, gentle touch and kinesthetic stimulation, and the combined therapies were non-nutritive sucking and swaddling, oral sucrose and swaddling, sensory stimulation and familiar odors, and sensory saturation. The outcomes found were relaxation, pain, and stress reduction after the application of painful procedures. The behavioral changes included crying, grimacing, yawning, sneezing, jerky arm or leg movements, startles, and finger flaring. The vital signs included heart rate, blood oxygen saturation level, and pulse respiration. CONCLUSIONS: Combined techniques lead to better results in controlling neonatal pain when compared to isolated techniques. They can be applied both in preterm and term infants in a safe way and are reproducible in any health unit in a simple and economical way.

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Introdução: As intervenções não farmacológicas consistem em quaisquer medidas ou ações, que não o uso de vacinas ou medicamentos, que podem ser implementadas para retardar a disseminação de determinada doença infecciosa na população. Objetivo: Fornecer evidências científicas relacionadas às intervenções não farmacológicas que conferem a prevenção de síndrome gripal na comunidade. Método: Revisão sistemática da literatura realizada nas bases de dados, Cochrane, MEDLINE, EMBASE, CINAHL, Web of Science e, no que tange à literatura cinzenta, uma busca adicional foi realizada no Google Scholar. A busca eletrônica foi realizada no dia 06 de setembro de 2021. Os critérios de inclusão foram ensaios clínicos randomizados que avaliassem a eficácia de intervenções não farmacológicas na comunidade para a prevenção da disseminação de síndrome gripal. A avaliação do risco de viés foi realizada por meio da ferramenta Risk of Bias 2.0. A síntese dos resultados foi apresentada de modo qualitativo. A síntese quantitativa (estatística) dos resultados não foi possível, devido à acentuada heterogeneidade de configurações metodológicas, bem como as qualidades metodológicas dos ensaios clínicos randomizados. Resultados: Foram compilados 34 ensaios clínicos randomizados. A avaliação metodológica demostrou que a maioria dos ensaios apresentam falhas na sua condução. No tocante aos países onde as intervenções foram utilizadas, destacam-se Estados Unidos da América, China e Espanha, respectivamente; e de acordo com o local onde foram realizadas - em domicílios, em escolas, em creches, em residências universitárias e em ambiente comunitário. Com relação à situação epidemiológica, observa-se que 13 estudos foram realizados no período sazonal de influenza, 11 estudos em períodos pontuais, cinco estudos em períodos pandêmicos por SARS-CoV-2, quatro estudos em períodos concomitantes e um estudo durante a pandemia de influenza. A respeito da infecção avaliada, observa-se estudos que avaliam infecções respiratórias agudas, influenza e COVID-19. Dos 34 ensaios clínicos, 30 avaliaram intervenções individuais, dois intervenção individual e ambiental, uma intervenção individual e comunitária; e um ensaio clínico avaliou uma intervenção comunitária. Intervenções individuais: máscara facial; higiene das mãos com água e sabão, com formulação à base de álcool, com cloreto benzalcônio; etiqueta respiratória; e limpeza nasal asséptica. Intervenções comunitárias: triagem, ventilação do ar, campanha publicitária (distanciamento social). Intervenção ambiental: limpeza de superfície. Conclusão: Algumas intervenções não farmacológicas individuais (higiene das mãos com água e sabão, higiene das mãos com formulação à base de álcool, etiqueta respiratória e limpeza nasal antisséptica) e ambientais não têm momento para início da implementação, elas devem se tornar cultural, pois são mais simples e de baixo custo. Essas intervenções e outras, como o uso de máscara facial, devem ser incentivadas durante os períodos sazonais desses vírus, considerando as particularidades de subgrupos populacionais, para prevenir maior disseminação. As intervenções combinadas (individuais/comunitárias e individuais/ambientais) potencializam os efeitos na redução da síndrome gripal e das infecções respiratórias agudas. Ressalta-se que as intervenções não farmacológicas representam a primeira escolha na prevenção da disseminação microbiana, são determinantes no controle das doenças e, de forma articulada, necessita da vacinação para minimizar os impactos deletérios na comunidade.

Introduction: Non-pharmacological interventions consist of any measures or actions, other than the use of vaccines or drugs, that can be implemented to delay the spread of a certain infectious disease in the population. Objective: To provide scientific evidence related to non-pharmacological interventions that prevent the flu syndrome in the community. Method: Systematic review of the literature carried out in the databases Cochrane, MEDLINE, EMBASE, CINAHL, Web of Science and, regarding the gray literature, an additional search was performed on Google Scholar. The electronic search was performed on September 6, 2021. The inclusion criteria were randomized clinical trials that evaluate the effectiveness of non-pharmacological interventions in the community to prevent the spread of flu-like illness. The risk of bias assessment was performed using the Risk of Bias 2.0 tool. The synthesis of the results was presented in a qualitative way. The quantitative (statistical) synthesis of the results was not possible, due to the marked heterogeneity of methodological settings, as well as the methodological qualities of the randomized clinical trials. Results: 34 randomized clinical trials were compiled. The methodological evaluation showed that most of the trials have flaws in their conduction. With regard to the countries where the interventions were used, the United States of America, China and Spain, respectively, stand out. According to the place where they were carried out, at home, in schools, in day care centers, in university residences and in a community environment. Regarding the epidemiological situation, it is observed that 13 studies were carried out in the seasonal period of influenza, 11 studies in specific periods, five studies in pandemic periods due to SARS-CoV-2, four studies in concomitant periods and one study during the pandemic of influenza. Regarding the evaluated infection, there are studies that evaluate acute respiratory infections, influenza and COVID-19. Of the 34 clinical trials, 30 evaluated individual interventions, two individual and environmental intervention, one individual and community intervention; and a clinical trial evaluated a community intervention. Individual interventions: face mask; hand hygiene with soapy water, with alcohol-based formulation, with benzalkonium chloride; respiratory etiquette; and aseptic nasal cleaning. Community interventions: triage, air ventilation, publicity campaign (social distancing). Environmental intervention: surface cleaning. Conclusion: Some individual non-pharmacological interventions (hand hygiene with soap and water, hand hygiene with alcohol-based chemical formulation, respiratory etiquette and antiseptic nasal cleaning) and environmental do not have a time to start implementation, they must become cultural, because they are simpler and of low cost. These interventions, and others such as the use of a face mask, should be encouraged during the seasonal periods of these viruses, taking into account the particularities of population subgroups, to prevent further spread. Combined interventions (individual/community and individual/environmental) potentiate the effects in reducing flu syndrome and acute respiratory infections. It should be noted that non-pharmacological interventions represent the first choice in preventing microbial dissemination, are crucial in disease control and, in an articulated way, require vaccination to minimize deleterious impacts on the community.

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The COVID-19 pandemic and its effects on public health have urgently demanded effective health policies to avoid the spread of COVID-19. Thus, public administrators have implemented non-pharmacological and pharmacological interventions to mitigate the pandemic's impacts and strengthen health services. The aim of this ecological study is to describe the scenario of COVID-19 pandemic in a Brazilian city, during 2 years. This ecological study was carried out in Nova Friburgo, a Brazilian city, for 105 weeks (two years), from March 29, 2020 (week 1) to April 02, 2022 (week 105). Data on COVID-19 cases and COVID-19 deaths, occupation of COVID-19 exclusive beds in hospitals, community mobility, vaccination, government regulation on the opening of city establishments and city risk assessment were collected from public datasets. Four waves of COVID-19 cases and deaths were observed during this period. The first case occurred in week 1 and first death in week 3 of this study. The highest peaks of cases and deaths were observed during the third wave with 1,131 cases (week 54) and 47 deaths (week 55) and where the highest occupation of COVID-19 exclusive beds in local hospitals occurred. Interventions from more restrictive to more flexible, were implemented throughout this study, including lockdown and gradual return in economic and social strata levels. Vaccination began on week 43 and at the end of this study 89.91% of the total population was vaccinated with at least one dose, being 83.22% fully vaccinated. A deep description of several interventions used to avoid COVID-19 spread in a Brazilian city during 2 years of this pandemic can help promote better decision-making in the future while it exposes the challenges of conducting public health policies in a pandemic scenario.

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Abstract Objective To investigate the effect of non-pharmacological interventions to improve sleep quality during pregnancy. Data sources A search was made in the NCBI/PubMed, ClinicalTrials.gov, Embase, BVS, and Web of Science databases. There were no limitations regarding language, sample size, and type of non-pharmacological intervention. We have included prospective clinical trials between July 2014 and July 2019. Selection of studies This study was registered in the Prospective International Registration of Systematic Reviews (PROSPERO) database was performed. Publication bias was also assessed with funnel plots. the primary outcome was the total score in the Pittsburgh Sleep Quality Index (PSQI) before and after intervention. Risk of bias and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were used for assessing methodological quality. From the 28 retrieved studies, we have selected 8 for qualitative analysis and 6 for meta-analysis. Data collection Two independent reviewers performed the study selection. In the case of disagreement, a third senior reviewer was consulted. The study was initially assessed based on the title, followed by abstract. Lastly, the full text was assessed to be included. Data Synthesis A significant improvement on the sleep quality (PSQI score) was observed when all interventions were grouped (MD = -3.03, 95%CI -4.15 to -1.92, n= 623, i2= 84%, p< 0.001). Analysis by subgroup (music listening: MD = -1.96, 95% CI -3.27 to -0.65, n= 207, i2= 67%, p= 0.003 and other interventions: MD = -3.66, 95% CI -4.93 to -2.40, n= 416, i2 = 80%, p< 0.001) showed an improvement, with high heterogeneity. Risk of bias has shown performance and detection bias for almost studies, and GRADE evidence was very low for all analyzed variables. Conclusion Non-pharmacological interventions—listening to music, physical exercise, relaxation exercises, lettuce seed, sleep hygiene, and acupressure—are effective for improving sleep quality during pregnancy.

Resumo Objetivo Investigar o efeito de intervenções não-farmacológicas para melhorar a qualidade do sono durante a gravidez. Fontes dos dados Uma busca foi feita nas bases de dados NBCI/PubMed, ClinicalTrials.gov, Embase, BVS, e Web of Science. Não houve limitações quanto ao idioma, tamanho da amostra e tipo de intervenção não-farmacológica. Incluímos estudos clínicos prospectivos entre julho de 2014 e julho de 2019. Seleção dos estudos Foi realizado um registro no banco de dados Prospective International Registration of Systematic Reviews (PROSPERO). O viés de publicação foi avaliado com gráficos de funil. O desfecho primário foi a pontuação total do Pittsburgh Sleep Quality Index (PSQI) antes e depois da intervenção. O risco de viés e os critérios Grading of Recommendations Assessment, Development, and Evaluation (GRADE) foram usados para avaliar a qualidade metodológica. Dos 28 estudos encontrados, selecionamos 8 para análise qualitativa e 6 para a metanálise. Coleta de dados Dois revisores independentes realizaram a seleção dos estudos. Em caso de discordância, um terceiro revisor foi consultado. Inicialmente o estudo foi avaliado com base no título e resumo. Para a inclusão, foi avaliado o texto completo. Síntese dos dados Uma melhora significativa na qualidade do sono (PSQI score) foi observada quando todas as intervenções foram agrupadas (MD = -3.03, 95% CI -4.15 a -1.92, n= 623, i2= 84%, p< 0.001). A análise por subgrupo (escutar música: MD = -1.96, 95% CI -3.27 a -0.65, n= 207, i2= 67%, p= 0.003 e outras intervenções: MD = -3.66, 95% CI -4.93 a -2.40, n= 416, i2 = 80%, p< 0.001) também mostrou uma melhora da qualidade do sono, porém com alta heterogeneidade. A análise do risco de viés mostrou que quase todos os estudos avaliados apresentaram viés de desempenho e detecção, e o nível de evidência GRADE foi muito baixo para todas as variáveis analisadas. Conclusão Intervenções não-farmacológicas - ouvir música, exercícios físicos, exercícios de relaxamento, sementes de alface, higiene do sono e acupressão - são eficazes para melhorar a qualidade do sono durante a gravidez.

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Background: The pandemic propagation of SARS-CoV-2 led to the adoption of a myriad of non-pharmacological interventions (NPIs, e.g., social distancing, mobility restrictions, gathering restrictions) in the Americas. Using national epidemiological data, here we report the impact of the layered adoption of multiple NPIs aimed at curving SARS-CoV-2 transmission in Yucatan State, Mexico. Methods: Data from suspected and laboratory confirmed COVID-19 cases during 2020 were analyzed by age groups and sex, clinical signs, and symptoms as well as outcome. The impact of NPIs was quantified using time-varying reproduction numbers (R t) estimated as a time-series and by sectors of the city. Findings: A total of 69,602 suspected cases were reported, 39.3% were laboratory-confirmed. Men were hospitalized (60.2%), more severely ill (3% vs 1.9%) and more likely to die (62%) than women. Early in the outbreak, all sectors in Merida had R t estimates above unity. Once all NPÍs were in place, R t values were dramatically reduced below one, and in the last interval transmission estimates of R t remained below one in all sectors. Interpretation: In the absence of a COVID-19 vaccination program, the combination and wide adherence of NPÍs led to a low and stable trend in SARS-CoV-2 transmission that did not overwhelm the health sector. Our study reflects that a controlled and planned ease of restrictions to balance health, social and economic recovery resulted in a single wave of transmission that prolonged at low and stable levels. Funding: GVP received funding from Emory University via the MP3 Initiative.

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Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an essential role in regulating many physiological processes, such as intracellular signaling and synaptic transmission. Changes in parvalbumin expression are deeply related to epilepsy, which is considered one of the most disabling neuropathologies. Epilepsy is a complex multi-factor group of disorders characterized by periods of hypersynchronous activity and hyperexcitability within brain networks. In this scenario, inhibitory neurotransmission dysfunction in modulating excitatory transmission related to the loss of subsets of parvalbumin-expressing inhibitory interneuron may have a prominent role in disrupted excitability. Some studies also reported that parvalbumin-positive interneurons altered function might contribute to psychiatric comorbidities associated with epilepsy, such as depression, anxiety, and psychosis. Understanding the epileptogenic process and comorbidities associated with epilepsy have significantly advanced through preclinical and clinical investigation. In this review, evidence from parvalbumin altered function in epilepsy and associated psychiatric comorbidities were explored with a translational perspective. Some advances in potential therapeutic interventions are highlighted, from current antiepileptic and neuroprotective drugs to cutting edge modulation of parvalbumin subpopulations using optogenetics, designer receptors exclusively activated by designer drugs (DREADD) techniques, transcranial magnetic stimulation, genome engineering, and cell grafting. Creating new perspectives on mechanisms and therapeutic strategies is valuable for understanding the pathophysiology of epilepsy and its psychiatric comorbidities and improving efficiency in clinical intervention.

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BACKGROUND: Our aim was to study the association between case rates and reductions in urban mobility in state capitals of Colombia. METHODS: We designed an ecological time-series study to correlate the Colombian incidence rate with reductions in mobility trends of retail stores. RESULTS: The meta-analysis of ß coefficients describing the association between case rates and reductions in mobility trends of retail stores resulted in a mean estimate of 0.0637 (95% confidence interval 0.027 to 0.101; p<0.001) with nearly 100% heterogeneity. CONCLUSIONS: We recommend continuing to consider mobility restrictions when the number of cases starts to climb in each local jurisdiction.

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The present review will focus on the role of chloride anion in cardiovascular disease, with special emphasis in the development of hypertensive disease and vascular inflammation. It is known that acute and chronic overload of sodium chloride increase blood pressure and have pro-inflammatory and pro-fibrotic effects on different target organs, but it is unknown how chloride may influence these processes. Chloride anion is the predominant anion in the extracellular fluid and its intracellular concentration is dynamically regulated. As the queen of the electrolytes, it is of crucial importance to understand the physiological mechanisms that regulate the cellular handling of this anion including the different transporters and cellular chloride channels, which exert a variety of functions, such as regulation of cellular proliferation, differentiation, migration, apoptosis, intracellular pH and cellular redox state. In this article, we will also review the relationship between dietary, serum and intracellular chloride and how these different sources of chloride in the organism are affected in hypertension and their impact on cardiovascular disease. Additionally, we will discuss the approach of potential strategies that affect chloride handling and its potential effect on cardiovascular system, including pharmacological blockade of chloride channels and non-pharmacological interventions by replacing chloride by another anion.

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We conducted a double-blind randomized clinical trial in order to examine the effects and the safety of home-based transcranial direct current stimulation (tDCS) on depressive and anxious symptoms of patients with temporal lobe epilepsy (TLE). We evaluated 26 adults with TLE and depressive symptoms randomized into two different groups: active tDCS (tDCSa) and Sham (tDCSs). The patients were first submitted to 20 sessions of tDCS for 20 min daily, 5 days a week for 4 weeks and then received a maintenance tDCS application in the research laboratory once a week for 3 weeks. The intensity of the current was 2 mA, applied bilaterally over the dorsolateral prefrontal cortex, with the anode positioned on the left side and the cathode on the right side. Participants were evaluated on days 1, 15, 30, and 60 of the study using the Beck Depression Inventory II (BDI). A follow-up evaluation was performed 1 year after the end of treatment. They were also evaluated for quality of life and for anxious symptoms as secondary outcomes. The groups did not differ in clinical, socioeconomic or psychometric characteristics at the initial assessment. There was no statistically significant difference between groups regarding reported adverse effects, seizure frequency or dropouts. On average, between the 1st and 60th day, the BDI score decreased by 43.93% in the active group and by 44.67% in the Sham group (ΔBDIfinal - initial = -12.54 vs. -12.20, p = 0.68). The similar improvement in depressive symptoms observed in both groups was attributed to placebo effect and interaction between participants and research group and not to tDCS intervention per se. In our study, tDCS was safe and well tolerated, but it was not effective in reducing depressive or anxiety symptoms in patients with temporal lobe epilepsy. Clinical Trial Registration: [ClinicalTrials.gov], identifier [NCT03871842].

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Resumen En el curso de la demencia, la etapa avanzada se caracteriza por un deterioro cognitivo y físico severo, definiéndola como una etapa que incluye profundos déficits de memoria, habilidades verbales mínimas, incapacidad para deambular de forma independiente, incontinencia urinaria y fecal, y necesidad de asistencia para realizar cualquier actividad de la vida diaria básica. El presente reporte tiene por objeto comunicar un caso de una usuaria con 89 años con demencia avanzada que acude a control neurológico en compañía de su familia, quienes solicitan información de cómo mejorar la calidad de vida en esa etapa. Describimos una propuesta desde el enfoque de cuidados paliativos, específicamente la concepción terapéutica activa, como una guía que permita observar a la persona no sólo desde el buen morir, sino también desde la incorporación de una actitud proactiva en función del bienestar. Este enfoque permite facilitar experiencias placenteras, definidas dentro del marco de intervenciones no farmacológicas, las cuales han demostrado en la última década importantes beneficios en personas con demencia avanzada, permitiendo individualizar las estrategias de intervención en esta etapa de la enfermedad.

In the course of dementia, the advanced stage is characterized by severe cognitive and physical impairment, defining it as a stage that includes deep memory deficits, minimal verbal skills, inability to walk independently, need of assistance to perform any basic daily life activity and urinary and fecal incontinence. The aim of this report is to describe a case of a 89-year-old woman with Advanced Dementia who goes to neurological control in the company of her family, who request information on how to improve the quality of life at this stage. We describe a proposal of palliative care approach, specifically the active therapeutic conception, as a guide that allows to observe the person not only from the good dying, but also from the incorporation of a proactive attitude in function of well-being. This approach allows to facilitate pleasurable experiences, defined within the framework of Nonpharmacological intervention, which have shown important benefits in people with advanced dementia in the last decade, allowing the identification of intervention strategies in this stage of the disease.

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A controversy exists on whether there is an over or underuse of medications for Attention-Deficit/Hyperactivity Disorder (ADHD). We conducted the first meta-analysis to estimate the rate of ADHD pharmacological treatment in both diagnosed and undiagnosed individuals. Based on a pre-registered protocol (CRD42018085233), we searched a broad set of electronic databases and grey literature. After screening 25,676 abstracts, we retained 36 studies including 104,305 subjects, from which 18 studies met our main analysis criteria. The pooled pharmacological treatment rates were 19.1 % and 0.9 % in school-age children/adolescents with and without ADHD, respectively. We estimated that for each individual using medication without a formal ADHD diagnosis, there are three patients with a formal diagnosis who might benefit from medication but do not receive it in the US. Our results indicate both overtreatment/misuse of medication in individuals without ADHD and pharmacological undertreatment in youths with the disorder. Our findings reinforce the need for public health policies improving education on ADHD and discussions on the benefits and limitations of ADHD medications.

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Resumen A lo largo de la historia, el ser humano ha buscado mejorar y tratar las diferentes patologías mentales. Con los avances en investigación, actualmente hay una amplia variedad de opciones terapéuticas que pueden resultar un factor de confusión a la hora de escoger el tratamiento más adecuado para combatir el trastorno depresivo. Por tanto, en el presente trabajo se realiza una revisión de las principales opciones de tratamiento para la depresión con el fin de brindar pautas que mejoren la toma de decisiones al abordar esta patología.

Abstract Throughout history, the human being has sought to improve and treat different mental pathologies, with advances in research, currently there is a wide variety of therapeutic options that can be a confounding factor when choosing the most appropriate treatment. This paper reviews the main treatment options for depression in order to provide guidelines that improve decision-making when addressing this pathology.

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RESUMEN La pandemia por el coronavirus del síndrome respiratorio agudo grave de tipo 2 (SARS-CoV-2) parece estar en un momento crítico en 2021. A la esperanzadora llegada de las vacunas se opone la emergencia de variantes del virus más agresivas. En Argentina comenzó la segunda ola, con 29 472 casos el 16 de abril de 2021. En el país se dispone de vacunas, aunque en cantidad insuficiente para alcanzar la inmunidad de rebaño. En consecuencia, urge diseñar estrategias sobre la base de intervenciones no farmacológicas para disminuir los casos mientras avanza la campaña de vacunación. En este artículo se realiza una revisión bibliográfica descriptiva sobre intervenciones de este tipo utilizadas en diferentes lugares del mundo.

ABSTRACT He severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic appears to be at a critical juncture in 2021. The hopeful arrival of vaccines is opposed by the emergence of more aggressive variants of the virus. The second wave began in Argentina, with 29,472 cases on April 16, 2021. Vaccines are available in the country, although in insufficient quantity to achieve herd immunity. Consequently, it is urgent to design strategies based on non-pharmacological interventions to reduce cases while the vaccination campaign progresses. In this article, a descriptive bibliographic review is carried out on interventions of this type? used in different parts of the world.

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RESUMEN Las opciones terapéuticas son limitadas para los pacientes con insuficiencia cardíaca avanzada que se vuelven refractarios a las terapias farmacológicas convencionales. Conocer las alternativas no farmacológicas en el tratamiento de estos enfermos resulta imprescindible en su evaluación integral, y es la segunda opción terapéutica en este grupo de enfermos cada vez más prevalentes.

ABSTRACT Therapeutic options are limited for patients with advanced heart failure who become refractory to conventional drug therapies. Knowing the non-pharmacological alternatives in the management of these patients is essential in their comprehensive evaluation, and it is the second therapeutic option in this group of increasingly prevalent patients.

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BACKGROUND: non-pharmacological interventions to prevent delirium are useful in hospitalised older adults. However, they are poorly implemented in clinical practice. We aimed to develop a software for bedside use by hospitalised older adults and to improve their access to these interventions. METHODS: a transdisciplinary team composed of healthcare professionals, designers, engineers and older adults participated in the development of the software. Scrum methodology was used to coordinate the work of the team, and the software was evaluated in a feasibility study. RESULTS: a software for touchscreen mobile devices that supports Android 5.0 or later was produced, including modules for time-spatial re-orientation, cognitive stimulation, early mobilisation, sensorial support use promotion, sleep hygiene and pain management optimisation. Horizontal disposition, use of colour contrast and large interaction areas were used to improve accessibility. The software's usability and accessibility were evaluated in 34 older adults (average age 73.2 ± 9.1 years) showing that 91.1% of them got access to all the software functions without previous instructions. The clinical feasibility assessment showed that 83.3% of the 30 enrolled hospitalised patients (76 ± 8 years) completed the 5-day protocol of software usage during hospitalisation. Software use was associated with a decreased trend in delirium incidence of 5 of 32 (15.6%) at baseline to 2 of 30 (6.6%) after its implementation. CONCLUSION: a highly accessible and implementable software, designed to improve access to non-pharmacological interventions to prevent delirium in hospitalised older adults, was developed. The effectiveness of the software will be evaluated in a randomised clinical trial.

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RESUMO

El dolor es una experiencia sensorial y emocional desagradable producida por daño tisular potencial o real y descrito de esta forma por el individuo que lo padece. Sin embargo, los recién nacidos no lo pueden comunicar, esto significa que la experiencia de dolor es subjetiva e implica la expresión de un componente emocional. El estrés es una amenaza real o percibida como tal, provocando una alteración del equilibrio dinámico entre el organismo y el medio. El estudio tuvo por objetivo determinar conocimiento e intervenciones no farmacológicas del profesional de enfermería para reducir dolor y estrés neonatal en el Hospital de Clínicas - Paraguay en el 2016. La investigación fue observacional, descriptiva, corte transversal, con enfoque cuantitativo. La población constó de 36 licenciados en enfermería seleccionados mediante muestreo no probabilístico por conveniencia. El método fue la encuesta, empleando como técnica la entrevista, el instrumento fue el cuestionario. Los datos fueron tabulados en planillas electrónicas Microsoft Excel 2010, interpretados por Epi Info 7.2.0.1., a partir de los resultados se construyeron tablas y gráficos elaborados en Microsoft Excel. La mayoría tenía entre 31 y 40 años de edad, predominaba el sexo femenino, y tenía una antigüedad de entre 1 a 10 años. Se identificó que un reducido grupo conocía las intervenciones no farmacológicas para reducir el dolor y el estrés, y la gran mayoría las realizaba. Estos resultados reflejan la carencia en la base de los conocimientos y la adquisición empírica de las prácticas(AU)

Pain is a disgusting sensorial and emotional experience, produced by potential or real tissue damage, and described in that way by the person who suffers. Nevertheless, newborns cannot communicate it. This means that pain experience is subjective and implies the expression of an emotional component. Stress is a real threat or perceived as such, provoking a disturbance on the dynamic equilibrium between the organism and the medium. The study had as objective to determinate the knowledge and non-pharmacological interventions of the professional nurse in order to reduce neonatal pain and stress at the Hospital de Clínicas in Paraguay during 2016. This was an observational, descriptive, cross-sectional study with quantitative approach. The population consisted of 36 nurses which were selected by non-probabilistic convenience sampling. The method was the survey, using the interview and the questionnaire as the instrument. The data was tabulated on Microsoft Excel 2010 electronic spreadsheets and analyzed by Epi Info 7.2.0.1. Then, tables and graphics were developed from the results elaborated in Microsoft Excel. The majority was between 31 and 40 years old, females predominated and has between 1 to 10 year careers. It was identified that a reduced group knew non-pharmacological interventions and a high percentage practiced them. These results reflect knowledge deficiency and empirical acquisition of practices(AU)

Assuntos