RESUMO
SUMMARY: The aim was to analyze the relationship between somatic maturation and physical performance in male youth soccer players belonging to a professional Mexican academy. In 121 male soccer aged 11 to 16 years from a professional academy the peak height velocity (PHV), percentage of adult height (PAS), jump capacity, sprint, intermittent speed and muscle mass were estimated. ANOVA was conducted to compare performance variables among maturity somatic categories and percentiles were calculated based on maturity offset using LMS method. Furthermore, a general linear model was employed to determine the explanatory variables for performance. Post-PHV soccer players demonstrated superior physical performance across several tests compared to Pre-PHV (p<0.001) and Circa-PHV (p<0.001) players. The smoothed percentile values of performance tests, based on somatic maturation, indicated progressive performance enhancement as individuals approached PHV (-2 to 2 years from PHV) (p<0.005). PHV was associated with jump capacity (p<0.001) and intermittent speed (p=0.007) while PAS was associated with time in sprint (p=.0004). In conclusion PHV and PAS explained better performance than chronological age, body composition characteristics, injuries, or training factors.
El objetivo fue analizar la relación entre la maduración somática y el rendimiento físico en futbolistas juveniles masculinos pertenecientes a una academia profesional mexicana. Métodos. En 121 futbolistas masculinos de 11 a 16 años de una academia profesional se estimó la velocidad máxima en altura (VPH), porcentaje de altura adulta (PAS), capacidad de salto, sprint, velocidad intermitente y masa muscular. Se realizó ANOVA para comparar variables de desempeño entre categorías somáticas de madurez y se calcularon percentiles en función de la compensación de madurez utilizando el método LMS. Además, se empleó un modelo lineal general para determinar las variables explicativas del desempeño. Los jugadores de fútbol post-PHV demostraron un rendimiento físico superior en varias pruebas en comparación con los jugadores Pre-PHV (p<0,001) y Circa-PHV (p<0,001). Los valores percentiles suavizados de las pruebas de rendimiento, basados en la maduración somática, indicaron una mejora progresiva del rendimiento a medida que los individuos se acercaban al PHV (-2 a 2 años desde el PHV) (p<0,005). PHV se asoció con la capacidad de salto (p<0,001) y velocidad intermitente (p=0,007) mientras que PAS se asoció con el tiempo en sprint (p=0,0004). En conclusión PHV y PEA explicaron un mejor rendimiento que la edad cronológica, las características de composición corporal, las lesiones o los factores de entrenamiento.
Assuntos
Humanos , Masculino , Criança , Adolescente , Futebol , Estatura , Aptidão Física , Antropometria , Estudos Transversais , Análise de VariânciaRESUMO
Abstract Objectives: The aim was to estimate the pubertal growth height of children and adolescents living in a high-altitude region of Peru using the Preece-Baines model 1 (1 PB). Methods: A cross-sectional study was conducted in schoolchildren from the department of Puno (Peru) between 3841 and 3874 masl. The age range was between 4 and 17 years. Standing height was evaluated. 1 PB was used to infer the mathematical and biological parameters of stature. Results: Mathematical parameters estimated by the 1 PB model reflected small residual standard error (RSE) values in both sexes (0.25 in boys and 0.27 in girls). In boys, the age at which peak velocity was reached (APHV) was estimated at 13.21 ± 0.33years. While in girls it was 9.96 ± 0.26years (p < 0.05). In general, girls reached APHV (y) 3.25 years earlier than boys. On the other hand, the growth velocity of maximum height [APHV (cm/y)] of boys was higher (6.33 ± 6.06 cm/y) relative to girls (6.06 ± 0.32 cm/y). Estimated final adult height (EFAH) in boys was reached at 166.020 ± 0.99 cm and height at maximum growth velocity (HPHV) was 153.07 ± 0.67 cm, while in girls they were significantly lower (EFAH; 153.74 ± 0.44 cm and HPHV: 139.73 ± 0.84 cm). Conclusions: This study showed that girls living in Puno at a high altitude in Peru reached APHV 3 years earlier than boys and at the same time reflected slower PHV. These results suggest that pubertal growth at high altitudes is slower in both sexes and especially in girls. Thus, modeling physical growth may be an important step in understanding the onset of puberty at different latitudes.
RESUMO
Existing research on human growth in Mexico is regionally focused, creating a gap in the understanding of growth patterns of children and adolescents at national level and regional variation. The objective of the present study was to characterize the height growth curve of the Mexican population by geographic area and to cluster the states of the Mexican Republic according to their somatic maturation characteristics, based on a national representative sample of boys. Data on age, height, socioeconomic level, and geographic area of 18,219 boys were obtained from the National Health and Nutrition Survey 2012 (ENSANUT) and ENSANUT 2018, carried out in 32 Mexican states. Both surveys had representative samples. Preece-Baines 1 model was applied to fit height growth curves. Biological parameters were estimated; principal component analysis and cluster analysis were performed to group Mexican states based on these biological parameters. The estimated age at peak height velocity (PHV) was 12.3 years in the sample. Significant regional differences in the timing and tempo of PHV among Mexican boys were observed. Boys in the northern region experienced PHV at an earlier age and had a shorter duration of growth compared with boys in the central and southern regions. Boys in the central region had a longer duration of growth and a later age of PHV compared with the boys in the southern region. The cluster that included the southern states of the country showed estimated lower adult height and earlier somatic maturation. A lower height was found in the low and low-middle socioeconomic levels compared with the medium-high and high socioeconomic levels. Future research in Mexico should focus on longitudinal studies to analyse the timing and tempo of growth and maturation, considering the impacts of environmental and genetic factors. Public health strategies should account for geographic variations.
Assuntos
Estatura , Inquéritos Nutricionais , Humanos , Masculino , México , Criança , Adolescente , Fatores Socioeconômicos , Análise por Conglomerados , Geografia , Desenvolvimento Infantil , Pré-EscolarRESUMO
The present study aimed to estimate the height growth curve for Mexican boys and girls based on their body mass index (BMI) status (normal and overweight/obese) and to develop a height Lambda, Mu, and Sigma (LMS) growth reference for Mexican children aged 2 to 18 years. Methods: Chronological age and height records (7,097 boys and 6,167 girls) were obtained from the Mexican National Survey of Health and Nutrition database. Height growth curves were fitted using the Preece-Baines 1 (PB1) model and the LMS method. Results: Age at peak height velocity (APHV) was 12.4 and 12.7 years for overweight-obese and normal-weight boys, respectively, and was 9.6 and 10.4 years for overweight-obese and normal-weight girls, respectively. Growth velocity was higher at the age of take-off (TO) in overweight-obese children than in normal-weight children (5.2 cm/year vs. 5 cm/year in boys and 6.1 cm/year vs. 5.6 cm/year in girls); nevertheless, the growth velocity at APHV was higher for normal-weight children than for overweight-obese children (7.4 cm/year vs. 6.6 cm/year in boys and 6.8 cm/year vs. 6.6 cm/year in girls, respectively). Distance curves developed in the present study and by the World Health Organization (WHO) using LMS showed similar values for L and S parameters and a higher M value compared with the WHO reference values. Conclusion: This study concluded that overweight-obese children had earlier APHV and lower PHV than normal-weight children. Furthermore, Mexican children and adolescents were shorter than the WHO growth reference by age and sex.
Assuntos
Sobrepeso , Obesidade Infantil , Masculino , Adolescente , Feminino , Humanos , Criança , Sobrepeso/epidemiologia , Peso Corporal , Obesidade Infantil/epidemiologia , Estatura , Índice de Massa CorporalRESUMO
PURPOSE: To evaluate whether there is a mismatch between Risser staging and the proximal humerus ossification system (PHOS); and to analyze the correlation in the skeletal maturity stages between the two humeral epiphyses. METHODS: Data from patients aged 10 to 18 years with adolescent idiopathic scoliosis (AIS) seen between 2018 to 2021 were analyzed. In an anteroposterior (AP) spine radiograph the ossification process was evaluated using the Risser classification method and bilateral PHOS (if both humeral epiphyses were visualized). A mismatch between methods was defined as a Risser 0-1 (relatively skeletally immature) with a PHOS 4-5 (skeletally mature), or a Risser 2-5 (relatively skeletally mature) with a PHOS 1-3 (skeletally immature). The McNemar test was used to calculate the significance of the mismatch. RESULTS: A mismatch between Risser and PHOS stages was observed in 28.5% of 105 patients, which was statistically significant (p < 0.001). Of the 49 patients with a Risser 0-1, 55.1% (n = 27) had a PHOS 4-5. None of the patients with a Risser 2-5 had a PHOS 1-3. In the 47 patients in whom both humeri were visualized, the absolute correlation between the left and right PHOS values was 95.7%. CONCLUSION: Of AIS patients who are relatively skeletally immature according to Risser staging, more than half may be skeletally mature when measured with PHOS. In patients with a Risser 0-1, it is recommended to measure skeletal maturity in an AP spine radiograph using the PHOS method, which may more accurately guide treatment decision-making, without the need to visualize both humeral epiphyses in this radiographic projection. LEVEL OF EVIDENCE: IV.
Assuntos
Úmero , Osteogênese , Escoliose , Humanos , Escoliose/diagnóstico por imagem , Escoliose/patologia , Adolescente , Feminino , Criança , Masculino , Osteogênese/fisiologia , Úmero/diagnóstico por imagem , Úmero/crescimento & desenvolvimento , Úmero/patologia , Radiografia/métodos , Estudos Retrospectivos , Epífises/diagnóstico por imagem , Epífises/crescimento & desenvolvimento , Epífises/patologia , Índice de Gravidade de Doença , Determinação da Idade pelo Esqueleto/métodosRESUMO
OBJECTIVES: The aim was to estimate the pubertal growth height of children and adolescents living in a high-altitude region of Peru using the Preece-Baines model 1 (1 PB). METHODS: A cross-sectional study was conducted in schoolchildren from the department of Puno (Peru) between 3841 and 3874 masl. The age range was between 4 and 17 years. Standing height was evaluated. 1 PB was used to infer the mathematical and biological parameters of stature. RESULTS: Mathematical parameters estimated by the 1 PB model reflected small residual standard error (RSE) values in both sexes (0.25 in boys and 0.27 in girls). In boys, the age at which peak velocity was reached (APHV) was estimated at 13.21 ± 0.33years. While in girls it was 9.96 ± 0.26years (p < 0.05). In general, girls reached APHV (y) 3.25 years earlier than boys. On the other hand, the growth velocity of maximum height [APHV (cm/y)] of boys was higher (6.33 ± 6.06 cm/y) relative to girls (6.06 ± 0.32 cm/y). Estimated final adult height (EFAH) in boys was reached at 166.020 ± 0.99 cm and height at maximum growth velocity (HPHV) was 153.07 ± 0.67 cm, while in girls they were significantly lower (EFAH; 153.74 ± 0.44 cm and HPHV: 139.73 ± 0.84 cm). CONCLUSIONS: This study showed that girls living in Puno at a high altitude in Peru reached APHV 3 years earlier than boys and at the same time reflected slower PHV. These results suggest that pubertal growth at high altitudes is slower in both sexes and especially in girls. Thus, modeling physical growth may be an important step in understanding the onset of puberty at different latitudes.
Assuntos
Altitude , Puberdade , Masculino , Criança , Feminino , Humanos , Adolescente , Pré-Escolar , Peru , Estudos Transversais , Estatura , CrescimentoRESUMO
CONTEXT: Prepubertal adiposity is associated with earlier puberty. It is unclear when this association starts, if all adiposity markers are similarly associated, and whether all pubertal milestones are similarly affected. OBJECTIVE: To evaluate the association between different adiposity markers during childhood and the timing of different pubertal milestones in Latino girls. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort recruited from childcare centers (mean age 3.5 years) from the southeast area of Santiago, Chile. Participants were singletons born between 2002 and 2003 within the normal birthweight range. Since 2006, a trained dietitian measured weight, height, waist circumference (WC) and skinfolds to estimate body mass index (BMI) Centers for Disease Control and Prevention percentiles, central obesity, percentage of fat mass (%FM), and fat mass index (FMI, fat mass/height2). MAIN OUTCOME: Since 2009, sexual maturation was assessed every 6 months to assess age at (1) thelarche, (2) pubarche, (3) menarche, and (4) peak height velocity (PHV). RESULTS: At thelarche, 12.5% were obese and 2% had central obesity. The median age of pubarche, menarche, and PHV were all associated with markers of adiposity at different time points during childhood whereas thelarche only with %FM and FMI. Adiposity clusters models showed that children with trajectories of high WC, %FM, and FMI during childhood were related with earlier thelarche, pubarche, menarche, and PHV but BMI trajectories only with menarche and PHV. CONCLUSIONS: Higher WC, %FM, and FMI were associated with earlier age at thelarche, pubarche, menarche, and PHV. The effect of BMI was less consistent.
Assuntos
Adiposidade , Hispânico ou Latino , Menarca , Criança , Pré-Escolar , Feminino , Humanos , Adiposidade/etnologia , Adiposidade/fisiologia , Índice de Massa Corporal , Hispânico ou Latino/estatística & dados numéricos , Menarca/etnologia , Menarca/fisiologia , Obesidade/epidemiologia , Obesidade/etnologia , Obesidade/fisiopatologia , Obesidade Abdominal/epidemiologia , Obesidade Abdominal/etnologia , Obesidade Abdominal/fisiopatologia , Puberdade , Chile/epidemiologiaRESUMO
This study examined the relationship between maturation and signal detection skills, as well as the effect of signal detection on the tactical behavior efficiency of young soccer players. Fifty-four male soccer players participated in the study (U-11, U-13, and U-15). Maturation was evaluated by the Khamis-Roche method, and peak height velocity was estimated. A computer-based test in the Vienna Test System® was used to assess signal detection skills, whereas tactical behavior efficiency was assessed using the System of Tactical Assessment in Soccer. Descriptive analysis, the Kolmogorov-Smirnov test, the Spearman bivariate correlation and the univariate analysis of variance (one-way ANOVA) were performed. Effect sizes were reported as Cohen's d, and the significance level was set at p < .05. Relationships were observed between the percentage of predicted adult height and signal detection performance. Also, signal detection skills were found to affect the tactical behavior efficiency of young soccer players. It is concluded that the players, as seen more mature, can perceive the game faster and more effectively, and are able to provide quicker responses in the game context.
Assuntos
Desempenho Atlético , Futebol , Análise de Variância , Desempenho Atlético/fisiologia , Estatura , Humanos , Masculino , Futebol/fisiologiaRESUMO
BACKGROUND: Data relating physical performance to the timing of the adolescent growth spurt are limited. Aim: This study identifies: (i) age-at-peak height velocity (APHV), (ii) physical performance spurt patterns aligned to APHV; and (iii) cross-cultural and time patterns in Canadian, Brazilian and Portuguese boys. Subjects and methods: A total of 512 boys (131 Canadian, 250 Portuguese and 131 Brazilian), 8-17 years of age were followed serially using longitudinal data. APHV was identified and five physical performance measures velocities [trunk extension (TE), trunk flexion (TF), standing long jump (SLJ), curl-ups (CU) and handgrip strength (HG)] were aligned at 6-month intervals, 4 years around the attainment of PHV. Velocities were estimated using a non-smooth mathematical procedure. Results: APHV was 13.9 ± 1.0, 13.4 ± 1.6 and 13.0 ± 0.8 years for Canadian, Brazilian and Portuguese boys, respectively. Maximal velocity in SLJ was attained between 12 and 6 months prior to PHV. For HG, peaks were attained 12-24 months after PHV. Maximal velocity in TE occurred between 12 and 0 months prior to PHV, while CU peaked between PHV and 6 months after PHV. Conclusion: Patterns of spurts in physical performance have remained relatively the same and do not appear to be influenced by cross-cultural differences.
Assuntos
Comparação Transcultural , Desempenho Físico Funcional , Adolescente , Brasil , Canadá , Criança , Humanos , Estudos Longitudinais , Masculino , PortugalRESUMO
Growth and physical performance scores were studied around three years of attainment of peak height velocity (PHV). We aimed to estimate the age at peak velocity, or at peak rate, in physical performance tasks, and sex-differences when aligned by biological age. A total of 131 boys and 123 girls, 8 to 14 years of age were recruited from the Cariri region of Brazil. A mixed longitudinal design was used with four overlapping age cohorts: 8, 10, 12, and 14 years, followed for three years, with measurements performed at 6 month intervals. Height, 12 min run (12mR), handgrip strength (HG), standing long jump (SLJ), and shuttle run (SR) velocities were estimated using a non-smooth mathematical procedure. Age at PHV was 13.4 ± 1.6 years in boys compared with 12.2 ± 2.3 years in girls. Maximal velocity in SLJ was attained 6 and 3 months prior to PHV in boys and girls, respectively. For HG, peaks were attained 9 months after PHV in boys and 15 months after PHV in girls. Maximal velocity in 12mR was attained 6 months before PHV in boys and at PHV in girls, whereas a peak in SR occurred 12 months after PHV in both sexes. In conclusion, dynamic changes in physical performance relative to PHV appear similar in both sexes, although sex differences were evident in some motor tests.
Assuntos
Desenvolvimento do Adolescente/fisiologia , Estatura/fisiologia , Desenvolvimento Infantil/fisiologia , Desempenho Físico Funcional , Adolescente , Fatores Etários , Brasil , Criança , Feminino , Força da Mão/fisiologia , Nível de Saúde , Humanos , Estudos Longitudinais , Masculino , Caracteres SexuaisRESUMO
O objetivo do estudo foi investigar a relação entre maturação biológica, modulação parassimpática da frequência cardíaca e teste de resistência intermitente em jovens jogadores de futebol. Participaram do estudo 23 jovens futebolistas (15,3 ± 1,1 anos, 175 ± 6 cm, 64 ± 7 kg) das categorias sub15 e sub17 de uma equipe da 1ª divisão do campeonato paulista. O estado maturacional foi determinado pela idade do pico de velocidade de crescimento (PVC), usado como indicador relativo de maturidade somática calculada através das medidas de estatura, altura tronco-cefálica, comprimento das pernas, massa corporal e as dobras cutâneas. As medidas de variabilidade da frequência cardíaca (VFC) foram obtidas em repouso durante 5 minutos e, posteriormente, analisadas pela variável raiz quadrada da média dos quadrados das diferenças entre intervalos RR normais adjacentes (rMSSD). Os indivíduos realizaram o teste de resistência intermitente, Yoyo intermittent recovery test level 2 (YIRT 2), após as medidas de VFC terem sido obtidas. Os resultados do presente estudo mostram que não há relação entre modulação parassimpática da frequência cardíaca (rMSSD = 57,4 ± 26,4 ms) e o estado de maturação biológica (0,67 ± 0,81 anos) dos jovens futebolistas (r= 0,30; p=0,163), enquanto que o teste de resistência intermitente (YIRT 2= 658 ± 151 m) possui uma grande correlação com o pico de velocidade de crescimento (r= 0,71; p< 0,001). A modulação parassimpática da frequência cardíaca possui grande correlação com o teste de resistência intermitente dos jogadores (r= 0,54; p= 0,007). Conclui-se que a utilização da idade do PVC e da VFC como indicador de desempenho no YIRT2 em jovens futebolistas....(AU)
The aim of the study was to investigate the relationship between biological maturation, parasympathetic heart rate modulation and intermittent endurance test in young soccer players. Participated of the study 23 young soccer players (15.3 ± 1.1 years, 175 ± 6 cm, 64 ± 7 kg) of the sub15 and sub17 categories of the team from the 1st division championship Paulista. The maturational status was determined by the age of the peak height velocity (PHV), used as relative indicator of somatic maturity and are calculated trhough measures of height, trunk-cephalic height, leg length, body weight, and skinfolds. The Heart rate variability (HRV) measures were obtained in rest during 5 minutes and, posteriorly, analyzed by the variable root mean square of the successive difference (rMSSD). For the intermittent endurance test the subjects performed the Yoyo intermittent recovery test level 2 (YIRT 2), before the HRV measures has been taken. The results of the present study shown which there was not relationship between parasympathetic heart rate modulation (rMSSD = 57,4 ± 26,4 ms) and status biological maturation (0,67 ± 0,81 years) of the young soccer players (r= 0,30; p=0,163), then that the intermittent endurance test (YIRT 2= 658 ± 151 m) has a great correlation with PHV (r= 0,71; p< 0,001). The parasympathetic heart rate modulation has a great correlation with intermittent endurance test of the players (r= 0,54; p= 0,007). In this way, the use of the PHV age and HRV as indicator of performance in YIRT2 in young soccer players is suggested....(AU)
Assuntos
Humanos , Masculino , Adolescente , Educação Física e Treinamento , Futebol , Frequência CardíacaRESUMO
OBJECTIVE: To examine the associations of in utero exposure to maternal diabetes with surrogate measures of offspring pubertal timing (age at peak height velocity [APHV]) and speed of pubertal growth (peak height velocity [PHV]). STUDY DESIGN: Data from 77 exposed and 340 unexposed youth followed from age 2 to 19 years (51% non-Hispanic white, 50% female) were analyzed using the Exploring Perinatal Outcomes among Children study, a historical prospective cohort. Maternal diabetes status was collected from obstetric records, and child heights from 2 years to current age from pediatric records. Other covariates were collected during research visits. The superimposition by translation and rotation method, using height measurements (4-52 per participant), modeled APHV and PHV. Accelerated failure time analyses were used to test whether exposure to maternal diabetes was associated with younger APHV and faster PHV. RESULTS: Adjusting for child's sex, race/ethnicity, and socioeconomic status, median APHV was reached ~3 months earlier in youth exposed to maternal diabetes compared with unexposed youth (P < .03). Youth exposed to maternal diabetes had a faster PHV than unexposed youth: exposed girls had 10.5% greater median PHV compared with unexposed girls and exposed boys had a 4.0% greater median PHV compared with unexposed boys (P < .001 for exposure by sex interaction). CONCLUSIONS: Our findings provide evidence that exposure to maternal diabetes in utero is associated with earlier pubertal timing and faster pubertal growth. Whether earlier puberty or faster speed of pubertal growth mediates the association between maternal diabetes exposure and later chronic disease risk remains to be studied.
Assuntos
Diabetes Mellitus Tipo 1/fisiopatologia , Diabetes Gestacional/fisiopatologia , Gravidez em Diabéticas/fisiopatologia , Efeitos Tardios da Exposição Pré-Natal , Puberdade Precoce/etiologia , Adolescente , Antropometria , Estatura , Índice de Massa Corporal , Criança , Pré-Escolar , Colorado/epidemiologia , Diabetes Mellitus Tipo 1/complicações , Feminino , Humanos , Masculino , Menarca , Gravidez , Estudos Prospectivos , Puberdade , Maturidade Sexual , Classe Social , Adulto JovemRESUMO
The aim was to analyse the physical growth and body composition of rhythmic gymnastics athletes relative to their level of somatic maturation. This was a cross-sectional study of 136 athletes on 23 teams from Brazil. Mass, standing height and sitting height were measured. Fat-free and fat masses, body fat percentages and ages of the predicted peak height velocity (PHV) were calculated. The z scores for mass were negative during all ages according to both WHO and Brazilian references, and that for standing height were also negative for all ages according to WHO reference but only until 12 years old according to Brazilian reference. The mean age of the predicted PHV was 12.1 years. The mean mass, standing and sitting heights, body fat percentage, fat-free mass and fat mass increased significantly until 4 to 5 years after the age of the PHV. Menarche was reached in only 26% of these athletes and mean age was 13.2 years. The mass was below the national reference standards, and the standing height was below only for the international reference, but they also had late recovery of mass and standing height during puberty. In conclusion, these athletes had a potential to gain mass and standing height several years after PHV, indicating late maturation.
Assuntos
Composição Corporal , Estatura , Ginástica/fisiologia , Adolescente , Índice de Massa Corporal , Criança , Estudos Transversais , Feminino , Humanos , Menarca , Educação Física e Treinamento , Maturidade Sexual , Fatores de TempoRESUMO
OBJECTIVES: To test the hypothesis that pubertal peak height velocity (PHV) in cystic fibrosis (CF) has improved and is influenced by prepubertal growth and genetic potential. STUDY DESIGN: PHV from 1862 children born in 1984-87 and documented in the 1986-2008 US CF Foundation Registry was determined by statistical modeling and classified into normal, delayed (2-SD > average age), attenuated (magnitude <5th percentile), or both delayed and attenuated (D&A). Genetic potential for height was estimated by parental stature. RESULTS: PHV averaged 8.4 cm/year at age 14.0 years in boys and 7.0 cm/year at age 12.1 years in girls, â¼6-month delay and â¼15% reduction compared with healthy children. PHV was normal in 60%, delayed in 9%, attenuated in 21%, and D&A in 5%. Patients with delayed PHV reached similar adult height percentile (boys: 34th, girls: 46th) to those with normal PHV (boys: 33rd, girls: 34th); both were significantly taller than the attenuated (boys: 11th, girls: 19th) and D&A PHV subgroups (boys: 8th, girls: 14th). Pancreatic-sufficient patients had taller prepubertal and adult heights but similar PHV compared with pancreatic-insufficient or meconium ileus patients. Adjusting for genetic potential reduced adult height percentiles more in boys (from 25th to 16th) than girls (from 28th to 24th). Height at age 7 years, PHV age and magnitude, and parental stature significantly predicted adult height. CONCLUSIONS: Pubertal PHV has improved in children with CF born after mid-1980s compared with older cohorts but remains below normal. Suboptimal prepubertal and pubertal growth led to adult height below genetic potential in CF.