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BACKGROUND: Morus nigra L. is a plant with significant potential for drug development due to the presence of numerous bioactive compounds in its various parts. OBJECTIVES: This article aims to compile the technological perspectives of Morus nigra L. towards drug development and therapeutic indications based on registered patents in databases. METHODS: The study analyzed patents published within the last five years, focusing on products derived from different parts of the Morus nigra L. plant. Patent databases such as the European Patent Office (EPO), the United States Patent and Trademark Office (USPTO), the World Intellectual Property Organization (WIPO), and the National Institute of Industrial Property Databases (INPI) were examined. RESULTS: A total of 45 patents were categorized by country of origin, type of applicant, extraction method, and therapeutic indications. China had the highest number of patent filings (43.48%), and private companies were the primary technology patent holders (38.64%). Noteworthy extraction methods included ultrasound-assisted extraction, decoction, infusion, and maceration. The most utilized plant parts were leaves (44.44%), followed by fruits (35.56%), root bark (15.56%), and stems (4.44%). The main therapeutic indications identified were the treatment of hyperglycemia and dyslipidemia (43.33%), along with digestive problems, cosmetics, nutrition, and cleaning applications. CONCLUSION: The study of patents covers discoveries and advancements often absent in scientific articles, making a review focused on this advanced information crucial for expanding existing scientific knowledge. Even if some therapies have been explored previously, patents can reveal innovative approaches and fresh perspectives that contribute to sustained scientific progress.

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Food science innovation depends on consumers' needs and is currently seeking functional food with health effects. Non-centrifugal cane sugar (NCS) is known for its potential health effects, but there is a lack of holistic analysis on technological advancement and socio-economic and market trends for decision-making in the development of the technology. The aim of this article was to analyse the research trends, recent patents, and market trends and niches for NCS to structure an NCS technological roadmap. Scientometric, bibliometric methods, and global and local market information on NCS were used. Comprehensive analysis of the worldwide research trends and patents on NCS processing and of the growth of the main niche markets for Colombian NCS exports in the last five years was conducted. Finally, with the information obtained, an NCS technological roadmap was structured, which can be used as a tool for planning innovation processes and supporting the development of new research using market information and new norms forged by the COVID-19 pandemic for Colombian case. Furthermore, the methodological design could be used for other NCS producer countries. Supplementary Information: The online version contains supplementary material available at 10.1007/s12355-022-01200-9.

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BACKGROUND: Cancer is caused by mutations in oncogenes and loss of tumor suppressor activity. Despite the efforts of the pharmaceutical industry to fight cancer, it is necessary to investigate new methods to enhance the action against this disease. In this scenario, liposome technology has emerged as a drug delivery system for cancer treatment. The objective of this study was to evaluate the use of liposome technology in the treatment of cancer through analysis of patent documents. METHODS: We analyzed prospective documents in the Derwent Innovation Index database. RESULTS: A total of 203 patent documents were related to the area of interest, published between 2000 and 2020, and the USA and Japan were shown as countries with the largest number of publications. Moreover, most of these publications came from companies, however, also with the representation of important universities, mainly the University of California. According to the International Patent Classification, the codes most applicable to the documents were in the areas of human necessities and chemistry. CONCLUSION: The results of this study showed that the study and application of liposomes for the development of cancer treatment tended to grow, along with the number of related patents.

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This work shows a patent database for Coronaviruses that provides an overview of the patenting activity and trends in focused antiviral therapy with the use of triazole based compounds, glycoprotein, and protease inhibitors as possible treatment. The patent data was obtained from Orbit Intelligence Software using a patent family structure to get a big database that could be used for built patent landscape report (PLR), market analysis, technical and competitive intelligence, and monitoring and survey of a new ideas for the treatment of coronavirus diseases. The raw data is reported in four databases, which were classified according to different items: legal status (alive, dead), 1st application year (after 2015, 2011-2015, 2006-2010, 2001-2005), and Top 5 International Patents Classifications (IPC). The main players, the investment trend, markets, geographical distribution, technology overview, technologies distribution, and patent citation are showed by this analysed data report.

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Scientific research at universities has a crucial role in leveraging a country's innovative potential. Sectors that require greater investments in technology for the development of their research, such as biotechnology, need to be aware of the frontier state-of-the-art technology and the knowledge incrusted within it. Although the information available in scientific articles is well explored in academic environment, the patent literature, where much of the technological information is present, is still poorly accessed. This chapter is intended to instruct students and researchers at universities to look at patent document analysis as a source of scientific and technological information and explore its applications. Within this chapter, we use the technological area regarding immunoglobulins inventions (monoclonal and polyclonal antibodies) as example to provide directions on how to develop a patent landscape to get an overview of the inventions in a certain field; how to map a collaborative network of inventors/assignees to help the pursuit and identification of future partnerships; and lastly we describe the steps of how to set up a network of patent citations with the aim of forecasting emerging technologies. We strongly believe that incorporate data from patents in planning phase of research projects at academia, as well as to establish partnerships and join R&D efforts to invest on promising technologies, is of great relevance to leverage the growth of the biotechnology sector.

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El pasado siglo demostró que la capacidad de innovación tecnológica de un país se ha convertido en un factor determinante en sus resultados socioeconómicos. Esta situación, entre otras causas, ha propiciado una fuerte tendencia a realizar análisis con diferentes fuentes de información especializadas, con la intención de lograr por medio de ellos una orientación para obtener innovaciones aún más exitosas y radicales. Entre estas fuentes de información se distinguen, con gran protagonismo, los documentos de patentes. La consulta y análisis con técnicas métricas de la información contenida en las patentes se ha transformado en una de las principales herramientas para modelar los escenarios tecnológicos de países, empresas, institutos de investigación, temáticas, proyectos, etcétera. Con el empleo de una serie de indicadores métricos es posible identificar patrones y tendencias a partir de la evidencia tecnológica disponible y detectar posibles redes sociales encubiertas de innovación con diferentes comportamientos en la investigación, con vista, entre otras funciones, a la toma de decisiones oportunas si esta lo requiere. Para ilustrar el procedimiento, se utilizó un caso práctico: el proyecto “Composición química de la madera, la corteza y el follaje de tres especies de eucaliptos de la provincia de Pinar del Río”. Se emplearon los registros de patentes de la base de datos de Estados Unidos como fuente de información y se procesaron con una herramienta propia, desarrollada por la Universidad de Pinar del Río y Ucinet, un software para representar las posibles redes existentes. Los resultados obtenidos posibilitaron reorientar las investigaciones hacia aspectos más prometedores.

The last century demonstrated that a country’s capacity of technological innovation has become a decisive factor of its socio-economical results. This state of affairs, among other causes, has brought about a strong tendency towards the analysis of different specialized information sources, with the intention of setting a course towards even more radical and successful innovations. Among these information sources, patent documents stand out as main protagonists. The analysis with metric techniques of the information contained in the patents has become one of the main tools for the modeling of the technological scenarios of countries, enterprises, research institutes, subject matters, projects, etcetera. Based on the use of a series of metric indicators, it is possible to identify patterns and tendencies, with the available technological evidence, as well as to detect possible unidentified innovation social webs with a different investigative behavior, which is useful for, among other functions, the making of opportune decisions if the investigation so requires. To illustrate this project was used a practical case: the project: Chemical Composition of the Wood, Bark and Foliage of Three Species of Eucalyptus in the Province of Pinar del Río. The records of patents from the United States database were used as information source, and processed with a tool of our own, developed by the University of Pinar del Río and Ucinet, a software to represent the possibly existing webs. The obtained results made possible the reorientation of the research towards more promising aspects.