RESUMO

BACKGROUND: Patterns of cognitive change and modifiable factors for cognitive decline versus stable cognitive trajectories have rarely been described in lower-educated older adults. OBJECTIVES: We aimed to identify long-term trajectories of cognitive functioning and possible factors associated with cognitive decline. DESIGN AND PARTICIPANTS: We used data from 1,042 adults aged ≥ 60 participating in the Health, Welfare and Aging Study (SABE), São Paulo, Brazil, without cognitive impairment at baseline. Data were collected across four waves (2000-2015). Group-based trajectory modelling was used to identify cognitive trajectories. Associations with socioeconomic variables, childhood background, lifestyle, and cardiovascular risk factors were explored using weighted multinomial logistic regressions. MEASUREMENTS: The abbreviated Mini-Mental State Examination was used to measure cognition. RESULTS: Three cognitive trajectories were identified: stable (n= 754, 68.6%), mild-decline (n= 183, 20.8%), and strong-decline (n= 105, 10.7%). At baseline, respondents in the strong-decline group were more likely to be older than those with stable and mild-decline trajectories. Furthermore, participants in both the mild and strong-decline groups were more likely to have no schooling, be divorced/separated, receive less than 4 monthly wages, and be underweight (BMI < 18.5) compared to the stable group. Finally, the mild-decline group was more likely to have lived in rural areas during childhood than participants located in a stable trajectory. CONCLUSIONS: Our findings suggest that interventions to reduce cognitive decline for low-educated older adults might include strategies addressing inequalities and improving modifiable risk factor burden.

Assuntos

RESUMO

OBJECTIVES: The populational impact of poor sleep quality and the risk of dementia is unclear. We analyzed the Population Attributable Fraction (PAF) of poor sleep quality for dementia, and its association with other two sleep parameters through self-reported and single questions collected in a large-scale Brazilian cohort (ELSI-Brazil). METHODS: A subset of the ELSI-Brazil with complete responses to sleep quality was retrieved for this study. This is a large representative sample of the Brazilian elderly population with an extensive assessment of sociodemographic and health risk variables. Prevalence of poor sleep quality was estimated according to the complex sample design, and its PAF was measured using a meta-analytic relative risk. A total of 6024 (56.3% women, mean 62.8 ± 9.5 years of age) individuals had complete responses. RESULTS: The prevalence of poor sleep quality was 24.9% (95%CI 23%-26%), and the PAF of poor sleep quality including other 10 modifiable risk factors of dementia was 52.5% in Brazil. Secondary analyses identified that sleep quality, restorative sleep and sleep drug usage varied considerably according to age ranges, race, and gender. CONCLUSIONS: Poor sleep quality is an important populational modifiable risk factor for dementia in Brazil. Targeted interventions may provide an important impact in preventing dementia in low- and middle-income countries.

Assuntos

RESUMO

BACKGROUND: Limited evidence exists on the population attributable fraction (PAF) of cancer cases and deaths in Latin America. In Peru several studies have been published regarding the PAF of various risk factors and their associated diseases. The objective of this study was to estimate the fraction of cancer cases and deaths attributable to potentially modifiable risk factors in Peru in 2018, before the COVID-19 pandemic in the population of 15 years old and older. METHODS: An ecological study was conducted using the prevalence of exposure of the Peruvian population to modifiable risk factors for cancer, the relative risk associated with each factor, and the number of cancer cases and deaths in 2018 as inputs. We used the Parkin formula with a Montecarlo statistical simulation model to calculate the PAF and confidence intervals. The number of new cancer cases and deaths attributed to each risk factor was determined by multiplying the number of cases and deaths in each gender by the PAF of each risk factor. FINDINGS: In Peru, 38.5% of new cases (34.5% in men and 42% in women) and 43.4% of cancer-related deaths (43.4% in men and 43.4% in women) were attributable to modifiable risk factors. The number of cancers attributable was 25,308 (10,439 in men and 14,869 in women) and the number of deaths attributable to cancer was 14,839 (6,953 in men and 7,886 in women). The predominant modifiable risk factors contributing to the highest number of cases and deaths were HPV infection (4,563 cases, 2,409 deaths), current tobacco use (3,348 cases, 2,180 deaths), and helicobacter pylori infection (2,677 cases, 1,873 deaths). Among the risk factors, oncogenic infections constituted the group with the highest PAF (16.6% for cases, 19.2% for deaths) followed by other unhealthy lifestyle factors (14.2% for cases, 16.7% for deaths), tobacco (7.2% for cases, 7.2% for deaths) and ultraviolet radiation (0.5% for cases, 0.3% for deaths). CONCLUSIONS: Prior to the COVID-19 pandemic, 38.5% of cancer cases and 43.4% of cancer-related deaths in Peru were linked to modifiable risk factors in the population of 15 years old and older. Most preventable cancer cases and deaths were related to oncogenic infections, primarily caused by HPV and helicobacter pylori, followed by tobacco and obesity.

Assuntos

RESUMO

BACKGROUND: An aging population with a resultant higher incidence of osteoarthritis have increased the need for total hip (THA) and knee arthroplasty (TKA) worldwide. The purpose of this study was to explore what medical and social risk factors are considered relevant by Chilean orthopaedic surgeons in decisions regarding indications for THA or TKA. METHODS: An anonymous survey was sent to 165 hip and knee arthroplasty surgeons who were members of the Chilean Orthopedics and Traumatology Society. From a total of 165 surgeons, 128 (78%) completed the survey. The questionnaire included demographic data, place of work, and inquired about medical and socioeconomic factors that could affect surgical indications. RESULTS: Factors that limited indications for elective THA/TKA included body mass index (81%), elevated hemoglobin A1c (92%), lack of social support network (58%), and low socioeconomic status (40%). Most respondents made decisions based on personal experience or literature review rather than hospital or departmental pressures. Of the respondents, 64% believe that some patient populations would benefit from better care if payment systems adjusted for their socioeconomic risk factors. CONCLUSION: In Chile, limitations regarding the indication for THA/TKA are most influenced by the presence of modifiable medical risk factors such as obesity, uncompensated diabetes, or malnutrition. We believe that the reason surgeons limit surgeries for such individuals is to promote better clinical outcomes, and not in response to pressure from paying entities. However, low socioeconomic status was perceived to impair the ability to achieve good clinical outcomes by 40% of the surgeons.

Assuntos

RESUMO

La hipertensión arterial (HTA) es una de las causas de muertes a nivel mundial, esta enfermedad incrementa significativamente los riesgos de sufrir cardiopatías, encefalopatías, nefropatías y otras enfermedades. Su prevalencia está asociada a países de bajos y medianos ingresos, y se consideran factores de riesgos al estrés, alcoholismo, obesidad, tabaquismo, drogas, alimentación, genética, raza, y ciertas patologías como diabetes mellitus, algunas de ellas consideradas como factores de riesgo modificables y que pueden ser medidas de prevención y control en su tratamiento. Objetivo: Recopilar información sobre los transcriptores riesgos modificables relacionados a la hipertensión arterial. Materiales y Métodos: El estudio es del tipo descriptivo, La metodología es una revisión narrativa, con recopilación de literatura referente al tema y disponible en la web, se emplearon los descriptores: hipertensión, factores de riesgo. Resultados: Aporte de información relevante sobre los factores de riesgos modificables entre ellos el consumo de tabaco y alcohol, reducción de peso, alimentación, actividades físicas, reducción del consumo de sal, aumento del consumo de hortalizas y frutas, además de la disminución en el consumo de alimentos grasos, sales, y un control periódico de la tensión arterial, bajo la supervisión médica que son considerados para la prevención y control de la HTA, como métodos alternativos para control y prevención de esta enfermedad. Conclusiones: Los factores de riesgo modificables que predominan son el consumo de grasas, ausencia del control del índice de masa corporal y de la presión arterial, así como el consumo excesivo de sal y presencia de estrés. Los factores de riesgo no modificables que predisponen a hipertensión arterial prevalentemente son los antecedentes familiares de HTA y de obesidad. Se ha determinado que los cambios en el estilo de vida, así como una conducta sana para la prevención y control de riesgos que son modificables atenúan la prevalencia de la misma(AU)

Arterial hypertension (AHT) is one of the causes of death at the Worldwide, this disease significantly increases the risk of heart disease, encephalopathies, nephropathies and other diseases. Its prevalence is associated with countries of low and medium income, and are considered risk factors for stress, alcoholism, obesity, smoking, drugs, food, genetics, race, and certain pathologies such as diabetes mellitus, some of them considered as modifiable risk factors and that can be prevention and control measures in their treatment. Objective: Collect information on transcriptionists modifiable risks related to hypertension arterial. Materials and methods: The study is of the descriptive type, the methodology is a narrative review, with a compilation of literature on the subject and available on the web, used the descriptors: hypertension, risk factors. Results: Contribution of relevant information on modifiable risk factors, including the consumption of tobacco and alcohol, weight reduction, nutrition, physical activities, reduction of salt intake, increased consumption of vegetables and fruits, in addition to the decrease in the consumption of fatty foods, salts, and periodic control of blood pressure, under the medical supervision that are considered for the prevention and control of hypertension, such as alternative methods for control and prevention of this disease. Conclusions: The modifiable risk factors that predominate are the consumption of fats, absence of control of body mass index and blood pressure, as well as excessive consumption of salt and presence of stress. Non-modifiable risk factors that predispose to high blood pressure are predominantly a family history of hypertension and obesity. It has been determined that changes in lifestyle, as well as behavior healthy for the prevention and control of risks that are modifiable attenuate the prevalence ofthe same(AU)

Assuntos

RESUMO

INTRODUCTION: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. METHODS: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. RESULTS: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. DISCUSSION: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%.The main modifiable risk factors are high blood pressure, obesity, and hearing loss.Women had a greater prevalence of physical inactivity and depression than men.Chile had a greater prevalence of metabolic risk factors than other world regions.

RESUMO

Background: Knowledge regarding the modifiable risk factors of dementia is fundamental to guide public health policy. We aimed to estimate the population attributable fraction of modifiable risk factors of dementia among adults from a nationwide epidemiological study. Methods: We used the public database of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) to calculate the Population Attributable Fraction (PAF) for ten risk factors, including education level, hearing loss, hypertension, alcohol consumption, obesity, active smoking, depression, social isolation, physical inactivity, and diabetes. PAF was estimated for this sample after accounting for the communality of each risk factor. Findings: The ten preventable risk factors for dementia accounted for 50·5% of the Population Attributable Fraction in Brazil. Hearing loss (14·2%), physical inactivity (11·2%), and hypertension (10·4%) accounted for the highest PAF among all the risk factors. Considerable variation in the relative contribution of the different risk factors was found in different regions. Interpretation: This study might provide an opportunity to change the impact of dementia in Brazil. By targeting modifiable risk factors of dementia, the health of individuals in Brazil might be considerably improved. Funding: This study did not receive any funding.

RESUMO

BACKGROUND: The population in Mexico has high prevalence rates of noncommunicable diseases (NCDs). Hospitalization and death of COVID-19 patients in the countries most affected by the pandemic has been associated to chronic comorbidities. OBJECTIVE: To describe the prevalence of NCDs in patients with COVID-19 in Mexico and analyze the increased risk due to comorbidities and risk factors on hospitalization, utilization of intensive care units and death. METHODS: A cross-sectional study was performed from 212,802 confirmed COVID-19 cases reported by the Ministry of Health up to June 27, 2020. Odds ratios were performed using logistic regression model. RESULTS: Up to 47.40% of patients with COVID-19 diagnosis were also reported with a comorbidity, with hypertension being the most frequent (20.12%). The report of at least one NCD significantly increased the risk of death with respect to patients without such diagnoses. Chronic kidney disease increased the risk of death the most (OR 2.31), followed by diabetes (OR 1.69), immunosuppression (OR 1.62), obesity (OR 1.42), hypertension (OR 1.24), chronic obstructive pulmonary disease (OR 1.20). The comorbidities that most increased the risk of ICU and of intubation were diabetes, immunosuppression and obesity. CONCLUSION: NCD comorbidities increase the severity of COVID-19 infection. Given high NCD prevalence rates among the Mexican population, the pandemic poses a special threat to the health system and to society. Special prevention measures need to be strengthened for persons with NCD diagnoses in the short-term. In the mid-term, disease control strategies need to be improved to protect these patients against COVID-19 severity.

Assuntos

RESUMO

Introducción: La hipertensión arterial constituye uno de los problemas médicos más importantes de la medicina contemporánea en los países desarrollados y se le ha denominado la plaga silenciosa del Siglo XXI. Objetivo: Caracterizar clínica y epidemiológicamente la hipertensión arterial en pacientes hipertensos. Métodos: Se realizó un estudio observacional, descriptivo, de corte longitudinal prospectivo. El universo estuvo constituido por 193 pacientes hipertensos de la población del consultorio 7 del Policlínico: Aleida Fernández Chardiet, en el período comprendido entre enero y diciembre del año 2017. Se utilizaron distribuciones de frecuencias, cálculos porcentuales y medidas de tendencia central. Resultados: Del total de pacientes, 48,7 por ciento pertenecía al grupo de edad 40 y 59 años. Predominaron las féminas (112/58,03 por ciento) y los pacientes de piel negra (36,8 por ciento). El factor de riesgo modificable que predominó fue el tabaquismo, presente en 62,7 por ciento 55,4 por ciento presentó cifras de tensión arterial controladas. La mayoría usaba 2 fármacos antihipertensivos (44,6 por ciento). Conclusiones: La hipertensión arterial en el adulto es mejor controlada a menor edad y cuando se utilizan dos fármacos. El principal factor de riesgo de los hipertensos fue el tabaquismo(AU)

Introduction: Hypertension is one of the most important medical problems of contemporary medicine in developed countries and it has been named the silent plague of the twenty-first century. Objective: To describe clinical and epidemiologically arterial hypertension in hypertensive patients. Methods: An observational, descriptive and prospective longitudinal study was carried out. The sample was of 193 hypertensive patients of the population belonging to the Family Doctor's office num. 7, Aleyda Fernández Chardiet Teaching Polyclinic, in the period between January and December, 2017. Frequency distributions, percentage calculations and measures of central tendency were used. Results: Of the total number of patients, 48.7 percent belonged to the age group from 40 to 59 years. There was a predominance of females (112; 58.03 percent) and patients with black skin (36.8 percent). The predominant modifiable risk factor was smoking habit that was present in the 62.7 percent; while the 55.4 percent presented controlled blood pressure´s numbers. Most of the patients used two antihypertensive drugs (44.6 percent). Conclusions: Hypertension in adults is better controlled at a lower age and when using two drugs. The main risk factor of hypertensive patients was smoking habit(AU)

Assuntos

RESUMO

Introducción: El pie diabético es una de las complicaciones más graves y frecuentes de la diabetes mellitus, por tal motivo es importante conocer los factores de riesgo que lo desencadenan. Objetivo:Determinar los factores de riesgo asociados a pie diabético en el hospital PNP Luis N. Sáenz, año 2017. Métodos: Estudio observacional, cuantitativo, retrospectivo, analítico, de casos y controles. La muestra la conformó 165 pacientes (55 casos y 110 controles) atendidos en el servicio de endocrinología en el año 2017. Se estudiaron factores de riesgo, modificables y no modificables, asociados al desarrollo de pie diabético; se recogió la información de las historias clínicas mediante una ficha de recolección de datos, la cual fue analizada mediante el programa SPSS versión 25.0 utilizando los modelos estadísticos de Chi cuadrado y el odds ratios con un nivel de significancia menor a 0.05% y un intervalo de confianza de 95%. Resultados: Los factores de riesgo asociados a pie diabético son tiempo de enfermedad (p: 0,000; OR: 12.77; IC: 4.12 ­ 39.60), hemoglobina glicosilada mal controlada (p: 0.029; OR: 4.55; IC: 1.17 ­ 17.68), onicomicosis (p: 0.014; OR: 7.10; IC: 1.48 ­ 34.07); antecedente de tabaquismo (p: 0.031; OR: 2.66; IC: 1.09 ­ 6.34) y enfermedad renal crónica (p: 0.047; OR: 3.023; IC: 1.01 ­ 9.0). Conclusión: Se concluye que hay asociación estadística significativa entre tiempo de enfermedad, hemoglobina glicosilada mal controlada, onicomicosis, enfermedad renal crónica y antecedente de tabaquismo, con desarrollar pie diabético.

Introduction: Diabetic foot is one of the most serious and frequent complications of diabetes mellitus, for this reason it is important to know the risk factors that trigger it. Objective: To determine the risk factors associated with diabetic foot in the PNP Luis N. Sáenz Hospital, 2017. Methods: Observational, retrospective, analytical, case and control study of 165 patients (55 cases and 110 controls) treated in the endocrinology service in 2017. Modifiable and non-modifiable risk factors associated with the development of diabetic foot were studied; the information of the clinical histories was collected through a data collection form, which was analyzed by means of the SPSS program version 25.0 using the statistical models of Chi square and the odds ratios with a level of significance less than 0.05% and a range of 95% confidence. Results: The risk factors associated with diabetic foot are disease time (p: 0.000, OR: 12.77, CI: 4.12 - 39.60); poorly controlled glycosylated hemoglobin (p: 0.029, OR: 4.55, CI: 1.17 - 17.68); Onychomycosis (p: 0.014, OR: 7.10, CI: 1.48 - 34.07); antecedent of smoking (p: 0.031, OR: 2.66, CI: 1.09 - 6.34) and chronic kidney disease (p: 0.047, OR: 3.023, CI: 1.01 - 9.0). Conclusion: We conclude that there is a statistically significant association between time of illness, poorly controlled glycosylated hemoglobin, onychomycosis, chronic kidney disease, history of smoking and developing diabetic foot.

RESUMO

Asthma is one of the commonest chronic conditions in children and can occasionally be fatal. Little has changed regarding the risk factors for children dying from asthma in the last 30 years. The majority of deaths from asthma occur in children from socio-economically disadvantaged backgrounds. These should be preventable with better education of families, oversight of medication adherence and improved communication between health care professionals and families. More needs to be done to deliver basic messages more effectively about asthma management to the most vulnerable in communities around the world.

Assuntos

RESUMO

BACKGROUND: There is a lack of evidence regarding chronic disease modifiable risk factors among prisoner populations in Latin America. The purpose of this study was to estimate the prevalence of modifiable risk factors for chronic diseases and to assess their relationship with length of incarceration. METHODS: We analysed data from a cross sectional study in which 4241 prisoners were randomly selected to answer a questionnaire with socio-demographic and health behaviour content using an audio computer-assisted self-interview format. Physical activity (PA), low-quality diet, current smoking and alcohol or cocaine use during the last month in prison were our main outcomes. Quantile regression models and logistic regression models were performed. RESULTS: Our final analytical sample consisted of 3774 prisoners from four Mexico City prisons. PA was estimated as 579 median metabolic equivalents-min/week, prevalence of alcohol use was 23.4%, cocaine use was 24.2% and current smoking was 53.2%. Our results suggest that, as length of incarceration increased, PA as well as alcohol and cocaine use increased, whereas the quality of diet decreased. CONCLUSION: This study supports the hypothesis that exposure to prison environment (measured by length of incarceration) fosters modifiable risk factors for chronic diseases, particularly diet quality and cocaine use.

Assuntos