RESUMO
Aedes aegypti is the main vector of Dengue Virus, carrying the virus during the whole mosquito life post-infection. Few mosquito fitness costs have been associated to the virus infection, thereby allowing for a swift dissemination. In order to diminish the mosquito population, public health agency use persistent chemicals with environmental impact for disease control. Most countries barely use biological controls, if at all. With the purpose of developing novel Dengue control strategies, a detailed understanding of the unexplored virus-vector interactions is urgently needed. Damage induced (through tissue injury or bacterial invasion) DNA duplication (endoreplication) has been described in insects during epithelial cells renewal. Here, we delved into the mosquito midgut tissue ability to synthesize DNA de novo; postulating that Dengue virus infection could trigger a protective endoreplication mechanism in some mosquito cells. We hypothesized that the Aedes aegypti orthologue of the Drosophila melanogaster hindsight gene (not previously annotated in Aedes aegypti transcriptome/genome) is part of the Delta-Notch pathway. The activation of this transcriptional cascade leads to genomic DNA endoreplication. The amplification of the genomic copies of specific genes ultimately limits the viral spreading during infection. Conversely, inhibiting DNA synthesis capacity, hence endoreplication, leads to a higher viral replication.
RESUMO
O viés retrospectivo é o fenômeno de perceber e avaliar eventos diferentemente, uma vez que eles tenham ocorrido. Dada uma falha cognitiva, pessoas tendem a ter distorções da memória e a produzir falsas sensações de inevitabilidade e previsibilidade. Os objetivos deste trabalho foram fazer uma revisão de literatura do viés retrospectivo e discutir as implicações teóricas e práticas do tema. Uma pesquisa, realizada nas principais bases de dados do país, não encontrou nenhum artigo relacionado com o tema. A partir de uma seleção das principais pesquisas internacionais sobre o assunto, foi feita uma análise que mostrou os níveis cognitivos do viés retrospectivo, suas implicações e as estratégias usadas para atenuar o viés. Nas considerações finais, são discutidos o impacto e a importância do conhecimento desse fenômeno no dia a dia de tomadores de decisão e cidadãos, assim como a necessidade de se explorar o tema em pesquisas nacionais.
Hindsight bias is the phenomenon of perceiving and evaluating events differently once they are occurred. Given a cognitive flaw, people tend to have distortions of memory and produce false sensations of inevitability and predictability. The objective of this work is to make a literature review of the hindsight bias and to discuss both theoretical and practical implications of the theme. A search conducted in the Brazilian's main databases did not find any articles related to the topic. From a selection of the main international studies on the subject, an analysis was made showing the cognitive levels of the hindsight bias, its implications and the strategies used to attenuate the bias. In the final considerations, the impact and importance of day-to-day knowledge of the phenomenon and the need to explore the subject in national research are discussed.