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Biocompounds are metabolites synthesized by plants, with clinically proven capacity in preventing and treating degenerative diseases in humans. Carbon-based nanomaterials (CNMs) are atomic structures that assume different hybridization and shape. Due to the reactive property, CNMs can induce the synthesis of metabolites, such as biocompounds in cells and various plant species, by generating reactive oxygen species (ROS). In response, plants positively or negatively regulate the expression of various families of genes and enzymes involved in physiological and metabolomic pathways of plants, such as carbon and nitrogen metabolism, which are directly involved in plant development and growth. Likewise, ROS can modulate the expression of enzymes and genes related to the adaptation of plants to stress, such as the glutathione ascorbate cycle, the shikimic acid, and phenylpropanoid pathways, from which the largest amount of biocompounds in plants are derived. This document exposes the ability of three CNMs (fullerene, graphene, and carbon nanotubes) to positively or negatively regulate the activity of enzymes and genes involved in various plant species' primary and secondary metabolism. The mechanism of action of CNMs on the production of biocompounds and the effect of the translocation of CNMs on the growth and content of primary metabolites in plants are described. Adverse effects of CNMs on plants, prospects, and possible risks involved are also discussed. The use of CNMs as inducers of biocompounds in plants could have implications and relevance for human health, crop quality, and plant adaptation and resistance to biotic and abiotic stress.

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Arsenic (As), a metalloid of considerable toxicity, has become increasingly bioavailable through anthropogenic activities, raising As contamination levels in groundwater and agricultural soils worldwide. This bioavailability has profound implications for plant biology and farming systems. As can detrimentally affect crop yield and pose risks of bioaccumulation and subsequent entry into the food chain. Upon exposure to As, plants initiate a multifaceted molecular response involving crucial signaling pathways, such as those mediated by calcium, mitogen-activated protein kinases, and various phytohormones (e.g., auxin, methyl jasmonate, cytokinin). These pathways, in turn, activate enzymes within the antioxidant system, which combat the reactive oxygen/nitrogen species (ROS and RNS) generated by As-induced stress. Plants exhibit a sophisticated genomic response to As, involving the upregulation of genes associated with uptake, chelation, and sequestration. Specific gene families, such as those coding for aquaglyceroporins and ABC transporters, are key in mediating As uptake and translocation within plant tissues. Moreover, we explore the gene regulatory networks that orchestrate the synthesis of phytochelatins and metallothioneins, which are crucial for As chelation and detoxification. Transcription factors, particularly those belonging to the MYB, NAC, and WRKY families, emerge as central regulators in activating As-responsive genes. On a post-translational level, we examine how ubiquitination pathways modulate the stability and function of proteins involved in As metabolism. By integrating omics findings, this review provides a comprehensive overview of the complex genomic landscape that defines plant responses to As. Knowledge gained from these genomic and epigenetic insights is pivotal for developing biotechnological strategies to enhance crop As tolerance.

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Introduction: Alkaline soils with iron (Fe) deficiency are found in many regions of the world, and the use of silicon (Si) can mitigate the damages caused by such deficiency. The aim of this study was to evaluate the effect of Si in mitigating a moderate deficiency of Fe in two energy cane cultivars. Methods: Two experiments were performed, one with the VX2 cultivar and the other with the VX3 cultivar of energy cane, which were cultivated in pots with sand and a nutrient solution. In both experiments, treatments followed a factorial scheme 2x2, designed based on the sufficiency and deficiency of Fe, being combined with the absence or presence of Si (2.5 mmol L-1), disposed in a randomized blocks design with six replicates. In the condition of Fe sufficiency, plants were cultivated in a solution containing 368 µmol L-1 of Fe, while plants cultivated under deficiency were initially submitted to cultivation with a 54 µmol L-1 concentration of Fe for 30 days, and later, with Fe complete omission for 60 days. The supply of Si was carried out by applying 15 fertirrigations with Si (via root and leaf) during the initial stage of seedling development, and after transplanting, the nutrient solution was added daily (via root). Results and discussion: Both cultivars of energy cane were sensitive to Fe deficiency in the absence of Si, impairing its growth by causing stress and pigment degradation, thus reducing the photosynthesis efficiency. The supply of Si mitigated the damages caused by Fe deficiency in both cultivars, by increasing Fe accumulation in new and intermediate leaves, stem, and roots in the VX2 cultivar, and in new, intermediate, and old leaves and stem in the VX3 cultivar, which in turn reduced stress and favored both the nutritional and photosynthesis efficiency, while increasing the dry matter production. Si by modulating physiological and nutritional mechanisms, mitigates Fe deficiency in two energy cane cultivars. It was concluded that Si can be used as a strategy to improve growth and nutrition of energy cane in environments that are susceptible to Fe deficiency.

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OBJECTIVE: To evaluate the effect of psychotherapies on ego defense mechanisms and the reduction of depressive symptoms in a 12-month follow-up period. METHODS: This longitudinal and quasi-experimental study nested within a randomized clinical trial included a clinical sample of adults (18-60 years) diagnosed with major depressive disorder using the Mini-International Neuropsychiatric Interview. Two models of psychotherapy were used: Supportive Expressive Dynamic Psychotherapy (SEDP) and Cognitive Behavioral Therapy (CBT). Defense Style Questionnaire 40 was used to analyze defense mechanisms and the Beck Depression Inventory was used to measure the depressive symptoms. RESULTS: The total sample comprised 195 patients (113 SEDP and 82 CBT), with the mean age was 35.63 (11.44) years. After adjustments, increased mature defenses was significantly associated with reduced depressive symptoms at all follow-up times (p < 0.001) and the decrease in immature defenses was significantly associated with the reduction of depressive symptoms at all follow-up times (p < 0.001). While neurotic defenses were not associated with a reduction in depressive symptoms at any time of follow-up (p > 0.05). CONCLUSION: Both models of psychotherapy were effective in increasing mature defenses and decreasing immature ones, as well as decreasing depressive symptoms at all evaluation times. With this, it is understood that a greater understanding of these interactions will allow a more adequate diagnostic and prognostic evaluation and the design of useful strategies that adapt to the patient's reality.

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Objective: To evaluate the impact of defense mechanisms at baseline on depressive symptoms after brief psychotherapies and after 6-months of follow-up among depressed patients with and without cluster B personality disorders (PDs). Methods: This quasi-experimental study nested within a randomized clinical trial included a clinical sample of adults (18-60 years) diagnosed with major depressive disorder using the Mini-International Neuropsychiatric Interview. The Millon Clinical Multiaxial Inventory-III was applied to assess PD, the Defense Style Questionnaire 40 was used to analyze defense mechanisms, and the Beck Depression Inventory was used to measure the severity of depressive symptoms. Adjusted analysis was performed by linear regression. Results: The final sample consisted of 177 patients diagnosed with major depressive disorder, of whom 39.5% had cluster B PDs. Immature defenses at baseline significantly predicted the persistence of depressive symptoms at post-intervention and at 6-months of follow-up only in patients with PDs. Conclusion: In depressed patients with cluster B PDs, immature defenses predicted a poor response to brief therapies. The assessment of immature defenses at baseline can help identify patients at greater risk of poor therapeutic results and enable more appropriate treatment choices.

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MAIN CONCLUSION: This review highlights the most relevant and recent updated information available on the defense responses of selected hosts against Xanthomonas spp. Xanthomonas is one of the most important genera of Gram-negative phytopathogenic bacteria, severely affecting the productivity of economically important crops worldwide, colonizing either the vascular system or the mesophyll tissue of the host. Due to its rapid propagation, Xanthomonas poses an enormous challenge to farmers, because it is usually controlled using huge quantities of copper-based chemicals, adversely impacting the environment. Thus, developing new ways of preventing colonization by these bacteria has become essential. Advances in genomic and transcriptomic technologies have significantly elucidated at molecular level interactions between various crops and Xanthomonas species. Understanding how these hosts respond to the infection is crucial if we are to exploit potential approaches for improving crop breeding and cutting productivity losses. This review focuses on our current knowledge of the defense response mechanisms in agricultural crops after Xanthomonas infection. We describe the molecular basis of host-bacterium interactions over a broad spectrum with the aim of improving our fundamental understanding of which genes are involved and how they work in this interaction, providing information that can help to speed up plant breeding programs, namely using gene editing approaches.

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OBJECTIVE: To evaluate the impact of defense mechanisms at baseline on depressive symptoms after brief psychotherapies and after 6-months of follow-up among depressed patients with and without cluster B personality disorders (PDs). METHODS: This quasi-experimental study nested within a randomized clinical trial included a clinical sample of adults (18-60 years) diagnosed with major depressive disorder using the Mini-International Neuropsychiatric Interview. The Millon Clinical Multiaxial Inventory-III was applied to assess PD, the Defense Style Questionnaire 40 was used to analyze defense mechanisms, and the Beck Depression Inventory was used to measure the severity of depressive symptoms. Adjusted analysis was performed by linear regression. RESULTS: The final sample consisted of 177 patients diagnosed with major depressive disorder, of whom 39.5% had cluster B PDs. Immature defenses at baseline significantly predicted the persistence of depressive symptoms at post-intervention and at 6-months of follow-up only in patients with PDs. CONCLUSION: In depressed patients with cluster B PDs, immature defenses predicted a poor response to brief therapies. The assessment of immature defenses at baseline can help identify patients at greater risk of poor therapeutic results and enable more appropriate treatment choices.

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Abstract William Alanson White's views on the function and conceptualization of psychoanalysis shaped the practice of the analytic method in the hospital setting in the United States. Here I explore White's original work and maintain that his understanding of transference, the unconscious, symbolism, language, and defense mechanisms were rooted in both traditional intrapsychic and individualistically oriented conceptions and influenced by his orientation toward social psychiatry. In line with Progressive Era ideals, White considered the new science of psychoanalysis important for healing both the individual as well as society; this mutual influence helped shape the evolution of psychoanalytic principles and informed the treatment of patients undergoing psychoanalysis at St. Elizabeths Hospital.

Resumen Las opiniones de William Alanson White sobre la función y la conceptualización del psicoanálisis dieron forma a la práctica del método analítico en el ámbito hospitalario de los EEUU. Aquí exploro el trabajo original de White y sostengo que su comprensión de la transferencia, el inconsciente, el simbolismo, el lenguaje y los mecanismos de defensa estaban enraizados tanto en las concepciones intrapsíquicas tradicionales como en las de orientación individualista e influenciadas por su orientación hacia la psiquiatría social. Conforme con los ideales de la Era Progresista, White consideró que la nueva ciencia del psicoanálisis era importante para curar tanto al individuo como a la sociedad; esta influencia mutua ayudó a dar forma a la evolución de los principios psicoanalíticos y mostró el tratamiento de los pacientes sometidos a psicoanálisis en el Hospital St. Elizabeths.

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Introducción: muchos huesos que forman el esqueleto de la cabeza humana y muchas especies de animales están neumatizados. Se han planteado múltiples hipótesis con diversos enfoques con la intención de explicar la existencia de estos espacios aéreos. De todos los huesos con estas características en humanos, solamente los senos paranasales y la neumatización del hueso temporal han sido objeto de múltiples hipótesis. La diversidad de criterios denota un desacuerdo, si no con todos, con la mayoría de ellos. Material y métodos: esta teoría se basa en reflexiones personales apoyadas en radiografías e imágenes anatómicas de los huesos frontal y temporal, con el objetivo de ilustrar y reforzar las razones de la existencia de estas cavidades en todas las especies que las poseen. Resultados, discusión y conclusiones: estos espacios de aire se forman en el cuerpo de los huesos cortos como un mecanismo de defensa natural al reemplazar el tejido esponjoso para prevenir infecciones graves del mismo (osteomielitis), que dada su proximidad al cerebro y sus estructuras representaría un peligro para la vida. Consideramos que los laberintos etmoidales fueron creados con el objetivo de llenar el espacio vacío entre los huesos vecinos y dar estabilidad al esqueleto óseo circundante. La neumatización del hueso temporal (hueso compacto) fue creada para "alojar y proteger" importantes estructuras de los sentidos del oído y del equilibrio, los vasos y los nervios.

Introduction: Many bones that make up the skeleton of the human head and many species of animals are pneumatized. Multiple hypotheses with various approaches have been stated with the intention of explaining the existence of these airspaces. Of all the bones with these characteristics in humans, only the paranasal sinuses and pneumatization of the temporal bone have been the subject of multiple hypotheses. The diversity of criteria denotes disagreement, if not with all, with the majority of them. Material and methods: This theory is based on personal reflections supported by x-rays and anatomical images of the frontal and temporal bones, with the aim of illustrating and reinforcing the reasons for the existence of these cavities in all species that possess them. Results, discussion and conclusions: These air spaces are formed in the body of short bones as a natural defense mechanism by replacing the spongy tissue to prevent serious infections of the same (osteomyelitis), which given its close proximity to the brain and its structures would represent a danger to life from its emergence. We consider that the ethmoid labyrinths were created with the aim of filling the empty space between the neighboring bones to give stability to the surrounding bone skeleton. The pneumatization of the temporal bone, compact bone, was created to "house and protect" important structures of the senses of hearing and balance, vessels and nerves

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ABSTRACT Objective: To analyze the suffering and coping strategies of nurses working in Primary Health Care considering the psychodynamics of their work. Methods: Descriptive study with a qualitative approach, carried out with 11 nurses working in Primary Health Care. Data were collected through semi-structured interviews, systematized, and interpreted using Bardin's content analysis method applied to recurrent themes. Results: The suffering factors related to work in Primary Health Care are difficulties with management, the fragile structure of the health support network, and conflicts with the users. Defensive strategies to minimize these difficulties are the support of hierarchical superiors, the empowerment of the community and users, and communication between team members. Final considerations: It is important that there be changes in the organization of this line of work to improve the workers' health.

RESUMEN Objetivo: Analizar el sufrimiento y mecanismos de defensa de enfermeros actuantes en la Atención Primaria de Salud a la luz de la psicodinámica del trabajo. Métodos: Estudio descriptivo con abordaje cualitativo realizado con 11 enfermeras actuantes en la Atención Primaria de Salud. Datos fueron recolectados mediante entrevista semiestructurada, sistematizados e interpretados utilizándose el análisis de contenido de Bardin en la modalidad temática. Resultados: Factores de sufrimiento relacionados al trabajo en la Atención Primaria de Salud son las dificultades con la gestión, estructura debilitada de la red de apoyo a la salud y conflictos con los usuarios. Las estrategias defensivas para minimizar esas dificultades son el apoyo de los superiores jerárquicos, el empoderamiento de la comunidad o de los usuarios y la comunicación entre los miembros de equipe. Consideraciones finales: Es importante que haya cambios en la organización del trabajo para que mejorías sean alcanzadas en la salud de los trabajadores.

RESUMO Objetivo: Analisar o sofrimento e os mecanismos de defesa de enfermeiros atuantes na Atenção Primária à Saúde à luz da psicodinâmica do trabalho. Métodos: Estudo descritivo com abordagem qualitativa realizado com 11 enfermeiras atuantes na Atenção Primária à Saúde. Os dados foram coletados mediante entrevista semiestruturada, sistematizados e interpretados utilizando-se a análise de conteúdo de Bardin na modalidade temática. Resultados: Os fatores de sofrimento relacionados ao trabalho na Atenção Primária à Saúde são as dificuldades com a gestão, a estrutura fragilizada da rede de apoio à saúde e os conflitos com os usuários. As estratégias defensivas para minimizar essas dificuldades são o apoio dos superiores hierárquicos, o empoderamento da comunidade ou dos usuários e a comunicação entre os membros de equipe. Considerações finais: É importante que haja mudanças na organização do trabalho para que melhorias sejam alcançadas na saúde dos trabalhadores.

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INTRODUCTION: A relationship between different types of childhood trauma, parental care, and defensive styles and development of psychiatric symptoms in adulthood is proposed in this study. Understanding the nature of this association is essential to assist psychotherapists who treat patients with a history of past trauma. This study aims to examine the associations between childhood trauma, parental bonding, and defensive styles and current symptoms in adult patients who sought care at an analytical psychotherapy clinic. METHODS: The sample comprised 197 patients from an analytically oriented psychotherapy clinic. Participants responded to four self-report instruments that assessed, respectively, presence and frequency of several types of early trauma, type of parental attachment, styles of defenses, and current symptoms encompassing a wide variety of psychopathological syndromes. RESULTS: Only 5% of patients reported not having experienced any traumatic experience in childhood. Several traumas such as emotional and physical abuse, emotional neglect, and physical neglect showed positive and significant associations with several dimensions of current symptoms, and also with parental bonding and defensive styles. When analyzed together with the other variables, defensive styles explained the level of psychological suffering caused by the symptoms. CONCLUSIONS: This study offers additional support for understanding the associations between childhood trauma, parental bonding styles, and defense styles and the psychiatric symptoms of patients in analytically oriented psychotherapy.

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Abstract Introduction A relationship between different types of childhood trauma, parental care, and defensive styles and development of psychiatric symptoms in adulthood is proposed in this study. Understanding the nature of this association is essential to assist psychotherapists who treat patients with a history of past trauma. This study aims to examine the associations between childhood trauma, parental bonding, and defensive styles and current symptoms in adult patients who sought care at an analytical psychotherapy clinic. Methods The sample comprised 197 patients from an analytically oriented psychotherapy clinic. Participants responded to four self-report instruments that assessed, respectively, presence and frequency of several types of early trauma, type of parental attachment, styles of defenses, and current symptoms encompassing a wide variety of psychopathological syndromes. Results Only 5% of patients reported not having experienced any traumatic experience in childhood. Several traumas such as emotional and physical abuse, emotional neglect, and physical neglect showed positive and significant associations with several dimensions of current symptoms, and also with parental bonding and defensive styles. When analyzed together with the other variables, defensive styles explained the level of psychological suffering caused by the symptoms. Conclusions This study offers additional support for understanding the associations between childhood trauma, parental bonding styles, and defense styles and the psychiatric symptoms of patients in analytically oriented psychotherapy.

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Enterohemorrhagic Escherichia coli (EHEC) infections can result in a wide range of clinical presentations despite that EHEC strains belong to the O157:H7 serotype, one of the most pathogenic forms. Although pathogen virulence influences disease outcome, we emphasize the concept of host-pathogen interactions, which involve resistance or tolerance mechanisms in the host that determine total host fitness and bacterial virulence. Taking advantage of the genetic differences between mouse strains, we analyzed the clinical progression in C57BL/6 and BALB/c weaned mice infected with an E. coli O157:H7 strain. We carefully analyzed colonization with several bacterial doses, clinical parameters, intestinal histology, and the integrity of the intestinal barrier, as well as local and systemic levels of antibodies to pathogenic factors. We demonstrated that although both strains had comparable susceptibility to Shiga toxin (Stx) and the intestinal bacterial burden was similar, C57BL/6 showed increased intestinal damage, alteration of the integrity of the intestinal barrier, and impaired renal function that resulted in increased mortality. The increased survival rate in the BALB/c strain was associated with an early specific antibody response as part of a tolerance mechanism.

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Este estudo analisou as vivências de prazer-sofrimento dos policiais militares de um batalhão da região Norte e como estas influem na execução de suas atividades. Os pressupostos teórico-metodológicos procederam da Psicodinâmica do Trabalho. Foram realizados seis encontros em grupo com a participação de 17 policiais, sendo 14 homens e três mulheres. As temáticas investigadas foram divididas em cinco eixos: condições precárias de trabalho; perfil do policial; reconhecimento dos pares, superiores e sociedade; prazer-sofrimento no trabalho; e defesas contra o sofrimento, interpretados a partir da análise temática. O projeto foi aprovado pelo Comitê de Ética em Pesquisa da Universidade. Percebeu-se que a organização de trabalho desempenha papel importante nas vivências de prazer-sofrimento e que cooperação, reconhecimento, precarização, burocracia e os paradoxos da atividade policial interferem diretamente nesta dinâmica. O uso de estratégias defensivas, como a ironia e o humor, é responsável pela dicotomia entre ter que suportar o real no trabalho e não verbalizar o sofrimento, evidenciando alguns dos importantes paradigmas presentes na atividade militar estudada.

This study analyzed the experiences of pleasure-suffering of a Military Police Battalion from the Northern Region and how they influence the execution of their activities. The theoretical-methodological assumptions adopted were the Psychodynamics of Work. Six group meetings were held with the participation of seventeen policemen: fourteen men and three women. The investigated thematics were divided into five axes, namely: precarious working conditions; profiles of the police officers; acknowledgment among peers, superiors and society; pleasure-suffering at work; and defenses against suffering, according to thematic analysis. This project was approved by the university's Research Ethics Committee. The work organization played an important role in the pleasure-suffering experiences, and cooperation, recognition, precariousness, bureaucracy and paradoxes of the police activity directly interfere in this dynamic. The use of defensive mechanisms such as irony and humor is responsible for the dichotomy between having to endure reality at work and as a means to not verbalize suffering, showing some of the important paradigms present in the military activity studied.

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Resumen Esta investigación expone cómo la ausencia de ambos padres afecta la estructuración de la personalidad en los niños y niñas que vivencian el abandono, tomando como aporte lo planteado por la teoría sistémica respecto a la familia, la cual la considera como el primer ente de contacto y el espacio en que se inicia el desarrollo psicológico y social de las personas; igualmente lo planteado por la teoría psicoanalítica en cuanto a la estructuración de la personalidad. La familia es considerada como una pieza fundamental en el desarrollo psicológico del niño; por lo tanto, la presencia de ambos padres cumple un papel significativo durante el crecimiento físico y psicológico. El objetivo principal fue analizar cómo se está estructurando la personalidad en los niños y niñas abandonados por sus progenitores. La investigación se ajusta al método cualitativo, y en ella participaron seis menores de uno y otro sexo, cuyas edades oscilaron entre los nueve y once años de edad; los participantes formaban parte del ICBF (Instituto Colombiano de Bienestar Familiar). Se aplicaron entrevistas abiertas en total dos pruebas proyectivas: el CAT (Test de Apercepción Temática para niños CATA) y Test del Dibujo de la Familia, estudio de caso, historia clínica y observaciones personalizadas. Se destaca que los niños y niñas actualmente no cuentan con la presencia de una figura masculina que pueda cumplir con las funciones de una figura paterna y que pueda dar paso a que el Edipo encuentre una salida adecuada; además las mujeres encargadas de los cuidados de los participantes cambian con frecuencia lo cual genera en ellos dificultades en el establecimiento de vínculos afectivos seguros, y presentan un yo y superyó débiles y con notables vacíos afectivos en sus relaciones vinculares primarias.

Abstract This exposes how the absence of both parents affects the structuring of the personality in the boys and girls who experience the abandonment, taking as contribution what was proposed by the systemic theory in front of the family, which considers it as the first entity of contact and the space in which the psychological and social development of people begins, likewise what is posed by psychoanalytic theory regarding the structuring of personality. The family is considered as a fundamental piece in the child's psychological development, therefore the presence of both parents plays a significant role during physical and psychological growth. The main objective was to analyze how the personality is being structured in children abandoned by their parents. The research is adjusted to the qualitative method, where six minors of both sexes participated, whose ages ranged from nine to eleven years of age; the participants were part of the ICBF (Colombian Institute of Family Welfare). Two projective tests were applied to open interviews: the CAT (Thematic Apperception Test for children CATA) and the Family Drawing Test, case study, medical history and personalized observations. It is highlighted that boys and girls currently do not they have the presence of a male figure who can fulfill the functions of a father figure and who can make way for the Oedipus to find a suitable outlet; furthermore, the women in charge of the care of the participants change frequently, generating difficulties in establishing secure affective bonds, presenting a weak self and superego and with notable affective gaps in their primary bonding relationships.

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Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a frequent and devastating side effect of cancer therapy. No preventive strategies are currently available. We investigated the use of resveratrol (RESV) in the prevention of CIPNP and evaluated key components of the antioxidant defense system and neuroinflammatory factors as possible mediators contributing to RESV actions. Male rats were injected with oxaliplatin (OXA) and received daily oral RESV. Paw mechanical and thermal allodynia, oxidative stress, antioxidant, pro-inflammatory and neuronal injury/activation markers were evaluated in the sciatic nerve (SN), lumbar dorsal root ganglia (DRG) and spinal cord (SC). OXA-injected animals developed mechanical and thermal allodynia, while those receiving OXA + RESV showed patterns of response similar to control animals. Higher TBARS levels and lower GSH/GSSG ratios were observed in the SN of animals receiving OXA. The mRNA levels of the transcription factor NFκB and the pro-inflammatory cytokine TNFα were found to be upregulated both in lumbar DRG and SC. In addition, the antioxidant enzymes NQO-1 and HO-1 and the neuronal injury marker ATF3 showed increased levels of expression in lumbar DRG. In the dorsal SC the neuronal activation marker c-fos and the transcription factor Nrf2, main regulator of antioxidant defenses, were found to be upregulated. RESV early and sustained administration prevented NFκB, TNFα, ATF3 and c-fos upregulation, while increasing the expression of Nrf2, NQO-1, HO-1 and the redox-sensitive deacetylase SIRT1. RESV treatment was also able to restore TBARS levels and GSH/GSSG ratio. Thus, RESV administration resulted in the upregulation of antioxidant mediators, suppression of pro-inflammatory parameters and prevention of OXA-induced mechanical and thermal allodynia.

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Defense mechanisms are mental functions which facilitate coping when real or imagined events challenge personal wishes, needs, and feelings. Whether defense mechanisms have a specific neural basis is unknown. The present research tested the hypothesis that interhemispheric integration plays a critical role in defense mechanism development, by studying a unique sample of patients born without the corpus callosum (agenesis of the corpus callosum; AgCC). Adults with AgCC (N = 27) and matched healthy volunteers (N = 30) were compared on defense mechanism use across increasing levels of developmental maturity (denial, least; projection, intermediate; identification, most). Narratives generated in response to Thematic Apperception Test images were scored according to the Defense Mechanism Manual. Greater use of denial and less identification was found in persons with AgCC, compared to healthy comparisons. This difference emerged after age 18 when full maturation of defenses among healthy individuals was expected. The findings provide clinically important characterization of social and emotional processing in persons with AgCC. More broadly, the results support the hypothesis that functional integration across the hemispheres is important for the development of defense mechanisms.

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O presente trabalho objetiva analisar a etiologia das neuroses em Freud e Winnicott. Para tanto, parte das principais considerações sobre os mecanismos de defesa, o recalque, a sexualidade, o complexo edípico e o conflito psíquico na psicanálise clássica freudiana, para depois propor uma nova etiologia a partir da teoria das relações objetais em Donald W. Winnicott. Os autores não consideram apenas o conflito vivido em termos da dinâmica psíquica, mas aquele vivido na dinâmica mãe-bebê, principalmente a partir dos polos opostos entre o amor e o ódio na travessia do concernimento (posição depressiva). Os autores defendem um manejo clínico de pacientes com sofrimento psíquico neurótico a partir da psicanálise transmatricial, propondo, concomitantemente à associação livre, o uso da regressão à dependência a fases primitivas de falhas ambientais (AU)

This paper aims to analyze the etiology of the neuroses in Freud and Winnicott. In order to do so, the authors build upon the main considerations on defense mechanisms, repression, sexuality, the oedipal complex, and the psychic conflict in Freudian psychoanalysis. Then they propose a new etiology based on Donald W. Winnicott's object relations theory. The authors do not only consider the conflict experienced in terms of psychic dynamics, but also the conflict experienced in the mother-baby dynamics, particularly in regards to the opposition between love and hate in the development of concern (depressive position). The authors stand for the clinical management of patients with neurotic psychic suffering based on transmatricial psychoanalysis, proposing, along with free association, the use of regression to dependence on primitive phases of environmental failures (AU)

El presente trabajo tiene por objeto analizar la etiología de las neurosis en Freud y Winnicott. Para ello, parte de las principales consideraciones sobre los mecanismos de defensa, la represión, la sexualidad, el complejo edípico y el conflicto psíquico en el psicoanálisis freudiano, para proponer una nueva etiología a partir de la teoría de las relaciones objetivas en Donald W. Winnicott. Los autores no sólo consideran el conflicto vivido en términos de la dinámica psíquica, sino el conflicto vivido en la dinámica madre-bebé, principalmente a partir de los polos opuestos entre el amor y el odio en la travesía de la concernimiento (posición depresiva). Los autores defienden un manejo clínico de pacientes con sufrimiento psíquico neurótico a partir del psicoanálisis transmatricial, proponiendo junto a la asociación libre, el uso de la regresión a la dependencia a fases primitivas de fallas ambientales (AU)

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Genetic resistance is the main strategy to control one of the most destructive diseases of common bean (Phaseolus vulgaris L), i.e., the Fusarium wilt caused by Fusarium oxysporum f. sp. phaseoli (Fop). However, little is known on host defense reactions in Fop-bean interaction. Thus, this work examined the defense mechanisms in root and hypocotyl tissues of common bean against Fop. Resistant and susceptible bean plants were inoculated by dipping their roots in a conidial suspension. Cross sections of roots and hypocotyls were observed in light microscopy at 1, 3, 6, and 9 days after inoculation (dai) to monitor Fop colonization, and at 3 and 9 dai to detect callose, carbohydrates, lipids, phenolics, and protein, and under electronic microscopy at 9 dai to observe ultrastructural changes in xylem cells. The content of hydrogen peroxide (H2O2), lipid peroxidation, and activity of the antioxidant enzymes ascorbate peroxidase (EC 1.11.1.11) and catalase (EC 1.11.1.6) were monitored spectrophotometrically in roots and hypocotyls at 0, 1, 3, 6, and 9 dai. Fop colonized inter- and intracellularly the epidermis and cortex reaching the xylem vessels faster in susceptible genotype. Fop inoculation induced phenolics and carbohydrates accumulation, callose deposition, and formation of occlusion material inside xylem vessels mainly in resistant genotype. Lipid peroxidation occurred mainly in susceptible plants. In contrast, the antioxidant enzymes seem to have contributed to reducing damage caused by H2O2 accumulation in resistant plants. This study gives evidences that inter- and intracellular physicochemical mechanisms can act together to delay Fop colonization in resistant plants.

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