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Introduction: Caffeine and the selective A2A receptor antagonist SCH58261 both have ergogenic properties, effectively reducing fatigue and enhancing exercise capacity. This study investigates in male Swiss mice the interaction between adenosine A2A receptors and dopamine D2 receptors controlling central fatigue, with a focus on the striatum where these receptors are most abundant. Methods: We employed DPCPX and SCH58261 to antagonize A1 and A2A receptors, caffeine as a non-competitive antagonist for both receptors, and haloperidol as a D2 receptor antagonist; all compounds were tested upon systemic application and caffeine and SCH58261 were also directly applied in the striatum. Behavioral assessments using the open field, grip strength, and treadmill tests allowed estimating the effect of treatments on fatigue. Results and discussion: The results suggested a complex interplay between the dopamine and adenosine systems. While systemic DPCPX had little effect on motor performance or fatigue, the application of either caffeine or SCH58261 was ergogenic, and these effects were attenuated by haloperidol. The intra-striatal administration of caffeine or SCH58261 was also ergogenic, but these effects were unaffected by haloperidol. These findings confirm a role of striatal A2A receptors in the control of central fatigue but suggest that the D2 receptor-mediated control of the ergogenic effects of caffeine and of A2A receptor antagonists might occur outside the striatum. This prompts the need of additional efforts to unveil the role of different brain regions in the control of fatigue.
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This study compared central and peripheral fatigue development between the Sprint and Olympic distance triathlon. Fifteen male triathletes performed Sprint and Olympic triathlon simulations in a randomized and counterbalanced order. Central and peripheral fatigue was evaluated from changes in voluntary activation level (VAL) and twitch responses of quadriceps muscle (Qtw,pot), respectively. Qtw,pot reduced from baseline to post-swimming similarly between triathlon simulations (Sprint,-17±11%; Olympic, -13±9%). In post-cycling, Qtw,pot further declined to a similar extent between triathlon distances (Sprint, -31±15%; Olympic, -28±11%). In post-running, Qtw,pot was fully recovered in the Olympic triathlon (-4±10%), whereas there was only a partial recovery of Qtw,pot in the Sprint triathlon (-20±11%). VAL was not reduced in post-swimming, but reduction was similar between triathlon distances in post-cycling (Sprint, -10±9%; Olympic, -8±8%) and post-running (Sprint, -15±14%; Olympic, -16±8%). In the Sprint triathlon, the swimming speed (1.07±0.13m.s-1) was above (p <.001) critical speed (1.01±0.14m.s-1), the cycling power (179.7±27.2W) was below the respiratory compensation point (216.3±27.8W, p <.001) and running speed (13.7±1.05km.h-1) similar to the respiratory compensation point (13.2±0.70km.h-1, p =.124). In the Olympic triathlon, swimming speed (1.03±0.13m.s-1) was similar to critical speed (p =.392), and cycling power (165.3±27.3W) and running speed (12.6±1.05km.h-1) were below the respiratory compensation point (p ≤.007). In conclusion, peripheral fatigue progressed until post-cycling regardless of triathlon distances. However, peripheral fatigue was fully recovered after running in Olympic but not in Sprint triathlon. The central fatigue started in post-cycling and progressed until post-running regardless of triathlon distances.HighlightsThe quadriceps muscle peripheral fatigue progresses similarly in Sprint and Olympic triathlons until post-cycling.The quadriceps muscle peripheral fatigue is completely recovered after running in the Olympic triathlon, whereas it is partially recovered in the Sprint triathlon.The central fatigue starts in post-cycling and progresses similarly until post-running in Sprint and Olympic triathlons, regardless of triathlon distances.
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Músculo Quadríceps , Corrida , Humanos , Masculino , Corrida/fisiologia , Natação/fisiologia , Ciclismo/fisiologia , Fatores de TempoRESUMO
Previous systematic reviews have confirmed that carbohydrate (CHO) mouth rinse may boost physical exercise performance, despite some methodological aspects likely affecting its ergogenic effect. In this review, we discussed if the exercise mode, pre-exercise fasting status, CHO solutions concentration, CHO solutions temperature, mouth rinse duration, and CHO placebo effects may potentially reduce the CHO mouth rinse ergogenic effect, suggesting possible solutions to manage these potential confounders. The effectiveness of CHO mouth rinse as a performance booster is apparently related to the origin of the exercise-induced neuromuscular fatigue, as CHO mouth rinse unequivocally potentiates endurance rather than sprint and strength exercises performance. Furthermore, ergogenic effects have been greater in fasting than fed state, somehow explaining the varied magnitude of the CHO mouth rinse effects in exercise performance. In this regard, the CHO solution concentration and temperature, as well as the mouth rinse duration, may have increased the variability observed in CHO mouth rinse effects in fasting and fed state. Finally, placebo effects have challenged the potential of the CHO mouth rinse as an ergogenic aid. Therefore, we suggest that future studies should consider methodological controls such as sample size and sample homogeneity, proper familiarization with experimental procedures, and the use of alternative placebo designs to provide unbiased evidence regarding the potential of the CHO mouth rinse as an ergogenic aid.
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The current study analysed the effect of distinct pacing profiles (i.e. U, J, and inverted J) in the perceptual responses and neuromuscular fatigue (NMF) development following a 4-km cycling time trial (TT). Twenty-one cyclists with similar training status were allocated into three different groups based on their pacing profile spontaneously adopted during TT. Rating of perceived exertion (RPE), oxygen uptake (â©O2) and heart rate (HR) were continuously recorded. NMF was assessed by using isometric maximal voluntary contractions (IMVC), while the central [i.e. voluntary activation (VA)] and peripheral fatigue of knee extensors [i.e. peak torque of potentiated twitches (TwPt)] were evaluated using electrically evoked contractions performed pre and 2â min after the TT. TT performance was not different amongst pacing profiles (U = 377 ± 20 s; J = 392 ± 23 s; J-i = 381 ± 20 s) (all P > 0.05). RPE, â©O2 and HR increased similarly throughout the TT regardless the pacing strategy (all P > 0.05). Similarly, IMVC (U = -9.9 ± 8.8; J = -9.6 ± 4.5%; J-i = -13.8 ± 11.3%), VA (U = -2.3 ± 1.7%; J = -5.4 ± 2.2%; J-i = -6.4 ± 4.5%) and TwPt (U = -32.5 ± 12.0%; J = -29.5 ± 8.0%; J-i = -33.6 ± 13.6%) were similar amongst pacing profiles (all P > 0.05). Therefore, endurance athletes with similar training status showed the same perceived responses and NMF development regardless the pacing profile spontaneously adopted. It was suggested that these responses occurred in order to preserve a similar rate of change in systemic responses (i.e. RPE, â©O2 and HR) and NMF development, ultimately resulting in same TT performance. HighlightsDifferent pacing profiles resulted in the same performance in a 4-km cycling time trial.The similar performance might be due to achievement of the same sensory tolerance limit.There was no difference for perceptual, metabolic and neuromuscular fatigue responses.
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Ciclismo , Fadiga Muscular , Atletas , Ciclismo/fisiologia , Humanos , Contração Isométrica , TorqueRESUMO
We examined whether endurance performance and neuromuscular fatigue would be affected by caffeine ingestion during closed- and open-loop exercises. Nine cyclists performed a closed-loop (4,000-m cycling time trial) and an open-loop exercise (work rate fixed at mean power of the closed-loop trial) 60 min after ingesting caffeine (CAF, 5 mg/kg) or placebo (PLA, cellulose). Central and peripheral fatigue was quantified via pre- to post-exercise decrease in quadriceps voluntary activation and potentiated twitch force, respectively. Test sensitivity for detecting caffeine-induced improvements in exercise performance was calculated as the mean change in time divided by the error of measurement. Caffeine ingestion reduced the time of the closed-loop trial (PLA: 375.1±14.5 s vs CAF: 368.2±14.9 s, P=0.024) and increased exercise tolerance during the open-loop trial (PLA: 418.2±99.5 s vs CAF: 552.5±106.5 s, P=0.001), with similar calculated sensitivity indices (1.5, 90%CI: 0.7-2.9 vs 2.8, 90%CI: 1.9-5.1). The reduction in voluntary activation was more pronounced (P=0.019) in open- (-6.8±8.3%) than in closed-loop exercises (-1.9±4.4%), but there was no difference between open- and closed-loop exercises for the potentiated twitch force reduction (-25.6±12.8 vs -26.6±12.0%, P>0.05). Caffeine had no effect on central and peripheral fatigue development in either mode of exercise. In conclusion, caffeine improved endurance performance in both modes of exercise without influence on post-exercise central and peripheral fatigue, with the open-loop exercise imposing a greater challenge to central fatigue tolerance.
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Background: Low-load resistance exercise (LL-RE) with blood flow restriction (BFR) promotes increased metabolic response and fatigue, as well as more pronounced myoelectric activity than traditional LL-RE. Some studies have shown that the relative pressure applied during exercise may have an effect on these variables, but existing evidence is contradictory. Purpose: The aim of this study was to systematically review and pool the available evidence on the differences in neuromuscular and metabolic responses at LL-RE with different pressure of BFR. Methods: The systematic review and meta-analysis was reported according to PRISMA items. Searches were performed in the following databases: CINAHL, PubMed, Scopus, SPORTDiscus and Web of Science, until June 15, 2021. Randomized or non-randomized experimental studies that analyzed LL-RE, associated with at least two relative BFR pressures [arterial occlusion pressure (AOP)%], on myoelectric activity, fatigue, or metabolic responses were included. Random-effects meta-analyses were performed for MVC torque (fatigue measure) and myoelectric activity. The quality of evidence was assessed using the PEDro scale. Results: Ten studies were included, all of moderate to high methodological quality. For MVC torque, there were no differences in the comparisons between exercise with 40-50% vs. 80-90% AOP. When analyzing the meta-analysis data, the results indicated differences in comparisons in exercise with 15-20% 1 repetition maximum (1RM), with higher restriction pressure evoking greater MVC torque decline (4 interventions, 73 participants; MD = -5.05 Nm [95%CI = -8.09; -2.01], p = 0.001, I 2 = 0%). For myoelectric activity, meta-analyses indicated a difference between exercise with 40% vs. 60% AOP (3 interventions, 38 participants; SMD = 0.47 [95%CI = 0.02; 0.93], p = 0.04, I2 = 0%), with higher pressure of restriction causing greater myoelectric activity. This result was not identified in the comparisons between 40% vs. 80% AOP. In analysis of studies that adopted pre-defined repetition schemes, differences were found (4 interventions, 52 participants; SMD = 0.58 [95%CI = 0.11; 1.05], p = 0.02, I 2 = 27%). Conclusion: The BFR pressure applied during the LL-RE may affect the magnitude of muscle fatigue and excitability when loads between 15 and 20% of 1RM and predefined repetition protocols (not failure) are prescribed, respectively. Systematic Review Registration: [http://www.crd.york.ac.uk/prospero], identifier [CRD42021229345].
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Caffeine is one of the most consumed ergogenic aids around the world. Many studies support the ergogenic effect of caffeine over a large spectrum of exercise types. While the stimulatory effect of caffeine on the central nervous system is the well-accepted mechanism explaining improvements in exercise performance during high-intensity whole-body exercise, in which other physiological systems such as pulmonary, cardiovascular, and muscular systems are maximally activated, a direct effect of caffeine on such systems cannot be ignored. A better understanding of the effects of caffeine on multiple physiological systems during high-intensity whole-body exercise might help to expand its use in different sporting contexts (e.g., competitions in different environments, such as altitude) or even assist the treatment of some diseases (e.g., chronic obstructive pulmonary disease). In the present narrative review, we explore the potential effects of caffeine on the pulmonary, cardiovascular, and muscular systems, and describe how such alterations may interact and thus contribute to the ergogenic effects of caffeine during high-intensity whole-body exercise. This integrative approach provides insights regarding how caffeine influences endurance performance and may drive further studies exploring its mechanisms of action in a broader perspective.
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Cafeína/farmacologia , Fenômenos Fisiológicos Cardiovasculares/efeitos dos fármacos , Sistema Nervoso Central/efeitos dos fármacos , Exercício Físico/fisiologia , Pulmão/efeitos dos fármacos , Músculo Esquelético/efeitos dos fármacos , Substâncias para Melhoria do Desempenho/farmacologia , Resistência Física/efeitos dos fármacos , Animais , Sistema Nervoso Central/fisiologia , Humanos , Pulmão/fisiologia , Músculo Esquelético/fisiologiaRESUMO
The present study analyzed the effects of local ischemia during endurance exercise on neuromuscular fatigue (NMF). Nine cyclists performed, in a counterbalanced order, two separate 4-km cycling time trials (TT) with (ISCH) or without (CONTR) induced local ischemia. NMF was characterized by using isometric maximal voluntary contractions (IMVC), whereas central [voluntary activation (VA)] and peripheral fatigue [peak torque of potentiated twitch (TwPt)] of knee extensors were evaluated using electrically evoked contractions performed before (PRE) and 1 min after (POST) the TT. Electromyographic activity (EMG), power output (PO), oxygen uptake (VÌo2), and rating of perceived exertion (RPE) were also recorded. The decrease in IMVC (-15 ± 9% vs. -10 ± 8%, P = 0.66), VA (-4 ± 3% vs. -3 ± 3%, P = 0.46), and TwPt (-16 ± 7% vs. -19 ± 14%, P = 0.67) was similar in ISCH and CONTR. Endurance performance was drastically reduced in ISCH condition (512 ± 29 s) compared with CONTR (386 ± 17 s) (P < 0.001), which was accompanied by lower EMG, PO, and VÌo2 responses (all P < 0.05). RPE was greater in ISCH compared with CONTR (P < 0.05), but the rate of change was similar throughout the TT (8.19 ± 2.59 vs. 7.81 ± 2.01 RPE.% of total time-1, P > 0.05). These results indicate that similar end-exercise NMF levels were accompanied by impaired endurance performance in ISCH compared with CONTR. These novel findings suggest that the local reduced oxygen availability affected the afferent feedback signals to the central nervous system, ultimately increasing perceived effort and reducing muscle activity and exercise intensity to avoid surpassing a sensory tolerance limit before the finish line.
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Desempenho Atlético/fisiologia , Isquemia/fisiopatologia , Fadiga Muscular/fisiologia , Músculo Esquelético/fisiopatologia , Adulto , Ciclismo/fisiologia , Exercício Físico/fisiologia , Humanos , Contração Isométrica/fisiologia , Articulação do Joelho/fisiologia , Articulação do Joelho/fisiopatologia , Masculino , Músculo Esquelético/fisiologiaRESUMO
Performance in self-paced endurance exercises results from continuous fatigue symptom management. While it is suggested that perceived responses and neuromuscular fatigue development may determine variations in exercise intensity, it is uncertain how these fatigue components interact throughout the task. To address the fatigue development in self-paced endurance exercises, the following topics were addressed in the present review: (1) fatigue development during constant-load vs. self-paced endurance exercises; (2) central and peripheral fatigue and perceived exertion interconnections throughout the self-paced endurance exercises; and (3) future directions and recommendations. Based on the available literature, it is suggested (1) the work rate variations during a self-paced endurance exercise result in transitions between exercise intensity domains, directly impacting the end-exercise central and peripheral fatigue level when compared to constant-load exercise mode; (2) central and peripheral fatigue, as well as perceived exertion response contribute to exercise intensity regulation at the different stages of the trial. It seems that while neuromuscular fatigue development might be relevant at beginning of the trial, the perceived exertion might interfere in the remaining parts to achieve maximal values only at the finish line; (3) future studies should focus on the mechanisms underpinning fatigue components interactions throughout the task and its influence on exercise intensity variations.
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Exercício Físico , Fadiga Mental/fisiopatologia , Fadiga Muscular/fisiologia , Resistência Física , Esforço Físico , Corrida , HumanosRESUMO
NEW FINDINGS: What is the central question of this study? Does creatine supplementation augment the total torque impulse accumulated above end-test torque (IET) during severe-intensity knee-extensor exercise by attenuating the rate of decrease in peak potentiated twitch torque (PT)? What is the main finding and its importance? Creatine augmented the IET and attenuated the rate of decrease in both voluntary activation and PT during severe-intensity exercise. The IET was related to the rate of decrease in PT. These findings reveal an important role for the rates of neuromuscular fatigue development as key determinants of exercise tolerance within the severe domain. ABSTRACT: This study investigated the effect of creatine supplementation on exercise tolerance, total torque impulse accumulated above end-test torque (total IET) and neuromuscular fatigue development of the knee extensors during severe-intensity intermittent isometric exercise. Sixteen men were randomly allocated into Creatine (n = 8, 20 g day-1 for 5 days) or Placebo (n = 8) groups and performed knee-extensor maximal voluntary contraction (MVC) testing, all-out testing to determine end-test torque (ET) and the finite torque impulse accumulated above end-test torque (IET'), and three submaximal tests at ET + 10%: (i) time to task failure without supplementation (Baseline); (ii) time to task failure after creatine or placebo supplementation; and (iii) time matched to Baseline after creatine (Creatine-Isotime) or placebo (Placebo-Isotime) supplementation. Creatine supplementation significantly increased the time to task failure (Baseline = 572 ± 144 s versus Creatine = 833 ± 221 s) and total IET (Baseline = 5761 ± 1710 N m s versus Creatine = 7878 ± 1903 N m s), but there were no significant differences within the Placebo group. The percentage change pre- to postexercise in MVC, voluntary activation, peak potentiated twitch torque and integrated EMG during MVC were not significantly different between Baseline and Creatine but were all significantly attenuated in Creatine-Isotime compared with Baseline. There were no significant differences in these variables within the placebo group. The total IET was significantly correlated with the rates of change in potentiated twitch torque peak (r = 0.83-0.87) and rate of torque development (r = -0.83 to -0.87) for the submaximal tests to task failure. These findings reveal an important role for the rates of neuromuscular fatigue development as key determinants of exercise tolerance during severe-intensity intermittent isometric exercise.
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Creatina/administração & dosagem , Exercício Físico/fisiologia , Contração Isométrica/efeitos dos fármacos , Fadiga Muscular/efeitos dos fármacos , Músculo Esquelético/efeitos dos fármacos , Adulto , Suplementos Nutricionais , Tolerância ao Exercício/efeitos dos fármacos , Humanos , Articulação do Joelho/efeitos dos fármacos , Masculino , Contração Muscular/efeitos dos fármacos , TorqueRESUMO
This study compared the electromyographic response, the blood lactate concentration (BLC), and the maximum number of repetitions (MNR) between protocols of different concentric/eccentric duration taken to muscle failure. This comparison may help to understand how different concentric/eccentric duration may influence performance and the central and metabolic responses in trained men. Seventeen strength-trained men performed two protocols in a counterbalanced design. Three sets of the Smith bench press exercise were performed to failure at 60% of the one-repetition maximum (1RM) using each protocol (4-s concentric/2-s eccentric [4 s: 2 s]; and 2-s concentric/4-s eccentric [2 s: 4 s]). The normalized root mean square (EMGRMS) and the mean frequency (EMGMF) of the electromyographic signals for the pectoralis major and the triceps brachii were compared in the first, middle, and last repetitions. The BLC was assessed at rest, during and after the test sessions. To compare the EMG and BLC, a 3-way ANOVA with repeated measures with a post hoc Tukey's test was used. To compare the MNR performed across the sets, an ANOVA-type rank test with the Dunn's post hoc test was used. The ANOVA indicated a greater EMGRMS for Protocol 4 s: 2 s in the pectoralis major and a lower EMGMF for Protocol 4 s: 2 s in the triceps brachii at the middle and last repetitions. Both protocols increased the EMGRMS and decreased the EMGMF across repetitions. Despite the results show different levels of activation and neuromuscular fatigue between protocols, the BLC and the MNR were similar.
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Fatigue is defined as the inability to maintain muscle power and strength, impairing performance. Nutritional interventions have been used to delay this phenomenon, such as glutamine and alanine supplementation. These amino acids might attenuate several causes of fatigue, since they are important energy substrates, transport ammonia avoiding the accumulation of this toxic metabolite and attenuate muscle damage and oxidative stress. Thus, the aim of this study was to evaluate the effects of glutamine and alanine supplementation on central and muscle fatigue parameters of rats submitted to resistance training (RT). Forty adult Wistar rats (60 days) were distributed into five groups: SED (sedentary, receiving water), CON (trained, receiving water), ALA, G+A and DIP (trained and supplemented with alanine, glutamine and alanine in their free form, and Lalanyl-L-glutamine, respectively). Trained groups underwent a ladder-climbing exercise, with progressive loads, for eight weeks. Supplements were diluted in water to a 4% concentration and offered ad libitum during the last 21 days of experiment. RT increased plasma glucose, the muscle concentrations of ammonia and glutathione (GSH) and the muscle damage parameters - plasma creatine kinase (CK) and lactate dehydrogenase (LDH), whereas decreased muscle glycogen. G+A supplementation prevented the increase of muscle ammonia by RT, while ALA and G+A administration reduced plasma CK and LDH, and DIP supplementation increased the muscle content of glycogen and LDH. Contrary to expectations, DIP administration increased central fatigue parameters, such as plasma concentration of free fatty acids (FFA), hypothalamic content of serotonin and serotonin/dopamine ratio. Despite these results, there was no difference between groups in the maximum carrying capacity (MCC) tests. In conclusion, supplementation with glutamine and alanine improves some fatigue parameters, but does not affect physical performance of rats submitted to RT
O termo fadiga é definido como a incapacidade de manutenção da força e da potência musculares, prejudicando a performance. Intervenções nutricionais têm sido utilizadas para retardar este fenômeno, como a suplementação com glutamina e alanina. Estes aminoácidos poderiam atenuar diversas causas de fadiga, pois são importantes substratos energéticos, carreiam amônia evitando o acúmulo deste metabólito tóxico e atenuam a lesão muscular e o estresse oxidativo. Logo, o objetivo deste estudo foi avaliar os efeitos da suplementação com glutamina e alanina sobre parâmetros de fadiga central e muscular em ratos submetidos ao treinamento resistido (TR). Foram utilizados 40 ratos Wistar adultos (60 dias de idade), distribuídos nos grupos: SED (não treinados, recebendo água), CON (treinados, recebendo água), ALA, G+A e DIP (treinados e suplementados com alanina, glutamina e alanina livres, e L-alanil-L-glutamina, respectivamente). Os grupos treinados realizaram um exercício de escalada em escada, com aumento progressivo de carga, durante oito semanas. A suplementação foi diluída a 4% em água e ofertada via oral, ad libitum, durante os últimos 21 dias de experimento. O TR aumentou a glicemia, as concentrações musculares de amônia e de glutationa (GSH) e os parâmetros de lesão muscular - creatina quinase (CK) e lactato desidrogenase (LDH) no plasma, enquanto reduziu o glicogênio no músculo. A suplementação com G+A preveniu o aumento de amônia muscular promovido pelo TR, enquanto a administração de ALA e G+A reduziu as concentrações de CK e LDH no plasma, e a suplementação com DIP aumentou o conteúdo muscular de glicogênio e de LDH. Ao contrário do esperado, a administração de DIP aumentou parâmetros de fadiga central, como as concentrações plasmáticas de ácidos graxos livres, o conteúdo hipotalâmico de serotonina e a razão serotonina/dopamina. Apesar disso, não houve diferença entre os grupos nos testes de carga máxima. Em conclusão, a suplementação com glutamina e alanina melhora alguns parâmetros de fadiga, mas não afeta o desempenho físico em ratos submetidos ao TR
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Animais , Masculino , Feminino , Ratos , Suplementos Nutricionais/classificação , Alanina/antagonistas & inibidores , Fadiga/classificação , Glutamina/antagonistas & inibidores , Glicemia/imunologia , Água/farmacologia , Exercício Físico/fisiologia , Treinamento Resistido/métodos , Desempenho Físico FuncionalRESUMO
Pacing during a high-intensity cycling time trial (TT) appears to prevent premature task failure, but the performance fatigability during a self-paced exercise is currently unknown. Therefore, the current study characterized the time course of performance fatigability during a 4-km TT. Eleven male cyclists performed three separated TTs in a crossover, counterbalanced design. The TTs lasted until the end of the fast-start (FS; 600 ± 205 m), even-pace (EP; 3,600 ± 190 m), and end-spurt (ES; 4,000 m) phases. Performance fatigability was characterized by using isometric maximal voluntary contractions (IMVCs), whereas the muscle activation [i.e., voluntary activation (VA)] and contractile function of knee extensors [e.g., peak torque of potentiated twitches (TwPt)] were evaluated using electrically evoked contractions performed before and 1 min after each specific part of the trial. Gas exchange, power output (PO), and electromyographic activity (EMG) were also recorded. EMG/PO showed an abrupt increase followed by a continuous decrease toward the end of FS, resulting in a drop in IMVC (-12%), VA (-8%), and TwPt (-23%). EMG/PO was stable during EP, with no additional drop on IMVC, VA, or TwPt (-12%, -6%, and -22%, respectively). EMG/PO increased abruptly during the ES, but there was no change in IMVCs, VA, or TwPt (-13%, -8%, and -26%, respectively). These findings demonstrate that the performance fatigability during a self-paced exercise is characterized by a large drop in contractile function and muscle activation at the beginning of the trial (i.e., FS), without additional change during the middle and end phases (i.e., EP and ES).NEW & NOTEWORTHY The time course of performance fatigability throughout a self-paced exercise is currently unknown. The results showed that a large amount of muscle activation and contractile function impairments are attained early on a self-paced exercise (first â¼15% of the total time trial distance) and maintained throughout the test. This novel finding characterizes the performance fatigability from a contractile function and muscle activation perspective, which brings new insights for future studies focused on real-world exercise training and competition.
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Desempenho Atlético/fisiologia , Ciclismo/fisiologia , Contração Muscular , Fadiga Muscular , Adulto , Humanos , MasculinoRESUMO
Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. Notwithstanding, glutamine plays several other biological functions, such as cell proliferation, energy production, glycogenesis, ammonia buffering, maintenance of the acid-base balance, among others. Thus, this amino acid began to be investigated in sports nutrition beyond its effect on the immune system, attributing to glutamine various properties, such as an anti-fatigue role. Considering that the ergogenic potential of this amino acid is still not completely known, this review aimed to address the main properties by which glutamine could delay fatigue, as well as the effects of glutamine supplementation, alone or associated with other nutrients, on fatigue markers and performance in the context of physical exercise. PubMed database was selected to examine the literature, using the keywords combination "glutamine" and "fatigue". Fifty-five studies met the inclusion criteria and were evaluated in this integrative literature review. Most of the studies evaluated observed that glutamine supplementation improved some fatigue markers, such as increased glycogen synthesis and reduced ammonia accumulation, but this intervention did not increase physical performance. Thus, despite improving some fatigue parameters, glutamine supplementation seems to have limited effects on performance.
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Exercício Físico , Fadiga/prevenção & controle , Glutamina/farmacologia , Ciências da Nutrição e do Esporte , Glutamina/administração & dosagem , HumanosRESUMO
OBJECTIVE: This study aimed to verify the acute and prolonged effects of stretch-shortening cycle exercise (SSC) on performance and neuromuscular function following a 4-km cycling time trial (4-km TT). METHODS: On separate days, individuals performed a 4-km TT without any previous exercise (CON), immediately (ACUTE) and 48 h after (PROL) SSC protocol (i.e., 100-drop jumps). Neuromuscular function was measured at baseline SSC (baseline), before (pre-TT) and after (post-TT) 4-km TT. Muscle soreness and inflammatory responses also were assessed. RESULTS: The endurance performance was impaired in both ACUTE (- 2.3 ± 1.8%) and PROL (- 1.8 ± 2.4%) compared with CON. The SSC protocol caused also an acute reduction in neuromuscular function, with a greater decrease in potentiated quadriceps twitch-force (Qtw.pot - 49 ± 16%) and voluntary activation (VA - 6.5 ± 7%) compared for CON and PROL at pre-TT. The neuromuscular function was fully recovered 48 h after SSC protocol. Muscle soreness and IL-10 were elevated only 48 h after SSC protocol. At post-TT, Qtw.pot remained lower in ACUTE (- 52 ± 14%) compared to CON (- 29 ± 7%) and PROL (- 31 ± 16%). CONCLUSION: These findings demonstrate that impairment in endurance performance induced by prior SSC protocol was mediated by two distinct mechanisms, where the acute impairment was related to an exacerbated degree of peripheral and central fatigue, and the prolonged impairment was due to elevated perceived muscle soreness.
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Fadiga/etiologia , Contração Isométrica , Fadiga Muscular , Resistência Física , Exercício Pliométrico/métodos , Adulto , Fadiga/fisiopatologia , Humanos , Interleucinas/sangue , Ácido Láctico/sangue , Masculino , Exercício Pliométrico/efeitos adversosRESUMO
PURPOSE: The purpose of this study was to investigate the effects of mental fatigue, characterized by a subjective feeling of tiredness, on the development of neuromuscular fatigue during a 4-km cycling time trial (4-km TT). METHODS: Eight recreationally trained male cyclists performed a 4-km TT after either performing a prolonged cognitive task (mental fatigue) or after viewing emotionally neutral documentaries (control). The neuromuscular function of the knee extensors was assessed using electrical nerve stimulation at baseline, before (pre-TT), and after (post-TT) the 4-km TT. Rating of perceived exertion (RPE) and physiological variables were periodically measured during 4-km TT. RESULTS: Subjective ratings of fatigue increased significantly only after a prolonged cognitive task (P = 0.022). Neuromuscular function at baseline was similar between conditions and remained unchanged at pre-TT. Time to complete the 4-km TT was similar between control (376 ± 27 s) and mental fatigue (376 ± 26 s). There was no significant difference between conditions for RPE, [Formula: see text], [Formula: see text], and HR throughout the exercise. The 4-km TT-induced similar decrease (from baseline to post-TT) in maximal voluntary contraction (mental fatigue - 11 ± 10%, control - 16 ± 12%), twitch force (mental fatigue - 26 ± 16%, control - 24 ± 17%), and voluntary activation (mental fatigue - 5 ± 7%, control - 3 ± 2%) for both conditions. CONCLUSION: Mental fatigue induced by prolonged cognitive task does not impair performance nor alter the degree of central and peripheral fatigue development during self-paced exercise in recreationally trained cyclists.
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Desempenho Atlético/fisiologia , Ciclismo/fisiologia , Cognição/fisiologia , Exercício Físico/fisiologia , Fadiga Mental/fisiopatologia , Fadiga Muscular/fisiologia , Adulto , Eletromiografia , Humanos , Masculino , Músculo Esquelético/fisiopatologia , Resistência Física/fisiologiaRESUMO
INTRODUCTION: In this study we investigated fatigue origins induced by low-frequency pulsed current (PC) and medium-frequency current (MF) neuromuscular electrical stimulation (NMES) after a clinical-like session. METHODS: Eleven healthy men randomly underwent 2 NMES sessions, PC and MF, on quadriceps muscle (15-minute duration, 6 seconds on and 18 seconds off). Maximal voluntary contraction (MVC), central activation ratio (CAR), vastus lateralis electromyographic activity (EMG), and evoked contractile properties were determined before and after the sessions. Evoked torque and discomfort during the sessions were also measured. RESULTS: Both currents produced decreases in MVC, EMG, and evoked contractile properties after the sessions. No difference was found between currents for all variables (P > 0.05). Evoked torque during sessions decreased (P < 0.05). No difference was observed in mean evoked torque and discomfort (P > 0.05). DISCUSSION: Both currents induced similar neuromuscular fatigue. Clinicians can choose either PC or MF and expect similar treatment effects when the goal is to generate gains in muscle strength. Muscle Nerve 58: 293-299, 2018.
Assuntos
Estimulação Elétrica/efeitos adversos , Fadiga Muscular/fisiologia , Adulto , Estudos Cross-Over , Método Duplo-Cego , Eletromiografia , Voluntários Saudáveis , Humanos , Masculino , Contração Muscular/fisiologia , Dinamômetro de Força Muscular , Músculo Quadríceps/fisiologia , Torque , Adulto JovemRESUMO
We investigated if a carbohydrate (CHO) mouth rinse may attenuate global fatigue and improve 4-km cycling time trial (TT4km) performance. After a preliminary session, cyclists (n = 9) performed a TT4km after a CHO or placebo (PLA) mouth rinse. Mean power output, time, and ratings of perceived exertion (RPE) were recorded throughout the TT4km. Twitch interpolation responses (%VA; voluntary activation and ∆Tw; delta peak twitch torque) were compared pre and post TT4km with traditional statistics and effect size (ES) analysis. Time-to-complete the 4 km and mean power output were comparable between CHO (386.4 ± 28.0 s) and PLA (385.4 ± 22.4 s). A lower central (p = 0.054) and peripheral (p = 0.02) fatigue in CHO than in PLA were suggested by an extremely-large ES in %VA (manipulation main effect: p = 0.052, d = 1.18; manipulation-by-time interaction effect: p = 0.08, d = 1.00) and an extremely, very-large ES in ∆Tw (manipulation main effect: p = 0.07, d = 0.97; time-by-manipulation interaction effect: p = 0.09, d = 0.89). The RPE increased slower in CHO than in PLA (p = 0.051; d = 0.7). The apparent reduction in global fatigue (central and peripheral) and RPESLOPE with only one CHO mouth rinse were not translated into improved TT4km performance. Further tests may be required to verify if these likely differences in global fatigue might represent an edge in the short-lasting cycling time trial performance.
Assuntos
Desempenho Atlético , Ciclismo , Carboidratos da Dieta/administração & dosagem , Fadiga/prevenção & controle , Antissépticos Bucais/administração & dosagem , Substâncias para Melhoria do Desempenho/administração & dosagem , Administração através da Mucosa , Adulto , Brasil , Carboidratos da Dieta/metabolismo , Carboidratos da Dieta/uso terapêutico , Suplementos Nutricionais , Método Duplo-Cego , Fadiga/etiologia , Fadiga/metabolismo , Humanos , Masculino , Antissépticos Bucais/metabolismo , Antissépticos Bucais/uso terapêutico , Fadiga Muscular , Absorção pela Mucosa Oral , Consumo de Oxigênio , Substâncias para Melhoria do Desempenho/metabolismo , Substâncias para Melhoria do Desempenho/uso terapêutico , Esforço Físico , Recreação , Fenômenos Fisiológicos da Nutrição Esportiva , Fatores de TempoRESUMO
Recent evidence suggests that increased brain serotonin synthesis impairs performance in high-intensity intermittent exercise and specific amino acids may modulate this condition, delaying fatigue. This study investigated the effects of glutamine and alanine supplementation on central fatigue markers in rats submitted to resistance training (RT). Wistar rats were distributed in: sedentary (SED), trained (CON), trained and supplemented with alanine (ALA), glutamine and alanine in their free form (G + A), or as dipeptide (DIP). Trained groups underwent a ladder-climbing exercise for eight weeks, with progressive loads. In the last 21 days, supplementations were offered in water with a 4% concentration. Albeit without statistically significance difference, RT decreased liver glycogen, and enhanced the concentrations of plasma glucose, free fatty acids (FFA), hypothalamic serotonin, and ammonia in muscle and the liver. Amino acids affected fatigue parameters depending on the supplementation form. G + A prevented the muscle ammonia increase by RT, whereas ALA and DIP augmented ammonia and glycogen concentrations in muscle. DIP also increased liver ammonia. ALA and G + A reduced plasma FFA, whereas DIP increased this parameter, free tryptophan/total tryptophan ratio, hypothalamic serotonin, and the serotonin/dopamine ratio. The supplementations did not affect physical performance. In conclusion, glutamine and alanine may improve or impair central fatigue markers depending on their supplementation form.
Assuntos
Alanina/farmacologia , Fadiga/tratamento farmacológico , Glutamina/farmacologia , Condicionamento Físico Animal , Amônia/metabolismo , Animais , Glicemia/metabolismo , Suplementos Nutricionais , Dipeptídeos/sangue , Dopamina/sangue , Fadiga/sangue , Ácidos Graxos não Esterificados/sangue , Glicogênio/metabolismo , Fígado/efeitos dos fármacos , Fígado/metabolismo , Masculino , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/metabolismo , Ratos , Ratos Wistar , Serotonina/sangueRESUMO
PURPOSE: To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia. METHODS: Seven adult male participants firstly underwent an incremental exercise test on a cycle ergometer in conditions of acute normobaric hypoxia (fraction inspired oxygen = 0.15) to establish peak power output (PPO). In the following two visits, they performed a time to exhaustion test (78 ± 3% PPO) in the same hypoxic conditions after caffeine ingestion (4 mg kg-1) and one after placebo ingestion in a double-blind, randomized, counterbalanced cross-over design. RESULTS: Caffeine significantly improved time to exhaustion by 12%. A significant decrease in subjective fatigue was found after caffeine consumption. Perception of effort and surface electromyographic signal amplitude of the vastus lateralis were lower and heart rate was higher in the caffeine condition when compared to placebo. However, caffeine did not reduce the peripheral and central fatigue induced by high-intensity cycling exercise in moderate hypoxia. CONCLUSION: The caffeine-induced improvement in time to exhaustion during high-intensity cycling exercise in moderate hypoxia seems to be mediated by a reduction in perception of effort, which occurs despite no reduction in neuromuscular fatigue.