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J Mol Evol ; 88(8-9): 703-713, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33029646

RESUMO

The most paradigmatic examples of molecular evolution under positive selection involve genes related to the immune system. Recently, different chloroplastic factors have been shown to be important for plant defenses, among them, the α- and ß-subunits of the ATP synthase. The ß-subunit has been reported to interact with several viral proteins while both proteins have been implicated with sensitivity to tentoxin, a phytotoxin produced by the widespread fungus Alternaria alternata. Given the relation of both protein to virulence factors, we studied whether these proteins are evolving under positive selection. To this end, we used the dN/dS ratio to examine possible sites under positive selection in several Angiosperm clades. After examining 79 plant genera and 1232 species, we found three times more sites under pervasive diversifying selection in the N-terminal region of the ß-subunit compared to the α-subunit, supporting previous results which identified this region as responsible for interacting with viral proteins. Moreover, we found the site 83 of ß-subunit under positive selection in several plant genera, a site clearly related to the sensitivity to tentoxin according to biochemistry assays, which possibly reflects the selective pressure of the non-host specific tentoxin across various Angiosperm clades.


Assuntos
ATPases de Cloroplastos Translocadoras de Prótons , Magnoliopsida , Seleção Genética , Fatores de Virulência , Alternaria , ATPases de Cloroplastos Translocadoras de Prótons/genética , Magnoliopsida/enzimologia , Magnoliopsida/genética , Fatores de Virulência/genética
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