RESUMO
Influenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, co-circulate worldwide and they present challenges for vaccine strain selection. Until the present study, there was little information regarding the pattern of the circulating strains of IBV in Uruguay. A subset of positive influenza B samples from influenza-like illness (ILI) outpatients and severe acute respiratory illness (SARI) inpatients detected in sentinel hospitals in Uruguay during 2012-2019 were selected. The sequencing of the hemagglutinin (HA) and neuraminidase (NA) genes showed substitutions at the amino acid level. Phylogenetic analysis reveals the co-circulation of both lineages in almost all seasonal epidemics in Uruguay, and allows recognizing a lineage-level vaccine mismatch in approximately one-third of the seasons studied. The epidemiological results show that the proportion of IBV found in ILI was significantly higher than the observed in SARI cases across different groups of age (9.7% ILI, 3.2% SARI) and patients between 5-14 years constituted the majority (33%) of all influenza B infection (p < 0.05). Interestingly, we found that individuals >25 years were particularly vulnerable to Yamagata lineage infections.
RESUMO
Currently, 2 genotypes of Influenza B viruses (IFB) are cocirculating in humans: Victoria (VIC) and Yamagata (YAM). Infection and viral load (VL) were analyzed in 105 genotyped IFB (59 VIC and 46 YAM) out of 3452 respiratory samples from immunodepressed (ID), immunocompetent (IC) including outpatients (OP) and hospitalized patients (HP) attended during 2001-2013 at São Paulo Hospital. VL (Log10 RNA copies/mL) calculation was possible in 78 samples (47 VIC, 31 YAM). The age group of 12 to 18 years presented the highest detection (14.13%). Rates of infection among groups were of 3.67% (IC), 1.68% (ID), 3.50% (OP), 0.6% (HP), and VLs varied from 2.8 to 10.13 with no difference regarding age, immune status, and disease severity. From 10 OP vaccinated against influenza, 8 (7 children, 1 ID) received a matching strain shot (VIC), and 2 a monovalent influenza A H1N1pdm09. Those patients presented a VL of 6.31 ± 1.62 (mean ± SD). IFB infection rates follow an age pattern, but VL seems not to be related to frequency or clinical outcome. IFB patients with previous immunization could point to some protection for VIC infections since there was no HP. Other immunological aspects, such as lineage infection immune priming, previous infections, and vaccinations, should be further investigated.
Assuntos
Vírus da Influenza B/genética , Influenza Humana/virologia , Infecções Respiratórias/virologia , Carga Viral/estatística & dados numéricos , Adolescente , Adulto , Idoso , Anticorpos Antivirais/sangue , Brasil , Criança , Pré-Escolar , Feminino , Humanos , Imunização/estatística & dados numéricos , Lactente , Vírus da Influenza B/imunologia , Vacinas contra Influenza/administração & dosagem , Influenza Humana/imunologia , Pessoa de Meia-Idade , Infecções Respiratórias/imunologia , Índice de Gravidade de Doença , Centros de Atenção Terciária , Adulto JovemRESUMO
Resumen: La pandemia generada por el SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus) ha constituido un desafío mundial. En momentos de dificultad como los que se han presentado recientemente, es aún más necesaria la investigación para avanzar en el diagnóstico y tratamiento de las diferentes patologías. Utilizando el amplio desarrollo de los medios de comunicación, este año el Congreso del Colegio Americano de Cardiología (ACC por su sigla en inglés) se celebró del 28 al 30 de marzo en un formato virtual, permitiendo a profesionales de todo el mundo acceder a múltiples actividades científicas con el mismo nivel de excelencia que en las sesiones presenciales. Realizaremos un breve resumen de alguno de los principales trabajos científicos presentados: - Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention: TAILOR-PCI. - Rivaroxaban in Peripheral Artery Disease after Revascularization: VOYAGER PAD trial. - Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction: VICTORIA Study Group. - The Evolut Low Risk Bicuspid Study. - PARTNER 3. Two-year clinical and echocardiographic outcomes. - Ticagrelor with and without Aspirin in Acute Coronary Syndrome After PCI: the TICO Trial - Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer: Caravaggio trial. - Ten-year Outcomes After Drug-eluting Stents Versus Coronary Artery Bypass Grafting for Left Main Coronary Disease: Extended Follow Up of the PRECOMBAT Trial. - Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation: POPular TAVI.
Summary The SARS-CoV-2 pandemic has been a global challenge. In times of difficulty such as those that have recently arisen, research is even more necessary to advance in the diagnosis and treatment of different pathologies. Using the extensive development of the media, this year the American Congress of Cardiology was held from March 28 to 30 in a virtual format, allowing professionals from around the world to access multiple scientific activities with the same level of excellence as in face-to-face sessions. We will make a brief summary of some of the main scientific papers presented: - Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention: TAILOR-PCI. - Rivaroxaban in Peripheral Artery Disease after Revascularization: VOYAGER PAD trial:. - Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction: VICTORIA Study Group. - The Evolut Low Risk Bicuspid Study. - PARTNER 3. Two-year clinical and echocardiographic outcomes. - Ticagrelor with and without Aspirin in Acute Coronary Syndrome After PCI: the TICO Trial. - Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer: Caravaggio trial. - Ten-year Outcomes After Drug-eluting Stents Versus Coronary Artery Bypass Grafting for Left Main Coronary Disease: Extended Follow Up of the PRECOMBAT Trial. - Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation: POPular TAVI.
Resumo: A pandemia de SARS-CoV-2 tem sido um desafio global. Em tempos de dificuldade como os que surgiram recentemente, a pesquisa é ainda mais necessária para avançar no diagnóstico e tratamento de diferentes patologias. Utilizando o amplo desenvolvimento da mídia, este ano o Congresso Americano de Cardiologia foi realizado de 28 ao 30 de março em um formato virtual, permitindo que profissionais de todo o mundo acessassem diversas atividades científicas com o mesmo nível de excelência que nas sessões presenciais. Faremos um breve resumo de alguns dos principais trabalhos científicos apresentados: - Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention: TAILOR - PCI. - Rivaroxaban in Peripheral Artery Disease after Revascularization: VOYAGER PAD trial. - Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction: VICTORIA Study Group. - The Evolut Low Risk Bicuspid Study. - PARTNER 3. Two-year clinical and echocardiographic outcomes. - Ticagrelor with and without Aspirin in Acute Coronary Syndrome After PCI: the TICO Trial. - Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer: Caravaggio trial. - Ten-year Outcomes After Drug-eluting Stents Versus Coronary Artery Bypass Grafting for Left Main Coronary Disease: Extended Follow Up of the PRECOMBAT Trial. - Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation: POPular TAVI.
RESUMO
El Dr. Enrique Alberto Suárez Hernández matriculó en la Universidad de La Habana la carrera de Medicina en 1938 y se graduó en 1945. Ejerció como médico Municipal en Oriente, como médico forense en Banes, médico en Guanabacoa y profesor de Anatomía en la Escuela de Medicina de la Universidad de La Habana. En los años de la clandestinidad, colaboró con combatientes y campesinos que iban a verlo por problemas de salud. Al triunfo revolucionario se incorporó a las Milicias Nacionales Revolucionarias, fue fundador de los Comités de Defensa de la Revolución y miembro de la Central de trabajadores de Cuba. Participó en movilizaciones y trabajos voluntarios. Fundador del Instituto de Ciencias Básicas y Preclínicas "Victoria de Girón", Profesor Titular de Anatomía.
Dr. Enrique Alberto Suárez Hernández enrolled in the medical studies at the University of Havana in 1938 and graduated in 1945. He worked as Municipal Doctor in the East of Cuba, forensic doctor in the region of Banes, doctor in Guanabacoa, and Professor of Anatomy in the Medical School of the University of Havana. During the years of the clandestineness, he collaborated with combatants and farmers that went to see him with health problems. After the triumph of the Cuban Revolution, he became member of the National Revolutionary Militia. Dr. Enrique was one of the founders of the "Comités de Defensa de la Revolución" (CDR) and a member of the "Central de Trabajadores de Cuba" (CTC). He participated in mobilizations and voluntary works. Dr. Enrique Suárez Hernández was one of founders of the Institute of Basic and Pre-Clinical Sciences "Victoria de Girón"; full professor of Anatomy.
RESUMO
In this work, we describe a SYBR-Green one-step reverse transcription-PCR protocol coupled with a melting temperature analysis (RT-PCR-Tm ), which allows the discrimination of influenza B lineages Yamagata and Victoria. The assay is performed using a regular real-time thermocycler and is based on differences in melting temperature (Tm ) of a 131-bp amplicon, obtained from a conserved region of hemagglutinin gene. A total of 410 samples collected during the 2004, 2008, and 2010-2017 influenza seasons in Brazil were tested, and the lineages were correctly characterized using their melting profiles. The temperature range is significantly different between both lineages throughout the time (Mann-Whitney test; P < 0.0001, confidence interval = 95%), and the Tm is not affected by viral load (Spearman correlation test; r = 0.287, P = 2.245 × 10-9). The simplicity and cost-effectiveness of this protocol make it an option for influenza B lineage surveillance worldwide.
Assuntos
Vírus da Influenza B/classificação , Vírus da Influenza B/isolamento & purificação , Influenza Humana/diagnóstico , Desnaturação de Ácido Nucleico , Reação em Cadeia da Polimerase em Tempo Real/métodos , Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos , Brasil , Custos e Análise de Custo , Glicoproteínas de Hemaglutininação de Vírus da Influenza/genética , Humanos , Vírus da Influenza B/genética , Influenza Humana/virologia , Reação em Cadeia da Polimerase em Tempo Real/economia , Reação em Cadeia da Polimerase Via Transcriptase Reversa/economia , Fatores de TempoRESUMO
BACKGROUND: Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage. OBJECTIVES: To describe the influenza cases and viral circulation among hospitalized patients. METHODS: A prospective study based on active surveillance of inpatients with influenza-like illness from a tertiary hospital in Bucharest, Romania, in the season 2016/17. RESULTS: A total of 446 patients were tested, with a balanced gender distribution. Overall, 192 (43%) patients tested positive for influenza, with the highest positivity rate in the age groups 3-13 years and >65 years. Peak activity occurred between weeks 1 and 16/2017, with biphasic distribution: A viruses were replaced by B viruses from week 9/2017; B viruses predominated (66.1%). Among the 133 (69.3%) subtyped samples, all influenza A were subtype H3 (n=57) and all influenza B were B/Victoria (n=76). Patients who tested positive for influenza presented fewer comorbidities (p=0.012), except for the elderly, in whom influenza was more common in patients with comorbidities (p=0.050). Disease evolution was generally favorable under antiviral treatment. The length of hospital stay was slightly longer in patients with influenza-like illness who tested patients negative for influenza (p=0.031). CONCLUSIONS: Distinctive co-circulation of A/H3 and B/Victoria in Bucharest, Romania in the 2016/17 influenza season was found. While the A/H3 subtype was predominant throughout Europe that season, B/Victoria appears to have circulated specifically in Romania and the Eastern European region, predominantly affecting preschoolers and school children.
Assuntos
Monitoramento Epidemiológico , Influenza Humana/epidemiologia , Estações do Ano , Síndrome Respiratória Aguda Grave/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Criança , Pré-Escolar , Comorbidade , Feminino , Humanos , Lactente , Vírus da Influenza A/isolamento & purificação , Vírus da Influenza B/isolamento & purificação , Influenza Humana/patologia , Influenza Humana/virologia , Masculino , Vacinação em Massa/estatística & dados numéricos , Pessoa de Meia-Idade , Vigilância da População , Estudos Prospectivos , Romênia/epidemiologia , Síndrome Respiratória Aguda Grave/patologia , Síndrome Respiratória Aguda Grave/virologia , Centros de Atenção Terciária/estatística & dados numéricos , Fatores de Tempo , Adulto JovemRESUMO
ABSTRACT Background: Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage. Objectives: To describe the influenza cases and viral circulation among hospitalized patients. Methods: A prospective study based on active surveillance of inpatients with influenza-like illness from a tertiary hospital in Bucharest, Romania, in the season 2016/17. Results: A total of 446 patients were tested, with a balanced gender distribution. Overall, 192 (43%) patients tested positive for influenza, with the highest positivity rate in the age groups 3-13 years and >65 years. Peak activity occurred between weeks 1 and 16/2017, with biphasic distribution: A viruses were replaced by B viruses from week 9/2017; B viruses predominated (66.1%). Among the 133 (69.3%) subtyped samples, all influenza A were subtype H3 (n = 57) and all influenza B were B/Victoria (n = 76). Patients who tested positive for influenza presented fewer comorbidities (p = 0.012), except for the elderly, in whom influenza was more common in patients with comorbidities (p = 0.050). Disease evolution was generally favorable under antiviral treatment. The length of hospital stay was slightly longer in patients with influenza-like illness who tested patients negative for influenza (p = 0.031). Conclusions: Distinctive co-circulation of A/H3 and B/Victoria in Bucharest, Romania in the 2016/17 influenza season was found. While the A/H3 subtype was predominant throughout Europe that season, B/Victoria appears to have circulated specifically in Romania and the Eastern European region, predominantly affecting preschoolers and school children.
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Estações do Ano , Síndrome Respiratória Aguda Grave/epidemiologia , Influenza Humana/epidemiologia , Monitoramento Epidemiológico , Vírus da Influenza A/isolamento & purificação , Vírus da Influenza B/isolamento & purificação , Romênia/epidemiologia , Fatores de Tempo , Comorbidade , Vigilância da População , Vacinação em Massa/estatística & dados numéricos , Estudos Prospectivos , Distribuição por Idade , Síndrome Respiratória Aguda Grave/patologia , Síndrome Respiratória Aguda Grave/virologia , Influenza Humana/patologia , Influenza Humana/virologia , Centros de Atenção Terciária/estatística & dados numéricosRESUMO
The perianth organs of six species of Nymphaeaceae, representing Euryale, Nymphaea and Victoria, were studied on the basis of macroscopical, micromorphological, and anatomical characters. The aims were to determine whether perianth is differentiated among tepal whorls considering the presence of sepaloid and petaloid characters, and to evaluate the occurrence of both features in individual tepals. Selected perianth series were examined macroscopically, with light microscopy, and scanning electron microscopy. Osmophores were detected using neutral red and Sudan. In all tepals examined, stomata and hydropotes were present on the abaxial and adaxial surfaces. These are anomocytic or stephanocytic; hydropotes of irregular type are also present. The outer series of tepals display morpho-anatomical characters in most part related with photosynthetic and protective functions. Osmophore activity is very scarce and petaloid epidermal morphology is present only in N. lotus, thus allowing interpretation of this whorl as primarily sepaloid. The second series exhibits both petal-like and sepal-like characters; in N. amazonum and N. gardneriana sepaloid and petaloid group of cells are present on the abaxial surface of individual tepals. Therefore, this whorl is transitional between the outer and the innermost ones. Both the morpho-anatomy and presence of osmophore activity indicate that the innermost series is entirely petaloid. Inner tepals of E. ferox, N. alba, and V. cruziana share the presence of epidermal cells with predominantly smooth cuticle, whereas those of N. amazonum, N. gardneriana, and N. lotus share a cuticular ornamentation consisting of numerous papillae on each cell. Morphological characters of the perianth epidermis are in some respects congruent with the molecular phylogeny of Nymphaeaceae. Our results support the co-expression of sepaloidy and petaloidy within individual tepals and the mosaic model of perianth evolution proposed for the angiosperms.
Assuntos
Flores/ultraestrutura , Nymphaeaceae/ultraestrutura , Flores/genética , Microscopia Eletrônica de Varredura , Nymphaeaceae/genética , Epiderme Vegetal/genética , Epiderme Vegetal/ultraestrutura , Estômatos de Plantas/genética , Estômatos de Plantas/ultraestruturaRESUMO
Este estudo compreendeu as representações sociais da vitória/derrota para os pais segundo atletas adolescentes do esporte de alto rendimento, na cidade do Recife. A adolescência é compreendida a partir da Psicologia Social histórica, e o embasamento teórico metodológico da Teoria das Representações Sociais abordou os sujeitos em diferentes contextos socioculturais, lugares de pertencimento, experiências, crenças, saberes e sentimentos compartilhados. Adotou-se a perspectiva pluri metodológica com variados recursos de coleta e análise progressiva de dados. Participaram 101 atletas adolescentes do esporte de alto rendimento, nas modalidades natação e vôlei. Os instrumentos utilizados foram questionários de associação livre e entrevistas semi dirigidas. Na análise dos dados, o software EVOC e as técnicas de análise temática de conteúdo de Bardin. Identificamos as representações de vitória para os pais, nas dimensões: pessoal e motivacional, e afetivo emocional e, nas representações sociais da derrota para os pais, além destas, a dimensão técnica. O sentido de vitória para os pais apareceu ampliado: o contexto esportivo, a escolarização, e o crescimento pessoal e profissional na vida. A derrota para os pais é representada como oportunidade de aprendizado e superação para o adolescente, porém, eles mostraram que necessitam do apoio afetivo de sua família para lidar com a auto culpabilização nas situações de fracasso.
This study examined the social representations of victory and defeat held by parents of teenage athletes who participated in a high performance sports in the city of Recife. The developmental stage of adolescence is understood based on sociohistorical psychology, while the social representations theory constituted the frame of reference for approaching individuals from different social-cultural contexts, places, experiences, beliefs, knowledge, and shared feelings. A multi-methodological orientation was employed with a wide range of resources for the collection and progressive analysis of data. In this study, participants involved 101 teenager athletes, who participated in a high performance sport, either swimming or volleyball. The tools utilized included a free association questionnaire and semi-structured interviews. EVOC 2000 and Bardin's thematic content analysis were used for data analysis. Representations of victory were identified from the parents for the following dimensions: personal and motivational and affectiveemotional. In addition to those two dimensions, the technical dimension was also identified for the parental representation of defeat. The victory meaning for parents was not restricted just to the sport area, it was extended to other contexts such as education level, professional and personal growth. The value of defeat for parents was represented as an opportunity for learning and overcoming situations to the teenage athlete. However, they also showed the need for affective support from their families to deal with self-blame in the event of failure.
Este estudio comprendió las representaciones sociales de la victoria/derrota para los padres según adolescentes atletas de deporte de alto rendimiento en la ciudad de Recife. La Adolescencia comprendida a partir de la Psicología Socio Histórica y la base teórico- metodológica de la Teoría de las Representaciones Sociales abordó los sujetos en diferentes contextos socioculturales, lugares de origen, experiencias, creencias, saberes y sentimientos compartidos. Se adoptó una perspectiva plurimetodológica con variados recursos de recolección de análisis progresivo de datos. Participaron 101 atletas adolescentes de deporte de alto rendimiento en las modalidades de natación y volibol. Los instrumentos utilizados fueron cuestionarios de asociación libre y entrevistas semi-dirigidas. En el análisis de los datos, se usó el software EVOC y las técnicas de análisis temático del contenido de Bardin. Identificamos las representaciones de victoria para los padres en las dimensiones: personal-motivacional y afectivo-emocional y, en las representaciones sociales de la derrota para los padres, además de éstas, se consideró la dimensión técnica. El sentido de victoria para los padres apareció ampliado: el contexto deportivo, la escolarización y el crecimiento personal y profesional en la vida. La derrota para los padres es representada como oportunidad de aprendizaje y superación para el atleta adolescente, sin embargo, ellos demostraron que necesitan apoyo afectivo de su familia para lidiar con la auto culpabilidad en las situaciones de fracaso.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Psicologia Social , EsportesRESUMO
Este estudo compreendeu as representações sociais da vitória/derrota para os pais segundo atletas-adolescentes do esporte de alto rendimento, na cidade do Recife. A adolescência é compreendida a partir da Psicologia Social-histórica, e o embasamento teórico-metodológico da Teoria das Representações Sociais abordou os sujeitos em diferentes contextos socioculturais, lugares de pertencimento, experiências, crenças, saberes e sentimentos compartilhados. Adotou-se a perspectiva pluri metodológica com variados recursos de coleta e análise progressiva de dados. Participaram 101 atletas-adolescentes do esporte de alto rendimento, nas modalidades natação e vôlei. Os instrumentos utilizados foram questionários de associação livre e entrevistas semidirigidas. Na análise dos dados, o software EVOC e as técnicas de análise temática de conteúdo de Bardin. Identificamos as representações de vitória para os pais, nas dimensões: pessoal e motivacional, e afetivo-emocional e, nas representações sociais da derrota para os pais, além destas, a dimensão técnica. O sentido de vitória para os pais apareceu ampliado: o contexto esportivo, a escolarização, e o crescimento pessoal e profissional na vida. A derrota para os pais é representada como oportunidade de aprendizado e superação para o atleta-adolescente, porém, eles mostraram que necessitam do apoio afetivo de sua família para lidar com a autoculpabilização nas situações de fracasso.(AU)
This study examined the social representations of victory and defeat held by parents of teenage athletes who participated in a high performance sports in the city of Recife. The developmental stage of adolescence is understood based on sociohistorical psychology, while the social representations theory constituted the frame of reference for approaching individuals from different social-cultural contexts, places, experiences, beliefs, knowledge, and shared feelings. A multi-methodological orientation was employed with a wide range of resources for the collection and progressive analysis of data. In this study, participants involved 101 teenager athletes, who participated in a high performance sport, either swimming or volleyball. The tools utilized included a free association questionnaire and semi-structured interviews. EVOC 2000 and Bardin's thematic content analysis were used for data analysis. Representations of victory were identified from the parents for the following dimensions: personal and motivational and affectiveemotional. In addition to those two dimensions, the technical dimension was also identified for the parental representation of defeat. The victory meaning for parents was not restricted just to the sport area, it was extended to other contexts such as education level, professional and personal growth. The value of defeat for parents was represented as an opportunity for learning and overcoming situations to the teenage athlete. However, they also showed the need for affective support from their families to deal with self-blame in the event of failure.(AU)
Este estudio comprendió las representaciones sociales de la victoria/derrota para los padres según adolescentes atletas de deporte de alto rendimiento en la ciudad de Recife. La Adolescencia comprendida a partir de la Psicología Socio Histórica y la base teórico- metodológica de la Teoría de las Representaciones Sociales abordó los sujetos en diferentes contextos socioculturales, lugares de origen, experiencias, creencias, saberes y sentimientos compartidos. Se adoptó una perspectiva plurimetodológica con variados recursos de recolección de análisis progresivo de datos. Participaron 101 atletas adolescentes de deporte de alto rendimiento en las modalidades de natación y volibol. Los instrumentos utilizados fueron cuestionarios de asociación libre y entrevistas semi-dirigidas. En el análisis de los datos, se usó el software EVOC y las técnicas de análisis temático del contenido de Bardin. Identificamos las representaciones de victoria para los padres en las dimensiones: personal-motivacional y afectivo-emocional y, en las representaciones sociales de la derrota para los padres, además de éstas, se consideró la dimensión técnica. El sentido de victoria para los padres apareció ampliado: el contexto deportivo, la escolarización y el crecimiento personal y profesional en la vida. La derrota para los padres es representada como oportunidad de aprendizaje y superación para el atleta adolescente, sin embargo, ellos demostraron que necesitan apoyo afectivo de su familia para lidiar con la auto culpabilidad en las situaciones de fracaso.(AU)
Assuntos
Humanos , Masculino , Feminino , Adolescente , Psicologia Social , EsportesRESUMO
Since the 1980s, 2 antigenically distinct influenza B lineages have cocirculated in the world: B/Victoria/2/87 (first appeared in the 1980s) and B/Yamagata/16/88 (became predominant in the 1990s). B/Victoria/2/87 isolates were geographically restricted to eastern Asia during 1991-2000. During 2000-2001 and 2001-2002, B/Victoria/2/87 isolates reemerged in North America, Europe, and South America, and then spread globally. During influenza virus surveillance, season 2002, an outbreak of acute respiratory illness, which quickly spread among the population, has been notified by public health authorities living in Araraquara, São Paulo, Brazil. Instituto Adolfo Lutz and Secretariat of Health of São Paulo state teams initiate an investigation towards to describe the pattern of infection in this population temporally and by age and to characterize the strains by virus isolation and hemagglutination inhibition assay. The outbreak lasted approximately 10 weeks; many cases occurred between mid-August and mid-September. Children younger than 13 years were the most affected; the elderly were mostly immune to infection. Analysis of the clinical respiratory samples helped in identifying the B/Hong Kong/330/2001 and B/Brisbane/32/2002 subtypes-recent variants of B/Victoria/02/88, a lineage restricted to Southeast Asia until 2001. The Araraquara outbreak confirms the reemergence of the B/Victoria viruses in South America and highlights the importance of monitoring local circulating strains, especially in light of the absence of cross-protection between antigenically distinct influenza lineages. Based on influenza virus surveillance, public health authorities worldwide should decide whether trivalent vaccines or quadrivalent vaccines (containing both influenza virus B lineages) are to be used in each country.