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INTRODUCTION: Intraoperative electron radiotherapy (IOERT) is a technique aiming to deliver radiotherapy during oncological surgery. In breast IOERT, the applicator and shielding disc placement are correlated with organs at risk (OAR) irradiation, in vivo verification of these parameters is scarcely reported. The aim of our study is to report and analyze possible causes of the misalignment using radiochromic films and compare our results to others reported in the bibliography. METHODS: From November 2019 to April 2023, in vivo verifications were performed for 33 patients. IOERT was performed using a LIAC 10 MeV (Sordina, Italy) electron accelerator. We attached a radiochromic film to the upper side of the polytetrafluoroethylene cover of the shielding disc. The percentage of the irradiation area outside the disc was recorded and various parameters (applicator angulations, prescription depth, tumor location and breast size) were analyzed to find possible correlations. RESULTS: For 29 patients, 20 Gy were prescribed while 10 Gy were prescribed to 4 patients. The average irradiated area outside the disc was 19% (0-56%) corresponding to a surface of 4.5 cm2 (0-17.4 cm2). The applicator of 5 cm was used for most of the patients. The mean prescription depth was 1.4 cm (0.5-2.5 cm). We found no correlation between the analyzed parameters and misalignment. CONCLUSION: This study confirms the presence and magnitude of the misalignments. We strongly recommend in vivo verifications as a quality check during IOERT procedures. The misalignment has no correlation with tumor localization parameters, so the solution could be based on technical improvements of the applicator.

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There are many security challenges in IoT, especially related to the authentication of restricted devices in long-distance and low-throughput networks. Problems such as impersonation, privacy issues, and excessive battery usage are some of the existing problems evaluated through the threat modeling of this work. A formal assessment of security solutions for their compliance in addressing such threats is desirable. Although several works address the verification of security protocols, verifying the security of components and their non-locking has been little explored. This work proposes to analyze the design-time security of the components of a multi-factor authentication mechanism with a reputation regarding security requirements that go beyond encryption or secrecy in data transmission. As a result, it was observed through temporal logic that the mechanism is deadlock-free and meets the requirements established in this work. Although it is not a work aimed at modeling the security mechanism, this document provides the necessary details for a better understanding of the mechanism and, consequently, the process of formal verification of its security properties.

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In the last decade, face-recognition and -verification methods based on deep learning have increasingly used deeper and more complex architectures to obtain state-of-the-art (SOTA) accuracy. Hence, these architectures are limited to powerful devices that can handle heavy computational resources. Conversely, lightweight and efficient methods have recently been proposed to achieve real-time performance on limited devices and embedded systems. However, real-time face-verification methods struggle with problems usually solved by their heavy counterparts-for example, illumination changes, occlusions, face rotation, and distance to the subject. These challenges are strongly related to surveillance applications that deal with low-resolution face images under unconstrained conditions. Therefore, this paper compares three SOTA real-time face-verification methods for coping with specific problems in surveillance applications. To this end, we created an evaluation subset from two available datasets consisting of 3000 face images presenting face rotation and low-resolution problems. We defined five groups of face rotation with five levels of resolutions that can appear in common surveillance scenarios. With our evaluation subset, we methodically evaluated the face-verification accuracy of MobileFaceNet, EfficientNet-B0, and GhostNet. Furthermore, we also evaluated them with conventional datasets, such as Cross-Pose LFW and QMUL-SurvFace. When examining the experimental results of the three mentioned datasets, we found that EfficientNet-B0 could deal with both surveillance problems, but MobileFaceNet was better at handling extreme face rotation over 80 degrees.

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O crescimento do setor de panificação traz consigo a importância, bem como a obrigatoriedade, em produzirem os alimentos levando em consideração as Boas Práticas de Fabricação. Nesse sentido, o presente estudo objetivou verificar as condições higiênico-sanitárias de padarias no município de GuanambiBA, por meio da aplicação de uma lista de verificação conforme a Resolução- RDC Nº 216, de 15 de setembro de 2004. De acordo com os resultados, nenhuma das padarias apresentaram resultados 100% satisfatórios, ou seja, muitos dos procedimentos avaliados devem ser adaptados para que atendam às normas previstas nos dispositivos legais. A padaria B apresentou 66,2% dos itens em conformidade, seguido das padarias A (58,3%), D (33,%8) e C (32,8%). Entre os meios de enfrentamento dessa problemática, um relatório informativo, de forma individual para cada estabelecimento foi elaborado a fim de incentivar os proprietários a adequarem os procedimentos às normas legais.(AU)

The growth of the bakery sector brings with it the importance, as well as the obligation, of producing food taking into account Good Manufacturing Practices. In this sense, the present study aimed to verify the hygienic-sanitary conditions of bakeries in the municipality of GuanambiBA, through the application of a checklist according to Resolution-RDC Nº 216, of September 15, 2004. According to the results, none of the bakeries presented 100% satisfactory results, that is, many of the evaluated procedures must be adapted to meet the standards provided for in the legal provisions. Bakery B presented 66.2% of items in conformity, followed by bakeries A (58.3%), D (33.8%) and C (32.8%). Among the means of coping with this problem, an informative report, individually for each establishment, was prepared in order to encourage owners to adapt procedures to legal standards.(AU)

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The present study aimed to investigate whether training status would influence the capacity of a verification phase (VER) to confirm maximal oxygen uptake (VO2max) of a previous graded exercise test (GXT) in individuals with hypertension. Twelve older adults with hypertension (8 women) were recruited. Using a within-subject design, participants performed a treadmill GXT to exhaustion followed by a multistage VER both before and after a 12-wkcombined exercise training programme. Individual VO2max, respiratory exchange ratio (RER), maximal heart rate (HRmax), and rating of perceived exertion (RPE) were measured during both GXT and VER tests. Absolute and relative VO2max values were higher in VER than in GXT at baseline, but only absolute VO2max differed between bouts post-intervention (all p < 0.05). Individual VO2max comparisons revealed that 75% of the participants (9/12) achieved a VO2max value that was ≥3% during VER both before (range: +4.9% to +21%) and after the intervention (range: +3.4% to +18.8%), whereas 91.7% (11/12) of the tests would have been validated as a maximal effort if the classic criteria were employed. A 12-wk combined training intervention could not improve the capacity of older adults with hypertension to achieve VO2max during a GXT, as assessed by VER.

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ABSTRACT Purpose The initial-fit provided by the hearing aid manufacturer's software is generally a display of measurement done in the ear simulators. The need for verification of hearing aid output and gain in the real ear using probe-microphone measurement to match the prescriptive target is highlighted. The objective of the study was to evaluate the difference in real-ear aided response (REAR), real-ear insertion gain (REIG), aided thresholds, articulation index (AI) and word recognition score (WRS) in quiet, with hearing aid programmed to NAL-NL1 first-fit and NAL-NL1 optimized-fit using the probe-microphone technique. Methods In a repeated measure experimental design, 11 participants with a mean age of 41.09 (SD=±9.95) years having moderate and moderately-severe sensorineural hearing loss were tested monaurally in two aided conditions, with a 16-channel hearing aid programmed for manufacturer's NAL-NL1 first-fit and optimized-fit to NAL-NL1 using probe-microphone verification. The REAR, REIG, aided threshold, articulation index and word recognition scores in quiet were obtained for both aided conditions. Results The REAR, REIG, aided threshold, AI and WRS in quiet were significantly better with the NAL-NL1 optimized-fit compared to manufacturer's NAL-NL1 first-fit. Conclusion The optimized-fit yields better audibility and improved word recognition in quiet. This supports best practice guidelines of many professional organizations regarding the use of probe-microphone measurement as the "Gold standard" for verification of hearing aid fitting, thereby providing better satisfaction and quality of life to hearing aid users.

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Distributed proofs are mechanisms that enable the nodes of a network to collectively and efficiently check the correctness of Boolean predicates on the structure of the network (e.g., having a specific diameter), or on objects distributed over the nodes (e.g., a spanning tree). We consider well known mechanisms consisting of two components: a prover that assigns a certificate to each node, and a distributed algorithm called a verifier that is in charge of verifying the distributed proof formed by the collection of all certificates. We show that many network predicates have distributed proofs offering a high level of redundancy, explicitly or implicitly. We use this remarkable property of distributed proofs to establish perfect tradeoffs between the size of the certificate stored at every node, and the number of rounds of the verification protocol.

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Mimblewimble (MW) is a privacy-oriented cryptocurrency technology that provides security and scalability properties that distinguish it from other protocols of its kind. We present and discuss those properties and outline the basis of a model-driven verification approach to address the certification of the correctness of the protocol implementations. In particular, we propose an idealized model that is key in the described verification process, and identify and precisely state the conditions for our model to ensure the verification of the relevant security properties of MW. Since MW is built on top of a consensus protocol, we develop a Z specification of one such protocol and present an excerpt of the {log} prototype after its Z specification. This {log} prototype can be used as an executable model. This allows us to analyze the behavior of the protocol without having to implement it in a low level programming language. Finally, we analyze the Grin and Beam implementations of MW in their current state of development.

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Resumen Introducción: El cáncer de páncreas se encuentra entre los tipos de cáncer más mortales en el mundo, con una tasa de supervivencia neta del 9% a los 5 años. Si bien ha mejorado la comprensión de la fisiopatología, las opciones de detección temprana y tratamiento siguen siendo un desafío importante para la Salud Pública mundial. Este artículo busca describir la tendencia temporal de incidencia y mortalidad en la ciudad de Quito, de 1986 a 2016, así como la evolución de su base diagnóstica. Metodología: Utilizando datos del Registro de Cáncer de Base Poblacional de Quito, se calcularon las tasas anuales de incidencia y mortalidad estandarizadas por edad según sexo. El análisis incluyó la distribución de los casos de acuerdo con la base diagnóstica. El análisis de regresión joinpoint se realizó para estimar el cambio porcentual anual promedio (CPAP). Resultados: Durante el período de análisis, la tasa de incidencia disminuyó de 3.8 a 3.1 casos en hombres (CPAP: -1.0* Intervalos de confianza al 95% (IC95%): -1,9; -0.1) y se mantuvo estable en mujeres. La tasa de mortalidad se incrementó en mujeres (CPAP: 1.3* IC95%:0.2; 2.4) y se mantuvo estable en hombres. Con el tiempo, la proporción de verificación histológica de los casos se incrementó en un 109% en hombres y en un 76% en mujeres. Conclusiones: Se evidencia una mejora en la calidad de registro de la información; sin embargo, la proporción de verificación histológica es aún baja en Quito comparado con las estimaciones a nivel regional. Se subraya la necesidad de intensificar los esfuerzos del diagnóstico oportuno y adecuado.

Abstract Introduction: Pancreatic cancer is one of the deadliest forms of cancer in the world, with a 9% net survival rate in 5 years. Although the understanding of its pathophysiology has improved, early detection options continue to be a challenge for global public health. This article describes the temporal trend of incidence and mortality in Quito, Ecuador, from 1986 to 2016, as well as the evolution of its diagnostic criteria. Methodology: Using data of the population-based Quito Cancer Registry, standardized annual incidence and mortality rates were calculated by age according to sex. The analysis included case distribution according to diagnostic basis. To estimate the average annual percentage change (AAPC), Joinpoint Regression Analysis was performed. Results: During the analysis period, incidence rate decreased from 3.8 to 3.5 cases in men (AAPC: -1.0; CI 95%: -1.9; -0.1) and remained stable in women. The mortality rate increased in women (AAPC: 1.3*; CI 95%: 0.2; 2.4) and remained stable in men. Over time, the proportion of histological verification has increased 109% in men and 76% in women. Conclusions: An improvement in the quality of information recording is evident; however, the proportion of histological verification is still low in Quito compared to the regional level. The study underscores the need to intensify efforts for adequate and timely diagnosis.

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The objective of the present report is to illustrate a proof-of-concept protocol for CAD/CAM fabrication of milled verification jigs during full-arch implant rehabilitation using photogrammetry for data acquisition. The present report aims to bridge the gap between analog and digital workflows by introducing a CAD/CAM technique to intraorally verify digitally acquired information without the use of the technique-sensitive and labor-intensive conventional resin verification jig. One patient was treated with a digital prosthodontic protocol where a digitally designed CAD/CAM milled verification jig (generated from intraoral digital scans) was used to confirm implant 3D positioning prior to the fabrication of double full-arch monolithic definitive zirconia prostheses. The procedures are presented step-by-step after clinical and radiographic observation.

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The illegal trade in counterfeit and fake drugs is a worldwide multi-billion dollar industry, not only generating enormous economic losses, but health problems for the general population, through direct toxicity, treatment failure and the increased generation of antibiotic resistance. Techniques for high-throughput testing of suspect medicines are needed to face the challenges of the problem. In this study we show that with nuclear magnetic resonance spectroscopy (NMR) drug compliance can be verified in a few minutes, providing data on drug identity, purity and quality without the necessity to develop a specific methodology and using a direct extraction with deuterated solvent. The evaluation of the data is facilitated by similarity calculations and differential NMR spectroscopy. The viability and limitations of this method were assessed, with the application on five different drugs, namely sertraline hydrochloride, alprazolam, vitamin D3, enalapril maleate and paracetamol, in which the individual dosage quantity of the active ingredient ranged from 750 mg down to 0.25 mg. The appropriate sample weight, solvent and internal standard were determined for each drug and quantification was carried out by choosing the most adequate NMR signals for each compound and the internal standard. With the method the accuracy of the quantification is somewhat sacrificed for increased speed in the analysis, but the measurements offer excellent precision and offer the possibility of external calibration. Spectral similarity calculations and differential NMR spectroscopy were used to compare different generic brands and detect eventual undeclared constituents and contaminants. In one brand of alprazolam tablets the undeclared constituent tristearin was found, while in paracetamol tablets the contaminant para-aminophenol was found at a level above the allowed by the legislation. The applicability and limitations of the method are discussed.

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INTRODUCTION: Hypofractionated radiation therapy for breast cancer requires highly precise delivery through the use of image-guided radiotherapy (IGRT). Surface-guided radiation therapy (SGRT) is being increasingly used for patient positioning in breast radiotherapy. We aimed to assess the role of SGRT for verification of breast radiotherapy and the tumour bed. MATERIALS AND METHODS: Prospective study of 252 patients with early stage breast cancer. A total of 1170 determinations of daily positioning were performed. Breast surface positioning was determined with SGRT (AlignRT) and correlated with the surgical clips in the tumour bed, verified by IGRT (ExacTrac). RESULTS: SGRT improved surface matching by a mean of 5.3 points compared to conventional skin markers (98.0 vs. 92.7), a statistically significant difference (p < 0.01, Wilcoxon Test). For surface matching values > 95%, ≥ 3 clips coincided in 99.7% of the determinations and all markers coincided in 92.5%. For surface matching rates > 90%, the location of ≥ 3 clips coincided in 99.55% of determinations. CONCLUSIONS: SGRT improves patient positioning accuracy compared to skin markers. Optimal breast SGRT can accurately verify the localisation of the tumour bed, ensuring matching with ≥ 3 surgical clips. SGRT can eliminate unwanted radiation from IGRT verification systems.

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Developing star trackers quickly is non-trivial. Achieving reproducible results and comparing different algorithms are also open problems. In this sense, this work proposes the use of synthetic star images (a simulated sky), allied with the standardized structure of the Universal Verification Methodology as the base of a design approach. The aim is to organize the project, speed up the development time by providing a standard verification methodology. Future rework is reduced through two methods: a verification platform that us shared under a free software licence; and the layout of Universal Verification Methodology enforces reusability of code through an object-oriented approach. We propose a black-box structure for the verification platform with standard interfaces, and provide examples showing how this approach can be applied to the development of a star tracker for small satellites, targeting a system-on-a-chip design. The same test benches were applied to both early conceptual software-only implementations, and later optimized software-hardware hybrid systems, in a hardware-in-the-loop configuration. This test bench reuse strategy was interesting also to show the regression test capability of the developed platform. Furthermore, the simulator was used to inject specific noise, in order to evaluate the system under some real-world conditions.

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Agent-based social simulations have historically been evaluated using two criteria: verification and validation. This article questions the adequacy of this dual evaluation scheme. It claims that the scheme does not conform to everyday practices of evaluation, and has, over time, fostered a theory-practice gap in the assessment of social simulations. This gap originates because the dual evaluation scheme, inherited from computer science and software engineering, on one hand, overemphasizes the technical and formal aspects of the implementation process and, on the other hand, misrepresents the connection between the conceptual and the computational model. The mismatch between evaluation theory and practice, it is suggested, might be overcome if practitioners of agent-based social simulation adopt a single criterion evaluation scheme in which: i) the technical/formal issues of the implementation process are tackled as a matter of debugging or instrument calibration, and ii) the epistemological issues surrounding the connection between conceptual and computational models are addressed as a matter of validation.

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In food establishments, cleaning and disinfection programmes contribute to provide the environmental conditions that are necessary for the production of safe and healthy food. Compliance with validated programmes is evaluated through verification activities, in order to establish, through objective evidence, if they are implemented as they were written and if they are effective, achieving continuous improvement of the sanitation programmes. In accordance with the specific guidelines of each country, food companies set up their technical specifications and develop their own cleaning and disinfection programmes. Depending on the analytical method used, one of the main challenges was to establish a reasonable limit of acceptability according to the impact that each surface has on the safety and hygiene of the food that is prepared. This review was focused on the procedures implemented to verify the cleaning and disinfection programmes in food establishments. In particular, this study examines the methodologies used (audits and analytical methods), sites for the collection of samples, acceptance criteria and main findings. The results of the analysed studies constitute a scientific basis for designing or improving sanitation procedures and their verification in food companies, and also provide relevant information for food safety authorities.

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Dipteryx timber has been heavily exploited in South America since 2000s due to the increasing international demand for hardwood. Developing tools for the genetic identification of Dipteryx species and their geographical origin can help to promote legal trading of timber. A collection of 800 individual trees, belonging to 6 different Dipteryx species, was genotyped based on 171 molecular markers. After the exclusion of markers out of Hardy-Weinberg equilibrium or with no polymorphism or low amplification, 83 nuclear, 29 chloroplast, 13 mitochondrial single nucleotide polymorphisms (SNPs), and 2 chloroplast and 5 mitochondrial INDELS remained. Six genetic groups were identified using Bayesian Structure analyses of the nuclear SNPs, which corresponded to the different Dipteryx species collected in the field. Seventeen highly informative markers were identified as suitable for species identification and obtained self-assignment success rates to species level of 78-96%. An additional set of 15 molecular markers was selected to determine the different genetic clusters found in Dipteryx odorata and Dipteryx ferrea, obtaining self-assignment success rates of 91-100%. The success to assign samples to the correct country of origin using all or only the informative markers improved when using the nearest neighbor approach (69-92%) compared to the Bayesian approach (33-80%). While nuclear and chloroplast SNPs were more suitable for differentiating the different Dipteryx species, mitochondrial SNPs were ideal for determining the genetic clusters of D. odorata and D. ferrea. These 32 selected SNPs will be invaluable genetic tools for the accurate identification of species and country of origin of Dipteryx timber.

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Objetivo. Verificar la operatividad de tres componentes del programa de control de Enfermedades Transmisibles por Vectores (ETV): Gerencia del Programa, Promoción de la Salud, Prevención Primaria de la transmisión, en dos municipios de la ecorregión litoral en Córdoba, 2015. Materiales y métodos. Es un estudio descriptivo, retrospectivo con enfoque cuantitativo. La población fue de 29 familias afectadas, cuyos casos de ETV se notificaron al Sistema de Vigilancia, la muestra fueron 20. En el análisis estadístico los datos se procesaron en el software SPSS versión 21. Se usó un p< 0.05, que equivale al 5% de error y 95% nivel de confianza. Resultados. La verificación del primer componente "Gerencia del Programa", arrojó un cumplimiento bajo, de 36.4%. En los otros dos componentes se evidenciaron falencias de operatividad relacionadas con el eje educación. El 21% de las familias no recibió educación de la enfermedad y el 68% de lo impartido no tuvo coherencia con la prevención. Conclusiones. Al caracterizar la población se encontró que las condiciones sociodemográficas acarrean barreras de acceso equitativo a la salud, como la ruralidad y las necesidades básicas insatisfechas (NBI), características que explican la baja participación social en el programa

Objective. Verify the operability of three components of the Vectors Control Program of Vector-Communicable Diseases (VCD): Program Management, Health Promotion, Primary Prevention of transmission, in two municipalities of the coastal ecoregion in Córdoba, 2015. Material and methods. It is a descriptive, retrospective study with a quantitative approach. The population was of 29 families affected, whose cases of VTE were notified to the Surveillance System, the sample was 20. In the statistical analysis the data were processed in SPSS version 21 software. A p <0.05 was used, which is equivalent to 5 % Error and 95% confidence level. Results. Verification of the first component the Program Management, showed a low compliance, of 36.4%. In the other two components were evidences of operational failures related to the education axis. Twenty-one percent of the families did not receive education on the disease and 68% of the teaching was not consistent with prevention. Conclusions. In characterizing the population, it was found that sociodemographic conditions bring barriers to equitable access to health, such as rurality and unmet basic needs (NBI), characteristics that conditioned social participation low, in the social mobilization of the program.

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The present study aimed to compare maximal oxygen uptake of a step incremental test with time to exhaustion verification tests (TLIM) performed on the same or different day. Nineteen recreationally trained cyclists (age: 23 ± 2.7 years; maximal oxygen uptake: 48.0 ± 5.8 mL·kg-1·min-1) performed 3 maximal tests as follows: (i) same day: an incremental test with 3-min stages followed by a TLIM at 100% of peak power output of the incremental test (TLIM-SAME) interspaced by 15 min; and (ii) different day: a TLIM at 100% of peak power output of the incremental test (TLIM-DIFF). The maximal oxygen uptake was determined for the 3 tests. The maximal oxygen uptake was not different among the tests (incremental: 3.83 ± 0.41; TLIM-SAME: 3.72 ± 0.42; TLIM-DIFF: 3.75 ± 0.41 L·min-1; P = 0.951). Seven subjects presented a variability greater than ±3% in both verification tests compared with the incremental test. The same-day verification test decreased the exercise tolerance (240 ± 38 vs. 310 ± 36 s) compared with TLIM-DIFF (P < 0.05). In conclusion, the incremental protocol is capable of measuring maximal oxygen uptake because similar values were observed in comparison with verification tests. Although the need for the verification phase is questionable, the additional tests are useful to evaluate individual variability. Novelty Step incremental test is capable of measuring maximal oxygen uptake with similar values during TLIM on the same or different day. Although the necessity of the verification phase is questionable, it can allow the determination of variability in maximal oxygen uptake.

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Resumen En 2013, la Asociación Europea de Medicina Nuclear (AEMN) recomendó un "Procedimiento estándar" para desarrollar la dosimetría individual pretratamiento del Hipertiroidismo con 131I basada en la captación y en cinética tiroidea del paciente. Para estimar las desviaciones en la distribución de dosis entregada vs planificada al volumen tiroideo bajo este procedimiento, se desarrolló y verificó una aplicación en Matlab. Esta aplicación desarrolla el ajuste de la farmacocinética tiroidea, los cálculos de actividad acumulada, la estimación de la masa funcional tiroidea, el cálculo de la actividad a administrar para garantizar la dosis prescrita por el médico, y estimar el mapa tridimensional (3D) de dosis y los parámetros estadísticos relacionados que la caracterizan. La aplicación desarrollada se verificó empleando una imagen-maniquí y 6 farmacocinéticas conocidas. Además, se estimaron y verificaron los parámetros dosimétricos de planificación en 6 pacientes con dosis prescritas entre 150-400 Gy (promedio 241,67 Gy). Las distribuciones de actividad acumulada y de dosis absorbida fueron marcadamente heterogéneas. La distribución de dosis 3D mostró desviaciones estándar entre 18,01-27,08 % de la dosis prescrita. Las diferencias entre la dosis máxima y mínima por voxel/MBq de actividad administrada fue de 74-129 %. De acuerdo a los resultados, sólo entre el 50,2 % y 71,4 % de volumen tiroideo se tratará con la dosis prescrita ±20 %. Conclusiones: la dosis administrada al tejido tiroideo es no-homogénea y discrepa significativamente de la prescrita en algunas regiones, situación que requiere estudios posteriores más profundos con el objetivo de optimizar el tratamiento y sus resultados.

Abstract In 2013, the European Association of Nuclear Medicine Dosimetry Committee recommends a "Standard Operational Procedures for Hyperthyroidism Pre-Therapeutic Dosimetry" based on the assessment of the individual 131I uptake and kinetics. To estimate the 3D dose delivery deviations from prescribed dose during patient specific application of this SOP, a computer Matlab application was developed and verified. It was design to execute: radiopharmaceutical curve fitting, cumulated activity calculations, functional thyroid mass estimation, obtain the therapeutic planning activity to warranty the prescribed dose and produce the 3D planning dose map and related dosimetry parameters. 6 patients with 150-400Gy prescribed dose data planning (average 241,67Gy) were analysed using the developed application. The developed system was verify successfully using a test image phantom and 6 known pharmacokinetics data. The tridimensional thyroid volume cumulated activity and dose distributions were heterogeneous. 3D dose distribution showed standard deviations between 18.01-27.08 % of prescribed dose. The differences between maximum and minimum dose value per voxel/MBq were 74-129%. According to the result, between 50,2 % and 71,4 % of patient's thyroid will be treat with a dose of DP±20 % of planned dose, the rest will be overdose or sub dose. Conclusions: the 3D treatment planning dose distribution were completely no-homogenous, the significant difference observed should be study in the future more deeply in order to optimized the hyperthyroidism iodine treatment.

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Brazilian green propolis is a complex mixture of natural compounds that is difficult to analyze and standardize; as a result, controlling its quality is challenging. In this study, we used the positive and negative modes of ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time of flight mass spectrometry in conjunction with high-performance liquid chromatography for the identification and characterization of seven phenolic acid compounds in Brazilian green propolis. The optimal operating conditions for the electrospray ionization source were capillary voltage of 3500 V and drying and sheath gas temperatures of 320 °C and 350 °C, respectively. Drying and sheath gas flows were set to 8 L/min and 11 L/min, respectively. Brazilian green propolis was separated using the HPLC method, with chromatograms for samples and standards measured at 310 nm. UPLC-ESI-QTOF-MS was used to identify the following phenolic compounds: Chlorogenic acid, caffeic acid, isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, caffeic acid phenethyl ester (CAPE), and artepillin C. Using a methodologically validated HPLC method, the seven identified phenolic acids were then quantified among different Brazilian green propolis. Results indicated that there were no significant differences in the content of a given phenolic acid across different Brazilian green propolis samples, owing to the same plant resin sources for each sample. Isochlorogenic acid B had the lowest content (0.08 ± 0.04) across all tested Brazilian green propolis samples, while the artepillin C levels were the highest (2.48 ± 0.94). The total phenolic acid content across Brazilian green propolis samples ranged from 2.14-9.32%. Notably, artepillin C quantification is an important factor in determining the quality index of Brazilian green propolis; importantly, it has potential as a chemical marker for the development of better quality control methods for Brazilian green propolis.

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