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INTRODUCCIÓN: El riesgo de sufrir un infarto cerebral se relaciona con factores de riesgo, el reconocimiento y actuación del paciente/familia se relaciona con el nivel educativo. Pese al avance en el tratamiento, la mejor forma de enfrentarla es la prevención. OBJETIVO: Determinar el nivel de conocimiento de infarto cerebral en población no médica. Demostrar la hipótesis de que la educación mejora los niveles de conocimiento de la enfermedad. MATERIALES Y MÉTODOS: Ensayo Clínico Cuasiexperimental de tipo antes/después con cohorte única. Población: 113 familiares de pacientes ingresados al área de Neurología del Hospital de Especialidades Carlos Andrade Marín en el periodo marzo septiembre del 2022. Criterios de inclusión: familiares en cuidado/vigilancia directa de pacientes ingresados con diagnóstico clínico/ imagenológico de infarto cerebral agudo, firma de consentimiento informado. Criterios de exclusión: No aceptación de participar. Se realizó a cada participante una encuesta a la admisión, luego se le entregó un documento educativo acerca del tema y posteriormente se aplicó nuevamente la encuesta. Se utilizó la prueba Chi cuadrado de Mcnemar para comprobación de hipótesis y los porcentajes de frecuencias se analizaron con diferencia porcentual. RESULTADOS: El síntoma más conocido fue la alteración del lenguaje con un 44,2% de conocimiento en la población estudiada, 25,7% sospecharon de ictus, 87,6% lo consideraban como emergencia, 31% sabían de la existencia de factores de riesgo, la diferencia porcentual luego de la intervención educativa incrementó en: 76,4% en la necesidad de llamar a una ambulancia, en más de 47,3% y de 111,1% en conocimiento de síntomas y de los factores de riesgo, respectivamente. El nombre del ictus más conocido fue ´Derrame´. DISCUSIÓN: El conocimiento para reconocer a un infarto cerebral es bajo, el de reconocerlo como emergencia es alto, la intervención educativa mejoró notablemente ese conocimiento al igual que literatura publicada. CONCLUSIÓN: Se comprobó la hipótesis de que es necesario incrementar el conocimiento de infarto cerebral y la conciencia de cómo proceder ante la presentación de esta enfermedad.
recognition and action of the patient/family is related to the educational level. Despite advances in treatment, the best way to deal with it is prevention. OBJECTIVE: To determine the level of knowledge of ischemic stroke in the non-medical population. To demonstrate the hypothesis that education improves levels of knowledge of the disease. MATERIALS AND METHODS: Quasi-experimental before/after clinical trial with single cohort. Population: 113 relatives of patients admitted to the Neurology area of the Carlos Andrade Marín Specialties Hospital during the period March - September 2022. Inclusion criteria: family members in direct care/monitoring of patients admitted with clinical/imaging diagnosis of acute ischemic stroke, signature of informed consent. Exclusion criteria: non-acceptance to participate. Each participant was given a survey at admission, then given an educational document about the topic, and then the survey was administered again. The Mcnemar Chi-square test was used for hypothesis testing and the percentages of frequencies were analyzed with percentage difference. RESULTS: The most known symptom was language impairment, with 44,2% of the population studied being aware of it, 25,7% suspected stroke, 87,6% considered it as an emergency, 31% knew of the existence of risk factors, the percentage difference after the educational intervention increased by: 76,4% in the need to call an ambulance, by more than 47,3% and 111,1% in knowledge of symptoms and risk factors, respectively. The name of the most known stroke was ´stroke´. DISCUSSION: The knowledge to recognize a stroke is low, the knowledge to recognize it as an emergency is high, the educational intervention improved notably this knowledge as well as published literature. CONCLUSION: The hypothesis that it is necessary to increase knowledge of stroke and awareness of how to proceed when faced with this disease was proven.
Assuntos
Humanos , Masculino , Feminino , Idoso , Conhecimentos, Atitudes e Prática em Saúde , Fatores de Risco , Prospecto para Educação de Pacientes , Equador , Educação , AVC Isquêmico , Família , Pacotes de Assistência ao Paciente , Transtorno Específico de Linguagem , Deficiência Intelectual , NeurologiaRESUMO
Despite anticoagulation recommendations, patients may present with recurrent events. While medication adherence is always a concern, assessment of anticoagulation failure demands a systematic approach, taking into account the potential limitations of anticoagulants and a review of differential diagnoses for comorbidities. We illustrate our approach in a case presentation.
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Los accidentes cerebrovasculares se han mantenido, a nivel mundial, como la tercera causa de muerte y la primera de discapacidad. Para disminuir la incidencia de casos de isquemia o hemorragia cerebral, así como sus consecuencias, se deben poseer los conocimientos sobre dichas entidades clínicas, los factores de riesgo asociados y las alternativas preventivas y terapéuticas como estrategias neuroprotectoras. Muchas de las intervenciones médicas realizadas hasta la fecha en modelos animales han resultado insatisfactorias en la fase clínica. Por ello, se realizó una revisión de las publicaciones más recientes donde se abordan los modelos experimentales para la isquemia cerebral más utilizados en las evaluaciones de las terapias neuroprotectoras, y se pudo concluir que si se analizan los protocolos empleados en la fase preclínica podrán optimizarse las investigaciones para lograr resultados más acertados en este campo.
The strokes have been considered, worldwide, as the third cause of death and the first cause of disability. To diminish the incidence of ischemia cases or cerebral hemorrhage, as well as their consequences, one should have the knowledge on this clinical entities, the associated risk factors and preventive and therapeutic alternatives as neuroprotector strategies. Many of the medical interventions carried out so far in animal models have been unsatisfactory in the clinical phase. Reason why, a review of the most recent publications was carried out, where the most used experimental models for the cerebral ischemia in the evaluations of the neuroprotector therapies are approached, and it was concluded that if protocols used in the preclinic phase are analyzed, the investigations could be optimize to achieve more relevant results in this field.
Assuntos
Isquemia Encefálica , Fármacos Neuroprotetores , Acidente Vascular Cerebral , Fatores de Risco , Modelos AnimaisRESUMO
Resumen La práctica del bádminton, desde sus inicios, en el alto rendimiento en la provincia Pinar del Río, ha logrado mantener un trabajo sistemático y con resultados que avalan la estancia de atletas pinareños en la élite nacional, fundamentalmente en la modalidad de doble y doble mixto, sin embargo, en la evaluación de los resultados de los test pedagógicos-técnicos y evaluaciones de los objetivos pedagógicos a nivel nacional, actualmente están evaluados de Mal. Con el objetivo de conocer tal comportamiento, se realizó un minucioso estudio de las particularidades de la ejecución técnica de los golpeos de mano alta, la cual resulta ser la técnica más afectada según observaciones realizadas a sesiones de entrenamientos y desarrollo de competencias. La investigación se desarrolló en los siete atletas de la categoría escolar de la EIDE "Ormani Arenado Llorch" de Pinar del Río. A través de la entrevista y la observación como métodos científicos, se pudo constatar el nivel de ejecución técnico de los golpeos de mano alta en los atletas de bádminton categoría escolar, detectándose insuficiencias que atentan con la obtención de resultados competitivos superiores.
Resumo A prática do badminton, desde o seu início, no alto desempenho na província de Pinar del Río, conseguiu manter um trabalho sistemático e com resultados que garantem a permanência dos atletas de Pinar del Río na elite nacional, principalmente na modalidade dupla e mista, no entanto, na avaliação dos resultados dos testes pedagógico-técnicos e avaliações dos objetivos pedagógicos a nível nacional, são atualmente avaliados por Mal. A fim de compreender este comportamento, foi realizado um estudo detalhado sobre as particularidades da execução técnica dos golpes de mão alta, que é a técnica mais afetada de acordo com as observações feitas durante as sessões de formação e o desenvolvimento de competências. A investigação foi desenvolvida nos sete atletas da categoria escolar do EIDE "Ormani Arenado Llorch" em Pinar del Río. Através da entrevista e da observação como métodos científicos, foi possível verificar o nível de execução técnica dos golpes de mão alta nos atletas de Badminton da categoria escolar, detectando deficiências que tentam com a obtenção de resultados competitivos superiores.
Abstract The practice of badminton since its beginnings in the high performance in the province of Pinar del Río, has managed to maintain a systematic work and with results that guarantee the stay of Pinar del Río athletes in the national elite, mainly in the double and mixed modality, however in the evaluation of the results of the pedagogic-technical tests and evaluations of the pedagogic objectives at national level are currently evaluated from Mal. With the objective of knowing such behavior, a meticulous study was made of the particularities of the technical execution of high hand strikes, which turns out to be the technique most affected according to observations made in training sessions and development of competencies. The research was developed in the seven athletes of the school category of the EIDE "Ormani Arenado Llorch" from Pinar del Río. Through the interview and the observation as scientific methods, it was possible to verify the level of technical execution of high hand strokes in the badminton athletes of school category, detecting deficiencies that attempt to obtain superior competitive results.
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Resumen La trombosis venosa cerebral representa 0.5% del evento vascular cerebral en el mundo. Sin embargo, la expresión fenotípica de la enfermedad en los países en desarrollo como México muchas veces es subestimada por múltiples factores, entre ellos la falta de sospecha de la enfermedad, la carencia de estudios diagnósticos y el patrón subclínico de la enfermedad. Desde hace más de 30 años se ha considerado a la población mexicana con un factor de riesgo de la aparición de fenómenos protrombóticos en sitios tradicionales; sin embargo, en la última década la prevalencia de trombosis venosa en sitios atípicos, como el sistema venoso cerebral, se ha incrementado. Por lo anterior, es importante para el médico no neurólogo el conocimiento de esta enfermedad, aparentemente no común, en nuestra población.
Abstract Cerebral venous thrombosis represents 0.5% of all strokes in the world. However, the phenotypic expression of the disease in developing countries such as Mexico is often underestimated by multiple factors, including low suspicion of the disease, lack of diagnostic studies and subclinical pattern of the disease. Since more than 30 years, Mexican population has been considered with a risk factor for the development of prothrombotic phenomena in traditional sites; however, in the last decade prevalence of venous thrombosis in atypical sites, such as the cerebral venous system, has increased dramatically, thus, it is mandatory for the non-neurologist physician to know about the disease, apparently uncommon in our population.
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BACKGROUND: Stroke is a leading cause of disability in developing countries. However, there are no studies assessing the impact of nonfatal strokes on mortality in rural areas of Latin America. Using a population-based, prospective cohort study, we aimed to assess the influence of nonfatal strokes on all-cause mortality in older adults living in an underserved rural setting. METHODS: Deaths occurring during a 5-year period in Atahualpa residents aged ≥60 years were identified from overlapping sources. Tests for equality of survivor functions were used to estimate differences between observed and expected deaths for each covariate investigated. Cox proportional hazards models were used to estimate Kaplan-Meier survival curves of variables reaching significance in univariate analyses. RESULTS: Of 437 individuals enrolled over 5 years, follow-up was achieved in 417 (95%), contributing 1776 years of follow-up (average 4.3 ± 1.3 years). Fifty-one deaths were detected, for an overall cumulative 5-year mortality rate of 12.2% (8.9%-15.6%). Being older than 70 years of age, having poor physical activity, edentulism, and history of a nonfatal stroke were related to mortality in univariate analyses. A fully adjusted Cox proportional hazards model showed that having history of a nonfatal stroke (P = 0.024) and being older than 70 years of age (P = 0.031) independently predicted mortality. In contrast, obesity was inversely correlated with mortality (P = 0.047). CONCLUSIONS: A nonfatal stroke and increasing age increase the risk of all-cause mortality in inhabitants of a remote rural village. The body mass index is inversely related to death (obesity paradox).
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OBJECTIVES: This review aimed to organize and consolidate the latest knowledge about mutations and genetic polymorphisms related to hereditary thrombophilia and their potential association with pediatric stroke and cerebral palsy (CP). SOURCES: Scientific articles published from 1993 to 2013, written in Portuguese, English, French, and Spanish, were selected and reviewed. The publications were searched in electronic databases, and also in the collections of local libraries. The terms "hereditary thrombophilia", "polymorphisms", "mutation", "pediatric strokes", and "cerebral palsy" were used for the research. SUMMARY OF THE FINDINGS: The search in databases and in the bibliographic references retrieved 75 articles for inclusion in this review. Studies that investigated hereditary thrombophilias and their associations to CP and arterial and venous pediatric stroke presented contradictory results. The meta-analysis and case-control studies that showed positive results for this association described only slightly increased relative risks and sometimes had questionable conclusions. The association of two or more hereditary thrombophilias, or the association between thrombophilia and other specific clinical risk factors, suggest a higher risk of CP and pediatric stroke than isolated hereditary thrombophilia. CONCLUSIONS: Larger, multicenter studies should be developed in order to elucidate the role of mutations leading to hereditary thrombophilia and the development of CP and pediatric stroke. The complex and multifactorial etiology of CP and stroke makes this an arduous and difficult task; however, the benefits generated by these studies are immeasurable. .
OBJETIVO: Sistematizar e integrar os últimos conhecimentos sobre mutações e polimorfismos genéticos relacionados às trombofilias hereditárias e suas potenciais associações com acidentes vasculares cerebrais pediátricos (AVC) e paralisia cerebral (PC). MATERIAL: Artigos científicos publicados de 1993 a 2013, escritos em português, inglês, francês e espanhol foram selecionados e revisados. As publicações foram pesquisadas nas bases de dados eletrônicas, como também nos acervos das bibliotecas locais. Os termos mutação, polimorfismos, trombofilias hereditárias, acidentes vasculares cerebrais pediátricos e paralisia cerebral foram usados para a pesquisa. RESULTADOS: A pesquisa nas bases de dados e nas referências bibliográficas identificou 75 artigos para inclusão nesta revisão. Os estudos que investigaram as trombofilias hereditárias e suas associações à PC e aos AVC pediátricos arteriais e venosos apresentaram resultados contraditórios. As metanálises e os estudos caso-controle que demonstraram resultados positivos para essa associação descreveram riscos relativos discretamente aumentados e, algumas vezes, questionáveis. A associação de duas ou mais trombofilias hereditárias, ou a junção de trombofilias específicas com demais fatores de riscos clínicos, sugerem maior risco no aparecimento da PC e do AVC pediátrico do que as trombofilias hereditárias isoladas. CONCLUSÃO: Estudos multicêntricos de grande porte devem ser conduzidos para elucidar o papel real das mutações que levam às trombofilias hereditárias e ao aparecimento da PC e AVC pediátricos. A etiologia multifatorial e complexa da PC e dos AVC torna essa tarefa árdua e difícil, porém, os benefícios gerados por esses estudos são incalculáveis. .
Assuntos
Criança , Pré-Escolar , Humanos , Lactente , Recém-Nascido , Paralisia Cerebral/complicações , Acidente Vascular Cerebral/complicações , Trombofilia/complicações , Trombofilia/genética , Estudos de Casos e Controles , Trombose Intracraniana/complicações , Metanálise como Assunto , Mutação , Polimorfismo Genético , Fatores de RiscoRESUMO
BACKGROUND: An abnormal ankle-brachial index has been associated with overt stroke and coronary heart disease, but little is known about its relationship with silent cerebral small vessel disease. AIM: To assess the value of ankle-brachial index as a predictor of silent small vessel disease in an Ecuadorian geriatric population. METHODS: Stroke-free Atahualpa residents aged ≥60 years were identified during a door-to-door survey. Ankle-brachial index determinations and brain magnetic resonance imaging were performed in consented persons. Ankle-brachial index ≤0.9 and ≥1.4 were proxies of peripheral artery disease and noncompressible arteries, respectively. Using logistic regression models adjusted for age, gender, and cardiovascular health status, we evaluated the association between abnormal ankle-brachial index with silent lacunar infarcts, white matter hyperintensities, and cerebral microbleeds. RESULTS: Mean age of the 224 participants was 70 ± 8 years, 60% were women, and 80% had poor cardiovascular health status. Ankle-brachial index was ≤0.90 in 37 persons and ≥1.4 in 17. Magnetic resonance imaging showed lacunar infarcts in 27 cases, moderate-to-severe white matter hyperintensities in 47, and cerebral microbleeds in 26. Adjusted models showed association of lacunar infarcts with ankle-brachial index ≤ 0.90 (OR: 3.72, 95% CI: 1.35-10.27, P = 0.01) and with ankle-brachial index ≥ 1.4 (OR: 3·85, 95% CI: 1.06-14.03, P = 0.04). White matter hyperintensities were associated with ankle-brachial index ≤ 0.90 (P = 0.03) and ankle-brachial index ≥ 1.4 (P = 0.02) in univariate analyses. There was no association between ankle-brachial index groups and cerebral microbleeds. CONCLUSIONS: In this population-based study conducted in rural Ecuador, apparently healthy individuals aged ≥60 years with ankle-brachial index values ≤0.90 and ≥1.4 are almost four times more likely to have a silent lacunar infarct. Ankle-brachial index screening might allow recognition of asymptomatic people who need further investigation and preventive therapy.
Assuntos
Índice Tornozelo-Braço , Encéfalo/patologia , Doenças de Pequenos Vasos Cerebrais/diagnóstico , Doenças de Pequenos Vasos Cerebrais/patologia , Idoso , Doenças de Pequenos Vasos Cerebrais/fisiopatologia , Equador , Feminino , Humanos , Modelos Logísticos , Imageamento por Ressonância Magnética , Masculino , População Rural , Acidente Vascular Cerebral Lacunar/patologia , Substância Branca/patologiaRESUMO
OBJECTIVES: This review aimed to organize and consolidate the latest knowledge about mutations and genetic polymorphisms related to hereditary thrombophilia and their potential association with pediatric stroke and cerebral palsy (CP). SOURCES: Scientific articles published from 1993 to 2013, written in Portuguese, English, French, and Spanish, were selected and reviewed. The publications were searched in electronic databases, and also in the collections of local libraries. The terms "hereditary thrombophilia", "polymorphisms", "mutation", "pediatric strokes", and "cerebral palsy" were used for the research. SUMMARY OF THE FINDINGS: The search in databases and in the bibliographic references retrieved 75 articles for inclusion in this review. Studies that investigated hereditary thrombophilias and their associations to CP and arterial and venous pediatric stroke presented contradictory results. The meta-analysis and case-control studies that showed positive results for this association described only slightly increased relative risks and sometimes had questionable conclusions. The association of two or more hereditary thrombophilias, or the association between thrombophilia and other specific clinical risk factors, suggest a higher risk of CP and pediatric stroke than isolated hereditary thrombophilia. CONCLUSIONS: Larger, multicenter studies should be developed in order to elucidate the role of mutations leading to hereditary thrombophilia and the development of CP and pediatric stroke. The complex and multifactorial etiology of CP and stroke makes this an arduous and difficult task; however, the benefits generated by these studies are immeasurable.
Assuntos
Paralisia Cerebral/complicações , Acidente Vascular Cerebral/complicações , Trombofilia/complicações , Trombofilia/genética , Estudos de Casos e Controles , Criança , Pré-Escolar , Humanos , Lactente , Recém-Nascido , Trombose Intracraniana/complicações , Metanálise como Assunto , Mutação , Polimorfismo Genético , Fatores de RiscoRESUMO
BACKGROUND: Studies looking for an association between incompleteness of the Circle of Willis (CoW) and small vessel disease (SVD) markers are scarce and conflicting. We aimed to evaluate this association in an unbiased population-based study conducted in Atahualpa (rural Ecuador). METHODS: Atahualpa residents 60 years of age or more were identified during a door-to-door survey and invited to undergo magnetic resonance imaging for identification of SVD markers, including white matter hyperintensities (WMHs), strokes, and deep microbleeds. Magnetic resonance imaging (MRA) was used for classifying the CoW according to the presence or absence of one A1 segment of the anterior cerebral artery or one or both P1 segments of posterior cerebral arteries. RESULTS: Of 311 eligible persons, 258 were enrolled. Mean age was 70 ± 8 years, 59% were women, and 74% had a poor cardiovascular health (CVH) status. Of these, 172 patients (67%) had WMH, 40 patients (16%) had SVD-related strokes, and 23 patients (9%) had deep microbleeds. MRA revealed a complete CoW in 157 persons (61%). Persons with SVD markers were older than those without markers (P < .0001). A poor CVH status was noted in 79% of persons with at least 1 SVD marker and in 65% of those with no markers (P = .02). Logistic regression models showed no association of incompleteness of the CoW with any marker of SVD-alone or in combination-after adjusting for age, sex, and CVH status. CONCLUSIONS: Lack of association between incompleteness of CoW and SVD markers suggest that genetically determined variants in the intracranial vasculature are not responsible for the high prevalence of SVD among native South American populations.