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1.
Exp Parasitol ; 242: 108364, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36027929

RESUMO

Ticks are a widely distributed arthropod of veterinary importance. Resistance of ticks to synthetic acaricides has become widespread, warranting the development of new drugs for tick management. Carvacrol is a volatile monoterpene, with promising results against various species of ticks; however, to be used for therapeutic purposes, carvacrol must be included in a formulation that makes its application feasible. This study aims to develop a formulation of a carvacrol-containing shampoo that is effective against two species of ticks: Rhipicephalus sanguineus and R. microplus. Shampoo sensory characteristics and pH were evaluated at 37, 25 and 5 °C, for a maximum of 15 days. The shampoo remained stable at 25 and 5 °C. The efficacy of the carvacrol-containing formulation against two species of ticks was assessed by the larval immersion test. Mortality of both tick species was significantly higher for the carvacrol shampoo than for a carvacrol hydroalcoholic solution. In conclusion, the carvacrol-containing shampoo showed larvicidal efficacy on ticks.


Assuntos
Acaricidas , Rhipicephalus , Infestações por Carrapato , Animais , Acaricidas/farmacologia , Larva , Monoterpenos/farmacologia , Infestações por Carrapato/tratamento farmacológico , Infestações por Carrapato/prevenção & controle , Infestações por Carrapato/veterinária
2.
J Pharm Biomed Anal ; 202: 114132, 2021 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-34000519

RESUMO

N-nitrosodiethanolamine (NDELA) is a carcinogenic contaminant of concern in the cosmetics industry. Contaminated raw material, degradation, reactions of ingredients of the formulation, or migration of packaging material can be responsible for the presence of NDELA in the final product. Liquid chromatography coupled to tandem mass spectrometry is the most widely accepted technique for the quantitation of NDELA in cosmetic products. Still, there is no consensus regarding the sample preparation procedure. The aim of this work was to evaluate the performance of two-dimensional liquid chromatography coupled with tandem mass spectrometry for the determination of NDELA in shampoo. In the first dimension an Oasis HLB SPE-column was used and in the second dimension a CSH C18 column. NDELA-d8 was used as an internal standard. The 2D-LC parameters were optimized by a central composite multivariate design. However, before quantitation, a sample preparation step using solid-phase extraction was necessary to eliminate compounds present in the formulation, especially surfactants that were not compatible with the chromatographic columns. Moreover, the complex matrices and singular compositions of shampoo from different manufacturers required adjustments of the sample preparation procedure for each sample. The limit of quantitation of the method for the determination of NDELA in shampoo was in the range of 5-10 ng g-1. The accuracy of the method at the LOQ (10 ng g-1) was 114 % and the inter-day precision of 15.3 % (n = 9). One sample out of 12 presented an NDELA concentration of 54 ng g-1.


Assuntos
Dietilnitrosamina , Espectrometria de Massas em Tandem , Cromatografia Líquida de Alta Pressão , Dietilnitrosamina/análogos & derivados , Extração em Fase Sólida
3.
Indian J Plast Surg ; 54(4): 507-513, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34984093

RESUMO

Medical professionals that treat patients with alopecia usually lack knowledge about hair cosmetics. Trichologists focus on hair cycling and growth problems and not on the hair shaft integrity. This may lead to abandon of the use of the prescribed treatment, such as topical minoxidil or to inadequate traumatic grooming habits that may jeopardize hair follicle health. Shampoos, hair dyes, and hair-straightening products may alter hair fiber structure, remove lipids, and elude protein. Hair procedures such as hair dying and straightening have side effects and health concerns, especially for pregnant women or sensitive hair and scalp patients. Hair breakage, follicle traction, frizz, contact dermatitis, and mutagenicity are possible side effects of hair cosmetics misuse. The proper use of hair care products may help to increase patients' adherence to alopecia treatments and avoid health problems related to inadequate application of hair cosmetics and procedures.

4.
Braz. J. Pharm. Sci. (Online) ; 56: e00087, 2020. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1089213

RESUMO

Ion-pairing liquid chromatographic method was validated for determination of ketoconazole in shampoo and cream samples as per ICH guidelines. The chromatographic conditions were carried out in the isocratic mode using a mixture of methanol and 8 mM sodium dodecyl sulfate (pH 5.5) in a ratio of 45:55 v/v %, as mobile phase. The flow rate was set at 1.0 mL min-1. Chromolith RP-18e (100×4.6 mm) was used as the analytical column with a fluorescence detection at an excitation wavelength of 260 nm and an emission wavelength of 375 nm. The average percentage recovery of shampoo A, shampoo B, shampoo C, cream A and cream B were 99.88, 97.06, 99.58, 96.77 and 97.26, respectively. The limit of detection was 0.12 mg L-1. The drug decomposition under acid degradation, base degradation and oxidative degradation were found to be in the range of 91.63-94.70% indicating that the drug is resistant towards acidic conditions. The drug decomposition under thermal condition and photolysis condition were found to be in the range of 69.05-87.15% and 47.31-66.83% respectively, indicating that the drug decomposition is more sensitive under photolysis conditions. This method is suitable for the quality control of ketoconazole in commercial shampoo and creams.

5.
Biotechnol Prog ; 34(6): 1482-1493, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30051974

RESUMO

The cosmetic industry is currently one of the fasting growing sections of the economy in many countries. The recent tendency toward the use of cosmetics of a natural origin has driven the industry to seek alternatives to synthetic components in the formulation of products. Biosurfactants are natural compounds that have considerable potential for application in the formulation of safe, effective cosmetics as a replacement for commonly used chemical tensioactive agents. The present review provides essential information on the physicochemical and biological properties of saponins and microbial biosurfactants employed in cosmetic products, with a focus on the use of these natural compounds in shampoos, addressing the current state of research and patents involving biosurfactants for this purpose. The challenges and prospects of this cosmetic application are also discussed. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 34:1482-1493, 2018.


Assuntos
Cosméticos/química , Saponinas/química , Tensoativos/química , Biotecnologia , Extratos Vegetais/química
6.
Rev. ciênc. farm. básica apl ; Rev. ciênc. farm. básica apl;36(1)mar. 2015.
Artigo em Português | LILACS | ID: lil-761218

RESUMO

O Brasil é um dos maiores mercados mundiais consumidores de cosméticos infantis. A utilização de produtos de higiene pessoal, como xampus, condicionadores e sabonetes infantis, e de produtos de beleza já se incorporou ao dia a dia de muitas crianças. Deste modo, é imprescindível que esses produtos estejam em consonância com os limites microbianos estabelecidos pela Farmacopeia Brasileira (2010) e pela Resolução da Diretoria Colegiada/ANVISA No 481/99 para serem comercializados. Neste trabalho, foi avaliada a qualidade microbiológica de amostras de 10 xampus e 10 cremes condicionadores de cabelos destinados à higiene infantil. Dentre as amostras analisadas, verificou-se que, em 50% dos xampus e 30% dos cremes condicionadores capilares, houve proliferação de micro- organismos, tais como bactérias aeróbias e fungos, acima dos limites máximos permitidos. Embora não se tenha encontrado micro-organismos patogênicos, essas percentagens indicam a necessidade do cumprimento das Boas Práticas de Fabricação por parte das indústrias farmacêuticas e cosméticas, para que os consumidores possam adquirir produtos confiáveis, com qualidade adequada para manutenção da saúde e do bem-estar.(AU)


Brazil is one of the largest commercial markets for children?s cosmetics. Personal-care products such as shampoos, conditioners and soaps for infants use, as well as beauty products are used daily by many children. Therefore, it is essential that these products are within microbial limits established by the most recent Brazilian Pharmacopoeia and the Brazilian Health Surveillance Agency Collegiate Board of Directors Resolution No 481/99. This study evaluated the microbiological quality of samples of 10 shampoos and 10 conditioners intended for infant hygiene. Of the samples analyzed, 50% of shampoos and 30% of conditioners showed microbial growth, such as aerobic bacteria and molds/yeasts, over the limits allowed. Although pathogenic micro- organisms were not found, these proportions indicate the need for pharmaceutical and cosmetic companies and businesses to comply with Good Manufacturing Practices, so that consumers are able to purchase reliable products with appropriate quality to maintain their health and well-being.(AU)


Assuntos
Microbiologia de Cosméticos , Preparações para Cabelo/análise , Controle de Qualidade , Produtos para Higiene Pessoal
7.
Arch Soc Esp Oftalmol ; 90(3): 112-8, 2015 Mar.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-25542616

RESUMO

OBJECTIVE: To compare the efficacy of 3 treatment options in patients with chronic blepharitis. METHODOLOGY: An experimental, randomized, controlled study was conducted on 45 patients (female 67%; Mean age: 40.5 years) diagnosed with chronic blepharitis, in order to compare the effectiveness of three treatment options. Group 1: eyelid hygiene with neutral shampoo three times/day; group 2: neutral shampoo eyelid hygiene plus topical metronidazole gel 0.75% twice/day; group 3: neutral eyelid hygiene with shampoo plus neomycin 3.5% and polymyxin 10% antibiotic ointment with 0.5% dexamethasone 3 times/day. The symptoms and signs were assessed by assigning scores from 0: no symptoms and/or signs; 1: mild symptoms and/or signs, 2: moderate symptoms and/or signs; and 3: severe symptoms and/or signs. RESULTS: A significant improvement was observed in the signs and symptoms in all 3 treatment groups. While groups 1 and 2 had more improvement in all variables studied (P<.05), Group 3 showed no clinical improvement for itching (P=.16), dry eye (P=.29), eyelashes falling (P=.16), and erythema at the eyelid margin (P=.29). CONCLUSIONS: Shampoo eyelid hygiene neutral and neutral shampoo combined with the use of metronidazole gel reported better hygiene results than neutral shampoo lid with antibiotic ointment and neomycin and polymyxin dexamethasone.


Assuntos
Antibacterianos/uso terapêutico , Blefarite/terapia , Irrigação Terapêutica , Administração Oftálmica , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Antibacterianos/administração & dosagem , Blefarite/tratamento farmacológico , Blefarite/microbiologia , Blefarite/parasitologia , Doença Crônica , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Pestanas , Feminino , Géis , Preparações para Cabelo , Humanos , Masculino , Metronidazol/administração & dosagem , Metronidazol/uso terapêutico , Pessoa de Meia-Idade , Infestações por Ácaros/tratamento farmacológico , Infestações por Ácaros/terapia , Ácaros , Neomicina/administração & dosagem , Neomicina/uso terapêutico , Pomadas , Infecções Pneumocócicas/tratamento farmacológico , Infecções Pneumocócicas/terapia , Polimixinas/administração & dosagem , Polimixinas/uso terapêutico , Índice de Gravidade de Doença , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/terapia , Resultado do Tratamento , Adulto Jovem
8.
Rev. colomb. ciencias quim. farm ; 42(2): 260-283, ene.-jun. 2013. ilus, graf, tab
Artigo em Espanhol | LILACS | ID: lil-709033

RESUMO

En el desarrollo de cosméticos, las fragancias constituyen un factor clave en términos de la aceptabilidad del producto por parte del consumidor. No obstante, durante la etapa de formulación, la atención se focaliza comúnmente en la evaluación de factores tales como el desempeño y la estabilidad del perfil olfativo, y no se profundiza en las consecuencias de las posibles interacciones causadas entre los ingredientes de la formulación y los ingredientes de la fragancia. Como un aporte en este sentido, el presente trabajo evidencia el efecto de diferentes fragancias en el desempeño funcional de productos cosméticos tipo champú. De acuerdo con los resultados obtenidos, el solvente orgánico presente en la composición de la fragancia podría influenciar de forma significativa en el comportamiento de materias primas de naturaleza polimérica que se emplean en las formulaciones de champús y que determinan tanto la viscosidad del producto como su desempeño sensorial en las pruebas de uso.


Fragrances are a key factor when cosmetics are developed because of their crucial influence on the consumer acceptance. However, the development stages of the product are frequently focused on factors such as the cosmetic performance and the olfactory profile, overlooking the potential chemical interactions between the recipe ingredients and the fragrance ingredients like their consequences in terms of the product performance. As a contribution on this regard, this research evidences the incidence of different fragrances on the functional performance of cosmetic shampoos. The results reveal that the organic solvent included into the fragrance recipe could influence in significant way the behavior of polymeric raw materials which govern both the product viscosity and the product sensorial performance when in use tests are carried out.

9.
Rev. ciênc. farm. básica apl ; Rev. ciênc. farm. básica apl;32(3)dez. 2011.
Artigo em Português | LILACS | ID: lil-621571

RESUMO

A fitocosmética é um setor em nítido crescimento por se ter verificado reais vantagens na incorporação de produtos vegetais em relação a certos produtos sintéticos em produtos cosméticos. O proposto trabalho foi desenvolvido enfocando-se o uso de xampu com a utilização de microesferas de biopolímero e extrato hidroalcoólico de Capsicum frutescens L., mais popularmente conhecida como pimenta-malagueta, para o tratamento de queda capilar simples (alopecia androgênica). As análises físico-químicas envolveram determinação de cinzas totais, pH, identificação de capsaicina e densidade do xampu, entre outros. Considerando-se os diversos aspectos exigidos para a garantia da qualidade do material botânico, que englobam não somente os aspectos físico-químicos, mas também o microbiológico, realizou-se, tanto no extrato quanto no produto final, a contagem total de micro-organismos, pesquisa de Salmonella sp e Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa. Foram realizadas análises sensoriais em voluntários, visando avaliar a qualidade sensorial do produto. Os voluntários avaliaram a amostra segundo questionário aplicado. Para as propriedades avaliadas, as microesferas esfoliantes incorporadas ao xampu mostraram-se ser bem aceitas pelos voluntários, principalmente devido à sensação transmitida pela esfoliação, fazendo com que o extrato hidroalcoólico promova uma maior oxigenação local.


Phytocosmetics is a sector of the market in rapid growth, since real advantages have been demonstrated in the incorporation of plant products in cosmetics, in place of certain synthetic products. The focus of this study was on the use of shampoo containing microspheres of biopolymer and a hydroalcoholic extract of the fruit of Capsicum frutescens L., more commonly known as chili pepper, for the treatment of hair loss (androgenic alopecia). The physical and chemical analysis included the determination of total ash, pH and density of the shampoo and the identification of capsaicin. Considering the various requirements for quality assurance of the plant material, encompassing not only physicochemical but also microbiological criteria, both the extract and the final product were subjected to a total count of microorganisms and tests for Salmonella sp, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The sensory quality of the product was assessed by a panel of volunteers, who rated the sample of shampoo in response to a questionnaire. For the properties assessed, the exfoliating microspheres incorporated into the shampoo proved to be well tolerated by the volunteers, mainly on account of the feeling conveyed by exfoliation, causing the hydroalcoholic extract to promote greater local oxygenation.


Assuntos
Humanos , Masculino , Feminino , Capsicum/química , Cosméticos/análise , Solução Hidroalcoólica , Extratos Vegetais , Preparações para Cabelo/toxicidade , Testes de Irritação da Pele/métodos , Controle de Qualidade
10.
RBCF, Rev. bras. ciênc. farm. (Impr.) ; RBCF, Rev. bras. ciênc. farm. (Impr.);43(2): 301-307, abr.-jun. 2007. ilus, graf, tab
Artigo em Português | LILACS | ID: lil-460191

RESUMO

Cetoconazol é um agente antifúngico, que pode ser incorporado em diferentes formas farmacêuticas, como, por exemplo, xampus e cremes. O objetivo do trabalho foi avaliar a segurança biológica in vivo (teste de irritação ocular) e in vitro (teste de citotoxicidade) do xampu de cetoconazol degradado sob ação da luz. Para tanto, a formulação foi exposta à radiação UV-C (254 nm) e foram empregados dois métodos para a determinação quantitativa do cetoconazol: CLAE e ensaio microbiológico. Os resultados demonstraram alteração do cetoconazol em presença da luz - presença de picos secundários no cromatograma e diminuição da atividade antifúngica - entretanto, não demonstraram alteração na segurança biológica entre xampu de cetoconazol e xampu de cetoconazol contendo produtos de degradação.


Ketoconazole is an antifungal agent and can be incorporated into several dosage forms, as an example it could be mentioned shampoos and creams. The aim of this work was to assess the biological reactivity in vivo (Draize eye test) and in vitro (cytotoxity test) of ketoconazole in shampoo degradeted under action of light. The formulation was exposed to UV-C (254 nm) radiation and two methods were used for the quantitative determination of ketoconazole: HPLC and microbiological assay. The results showed alteration in ketoconazole in presence of light - secondary peaks in chromatogram and decrease in antifungal activity - however, no alteration on the biological reactivity between ketoconazole shampoo and ketoconazole shampoo containing degradation products was observed.


Assuntos
Antifúngicos , Preparações para Cabelo/toxicidade , Cromatografia Líquida/métodos , Testes de Irritação da Pele/métodos
11.
R. Inst. Adolfo Lutz ; 66(3): 225-229, 2007.
Artigo em Português | VETINDEX | ID: vti-452441

RESUMO

Shampoos for children use are based on softer formulations, and including amphoterous detergents to avoid eyes irritation. The objective of this study was to assess the quality of children shampoos as for physical-chemical, microbiological, and toxicological parameters. Fifteen samples of shampoo from different brands commercialized in the city of Sao Paulo, Brazil, were evaluated. The analyzed shampoos samples were in conformity with the enforced laws for the active principles rate (between 3.0 and 5.0%); pH (within neutrality range); amines rate (below 0.5%), as well as for microbiological assays. In relation to ocular irritation, 6.7% of samples showed a moderate irritation; 93.3% caused slight irritation when the undiluted product was used. By diluting the product at 50%, 20% of the analyzed samples resulted in slight irritation, whereas the other 80% presented satisfactory results. No ocular irritation was observed in products diluted at 10%. This analysis showed that the shampoos from different brands are within the quality range expected for these products, although the consumers have to be mindful as for using undiluted shampoos in children, as they might cause ocular irritation in diverse degrees.


Os xampus infantis são formulações a base de formulações tensoativas mais suaves e contêm detergentes anfóteros que buscam o benefício de não irritar os olhos. O objetivo deste trabalho foi de verificar a qualidade de xampus infantis quanto aos parâmetros físico-químicos, microbiológicos e toxicológicos. Foram avaliadas 15 amostras de diferentes marcas comercializadas na cidade de São Paulo. As amostras apresentaram-se em conformidade com a Legislação vigente quanto à segurança de seu uso. O teor de princípio ativo (entre 3 e 5%), as aminas livres e o pH estavam de acordo com as formulações apresentadas; e no ensaio microbiológico o resultado foi satisfatório. Quanto à irritação ocular, 6,7% das amostras apresentaram índices de moderada irritação; 93,3% foram levemente irritantes quando foi aplicado o produto puro, conforme estabelecido no protocolo de Draize. Quando produto foi diluído a 50%, 20% das amostras apresentaram-se levemente irritantes, enquanto os demais demonstraram resultados satisfatórios. As amostras não apresentaram irritação ocular quando foram aplicadas diluídas a 10%. Os resultados obtidos mostraram que as diferentes marcas de xampus estudados estão dentro da qualidade esperada para o produto. Sugere-se que seja incluída no rótulo a advertência sobre o cuidado para evitar que o produto puro entre em contato com os olhos.

12.
Rev. Inst. Adolfo Lutz ; 38(1): e37111, jun.30,1978. ilus, tab
Artigo em Português | LILACS, CONASS, Coleciona SUS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: biblio-1411032

RESUMO

Os testes de irritabilidade da pele mostram que os xampus contendo alcatrão, quando aplicados na pele de cobaias por vários dias, causam irritações dérmicas, ao mesmo tempo em que ressecam a pele e impedem o crescimento normal dos pêlos. Essas anormalidades foram verificadas em animais de laboratório, submetidos aos produtos questionados. Os xampus testados podem ser obtidos no comércio e são indicados para o tratamento de seborréia, psoríase, combate à caspa e proteção do couro cabeludo (AU).


Assuntos
Pele , Alcatrão
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