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BACKGROUND: Recent studies on editorial team members of healthcare journals have been showing disparities in this distribution. However, there are limited data with respect to pharmacy journals. Thus, the aim of this study was to investigate the distribution of women among editorial board members of social, clinical, and educational pharmacy research journals around the globe. METHODS: A cross-sectional study was conducted between September and October 2022. Data were extracted from Scimago Journal & Country Rank and Clarivate Analytics Web of Science Journal Citation Reports The top 10 journals in each region of the world (continents) were analyzed. Editorial board members were categorized into four groups and determined based on information available on the journal's website. The sex was classified in binary form through name and photography, the personal and institutional web pages, or the Genderize program. RESULTS: A total of 45 journals were identified in the databases, of which 42 of them were analyzed. We identified 1482 editorial board members with only 527 (35.6%) being female. Analyzing the subgroups, there were 47 total editors-in-chief, 44 total co-editors, 272 associate editors, and 1119 editorial advisors. Of these, 10 (21.27%), 21 (47.72%), 115 (42.27%), and 381 (34.04%) were female, respectively. Only 9 journals (21.42%) presented more females among their editorial board members. CONCLUSION: A notable sex disparity among social, clinical, and educational pharmacy journals' editorial board members was identified. Efforts should be made to involve more female sex in their editorial teams.

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ABSTRACT Muscle strength is an essential part of the functional assessment of health professionals to select and analyze the effects of clinical interventions. This study aimed to determine the influence of gender and age on isometric strength of hip and knee muscle groups. A total of 127 subjects (50.4% men), aged from 20 to 49 years (stratified into three groups: 20-29 years; 30-39 years; and 40-49 years) participated in this study. A hand-held dynamometer was used to measure isometric normalized torque of the hip abductors, hip external rotators, knee extensors, and knee flexors muscles. Regressions and a two-way analysis of variance were used to identify the influence of age and gender on torque of each muscle group. Age and gender were included in the regression model for all groups. Generally, men aged 20-29 and 30-39 were stronger than age-paired women. For participants aged 40-49, torque was similar for men and women for all muscle groups. There was no difference among age groups for women. Generally, young men were stronger than older men. The association between age and gender in hip and knee strength was proved and liable of subgroup stratification after measurements with a hand-held isometric dynamometer.

RESUMEN La fuerza muscular es un componente básico de la evaluación funcional de los profesionales de la salud para seleccionar y analizar los efectos de las intervenciones clínicas. El objetivo de este estudio fue determinar la influencia del sexo y de la edad en las mediciones de fuerza isométrica de los grupos musculares de la cadera y la rodilla. En el estudio participaron 127 sujetos (50,4% hombres), de entre 20 y 49 años de edad (estratificados en grupos: 20 a 29 años; 30 a 39 años; y 40 a 49 años). El torque isométrico normalizado de los abductores y rotadores externos de la cadera y de los extensores y flexores de la rodilla se midió con un dinamómetro manual. Se utilizaron regresiones y el análisis de varianza (Anova) para identificar la influencia de la edad y el sexo en el torque. Tanto la edad como el sexo se incluyeron en el modelo para todos los grupos musculares. En general, los hombres de entre 20 y 29 años y los de 30 a 39 mostraron tener más fuerza que las mujeres del mismo grupo de edad. Para los participantes de 40 a 49 años, el torque fue similar entre hombres y mujeres para todos los grupos musculares. No hubo diferencias entre los grupos de edad en el grupo de mujeres. En general, los hombres más jóvenes demostraron ser más fuertes que los hombres de mediana edad. La relación entre la edad y el sexo en la fuerza muscular de la cadera y la rodilla se probó y demostró ser susceptible a la estratificación después de las mediciones realizadas con el dinamómetro manual.

RESUMO A força muscular é um componente essencial da avaliação funcional de profissionais da saúde para selecionar e analisar efeitos de intervenções clínicas. O objetivo do estudo foi determinar a influência do sexo e da idade sobre medidas de força isométrica de grupos musculares do quadril e do joelho. Participaram da pesquisa 127 sujeitos (50,4% homens), com idade de 20 a 49 anos (estratificados em grupos: 20 a 29 anos; 30 a 39 anos; e 40 a 49 anos). O torque isométrico normalizado de abdutores e rotadores externos de quadril e extensores e flexores de joelho foi medido com dinamômetro manual. Regressões e uma análise de variância (Anova) foram usados para identificar a influência da idade e do sexo sobre o torque. Tanto idade quanto sexo foram incluídos no modelo para todos os grupos musculares. Em geral, homens de 20 a 29 anos e de 30 a 39 anos demonstraram mais força do que mulheres da mesma faixa etária. Para participantes de 40 a 49 anos, o torque foi similar entre homens e mulheres para todos os grupos musculares. Não houve diferença entre as faixas etárias no grupo de mulheres. Em geral, homens mais jovens se mostraram mais fortes do que homens mais velhos. A relação entre idade e sexo na força muscular do quadril e do joelho foi provada e se mostrou passível de estratificação após as medições feitas com o dinamômetro manual.

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Resumo Objetivo: investigar fatores associados ao afastamento do trabalho por distúrbios musculoesqueléticos entre professores e professoras da educação básica brasileira. Métodos: estudo transversal com amostra probabilística e representativa das grandes regiões do Brasil. Por meio de entrevistas realizadas por telefone, foi aplicado questionário para coleta de informações sociodemográficas, sobre estado de saúde, afastamentos do trabalho e características do trabalho docente. Empregou-se regressão de Poisson com variância robusta, para estimar razões de prevalência (RP) e intervalos de confiança de 95% (IC95%). Resultados: entre os 6.510 professores participantes (63,2% do sexo feminino), a prevalência de afastamento por distúrbios musculoesqueléticos foi de 14,7%, sendo 16,5% para o sexo feminino e 11,7% para o masculino. Os resultados indicaram associação entre afastamento e indisciplina em sala de aula (feminino = RP: 1,36; IC95%: 1,11;1,67; masculino = RP: 1,35; IC95%: 1,02;1,78), violência verbal praticada por estudantes (feminino = RP: 1,16; IC95%: 1,01;1,35; masculino = RP: 1,54; IC95%: 1,22;1,95) e alta exigência das tarefas profissionais (feminino = RP: 1,17; IC95%: 1,01;1,36; masculino = RP: 1,27; IC95%: 1,01;1,60). Conclusão: os fatores associados aos afastamentos do trabalho por distúrbios musculoesqueléticos estão relacionados à exposição dos professores, de ambos os sexos, à sobrecarga de trabalho e a ambientes escolares estressantes.

Abstract Objective: to investigate factors associated with work absence due to musculoskeletal disorders among teachers of Brazilian basic education. Methods: a cross-sectional study, which used a probabilistic and representative sample of the major regions of Brazil. Through telephone interviews, a questionnaire was applied to collect socio-demographic information on health status, work absences, and characteristics of teaching work. Poisson regression with robust variance was used to estimate prevalence ratios (PR) and 95% confidence intervals (95%CI). Results: among the 6,510 participating teachers (63.2% female), the prevalence of leave due to musculoskeletal disorders was 14.7% (16.5% among women and 11.7% among men). The results indicated an association between absence and indiscipline in the classroom (female = PR: 1.36; 95%CI: 1.11;1.67; male = PR: 1.35; 95%CI: 1.02;1.78 ), verbal violence committed by students (female = PR: 1.16; 95%CI: 1.01;1.35; male = PR: 1.54; 95%CI: 1.22;1.95) and high professional tasks demands (female = PR: 1.17; 95%CI: 1.01;1.36; male = PR: 1.27; 95%CI: 1.01;1.60). Conclusion: the factors associated with work absences due to musculoskeletal disorders are related to teachers' exposure to work overload and stressful school environments.

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Postural balance and gait are important factors in the functional status of older people; however, few studies have addressed differences by sex. The objective of this study was to analyze the postural balance and temporal−spatial parameters of gait in independent older adults by sex. A cross-sectional study was conducted. Thirty-eight independent older women (69 ± 5 years), and 33 men (71 ± 5 years) were evaluated. The postural balance test with open and closed eyes was performed on two surfaces (hard/soft) on a force platform. Gait was recorded with cameras to analyze cycle duration and speed, step length, stride length, and foot clearance. The area of postural balance was greater in men in all tests (p < 0.001). Foot clearance height and cycle duration were lower in women (p < 0.05). Men showed a negative correlation between the area of balance and gait parameters. In women, a positive correlation was observed between foot clearance and balance with eyes closed. The postural balance and gait suggest discrepancies by sex, showing that older men behave differently according to the requirement of the motor task compared to women. These findings suggest being corroborated in more complex studies in the future.

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Introducción: existe una alta carga de enfermedad neuroquirúrgica en el mundo. La información sobre patología neuroquirúrgica en Perú es limitada. Objetivo. El objetivo del estudio es describir las características epidemiológicas y la distribución temporal de la patología neuroquirúrgica en un centro de alta complejidad. Material y Métodos: se realizó un estudio transversal analítico usando el registro de cirugías del servicio de neurocirugía del Hospital Nacional María Auxiliadora, en Lima-Perú entre 2008 y 2020. Se categorizó a los diagnósticos según la patología primaria en 10 categorías; y los diagnósticos específicos correspondientes a cada patología primaria. Se describieron frecuencias absolutas y relativas según patología. La distribución temporal se describió mediante un mapa de calor. Se usó la prueba de chi cuadrado para evaluar asociación entre los diagnósticos y el sexo. Resultados: se realizaron 2948 procedimientos quirúrgicos. La mediana de la edad fue de 38 años; y el 66,7% fue del sexo masculino. Los diagnósticos de traumatismo encefalocraneano, hidrocefalia y patología vascular representan el 60,0% de la carga de enfermedad neuroquirúrgica en el centro de estudio. El 20,2% de los TECs fueron hematomas subdurales crónicos y el 19,4% fueron hematomas epidurales. El 7,4% de todos los procedimientos fueron reintervenciones. Se encontró asociación entre el sexo y el diagnóstico primario (p < 0.001). Conclusiones: Los diagnósticos primarios más frecuentes fueron el traumatismo encefalocraneano, la hidrocefalia y los eventos vasculares. Es necesario comprender mejor el perfil de carga de enfermedad neuroquirúrgica en Perú.

Background: the neurosurgical burden of disease is high worldwide. Information regarding this in Peru is limited. We aim to describe epidemiological characteristics and temporal distribution of the neurosurgical burden of disease in a high complexity center in Peru. Material and Methods: we carried a cross-sectional analytical study using the surgery registry from the neurosurgical department of Hospital Nacional María Auxiliadora in Lima-Peru, which contains registers from 2008 to 2020. Diagnoses were classified into main diagnosis, a variable with 10 levels, each a broad category; and specific diagnosis, defining the etiology. Absolute and relative frequencies were described on a diagnosis basis. Temporal distribution was described using a heatmap. Chi-squared test was used to evaluate association between variables and sex. Results: there were 2948 surgeries in the studied period. The median age was 38, and 66,7% were male. Head trauma, hydrocephalus and vascular pathology represent 60,0% of neurosurgical burden of disease in our center. The most frequent specific diagnoses of head trauma were chronic subdural hematoma (20,2%) and epidural hematoma (19,4%). Reinterventions were 7,4% of all procedures. Sex and principal diagnosis were associated (p < 0.001). Conclusions: The most frequent diagnoses were head trauma, hydrocephalus and vascular pathology. We describe an association between principal diagnosis and sex. There is need for further understanding of the neurosurgical burden of disease in Peru.

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ABSTRACT OBJECTIVE To investigate the association between birth weight and bone mineral content (BMC), and whether this relationship differs between men and women. METHODS A total of 10,159 participants from the ELSA-Brasil cohort were eligible for this analysis. The outcome was the z-score of the ratio BMC (kg)/height (m). The exposure was the low birth weight (< 2.5kg). The magnitude of the associations was estimated by mean differences and their respective 95% confidence intervals (95%CI) using linear regression. All analyses were presented for the total population and stratified by sex. RESULTS Most were women (54.98%), and the mean age was 52.72 years (SD ± 6.6). In the crude model, we observed that low birth weight was associated with a lower mean BMC/height z-score, compared to adequate birth weight (mean difference: −0.30; 95%CI: −0.39 to −0.21), and this effect was stronger in men (mean difference: −0.43; 95%CI: −0.56 to −0.30) than in women (mean difference: −0.31; 95%CI: −0.44 to −0.19). After adjusting for age, sex per total population, race/skin color, maternal education, individual education, and current weight, there was a considerable reduction in the magnitude of the association (total population: −0.10; 95%CI: −0.14 to −0.06; men: −0.13; 95%CI: −0.21 to −0.06; women: −0.13; 95%CI: −0.21 to −0.05). CONCLUSION Low birth weight is related to BMC/height z-score in both sexes with no indication of differences by sex. The magnitude of the associations was attenuated after adjustment for the current weight.

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Objetivo: Avaliar a associação do autorrelato de problemas no sono com a presença de doenças crônicas não transmissíveis (DCNTs) e multimorbidades, e se essas associações diferem por sexo. Métodos: Estudo transversal realizado com dados da Pesquisa Nacional de Saúde 2019. Razões de prevalências entre morbidades, número de DCNTs e autorrelato de problemas no sono foram estimadas por regressão de Poisson com variância robusta, por sexo. Resultados: Foram analisados 85.531 brasileiros com idade ≥18 anos. Os problemas no sono autorrelados associaram-se a todas as morbidades e multimorbidades. A prevalência dos problemas no sono foi maior nos que declararam uma ou duas (RP = 2,37; IC95% 2,22;2,54) e três ou mais DCNTs (RP = 4,73; IC95% 4,37;5,11). As razões de prevalências da associação com diabetes, doenças pulmonares, mentais, renais e multimorbidades foram mais elevadas entre o sexo masculino. Conclusão: As DCNTs impactaram significativamente a qualidade do sono em ambos os sexos, com associação mais forte para o sexo masculino.

Objetivo: Evaluar la asociación de problemas de sueño con la presencia de enfermedades crónicas no transmisibles (ECNTs) y multimorbilidades, y si estas asociaciones difieren por sexo. Métodos: Estudio transversal con datos de la encuesta epidemiológica Pesquisa Nacional de Saúde 2019. Se estimaron las razones de prevalencia entre morbilidades, número de ECNTs y problemas de sueño por regresión de Poisson con variación robusta, por sexo. Resultados: Se analizaron 85.531 brasileños ≥ 18 años. El autoinforme de problemas de sueño se asoció con todas las morbilidades estudiadas y con multimorbilidades. La prevalencia de problemas de sueño fue mayor en aquellos que informaron uno o dos (PR = 2,37; IC95% 2,22;2,54) y tres o más ECNTs (RP = 4,73; IC95%4,37;5,11). Las razones de prevalencia de la asociación de diabetes con enfermedades pulmonares, mentales, renales y multimorbilidades han sido más fuertes en el sexo masculino. Conclusión: Las ECNTs tienen un impacto significativo en la calidad del sueño con fuerte asociación en ambos sexos, masculino y feminino.

Objective: To evaluate the association between self-reported sleep problems and the presence of non-communicable diseases (NCDs) and multimorbidity, and whether these associations differ by sex. Methods: This is a cross sectional study performed with data from the Brazilian National Health Survey, 2019. Prevalence ratios between morbidities, the number of NCDs, and the self-report of sleep problems were estimated by Poisson regression with robust variance, according to sex. Results: This study analysed data from 85,531 Brazilians age ≥ 18 years. The self-reported sleep problems were associated with all the herein studied morbidities and multimorbidities. The prevalence of sleep problems was higher in those who stated one or two (PR = 2.37; 95%CI 2.22;2.54) and three or more NCDs (PR = 4.73; 95%CI 4.37;5.11). Prevalence ratios of the association with diabetes, lung disease, mental disease, renal disease and multimorbidities were higher among males. Conclusion: NCDs significantly impacted sleep quality, with a particularly stronger association in both, males and females.

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Objetivo: Descrever as características dos óbitos por COVID-19 no estado de Rondônia. Métodos: Estudo descritivo, com dados do Sistema Estratégia de Informatização do Sistema Único de Saúde Vigilância Epidemiológica (E-SUS-VE), notificados entre 1º de janeiro e 20 de agosto de 2020. Foram aplicados testes estatísticos (qui-quadrado e procedimento de Marascuilo), considerando-se como diferenças significantes quando os testes apresentaram p-valor <0,05. Resultados: Foram notificados 184.146 casos suspeitos, dos quais 49.804 foram confirmados como COVID-19, e 1.020 evoluíram para óbito (letalidade 2,1%). Observaram-se diferenças significantes estatisticamente entre as faixas etárias e a letalidade (p-valor <0,001); maior letalidade quanto maior a idade (procedimento de Marascuilo, significativo na comparação entre maiores de 60 anos com as demais faixas etárias); maior óbito no sexo masculino (letalidade de 2,7%); e maior letalidade entre as pessoas de cor preta (3,0%). Conclusão: Em Rondônia, observou-se maior letalidade entre idosos, homens e pessoas pardas e pretas.

Objetivo: Describir las características de los óbitos debidos a COVID-19 en Rondônia. Métodos: Estudio descriptivo, con datos del Sistema de Estrategia de Computación del Sistema Unificado de Salud de Vigilancia Epidemiológica (E-SUS-VE), notificados entre el 1 de enero y el 20 de agosto de 2020. Se aplicaron pruebas estadísticas (procedimiento Chi-cuadrado y Marascuilo), considerando significativas cuando las pruebas presentaron valor p<0,05. Resultados: se notificaron 184.146 casos sospechosos, con 49.804 confirmados como COVID-19 y 1.020 muertes (letalidad 2,1%). Se observaron diferencias estadísticamente significativas entre grupos de edad y letalidad (valor p <0,001); a mayor edad mayor letalidad (procedimiento de Marascuilo, significativo en la comparación entre mayores de 60 años con los otros grupos de edad); mayor óbito en el sexo masculino (letalidad del 2,7%); y mayor letalidad entre la raza negra (3,0%). Conclusión: En Rondônia, hubo una mayor letalidad entre los adultos mayores, hombres y pardos y negros.

Objective: To describe the characteristics of deaths due to COVID-19 in the state of Rondônia. Methods: This was a descriptive study, with data from the Brazilian National Health System Epidemiological Surveillance System Computerization Strategy (E-SUS-VE, notified between January 1 and August 20, 2020. Statistical tests (Chi-square and Marascuilo procedure) were applied, where differences were considered to be significant when p< 0.05. Results 184,146 suspected cases were reported, of which 49,804 were confirmed as COVID-19, and 1,020 died (lethality 2.1%). Statistically significant differences were observed between age groups and lethality (p-value <0.001); lethality was greater as age increased (Marascuilo procedure, significant in the comparison between the over 60s and the other age groups); death was higher among males (2.7% lethality); and lethality was higher among Black people (3.0%). Conclusion: Lethality was greater among the elderly, males and people of brown and black skin color in Rondônia.

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Abstract: This study aimed to analyze the trend in the standardized suicide rates by gender, according to Brazil's geographic regions from 2000 to 2017. Mortality data were retrieved from the Brazilian Mortality Information System database. Linear regression models were used, and Durbin-Watson tests were applied to detect the independence of the residues, as well as Prais-Winsten to control serial autocorrelation. We classified the trends as increasing, decreasing, and stable at 5% significance level. The standardized rate of deaths by suicide for men increased by 75%, from 6.5 to 11.3 deaths per 100,000 inhabitants. For women, the increase was 85%, from 1.6 to 3.0 deaths per 100,000 inhabitants. We found a gradual increase in the standardized suicide rates in all regions for both genders. The growth magnitude of suicide rates in the South is twice for women, whereas for the Northeast it is greater for men. The South and the Central-West regions presented the highest rates, whereas the North the lowest. The trend of standardized rates of suicide is linear and significantly increasing for Brazil and its total geographic regions for both genders. Male and female suicide rates indicate different risk rates according to gender.

Resumo: O estudo buscou analisar a tendência nas taxas de suicídio padronizadas por gênero de acordo com as macrorregiões brasileiras entre 2000 e 2017. Os dados de mortalidade foram obtidos do Sistema de Informações sobre Mortalidade. Foram utilizados modelos de regressão linear, e testes de Durbin-Watson foram aplicados para verificar a independência dos resíduos, assim como testes de Prais-Winsten para controlar a autocorrelação seriada. As tendências foram classificadas como crescentes, decrescentes e estáveis, com nível de significância de 5%. A taxa de suicídio padronizada para o sexo masculino aumentou em 75%, de 6,5 para 11,3 óbitos por 100.000 habitantes. Para o sexo feminino, o aumento foi de 85%, de 1,6 para 3,0 óbitos por 100.000 habitantes. Foi observado um aumento gradual nas taxas de suicídio padronizadas em todas as macrorregiões e em ambos os sexos. O crescimento nas taxas de suicídio no Sul é o dobro para as mulheres, enquanto no Nordeste é maior para os homens. As regiões Sul e Centro-oeste apresentaram as maiores taxas, e a Região Norte apresentou a menor. A tendência das taxas de suicídio padronizadas é linear e cresce significativamente no Brasil e em todas as macrorregiões e em ambos os sexos. As taxas de suicídio em homens e mulheres evidenciam diferenças de risco de acordo com gênero.

Resumen: El objetivo del estudio fue analizar la tendencia en las tasas estandarizadas de suicidio por género, según las regiones geográficas brasileñas de 2000 a 2017. Los datos de mortalidad fueron recuperados de la base de datos del Sistema de Información sobre Mortalidad brasileño. Se usaron modelos de regresión lineal, y se aplicaron pruebas Durbin-Watson para detectar la independencia de los residuos, al igual que el de Prais-Winsten para controlar la autocorrelación en series. Las tendencias fueron clasificadas como crecientes, decrecientes y estables a un nivel de un 5% significancia. La tasa estandarizada de muertes por suicidio para hombres se incrementó en un 75%, de 6,5 a 11,3 muertes por 100.000 habitantes. Para las mujeres, el incremento fue de un 85%, de 1,6 a 3,0 muertes por 100.000 habitantes. El incremento gradual en las tasas de suicidio estandarizado se encontró en todas las regiones para ambos géneros. La magnitud del crecimiento de las tasas de suicidio en el Sur es el doble para mujeres, mientras que para el Noreste es más grande para hombres. Las regiones Sur y Centro-oeste presentaron las tasas más altas, mientras que el Norte la más baja. La tendencia de las tasas estandarizadas de suicidio es lineal y significativamente está aumentando en Brasil y en el total de regiones geográficas para ambos géneros. Las tasas de suicidios de hombres y mujeres mantienen la evidencia de diferencias de riesgo según el género.

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ABSTRACT Background and objective T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy. We report the characteristics and results of treatment for childhood T-cell ALL in children over 14 years at a Latin American reference center. Material and methods From January 2005 to December 2018, there occurred the analysis of twenty patients ≤ 16 years of age from a low-income open population diagnosed at a university hospital in Northeast Mexico. Clinical and laboratory characteristics, treatment regimens and outcomes were assessed by scrutinizing clinical records and electronic databases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7 and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method. Results There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p= .074), the median age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children, with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival (OS) was 44.3 % (95 % CI 41.96-46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32-24.51) vs. 53.1 % (95 % CI 50.30-55.82), (p= .035) in boys; there was no sex difference in the event-free survival (EFS) (p= .215). The survival was significantly higher after 2010 (p= .034). Conclusion The T-cell ALL was more frequent in boys, had a higher mortality in girls and the survival has increased over the last decade with improved chemotherapy and supportive care.

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AIM: The objective of this study was to know temporal, socio-demographic and diagnostic features of psychologically assisted patients at the General Emergency Service of the major hospital in Jujuy. METHODS: The study was transversal (01/20/2018 to 09/13/2018). Temporal, socio-demographic and diagnostic variables (according to ICD-10) were analyzed in 657 cases. For data analysis RStudio was used. Frequencies and descriptive statistics were reported. We evaluated differences in age according to sex (women-men) and according to age categories (adolescents-adults) with Wilcoxon Test, and differences in diagnostic clusters according to sex and age with Kruskal-Wallis Test. The type I error was set at ≤ 0.05. RESULTS: Cases assisted during weekends prevailed. From the total, 57.53% were women. The mean age in both sexes was 34.35 years (±15.08; Median = 32). A decreasing pattern of cases from younger to older age groups were found. There were no differences in age according to sex (p-value = 0.22), but they were differences according to age categories (p-value < 0.001). Cases with single marital status and employment were prevalent. The prevalent general diagnostic groups were: Neurotic, stress-related and somatoform disorders (31.51%); Disorders due to psychoactive substance use (12.48%); Intentional self-harm (10.20%); Assault (9.59%). CONCLUSIONS: We present the first diagnostic profile of mental health emergency-assisted casuistry in Jujuy. We highlight the need to design prevention strategies for alcohol and other psychoactive substances related disorders, aimed primarily at adolescents and young people. We discuss further implications of the results.

Objetivo: Este estudio tuvo como objetivo conocer características temporales, sociodemográficas y diagnósticas de usuarios asistidos psicológicamente en el Servicio de Guardia general del principal hospital de Jujuy. Métodos: El estudio fue transversal (20/01/18 al 13/09/18). Se analizaron variables temporales, sociodemográficas y diagnósticas (según la CIE-10) en 657 casos. Para los análisis de datos se usó RStudio. Se informaron frecuencias y estadísticos descriptivos. Se evaluaron diferencias en edad según sexo (mujeres-varones) y según categorías de edad (adolescentes-adultos) con prueba de Wilcoxon y diferencias en agrupaciones diagnósticas según sexo y edad con prueba de Kruskal-Wallis. El error tipo I se fijó en ≤ 0.05. Resultados: Prevalecieron los casos asistidos durante fines de semana. Del total, el 57.53% fueron mujeres. La media de edad en ambos sexos fue de 34.35 años (±15.08; Mediana = 32). Hubo un patrón decreciente de casos desde franjas etarias menores a mayores. No hubo diferencias en edad según sexo (p-valor = 0.22), pero sí según categorías de edad (p-valor < 0.001). Prevalecieron casos con estado civil soltero y ocupación laboral. Las agrupaciones diagnósticas generales prevalentes fueron: Trastornos neuróticos, relacionados con el estrés y somatomorfos (31.51%); Trastornos debidos al uso de sustancias psicoactivas (12.48%); Lesiones autoinfligidas intencionalmente (10.20%); Agresiones (9.59%). Conclusiones: Se presenta el primer perfil diagnóstico de casuística asistida por urgencias en salud mental en Jujuy. Se destaca la necesidad de diseñar estrategias de prevención para trastornos relacionados con alcohol y otras sustancias, dirigidas principalmente a adolescentes y jóvenes. Se discuten otras implicancias de los resultados presentados.

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OBJETIVO: investigar o efeito do consumo de álcool em geral e do tipo de bebida alcoólica consumida, em diferentes medidas lipídicas. MÉTODO: o efeito do consumo de álcool foi investigado, bem como do tipo de bebida alcoólica, em diferentes medidas lipídicas, em ambos os sexos de população do Estudo Longitudinal de Saúde do Adulto. RESULTADOS: foram realizadas análises em relação ao tipo e quantidade de consumo de bebida alcoólica por sexo. O consumo baixo-a-moderado de álcool, independentemente do tipo de bebida alcoólica consumida, resultou em níveis mais elevados de HDL-colesterol, HDL2-colesterol e HDL3-colesterol em homens e mulheres. Não houve participantes da pesquisa que consumiam quantidade baixa a moderada de bebidas alcoólicas destiladas. Os triglicerídeos tiveram efeitos inversos para homens e mulheres no perfil lipídico. Para homens, bebidas destiladas contribuíram para melhor perfil dos triglicerídeos, enquanto para mulheres foi o contrário. Homens que consumiam bebidas alcoólicas destiladas tiveram níveis menores de triglicerídeos e mulheres que consumiam bebidas alcóolicas destiladas tiveram níveis maiores. Nossos resultados estão de acordo com os de estudos anteriores. CONCLUSÃO: o consumo de álcool resultou em níveis diferentes de medidas lipídicas séricas em homens e mulheres. Dessa forma, conclui-se que a resposta ao álcool tem diferenças biológicas.

OBJECTIVE: to investigate the effect of general alcohol consumption and of the type of alcoholic beverage consumed, in different lipid measurements. METHOD: the effect of alcohol consumption as well as that of the type of alcoholic beverage consumed were investigated, in different lipid measurements, for the participants in the Longitudinal Study on Adults' Health for both sexes. RESULTS: analyses were conducted on the type and amount of alcoholic beverage consumed by sex. Low-to-moderate alcohol consumption, regardless of the type of alcoholic beverage, resulted in higher levels of HDL-cholesterol, HDL2- cholesterol and HDL3-cholesterol in males and females. No participants in the study consumed low-to-moderate amounts of spirits. Triglycerides showed inverse effects for men and women according to the lipid profile. For men, spirits contributed to a better triglyceride profile while for women it was the opposite. Men who consumed spirits showed lower triglyceride levels, and women who consumed that beverage type had higher levels. Our results are in agreement with those of previous studies. CONCLUSION: alcohol consumption resulted in different levels of serum lipid measurements in men and women. Thus, it is concluded that response to alcohol has biological differences.

OBJETIVO: investigar el efecto del consumo de alcohol general, así como el tipo de bebida alcohólica consumida, en diferentes medidas lipídicas. MÉTODO: el efecto del consumo de alcohol fue investigado, así como el tipo de bebida alcohólica, en diferentes medidas lipídicas en ambos sexos de población del Estudio Longitudinal de Salud del Adulto. RESULTADOS: se realizaron análisis en relación al tipo y cantidad de consumo de bebida alcohólica por sexo. El consumo bajo a moderado de alcohol, independientemente del tipo de bebida alcohólica consumida, resultó en niveles más altos de HDL-colesterol, HDL2-colesterol y HDL3-coleseterol en hombres y mujeres. No hubo participantes de investigación que consumían en cantidad baja a moderada de bebidas alcohólicas destiladas. Los triglicéridos tuvieron efectos inversos para hombres y mujeres en el perfil lipídico. Para los hombres, las bebidas destiladas contribuyeron a un mejor perfil de los triglicéridos, mientras que para las mujeres fue lo contrario. Los hombres que consumían bebidas alcohólicas destiladas tenían niveles más pequeños de triglicéridos y las mujeres que consumían bebidas alcohólicas destiladas tuvieron niveles más altos. Nuestros resultados están de acuerdo con estudios anteriores. CONCLUSIÓN: el consumo de alcohol resultó en niveles significativamente mayores de HDL-colesterol, HDL2-colesterol y HDL3-colesterol, tanto en mujeres como en hombres. De esta forma, se concluye que la respuesta al alcohol tiene diferencias biológicas.

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BACKGROUND AND OBJECTIVE: T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy. We report the characteristics and results of treatment for childhood T-cell ALL in children over 14 years at a Latin American reference center. MATERIAL AND METHODS: From January 2005 to December 2018, there occurred the analysis of twenty patients ≤ 16 years of age from a low-income open population diagnosed at a university hospital in Northeast Mexico. Clinical and laboratory characteristics, treatment regimens and outcomes were assessed by scrutinizing clinical records and electronic databases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7 and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method. RESULTS: There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p =  .074), the median age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children, with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival (OS) was 44.3 % (95 % CI 41.96-46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32-24.51) vs. 53.1 % (95 % CI 50.30-55.82), (p = .035) in boys; there was no sex difference in the event-free survival (EFS) (p = .215). The survival was significantly higher after 2010 (p = .034). CONCLUSION: The T-cell ALL was more frequent in boys, had a higher mortality in girls and the survival has increased over the last decade with improved chemotherapy and supportive care.

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Objetivo: Delinear o perfil sociodemográfico da população idosa de um município de pequeno porte do estado do Rio Grande do Sul e identificar a prevalência de fragilidade em idosos residentes na comunidade. Método: Trata-se de um estudo transversal, analítico e de base populacional. Foram incluídas pessoas com 60 anos ou mais, de ambos os sexos, que residiam na zona urbana e estavam adstritos às Estratégias de Saúde Família. Foram avaliados dados sociodemográficos e de saúde e o Fenótipo da Fragilidade, o qual inclui perda de peso, velocidade da marcha, força de preensão palmar, nível de atividade física e fadiga. Para análise dos dados utilizou-se medidas de tendência central, de dispersão e variabilidade, teste do qui-quadrado de Pearson e o teste Mann-Whitney, considerando valores de p menores ou igual a 0,05 significativos. Resultados: A prevalência de fragilidade foi de 14,3% e de pré- -fragilidade foi de 46,9%. As mulheres apresentaram maior fadiga, menor força de preensão palmar, menor velocidade de marcha e maior taxa de gasto metabólico, e houve diferença entre homens e mulheres quanto ao estado civil e número de condições crônicas. Conclusão: Enfatiza-se a importância de políticas públicas voltadas a população idosa, com ênfase nas diferenças entre os sexos e salienta-se a importância do rastreio da condição de fragilidade em idosos residentes na comunidade.

Objective: To outline the sociodemographic profile of older adults population of a small municipality in the state of Rio Grande do Sul and to identify the prevalence of frailty in elderly residents of the community. Method: This is a cross-sectional, analytical and population-based study. We included people aged 60 and over, both sexes, who lived in the urban area and were attached to the Family Health Strategies. Sociodemographic and health data and the Frailty Phenotype were evaluated, which included weight loss, walking speed, grip strength, physical activity level and fatigue. For the analysis of the data we used measures of central tendency, dispersion and variability, Pearson's chi-square test and the Mann-Whitney test, considering values of p less than or equal to 0.05 significant. Results: The prevalence of frailty was 14.3% and pre-frailty was 46.9%. The women presented greater fatigue, lower grip strength, lower gait velocity and higher rate of metabolic expenditure, and there were differences between males and females regarding marital status and number of chronic conditions. Conclusion: Emphasis is given to the importance of public policies aimed at older adults population, with emphasis on the differences between the sexes and the importance of the screening of the condition of frailty in elderly residents in the community.

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To assess the influences of sex and exercise mode on post-exercise Blood pressure (BP) immediately after exercise and during daily work. METHODS 20 healthy adults (9F/11M), randomly underwent three experimental sessions prior to their work routine: RE- Circuit resistance exercise at 40% of 1RM, AE- Aerobic exercise at 60-70% of heart rate (HR) reserve and CON- Control session. BP was assessed before and along the 1st hour of the post-intervention period (i.e. laboratory phase), and intermittently for 9h in the workplace. Results: RE promoted great BP reductions, but only in men, and this reduction persisted along the daily work (Men-RE: SBP= -1069±695 mmHg.540min; DBP= -612±325 mmHg.540min). On the other hand, AE produced slight DBP reduction in men during daily work (Men-AE: DBP= -241±730 mmHg.540min), and in women only in the laboratory phase (Women-AE: SBP= -108±65mmHg.60min). CONCLUSION Resistance exercise promotes a significant positive impact on BP in men but does not seem to be effective for women. On the other hand, AE produces moderate BP reductions in men and women.(AU)

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INTRODUCTION: Body composition and other components of physical fitness have proved to be important markers of health condition. OBJECTIVE: To analyze body composition and physical fitness in Colombian students from public high schools of Ibagué, as well as to study differences between sexes and age groups, and establish correlations between some of the variables. MATERIALS AND METHODS: The sample consisted of 1,253 students (601 males; 652 females), with an age range of 10-20 years. The ALPHA-Fitness test (extended version) was applied. Body Mass Index (BMI), waist circumference and fat percentage were assessed. RESULTS: Differences between sexes were found in the variables studied, with greater BMI and fat percentage among females (20.6 kg/m2 vs. 19.4 kg/m2 and 26.1% vs. 16.8%, respectively); however, waist circumference was greater in males (69.6 cm vs. 67.9 cm), who also showed better fitness in the rest of the physical tests (p<0.05). In both sexes, age was associated to increases in BMI (p<0.05), and among females to fat percentage as well (p<0.05); among males it was the opposite, as in them, age was inversely associated to fat percentage (p<0.05). For the rest of the physical tests, age was positively associated to fitness both in men and women, except for maximal oxygen uptake (VO2 max). Correlations were found between some of the variables studied. CONCLUSIONS: Adiposity was significantly greater in females than in males (p<0.05). Males showed better levels of aerobic, musculoskeletal and motor capacities.

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Resumen Introducción. La composición corporal y otros componentes de la condición física han demostrado ser importantes indicadores de la condición de salud. Objetivo. Analizar la composición corporal y la condición física de escolares colombianos de educación secundaria y media de las instituciones oficiales de Ibagué, estudiar las diferencias por sexo y edad, y establecer la correlación entre algunas variables. Materiales y métodos. Participaron 1.253 estudiantes (601 hombres y 652 mujeres), con un rango de edad entre los 10 y los 20 años. Se aplicaron las pruebas físicas de la batería ALPHA-Fitness en su versión extendida. Se evaluó el índice de masa corporal (IMC), el perímetro de la cintura y el porcentaje de grasa. Resultados. Se encontraron diferencias por sexo en lasvariables estudiadas, con mayor IMC y porcentaje de grasa en las mujeres queen los hombres (20,6 Vs. 19,4 kg/m2 y 26,1 Vs. 16,8 %, respectivamente); sin embargo, el perímetrode cintura fue mayor en los hombres (69,6 cmVs. 67,9 cm), aunque ellos registraron mejor rendimiento enel resto de pruebas físicas (p<0,05). En ambos sexos la edad se asoció con aumentos delIMC (p<0,05) y, en las mujeres, con el porcentaje de grasa (p<0,05), lo que no ocurrió en los hombres, en quienes la edad se asoció inversamente con la grasa corporal (p<0,05). En el resto de las pruebas físicas, la edad se asoció positivamente con el rendimiento en ambos sexos, excepto en el consumo máximo de oxígeno(VO2 máx). Se hallaron correlaciones entre algunas de las variables estudiadas. Conclusiones. La adiposidad fue significativamente mayor en las mujeres que en los hombres(p<0,05). Los hombres tuvieron mejores niveles de capacidad aeróbica, musculoesqueléticay motora.

Introduction: Body composition and other components of physical fitness have proved to be important markers of health condition. Objective: To analyze body composition and physical fitness in Colombian students from public high schools of Ibagué, as well as to study differences between sexes and age groups, and establish correlations between some of the variables. Materials and methods: The sample consisted of 1,253 students (601 males; 652 females), with an age range of 10-20 years. The ALPHA-Fitness test (extended version) was applied. Body Mass Index (BMI), waist circumference and fat percentage were assessed. Results: Differences between sexes were found in the variables studied, with greater BMI and fat percentage among females (20.6 kg/m2 vs. 19.4 kg/m2 and 26.1% vs. 16.8%, respectively); however, waist circumference was greater in males (69.6 cm vs. 67.9 cm), who also showed better fitness in the rest of the physical tests (p<0.05). In both sexes, age was associated to increases in BMI (p<0.05), and among females to fat percentage as well (p<0.05); among males it was the opposite, as in them, age was inversely associated to fat percentage (p<0.05). For the rest of the physical tests, age was positively associated to fitness both in men and women, except for maximal oxygen uptake (VO2 max). Correlations were found between some of the variables studied. Conclusions: Adiposity was significantly greater in females than in males (p<0.05). Males showed better levels of aerobic, musculoskeletal and motor capacities.

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OBJECTIVE: To determine whether the frequency and severity of congenital anorectal malformations (CARMs) differs by sex. STUDY DESIGN: We included 129 patients (0-319 weeks old) diagnosed with CARMs, who had been referred to our Department of Pediatric Surgery between 2004 and 2013. Rectoperineal and rectovestibular fistulas were classified as mild CARMs, all others as severe. If a patient was diagnosed with CARM within 48 hours after birth, this was considered an early diagnosis, all others as late. RESULTS: Seventy-five (58%) girls and 54 (42%) boys were diagnosed with different forms of CARM. More patients had mild rather than severe forms of CARM (67% and 33%, respectively, P <.001). We found that 89% of girls had a mild form of CARM, whereas 65% of boys had severe forms (P <.001). All severe forms were diagnosed early, whereas 54% mild forms were diagnosed early and 46% were diagnosed late. CONCLUSIONS: Girls more often have mild forms of CARM, whereas boys more often have severe forms. Overall, the distribution across the sexes is equal. Because chronic constipation can be the only symptom of mild CARMs, it often requires more time to diagnose than severe forms. Many women are, therefore, diagnosed with CARMs at an older age, or they may go undiagnosed altogether. Subsequently, these women have a greater risk of full rupture during vaginal delivery.

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Introdução: A asma, uma doença inflamatória crônica das vias aéreas, além de ser um problema de saúde pública no Brasil, compromete o desenvolvimento dos indivíduos jovens afetados. Sua etiologia poligênica leva a crer que a associação de determinados fatores, como baixa escolaridade materna, tabagismo no domicílio, higiene e imunização inadequados e menor período de amamentação exclusiva, gera maior incidência da patologia. Objetivos do estudo: traçar o perfil e os fatores associados às crianças portadoras de asma acompanhadas na UBS Vitória Régia, município de Sorocaba (SP). Modelo de estudo: Estudo descritivo. Metodologia: Estudo realizado com a população infantil atendida no Programa de Controle da Asma, composta por 42 crianças. Foram incluídas as crianças maiores de 5 anos e menores de 7 anos, e como critério de exclusão, as crianças cujos responsáveis não concordaram em participar do estudo. Durante o período de outubro de 2014 a abril de 2015 foram aplicados questionários aos responsáveis pelo menor participante, após assinatura do TCLE, em seu domicílio. Os dados foram analisados pela Estatística Multivariada. Resultados: As crianças participantes são majoritariamente do sexo masculino (66,7%), sem exposição ao tabagismo na gestação (89,7%) ou no domicílio (69,2%), tendo recebido amamentação exclusiva (92,3% das crianças) até cinco meses de vida em média. A maioria dessas crianças não apresentou diarreia e/ou infecção respiratória no primeiro ano de vida e não teve diagnóstico de rinite e/ou eczema; no entanto, verificou-se que a maior parte delas possui familiares com histórico de alergia ou asma. Pela análise fatorial aplicada, foi possível constatar que três primeiros fatores explicam 80,71% da variabilidade encontrada na amostra. Estatisticamente, as seguintes variáveis foram correlacionadas a tais fatores: sexo masculino, presença de animais de estimação, diagnóstico de rinite e/ou eczema e amamentação e sua duração. Conclusões: Foi possível concluir que a descrição do conjunto dos achados deste estudo encontra respaldo na literatura pertinente. Variáveis como sexo masculino e presença de animais de estimação, mesmo na amostra de conveniência, corroboraram com achados de outros estudos. Já para a variável amamentação e sua duração, os resultados contradizem algumas literaturas, reforçando que os achados são conflitantes neste aspecto. Apesar da existência de muitos estudos que relatam um efeito benéfico da amamentação sobre a prevenção de asma, a presença dessa variável esteve fortemente associada ao grupo em estudo. A utilização da análise multivariada permitiu caracterizar quais variáveis dentro dos fatores de risco para a asma foram as mais pertinentes para este grupo.(AU)

Introduction: Asthma is a chronic inflammatory disease of the airways that not only constitutes a public health issue, but also compromises the development of children affected by the condition. Its multifactorial origin suggests that the association of certain factors, such as low maternal education, passive smoking, inadequate hygiene and immunization and limited breast-feeding, causes higher asthma incidence. Study design: descriptive study. Aims of the study: to determine the profile and factors associated to the asthmatic children participating in the Asthma Control Program at the Health Center of Vitória Régia, Sorocaba/SP. Methods: Descriptive study conducted with the infant population of the Asthma Control Program, composed of 42 children. Children between 5 and 7 years old were included in the study and, as an exclusion criterion, children whose responsible did not agree to participate in the research. During the period of October 2014 to April 2015 questionnaires were applied to the responsible for the participating minor, after signature of a written informed consent. The collected data were analyzed by multivariate statistics. Results: Results indicated that the participating children are majorly male (66.7%), without history of intrauterine exposure to tobacco(89,7%) or passive smoking (69,2%), and received exclusive breast-feeding (92,3%) until approximately 5 months of age. The majority of children did not present diarrhea or respiratory infections in the first year of life and were not diagnosed with rhinitis and/or eczema. However, we verified that most infants have family history of asthma and/ or atopy. The factorial analysis showed that the first three factors describe 80,71% of the variability of the sample. Statistically, the variables gender, animal presence, rhinitis and/or eczema diagnosis and breastfeeding stand out in the description of the studied population. Conclusions: We concluded that the findings of this study are, in many of the analyzed items, compatible with current literature. Variables such as gender and animal presence were consistent with findings from other studies, even considering the convenience sample. Regarding breastfeeding and its duration, the results contradict some scientific references, reinforcing that conclusions are conflicting in this aspect. Despite many studies that refer a beneficial effect of breastfeeding on the prevention of asthma, this variable was strongly associated to the analyzed sample. The application of a multivariate analysis allowed the identification of the variables most relevant to this group, among the main existing risk factors for asthma. (AU)

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OBJECTIVE To analyze whether gender influence survival results of kidney transplant grafts and patients.METHODS Systematic review with meta-analysis of cohort studies available on Medline (PubMed), LILACS, CENTRAL, and Embase databases, including manual searching and in the grey literature. The selection of studies and the collection of data were conducted twice by independent reviewers, and disagreements were settled by a third reviewer. Graft and patient survival rates were evaluated as effectiveness measurements. Meta-analysis was conducted with the Review Manager® 5.2 software, through the application of a random effects model. Recipient, donor, and donor-recipient gender comparisons were evaluated.RESULTS : Twenty-nine studies involving 765,753 patients were included. Regarding graft survival, those from male donors were observed to have longer survival rates as compared to the ones from female donors, only regarding a 10-year follow-up period. Comparison between recipient genders was not found to have significant differences on any evaluated follow-up periods. In the evaluation between donor-recipient genders, male donor-male recipient transplants were favored in a statistically significant way. No statistically significant differences were observed in regards to patient survival for gender comparisons in all follow-up periods evaluated.CONCLUSIONS The quantitative analysis of the studies suggests that donor or recipient genders, when evaluated isolatedly, do not influence patient or graft survival rates. However, the combination between donor-recipient genders may be a determining factor for graft survival.

OBJETIVO Analisar se o gênero influencia os resultados da sobrevida do enxerto e do paciente no transplante renal.MÉTODOS Revisão sistemática com metanálise de estudos de coorte disponíveis nas bases de dados Medline (PubMed), Lilacs, Central e Embase, incluindo busca manual e na literatura cinzenta. A seleção dos estudos e a coleta dos dados foram realizadas em duplicata por revisores independentes e as discordâncias foram resolvidas por um terceiro revisor. A sobrevida do enxerto e do paciente foram avaliadas como medidas de efetividade. A metanálise foi conduzida no softwareReview Manager® 5.2, aplicando o modelo de efeitos aleatórios. Foram avaliadas as comparações entre gênero de receptor, doador e doador-receptor.RESULTADOS Foram incluídos 29 estudos envolvendo 765.753 pacientes. Em relação à sobrevida do enxerto, aqueles provenientes de doadores masculinos apresentaram maior sobrevida quando comparado com aqueles de doadores femininos, somente no tempo de acompanhamento de 10 anos. A comparação entre gênero de receptor não apresentou diferença significativa em nenhum tempo de acompanhamento avaliado. Na avaliação entre gênero de doador-receptor houve favorecimento estatisticamente significante para doador masculino-receptor masculino. Não houve diferença, estatisticamente significante, na sobrevida do paciente para as comparações entre gênero em todos os períodos de acompanhamento avaliados.CONCLUSÕES A análise quantitativa dos estudos sugere que o gênero do doador ou do receptor, avaliado isoladamente, não influencia na sobrevida do enxerto e paciente. Contudo, a combinação entre gênero de doador-receptor pode ser fator determinante para a sobrevida do enxerto.

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