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Resumen: El maíz contiene un gran número de compuestos antioxidantes, muchos de ellos unidos a componentes de la pared celular, por lo que requieren tratamientos para liberarlos, como el uso de enzimas o procesos de fermentación. La fermentación en medio sólido (FMS) con Rhizopus oryzae se ha aplicado para aumentar la capacidad antioxidante (CA) y el contenido fenólico en cereales y leguminosas. El objetivo del presente trabajo fue evaluar el efecto de la FMS con R. oryzae sobre la CA y el contenido de fenoles totales (CFT) del maíz. La FMS se realizó en bolsas zip-lock (25 cm2) a 30 °C/72 h, con un inóculo de 1 x 106 esporas/g. Se tomaron muestras cada 12 h, el extracto se recuperó con etanol al 80 % y se utilizó para determinar el CFT y la CA (ensayo ABTS+, DPPH y FRAP). Los valores más altos se obtuvieron a las 60 h de cultivo, con un CFT de 1.92 mg/ gramos de materia seca (gms) y una CA de 1.47 mg de equivalentes Trolox por gramo de materia seca (mg ET/gms), 1.27 mg ET/gms y 5.8 mg Fe+2/gms para los ensayos de ABTS+, DPPH y FRAP, respectivamente. El uso de FMS permitió aumentar hasta 0.83 y 1.25 veces el CFT y la CA del maíz, con respecto al tiempo 0 h. El maíz fermentado con R. oryzae mostró potencial para ser empleado como materia prima para el desarrollo de alimentos funciona les, al incrementar su CA a través de un bioproceso.

Abstract: Maize contains a large number of antioxidant compounds. However, many of them are not in free form, as they are bound to components of the cell wall of maize kernels. For this reason, the use of treatments is required to release them, such as the use of enzymes or fermentation processes. Fermentation in solid medium (FMS) with Rhizopus oryzae has been applied to increase the antioxidant capacity (AC) and phenolic content in cereals and legumes. The objective of the present work was to evaluate the effect of FMS with R. oryzae on AC and total phenolic content (TPC) of maize. Fermentation on solid medium was carried out in zip-lock bags (25 cm2) at 30 °C for 72 h, with an inoculum of 1 x 106 spores/g. Samples were taken every 12 h, the extract was recovered with 80% ethanol, and used to determine TPC and AC (ABTS+, DPPH and FRAP essay). The highest values were obtained at 60 h of culture, with a TPC of 1.92 mg/gram dry metter (gdm) and an AC of 1.47 mg TE/gmd, 1.27 mg TE/gdm and 5.8 mg Fe+2/gdm for the ABTS+, DPPH and FRAP assays, respectively. The use of FMS allowed to increase up to 0.83 and 1.25 times the CFT and CA of corn, with respect to time zero. Corn fermented with R. oryzae showed potential to be used as a raw material for the development of functional foods, by increase its AC through a bioprocess.

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ABSTRACT Purpose: This study aimed to evaluate the long-term safety and efficacy of neodymium-doped yttrium aluminum garnet (Nd:YAG) vitreolysis for symptomatic vitreous floaters as it remains a controversial procedure due to insufficient robust evidence in the literature for the maintenance of the results and absence of adverse effects. Methods: This is an observational extension to the previously presented prospective, randomized, double-blind clinical trial. Eight of thirteen subjects who underwent vitreolysis with YAG laser returned for a late reevaluation, 18 months after the procedure, to evaluate the efficacy and safety of the procedure. Results: All patients maintained the improvement in symptomatology noted after the procedure, with 25% showing complete improvement and a similar proportion (37.5%) reporting significant or partial improvement. Objective improvement in opacity was similar to that found at 6 months follow-up. The NEI-VFQ 25 quality of life questionnaire showed no statistically significant difference in responses between the 6th and 18th month. No adverse effects were noted on clinical examination or reported by patients. Conclusion: Vitreolysis efficacy observed at 6 months of follow-up was maintained until the eighteenth month, with all patients reporting improvement from the pre-procedure state. No late adverse effects were noted. A larger randomized clinical trial is needed to confirm the safety of the procedure.

RESUMO Objetivos: Avaliar a segurança e eficácia a longo prazo da vitreólise com Nd:YAG laser para moscas volantes sintomáticas, uma vez que permanece como um procedimento controverso devido a falta de evidência científica robusta sobre a manutenção dos resultados e ocorrência de efeitos adversos. Métodos: Este estudo é uma extensão observacional de um ensaio clínico prospectivo, randomizado, duplo cego, previamente publicado. Oito de treze pacientes que foram submetidos a vitreólise com YAG laser foram acompanhados para uma reavaliação tardia, dezoito meses após o procedimento, para avaliar a eficácia e segurança do procedimento. Resultados: Todos os pacientes mantiveram a melhora na sintomatologia notada ao final do procedimento original, com 25% dos casos apresentando melhora completa, e uma proporção semelhante (37,5%) demonstrando melhora significativa ou parcial. A melhora objetiva na opacidade foi similar ao achado no seguimento original de 6 meses. O questionário de qualidade de vida NEI-VFQ 25 não demonstrou diferença estatisticamente significativa nas respostas entre o sexto e o décimo oitavo mês de acompanhamento. Nenhum efeito adverso foi notado no exame clínico ou reportado pelos pacientes. Conclusão: A eficácia da vitreólise observada ao sexto mês do acompanhamento foi mantida até o décimo oitavo mês, com todos os pacientes notando algum grau de melhora quando comparado ao estado pré procedimento. Nenhum efeito adverso tardio foi notado. Um ensaio clínico randomizado maior é necessário para confirmar a segurança do procedimento.

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The current research was designed to reach extracellular protease production potential in different strains of Sordaria fimicola which were previously obtained from Dr. Lamb (Imperial College, London) from North Facing Slope and South Facing Slope of Evolution Canyon. After initial and secondary screening, two hyper-producers strains S2 and N6 were selected for submerged fermentation and cultural conditions including temperature, pH, incubation period, inoculum size, substrate concentration, and different carbon and nitrogen sources were optimized for enzyme production. S2 strain showed maximum protease production of 3.291 U/mL after 14 days of incubation at 30 °C with 7 pH, 1% substrate concentration and 1 mL inoculum, While N6 strain showed maximum protease production of 1.929 U/mL under fermentation optimized conditions. Another aim of the present research was to underpin the biodiversity of genetics and post-translational modifications (PTMs) of protease DPAP (peptidyl-aminopeptidase) in Sordaria fimicola. Five polymorphic sites were observed in amino acid sequence of S. fimicola strains with reference to Neurospora crassa. PTMs prediction from bioinformatics tools predicted 38 phosphorylation sites on serine residues for protease peptidyl-aminopeptidase in S1 strain of S. fimicola while 45 phosphorylation sites on serine in N7 strain and 47 serine phosphorylation modifications were predicted in N. crassa. Current research gave an insight that change in genetic makeup effected PTMs which ultimately affected the production of protease enzyme in different strains of same organism (S. fimicola). The production and molecular data of the research revealed that environmental stress has strong effects on the specific genes through mutations which may cause genetic diversity. S. fimicola is non- pathogenic fungus and has a short life cycle. This fungus can be chosen to produce protease enzyme on a commercial scale.

A pesquisa atual foi projetada para alcançar o potencial de produção de protease extracelular em diferentes cepas de Sordaria fimicola que foram previamente obtidas do Dr. Lamb (Imperial College, Londres) de North Facing Slope e South Facing Slope de Evolution Canyon. Após a triagem inicial e secundária, duas cepas hiperprodutoras S2 e N6 foram selecionadas para fermentação submersa e condições culturais, incluindo temperatura, pH, período de incubação, tamanho do inóculo, concentração de substrato, e diferentes fontes de carbono e nitrogênio foram otimizadas para produção de enzima. A cepa S2 apresentou produção máxima de protease de 3,291 U/mL após 14 dias de incubação a 30 °C com pH 7, concentração de substrato de 1% e inóculo de 1 mL, enquanto a cepa N6 apresentou produção máxima de protease de 1,929 U/mL em condições otimizadas de fermentação. Outro objetivo da presente pesquisa foi sustentar a biodiversidade da genética e modificações pós-tradicionais (PTMs) da protease DPAP (peptidil-aminopeptidase) em Sordaria fimicola. Cinco sítios polimórficos foram observados na sequência de aminoácidos de cepas de S. fimicola com referência a Neurospora crassa. A previsão de PTMs a partir de ferramentas de bioinformática previu 38 locais de fosforilação em resíduos de serina para protease peptidil-aminopeptidase na cepa S1 de S. fimicola, enquanto 45 locais de fosforilação em serina na cepa N7 e 47 modificações de fosforilação de serina foram previstas em N. crassa. A pesquisa atual deu uma ideia de que a mudança na composição genética afetou os PTMs que, em última análise, afetaram a produção da enzima protease em diferentes cepas do mesmo organismo (S. fimicola). A produção e os dados moleculares da pesquisa revelaram que o estresse ambiental tem fortes efeitos sobre genes específicos por meio de mutações que podem causar diversidade genética. S. fimicola é um fungo não patogênico e tem um ciclo de vida curto. Esse fungo pode ser escolhido para produzir enzima protease em escala comercial.

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The present study thus aimed at the development and physicochemical characterization of solid lipid nanoparticles loaded with crude extract of Piper corcovadensis roots (SLN - CEPc) and chitosan - coated solid lipid nanoparticles loaded with crude extract of P. corcovadensis roots (C - SLN - CEPc), as well as the determination of its antimycobacterial activity against Mycobacterium tuberculosis H37Rv, its cytotoxicity against the Vero cell line and evaluation in the hemolysis assay. Both formulat ions containing the encapsulated extract showed high encapsulation efficiency, formed by a monodispersed system with small and spherical particles, and there was no aggregation of particles. In the biological assays, SLN - CEPc and C - SLN - CEPc showed promisin g anti - M. tuberculosis activity with a minimum inhibitory concentration (MIC) of 12.5 µg/mL, whereas the cytotoxic concentrations obtained at 50% (CC 50 ) in Vero cells were 60.0 and 70.0 µg/mL, respectively. Therefore, nanoencapsulation showed satisfactory results, justifying its usage in the development of new products.

El presente estudio apuntó al desarrollo y caracterización fisicoquímica de na nopartículas lípidas en estado sólido, cargadas con extracto crudo de raíz de Piper c orcovadensis (SLN - CEPc) y nanopartículas lípidas en estado sólido cubiertas con quitosano cargadas co n extracto crudo de raíz de P. corcovadensis (C - SLN - CEPc), así como la determinación de su actividad antimico bacterial contra Mycobacterium tuberculosis H37Rv, su citotoxicidad contra la línea celular Vero y su evaluación en ensayo de hemólisis. Ambas formulaciones que contenían el extracto encapsulado mostraron alta eficien cia de encapsulación, formado por un sistema monodispersado con pequeñas partículas esféricas, y no hubo agregación de partículas. En los ensayos biológicos, SLN - CEPc y C - SLN - CEPc mostraron un a prometedora actividad anti - M. tuberculosis con una mínima conc entración inhibitoria (MIC) de 12,5 µg/mL, mientras que las concentraciones citotóxicas obtenidas al 50% (CC 50 ) en células Vero estuvo en 60,0 y 70,0 µg/mL, respectivamente. Por lo tanto, la nanoencapsulación mostró resultados satisfactorios, justificando su uso en el desarrollo de nuevos productos.

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Introduction. Over time, efforts have been invested in the design of new instruments that overcome the disadvantages of the gold standard instrument in surgery, the scalpel. As a result, electronic equipment has emerged such as the electric scalpel and laser devices. The available evidence on these instruments suggests that the tissue response is related to each instrument's physical and biological cutting principles. Objective. To compare the histological changes in gingiva samples associated with surgical cutting performed with a 940 nm diode laser, a 2780 nm erbium, chromium: yttriumscandium-gallium-garnet (Er,Cr:YSGG) laser, and an electric scalpel, by presenting a series of cases. Case presentation. We present three cases of healthy patients undergoing cosmetic surgery. The clinical examination revealed exposure of a keratinized gingiva band greater than 4 mm, normal color and texture in gingival tissue, with a firm consistency and no bleeding on periodontal probing. Gingivectomy was indicated with the following protocols: Diode laser of 940 nm at 1 W, in continuous mode; Er,Cr:YSGG laser of 2780 nm at 2.5 W, 75 Hz, H mode, air 20, water 40, gold tip MT4); and electric scalpel in cutting mode at power level four. Gingival tissue samples were taken and stored in 10% formaldehyde for histological analysis. Conclusion. All the evaluated cutting instruments generated histological changes produced by the thermal effect, the main ones being collagen coagulation and carbonization. The depth of thermal damage caused by the 2780 nm Er,Cr:YSGG laser was much lesser than that induced by the electric scalpel and the 940 nm diode laser.

Introducción. Históricamente se ha invertido esfuerzo en el diseño de nuevos instrumentos que superen las desventajas del estándar de referencia en cirugía, el bisturí. Como consecuencia de esto, han surgido equipos electrónicos como el electrobisturí y los diferentes dispositivos de tecnología láser. La información disponible sobre estos instrumentos sugiere que la respuesta del tejido intervenido está influenciada por los principios físicos y biológicos de corte del instrumento. Objetivo. Comparar los cambios histológicos en muestras de encía asociados al corte quirúrgico realizado con láser de diodo de 940 nm, láser de erbio, cromo: itrio-escandio-galio-granate (Er,Cr:YSGG) (2780nm) y electrobisturí mediante una presentación de serie de casos. Presentación de los casos. Se presentan tres casos de pacientes sanos sometidos a cirugía estética. El examen clínico reveló la exposición de una banda gingival queratinizada mayor de 4 mm, tejido gingival de color y textura normales, de consistencia firme y sin sangrado al sondaje periodontal. Se indicó gingivectomía con los siguientes protocolos: láser de diodo de 940 nm a 1 W, en modo continuo; láser de Er,Cr:YSGG de 2780 nm a 2,5 W, 75 Hz, modo H, aire 20, agua 40, punta de oro MT4; y bisturí eléctrico en modo de corte, a nivel de potencia cuatro. Se tomaron muestras de tejido gingival y se almacenaron en formaldehído al 10 % para su análisis histológico. Conclusión. Los tres instrumentos de corte generaron cambios histológicos producidos por el efecto térmico; los principales fueron coagulación del colágeno y carbonización. La profundización del daño térmico causada por el láser de Er,Cr:YSGG de 2780 nm fue mucho menor que la generada por el electrobisturí y por el láser de diodo de 940 nm.

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Objetivo: Comunicar el caso de un varón diagnosticado de tumor sólido pseudopapilar de páncreas (TSPP). Esta patología afecta fundamentalmente a mujeres jóvenes, siendo extremadamente infrecuente en hombres. Caso Clínico: Varón de 40 años diagnosticado por TC de masa intraabdominal sólida bien delimitada, de 12,5 × 13 × 8,5 cm, heterogénea, con calcificaciones periféricas y realce tras la administración de contraste en fase portal, dependiente de cuerpo-cola pancreática. Se realiza puncion, no concluyente. La laparotomía exploradora mostró tumoración sólida dependiente de cola pancreática que incluye vasos esplénicos. Se liberó el tumor de forma periférica, requiriendo pancreatectomía distal y esplenectomía. El resultado AP informó neoplasia pseudopapilar sólida de cola pancreática de bajo grado de malignidad, bien diferenciado (G1). Alta hospitalaria al 12° día sin complicaciones. Actualmente libre de enfermedad tras dos años de la intervención. Discusión: Este tumor infrecuente representa el 1%-3% de las neoplasias pancreáticas. El 90% afecta a mujeres jóvenes, con proporción de mujeres a hombres de 4:1. En estos, tiene mayor potencial maligno con peor pronóstico. Conclusión: La baja incidencia en varones puede dificultar el diagnóstico. Sin embargo, debemos tenerlo en cuenta en el diagnóstico diferencial, ya que el tratamiento quirúrgico radical aumenta significativamente la supervivencia al evitar la recurrencia local y las metástasis a distancia, lo que supone un reto quirúrgico.

Objective: To report the case of a male diagnosed with a solid pseudopapillary tumor of the páncreas. This pathology fundamentally affects young women, being extremely infrequent in men. Clinical Case: A 40-year-old man diagnosed by CT with a well-defined solid intra-abdominal mass, 12.5 × 13 × 8.5 cm, heterogeneous, with peripheral calcifications and enhancement after contrast administration in the portal phase, dependent on the body-tail of the pancreas. Fine needle puncture is performed, inconclusive. The exploratory laparotomy showed a solid tumor dependent on the pancreatic tail that included splenic vessels. The tumor was released peripherally, requiring distal pancreatectomy and splenectomy. The AP result reported solid pseudopapillary neoplasm of the pancreatic tail of low grade of malignancy, well differentiated (G1). Hospital discharge on the 12th day without complications. Currently free of disease two years after the intervention. Discussion: This rare tumor represents 2%-3% of pancreatic neoplasms. 90% affects young women, with a ratio of women to men of 4:1. In these, it has greater malignant potential with worse prognosis. Conclusion: The low incidence in males can make diagnosis difficult. However, we must take it into account in the differential diagnosis, since radical surgical treatment significantly increases survival by avoiding local recurrence and distant metastases, which is a surgical challenge.

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Introducción: la adaptación marginal e interna de nuestras restauraciones fabricadas por fundición sistemas de fresado y sinterización láser es uno de los factores clínicos más importantes para el éxito de las prótesis fijas, previniendo el riesgo de microfiltración y enfermedad periodontal. Objetivo: evaluar la adaptación marginal e interna de cofias metálicas en aleación Cr-Co confeccionadas por técnicas convencionales, CAD/ CAM de fresado y sinterizado por láser. Material y métodos: estudio de tipo experimental, comparativo e in vitro. Se imprimió un modelo maestro en Cr-Co, proveniente del escaneo de un premolar preparado para corona completa, sobre el cual se diseñaron 30 cofias divididas en tres grupos: el primero que corresponde al grupo cofias fundidas fresadas en disco de cera A (A = 10), el segundo grupo cofias fresadas en disco de metal presinterizado B (B = 10) y el tercer grupo cofias impresas por sinterización láser C (C = 10). Se empleó la réplica de silicona, colocando silicona al interior de cada cofia, sobre el modelo maestro, simulando al cemento, mediante una máquina de ensayo universal se realizó una compresión de 50 N. Luego de retirar cada cofia se rellenaron con silicona pesada de adición, obteniendo una réplica de silicona. Se efectuaron dos cortes transversales en sentido vestíbulolingual y mesiodistal. Se observó el espesor de silicona VPS (vinil poliéter silicona) mediante un estereomicroscopio (Nikon SMZ745T), obteniendo valores en micrómetros. Para el análisis estadístico se utilizó el software SPSS 25 con el fin de realizar la prueba de normalidad y ANOVA de dos vías bajo un nivel de confianza del 95%. Resultados: el menor gap lo obtuvo el grupo de fresadas, seguido de las impresas y por último las fundidas por métodos convencionales. ANOVA de dos vías reveló diferencias estadísticamente significativas entre los tres grupos (p < 0.0001). Conclusiones: se encontró que el gap varía con cada método de fabricación, la técnica convencional de fundido mostró un mayor gap, ninguna excediendo el rango clínicamente aceptable (AU)

Introduction: the marginal and internal adaptation of our restorations manufactured by casting, milling systems and laser sintering is one of the most important clinical factors for the success of fixed prostheses, preventing the risk of microleakage and periodontal disease. Objective: evaluate the marginal and internal adaptation of metal copings in Cr-Co alloy made by conventional techniques, CAD/CAM milling and laser sintering. Material and methods: an experimental, comparative and in vitro study, a Cr-Co master model was printed from the scan of a premolar prepared for a full crown. An experimental, comparative and in vitro study, a Cr-Co master model was printed from the scan of a premolar prepared for a full crown, on which 30 caps divided into three groups were designed; the first group corresponds to the cast copings milled on a wax disc A (A = 10), the second group milled copings on a presintered metal disc B (B = 10) and the third group printed by laser sintering copings C (C = 10). The silicone replica was used, placing silicone inside each coping, on the master model, simulating cement, using a universal testing machine, a 50 N compression was performed. After removing each coping, they were filled with heavy addition silicone, obtaining a silicone replica. Two cross-sections were made in the buccolingual and mesiodistal direction., observing the thickness of the VPS (vinyl polyeter silicone) silicone using a stereomicroscope (Nikon SMZ745T), obtaining values in micrometers. For the statistical analysis, the SPSS 25 software was used in order to perform the normality and two-way ANOVA tests under a 95% confidence level. Results: the smallest gap was obtained by the milled group, followed by the printed ones and finally those cast by conventional methods. Two-way ANOVA revealed statistically significant differences between the three groups (p < 0.0001). Conclusions: the gap was found to vary with each fabrication method, the conventional casting technique showed a larger gap, none exceeding the clinically acceptable range (AU)

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RESUMEN El tumor sólido pseudopapilar de páncreas (TSP) es un tumor infrecuente, de bajo grado de malignidad, que representa el 1-3% de todas las neoplasias pancreáticas, con predilección por el sexo femenino, y es el tumor sólido de páncreas más frecuente en la infancia. Mujer de 13 años que consultó por dolor abdominal de 5 días de evolución, en hipocondrio derecho e irradiado a espalda, con náuseas y vómitos. TSP es diagnosticado con ecografía, tomografía computarizada (TC) y resonancia magnética (RM). Se realizó duodenopancreatectomía cefálica. La paciente fue dada de alta. El examen anatomopatológico informó un TSP de páncreas. El abordaje quirúrgico de estos tumores, abierto o laparoscópico, permite una excelente supervivencia alejada.

ABSTRACT Solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm with a low malignant potential and represents 1- 3% of all pancreatic tumors. They usually occur in women and are the most common solid pancreatic tumor in children. A 13-year-old girl visited the emergency department due to abdominal pain in the right hypochondrium radiating to the back, nausea and vomiting lasting 5 days. A SPT was diagnosed by ultrasound, computed tomography (CT) scan and magnetic resonance imaging (MRI). The patient underwent cephalic pancreaticoduodenectomy and was discharged. The pathological study reported a SPT of the pancreas. The surgical approach of these tumors through open surgery or laparoscopy offers excellent long-term survival.

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Resumen Introducción: las neoplasias sólidas pseudopapilares de páncreas representan alrededor del 3% de los tumores pancreáticos quísticos resecados. Se presentan con mayor frecuencia en mujeres jóvenes entre la segunda y tercera décadas de la vida. Es un tumor con poco potencial maligno que se ubica principalmente en la cola; sin embargo, puede encontrarse en cualquier localización anatómica pancreática. Métodos: se presentan 5 casos de cuatro mujeres y un hombre, entre 16 y 36 años, que consultaron principalmente por dolor abdominal. Resultados: cuatro pacientes fueron llevados a pancreatectomía distal sin esplenectomía por laparoscopia, y una paciente a pancreatoduodenectomía por laparotomía. Se logró extraer por completo y satisfactoriamente el tumor a los cinco pacientes. No se evidenció metástasis. Los tumores se localizaron en la cabeza (1), cuello (1) y predominantemente en cuerpo y cola (3). El reporte histopatológico posoperatorio confirmó el diagnóstico en los cinco casos, en la paciente más joven se había realizado una biopsia percutánea previa a la intervención quirúrgica. Conclusiones: la resección quirúrgica completa del tumor con preservación del bazo es el tratamiento de elección en pacientes con neoplasia sólida pseudopapilar de páncreas.

Abstract Introduction: Solid pseudopapillary neoplasms of the pancreas represent around 3% of resected cystic pancreatic tumors. They occur more frequently in young women between the second and third decades of life. It is a tumor with little malignant potential located mainly in the tail; however, it can be found in any pancreatic anatomical location. Materials and methods: We reported five cases of four women and one man, between 16 and 36 years of age, who consulted mainly for abdominal pain. Results: Four patients underwent distal pancreatectomy without laparoscopic splenectomy, and one underwent laparotomy pancreatoduodenectomy. The tumor was completely and satisfactorily removed from all five patients. No metastasis was found. The tumors were located on the head (1), neck (1), and predominantly on the body and tail (3). The postoperative histopathological report confirmed the diagnosis in all five cases; in the youngest patient, a percutaneous biopsy had been performed before surgical intervention. Conclusions: Complete surgical resection of the tumor with preservation of the spleen is the treatment of choice in patients with solid pseudopapillary neoplasm of the pancreas.

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Aim: To assess the effect of different mechanical surface treatments on flexural strength of repaired denture base. Material and Methods: Sixty bar-shaped specimens of heat-polymerized acrylic resin were fabricated, and divided into six groups (n=10). All specimens, except the positive control group (group PC), were sectioned into halves to create a 1-mm clearance. A negative control group with no surface treatment (group NC) was also considered. Other groups underwent different surface treatments: group Laser; treated with erbium: yttrium-aluminum-garnet (Er:YAG) laser, group APA; airborne-particle abrasion (APA), group APA plus Laser; a combination of laser and APA, and group Bur; bur grinding. After measuring surface roughness (Ra) with a profilometer, all sectioned specimens were repaired by auto-polymerizing acrylic resin, and thermocycled afterward. Three-point bending test was performed by a universal testing machine. Data were statistically analyzed (α=0.05). Results: The mean surface roughness of all experimental groups were significantly higher than that of group NC (p<0.05). The mean flexural strength of all groups was significantly lower than that of group PC (p<0.05). Group B had significantly higher flexural strength than the other surface-treated groups (p<0.05). Group Laser had significantly higher flexural strength than groups APA (p=0.043) and APA plus Laser (p=0.023). No significant difference was found between groups APA and APA plus Laser (p=0.684). Conclusion: All surface treatments increased the surface roughness and flexural strength compared with the untreated group. The highest flexural strength was observed in specimens treated by bur grinding and then laser, however, it was still significantly lower than intact specimens.

Objetivo: Evaluar el efecto de diferentes tratamientos superficiales mecánicos sobre la resistencia a la flexión de la base de la prótesis reparada. Material y Métodos: Se fabricaron sesenta especímenes en forma de barra de resina acrílica termo-polimerizada y se dividieron en seis grupos (n=10). Todas las muestras, excepto el grupo de control positivo (grupo PC), se seccionaron en mitades para crear un espacio libre de 1 mm. También se consideró un grupo de control negativo sin tratamiento superficial (grupo NC). Otros grupos se sometieron a diferentes tratamientos superficiales: grupo Láser; tratados con láser de erbio: itrio-aluminio-granate (Er:YAG), grupo APA; abrasión por partículas en el aire (APA), grupo APA más láser; una combinación de láser y APA, y grupo Bur; molienda de fresas. Después de medir la rugosidad de la superficie (Ra) con un perfilómetro, todas las muestras seccionadas se repararon con resina acrílica de autopolimerización y se sometieron a termociclado. La prueba de flexión de tres puntos se realizó con una máquina de prueba universal. Los datos se analizaron estadísticamente (α=0,05). Resultados: La rugosidad superficial media de todos los grupos experimentales fue significativamente mayor que la del grupo NC (p<0,05). La resistencia media a la flexión de todos los grupos fue significativamente menor que la del grupo PC (p<0,05). El grupo B tenía una resistencia a la flexión significativamente mayor que los otros grupos tratados en la superficie (p<0,05). El grupo Láser tuvo una resistencia a la flexión significativamente mayor que los grupos APA (p=0,043) y APA más Láser (p=0,023). No se encontró diferencia significativa entre los grupos APA y APA más Láser (p=0,684). Conclusión: Todos los tratamientos superficiales aumentan la rugosidad de la superficie y la resistencia a la flexión en comparación con el grupo sin tratar. La resistencia a la flexión más alta se observó en las muestras tratadas con fresado y luego con láser; sin embargo, aún era significativamente más baja que las muestras intactas.

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This study evaluated the specific interactions between drug and polymers in amorphous spray dried dispersions (SDDs). Four Biopharmaceutics Classification System (BCS) II class drugs were evaluated. Binary and ternary SDDs were manufactured with conventional polymers and arabinogalactan. Specific interaction parameters between drug and polymer were determined using theoretical calculations and DSC data. Analytical methods were used to evaluate solid and solution state interactions. Maximum amorphous content for each formulation was calculated using DSC. Flory-Huggins Specific Interaction Parameters were calculated. Negative specific parameters were associated with solid-state interactions and improved capacity of drug in the amorphous state. Ternary SDDs containing drug, polymer, and arabinogalactan displayed similar hydrogen bonding as was observed with binary SDDs. Solution-state interactions observed in binary systems may be used in tertiary systems to improve the amorphous drug capacity and improved dissolution compared to the binary. The resultant tertiary systems are an improvement over binary drug polymer systems.

Este estudio evaluó las interacciones específicas entre el fármaco y los polímeros en dispersiones amorfas secadas por pulverización (SDD). Se evaluaron cuatro fármacos de clase II del Sistema de Clasificación Biofarmacéutica (BCS). Los SDD binarios y ternarios se fabricaron con polímeros convencionales y arabinogalactano. Los parámetros de interacción específicos entre el fármaco y el polímero se determinaron utilizando cálculos teóricos y datos de DSC. Se utilizaron métodos analíticos para evaluar las interacciones del estado sólido y de la solución. El contenido amorfo máximo para cada formulación se calculó usando DSC. Se calcularon los parámetros de interacción específicos de Flory-Huggins. Los parámetros específicos negativos se asociaron con interacciones en estado sólido y una capacidad mejorada del fármaco en el estado amorfo. Los SDD ternarios que contienen fármaco, polímero y arabinogalactano mostraron enlaces de hidrógeno similares a los observados con los SDD binarios. Las interacciones de estado de solución observadas en sistemas binarios pueden usarse en sistemas terciarios para mejorar la capacidad del fármaco amorfo y mejorar la disolución en comparación con el binario. Los sistemas terciarios resultantes son una mejora con respecto a los sistemas de polímeros de fármacos binarios.

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Abstract Background: Ischemic reperfusion injury (IRI) is a common hazard involved in many human diseases, such as cerebral stroke, myocardial infarction, solid organ transplant dysfunction or failure, and vascular diseases. Understanding the molecular bases of this injury is essential for the prevention and control of these life-threatening conditions. Ischemic and remote ischemic preconditioning techniques (IPC and RIPC, respectively) have gained increasing importance in the clinical practice to protect against the IRI; however, the exact mechanisms of these techniques are not fully understood, which renders their clinical application query. Possible effectors: Nitric oxide (NO) has been reported by multiple studies to be an important mediator of the protective effects of those techniques. While the physiological concentrations of NO and fibrinogen (FB) are known to antagonize each other, the circulating levels of both effectors increase in response to RIPC. Hypothesis: While NO has potential anti-inflammatory effects, non-soluble fibrinogen (sFB) shows pro- inflammatory effects. However, the sFB may have the potential to act synergistically rather than antagonistically with NO toward the attenuation of the IRI. Conclusion: While increased FB is considered a risk factor for cardiovascular and inflammatory conditions that is also able to decrease the efflux of NO, and increase the NO oxidative metabolits and S- nitroglutathione, the increased sFB during the acute phase reaction might have other protective aspects that should be carefully investigated.

Resumen Antecedentes: La lesión por isquemia-reperfusión (LIR) es un riesgo común involucrado en muchas enfermedades humanas tales como derrame cerebral, infarto del miocardio, disfunción o falla de trasplante de órgano sólido, y enfermedades vasculares. Una comprensión de la base molecular de esta lesión es fundamental para la prevención y el control de estas enfermedades potencialmente mortales. Las técnicas de preacondicionamiento isquémico y preacondicionamiento isquémico remoto (PIR) han cobrado una creciente importancia en la práctica clínica para la protección contra la LIR, sin embargo, los mecanismos precisos de estas técnicas no se entienden plenamente, lo cual pone en duda su aplicación clínica. Posibles efectores: El óxido nítrico (ON) ha sido reportado por varios estudios como un importante mediador de los efectos protectores de estas técnicas. Si bien se sabe que las concentraciones fisiológicas del ON y fibrinógeno son antagónicas, los niveles circulantes de ambos efectores aumentan en respuesta al PIR. Hipótesis: Aunque el ON tiene posibles efectos anti-inflamatorios, el fibrinógeno insoluble muestra efectos proinflamatorios. Sin embargo, el fibrinógeno soluble puede tener el potencial de actuar de manera sinérgica en lugar de antagónica con el ON hacia la atenuación de la LIR. Conclusión: Aunque el fibrinógeno elevado se considera un factor de riesgo para las enfermedades cardiovasculares e inflamatorias, que también puede disminuir la descarga de ON y aumentar los niveles de metabolitos oxidantes del ON y de S-nitrosoglutatión, el aumento de fibrinógeno soluble durante la reacción de fase aguda puede tener otros aspectos protectores que deben ser cuidadosamente investigados.

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Objective: This study aimed to determine the push-out-bond-strength(PBS) of mineral trioxide aggregate (BIOMTA+) and calcium-enriched-mixture-cement (CEM) in retrograde cavities prepared using Er: YAG laser and stainless-steel bur. Material and Methods: The root canals of 60 extracted single-rooted human teeth were prepared, filled and their apical portion of 3-mm were resected using a diamond bur and randomly divided into four groups according to technique of retrograde preparation and filling material as follows(n=15): Group1: bur/ BIOMTA+ ,Group2: bur/ CEM, Group3: Er:YAG laser/ BIOMTA+, Group4: Er:YAG laser/ CEM. PBS test were performed to specimens and failure modes were evaluated. The data were statistically analyzed with ANOVA, Post-Hoc Tukey and t tests (p< 0.05). Results: CEM was exhibited higher than bond strength compared to BIOMTA+ in retrograde cavity prepared using laser (p= 0.021) and BIOMTA+ in retrograde cavity prepared using bur was exhibited higher than bond strength compared to in retrograde cavities prepared using laser (p= 0.024). Failure modes were dominantly cohesive in all groups tested and one representative specimen each failure mode was examined in SEM and the general characteristics of the failure modes were confirmed. Conclusion: With in the limitations of the present study, when used CEM, Er: YAG laser-assisted retrograde cavity preparation positively affected the bond strength values compared to BIO MTA+. Considering its optimal adhesion, the calcium-enriched-mixture-cement (CEM) might be a good option as a filling material in retrograde cavities in clinical use. (AU)

Objetivo: O objetivo deste estudo foi determinar a força de união (PBS) de cimento de agregado trióxido mineral (BIO MTA+) e cimento enriquecido com cálcio (CEM) em preparos cavitários retrógrados realizados com: Laser Er-YAG e brocas de aço inoxidável. Material e Métodos: Canais radiculares de 60 dentes unirradiculares extraídos foram preparados, preenchidos e 3 mm de suas porções apicais foram ressecadas usando uma broca diamantada e divididos randomicamente em quatro grupos de acordo com a técnica de preparação retrógrada e o material de preenchimento (n=15): Grupo 1: Broca/BIO MTA+, Grupo 2: Broca/CEM, Grupo 3: Laser Er-YAG/BIO MTA+, Grupo 4: Laser Er-YAG/CEM. O teste de PBS foi realizado para as amostras e os modelos de falha foram avaliados. Os dados foram analisados estatisticamente pelos testes de ANOVA, Post-Hoc Tukey e testes t (p< 0.05). Resultados: CEM apresentou maior força de união que BIO MTA+ em cavidades retrógradas preparadas com laser (p= 0.021) e BIO MTA+ em cavidades retrógradas preparadas com brocas apresentou maior força de união quando comparado à cavidades retrógradas preparadas com laser (p= 0.024). Os modelos de falha foram predominantemente coesos em todos os grupos testados e um espécime representativo de cada modelo de falha foi examinado em MEV e as características gerais dos modelos de falha foram confirmadas. Conclusão: Com as limitações do presente estudo, quando usou-se CEM, o preparo de cavidades retrógradas através de Laser Er-YAG afetou positivamente os valores da força de união quando comparados com BIO MTA+. Considerando sua ótima adesão, o cimento enriquecido com cálcio (CEM) pode ser uma boa opção como um material de preenchimento em cavidades retrógradas no uso clínico.

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ABSTRACT Objective: To evaluate the efficacy of mitomycin C in anatomical and functional success after modified transcanalicular diode laser dacryocystorhinostomy. Methods: A prospective, double-blinded, randomized placebo-controlled study compared the effect of topical mitomycin C on modified transcanalicular diode laser dacryocystorhinostomy. Group 1 had modified transcanalicular diode laser dacryocystorhinostomy with topical saline, while Group 2 had modified transcanalicular diode laser dacryocystorhinostomy with topical mitomycin C. Success was defined as anatomical patency and relief of symptoms at the end of 6 months. Results: Six months after surgery, Group 1 (30 patients) showed anatomical and functional success rates of 86.7% and 83.3%, respectively. Group 2 (32 patients) showed anatomical and functional success rates of 87.5% and 84.3%, respectively. There was no statistically significant difference between the groups 1 and 2 (p = 1.000). Conclusion: The use of mitomycin C did not improve the anatomical and functional success rates of modified transcanalicular diode laser dacryocystorhinostomy compared to placebo.

RESUMO Objetivo: Avaliar a eficácia da mitomicina C no sucesso anatômico e funcional após dacriocistorrinostomia transcanalicular com laser de diodo. Métodos: Estudo prospectivo, duplo-cego, randomizado e controlado por placebo. Comparou o efeito da mitomicina C tópica na dacriocistorrinostomia transcanalicular com laser de diodo. No Grupo 1, foi utilizada apenas solução salina tópica, enquanto no Grupo 2 foi utilizada mitomicina C tópica. O sucesso foi definido como permeabilidade da via lacrimal e alívio dos sintomas ao final de 6 meses. Resultados: Seis meses após a cirurgia, o Grupo 1 (30 pacientes) apresentou taxas de sucesso anatômico e funcional de 86,7% e 83,3%, respectivamente. O Grupo 2 (32 pacientes) apresentou taxas de sucesso anatômico e funcional de 87,5% e 84,3%, respectivamente. Não houve diferença estatística significante entre os Grupos 1 e 2 (p=1,000). Conclusão: O uso de mitomicina C não melhora as taxas de sucesso anatômico e funcional do dacriocistorrinostomia transcanalicular com laser de diodo em comparação ao placebo.

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Resumen Introducción: el tumor sólido pseudopapilar corresponde al 1 %-2 % de todos los tumores sólidos del páncreas, con un curso poco agresivo. Serie de casos: en el departamento de patología de la Universidad de Antioquia se diagnosticaron 16 casos entre enero de 2004 y julio de 2019. Dos de los casos correspondían a pacientes pediátricos, uno de ellos de sexo masculino con posterior metástasis hepática, dos a mujeres mayores de 40 años y el resto a mujeres entre 17 y 26 años. Un caso presenta células de aspecto sarcomatoide, otros dos presentaron células gigantes multinucleadas y hubo un caso con pleomorfismo grave y presencia de mitosis atípicas. Se observó invasión de la cápsula en 6 de los casos, uno de ellos con invasión linfovascular y 3 casos con invasión perineural. Todos los casos mostraron hemorragia o necrosis, y presentaron en el perfil de inmunohistoquímica positividad para β-catenina, CD10, receptores de progesterona y CD56. La sinaptofisina fue positiva focalmente.

Abstract Introduction: Solid-pseudopapillary tumors represent 1 %-2 % of all the pancreatic solid tumors, with low malignant potential. Series of cases: In the department of pathology at the Universidad de Antioquia were diagnosed sixteen cases between January 2004 and July 2019. Two of those cases were pediatric patients, one male with subsequent hepatic metastasis. Two additional cases were represented by two females older than 40 years old and the rest of the cases were females between 17 and 26 years old. One of the cases had sarcomatoid aspect cells, two others revealed multinucleate giant cells, and one last case of severe pleomorphism and presence of atypical mitoses. Capsule invasion was observed in 6 cases: one of the cases with lymphovascular invasion and the other 3 cases with perineural invasion. All cases showed hemorrhage or necrosis, and the immunohistochemical profile was positive for β-catenin, CD10, progesterone receptors, and CD56. Synaptophysin was focally positive.

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Abstract Acute respiratory distress syndrome (ARDS) is a respiratory process of acute onset, showing on X rays as bilateral pulmonary infiltrates and severe respiratory failure, Coccidiodomycosis is a unusual cause of acute respiratory distress syndrome, the incidence of coccidiomycosis in a solid organ trasplant recipientes ranges from 1.4% a 6.9%, inadecuancy of cellular inmunity is a well established risk factor for development of coccididomcosis, less than 1% of patients develop disseminaded infecction and carrying high mortality, the case that we are presenting add to the small list of reports documenting the ocasionally acute and agressive nature of the disseminated clinical form of coccidiodomycosis.

Resumen El síndrome de dificultad respiratoria aguda (SDRA) es un proceso respiratorio de inicio agudo, que se manifiesta en las radiografías como infiltrados pulmonares bilaterales, clinicamente como insuficiencia respiratoria grave, la coccidiodomicosis es una causa inusual de síndrome de dificultad respiratoria aguda, la incidencia de coccidiomicosis en receptores de trasplante de órgano sólido varía desde 1.4% a 6.9%, una inadecuada inmunidad celular es un factor de riesgo bien establecido para el desarrollo de coccidomicosis, menos del 1% de los pacientes desarrollan enfermedad diseminada y alta mortalidad, el caso que presentamos se suma a la pequeña lista de informes que documentan la naturaleza ocasionalmente aguda y agresiva de la forma clínica diseminada de coccidiodomicosis.

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El traumatismo es una de las principales causas de morbimortalidad en pediatría. El trauma renal constituye del 1-5% de todos los traumas y la lesión traumática de órgano intraabdominal más frecuente. El manejo conservador de lesiones traumáticas de órganos sólidos se ha consolidado en la última década. Presentamos dos pacientes pediátricos atendidos conservadoramente por lesiones renales traumáticas de alto grado. Caso 1: Masculino de 9 años, sin antecedentes patológicos, con contusión en zona lumbar derecha por caída desde un árbol de 2 metros de altura que ingreso con hematuria macroscópica, dolor intenso y estable hemodinámicamente. Tomografía abdominal (TAC) contrastada evidencia lesión renal grado IV. Se brindó manejo conservador: analgesia, hidratación endovenosa de mantenimiento, terapia con antibióticos, reposo y colocación de catéter doble J, egresado 11 días después y citado en consulta externa a los 2 meses, TAC de control muestra evolución favorable, asintomático y con función renal sin alteraciones. Caso 2: Escolar masculino de 10 años, sin antecedentes patológicos, con trauma toracoabdominal derecho luego de caída en precipicio de 5 metros de altura. Ingreso con intenso dolor en flanco derecho, resistencia muscular voluntaria, hemodinámicamente estable y sin compromiso respiratorio. Ultrasonido abdominal informa hematoma perirrenal derecho. TAC abdominal Residente de Medicina Pediátrica, Universidad Nacional Autónoma de Honduras, Valle de Sula **Médico especialista en Cirugía Pediátrica, Honduras. Dirigir correpondencia a: dr.daniel.almazan@gmail.com Recibido: 20 de mayo de 2021 Aprobado: 13 de Julio de 2021 evidencia lesión renal derecha grado V. Manejo conservador con hidroterapia de mantenimiento, terapia con antibióticos, analgesia y reposo. Se colocó catéter doble J. Egresa y se cita al mes de evolución, TAC abdominal de control favorable y asintomático en el seguimiento. El manejo conservador de la lesión renal en pacientes pediátricos hemodinámicamente estables es exitoso individualizando el caso adecuadamente y clasificando apropiadamente el grado de lesión...(AU)

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Tilapia comprises one of the most cultivated fish species worldwide, mainly commercialized in the form of fillets. As a result, the amount of waste generated by processing is high, with tilapia skin being commonly discarded and not used as food for human consumption. In this context, the aim of this study was to dry residual filleted tilapia skins in a solar dehydrator and perform physical-chemical analyses after drying in order to evaluate the potential for the development of byproducts. The skins were collected at a fish market on Mercado do Peixe in Teresina - PI. Treatments consisted of four sodium chloride concentrations (0.0%; 25.0%; 50.0% and 100.0%), with five replications, totaling 25 samples. The skins were dried in the solar dehydrator for 24 hours, followed by moisture, ash, protein, lipids, pH and water activity analyses. Moisture in the in naturaskins was 57.7%, differing significantly from the dehydrated tilapia skins, which ranged from 9.4% to 10.6%. The ash in the in natura skins was 0.17%, while dehydrated tilapia skins displayed variations from 1.19% to 4.17%. The crude protein found of the in natura skins was 41.4%, significantly different (P <0.05) from the skins submitted to the solar dehydration method. Based on these findings, the use of solar dehydrator for short periods is confirmed to favor the uniform dehydration of residual tilapia skin from filleting, generating a product with satisfactory bromatological patterns for the development of fish-based by-products.(AU)

A tilápia é uma das espécies de peixe mais cultivadas no mundo, sendo comercializada principalmente na forma de filé, com isso, a quantidade de resíduos gerada com o processamento é elevada, sendo a pele de tilápia comumente descartada e não aproveitada como alimento de consumo humano. Desta forma, o objetivo desse estudo foi aproveitar peles de tilápia residuais de filetagem e realizar análises físico-química após secagem em desidratador solar afim de avaliar seu potencial para desenvolvimento de coprodutos. As peles foram coletadas no Mercado do Peixe em Teresina - PI. Foram definidos os tratamen-tos, adicionando quatro concentrações de cloreto de sódio (0,0%; 25,0%; 50,0% e 100,0%), com cinco repetições, totalizando 25 amostras. As peles foram encaminhadas para secagem no desidratador solar por 24 horas. Depois, realizou-se as análises de umidade, cinzas, proteína, lipídios, pH e atividade de água. O teor de umidade encontrado na pele em natureza foi de 57,7%, diferindo significativamente das peles de tilápia desidratadas que variaram de 9,4% a 10,6%. O teor de cinzas encontrado na pele em natureza foi de 0,17%, enquanto nas peles de tilápia desidratadas houve uma variação de 1,19% a 4,17%. A proteína bruta encontrada nas peles da tilápia em natureza foi de 41,4%, diferindo significativamente (P < 0,05) das peles submetidas ao método de desidratação solar. Com base nos resultados observados nesse estudo, conclui-se que a utilização de desidrata-dor solar em curtos períodos favorece a desidratação uniforme da pele de tilápia residual de filetagem, gerando produto com padrões bromatológicos satisfatórios para o desenvolvimento de coprodutos à base de pescado.(AU)

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Tilapia comprises one of the most cultivated fish species worldwide, mainly commercialized in the form of fillets. As a result, the amount of waste generated by processing is high, with tilapia skin being commonly discarded and not used as food for human consumption. In this context, the aim of this study was to dry residual filleted tilapia skins in a solar dehydrator and perform physical-chemical analyses after drying in order to evaluate the potential for the development of byproducts. The skins were collected at a fish market on Mercado do Peixe in Teresina - PI. Treatments consisted of four sodium chloride concentrations (0.0%; 25.0%; 50.0% and 100.0%), with five replications, totaling 25 samples. The skins were dried in the solar dehydrator for 24 hours, followed by moisture, ash, protein, lipids, pH and water activity analyses. Moisture in the in naturaskins was 57.7%, differing significantly from the dehydrated tilapia skins, which ranged from 9.4% to 10.6%. The ash in the in natura skins was 0.17%, while dehydrated tilapia skins displayed variations from 1.19% to 4.17%. The crude protein found of the in natura skins was 41.4%, significantly different (P <0.05) from the skins submitted to the solar dehydration method. Based on these findings, the use of solar dehydrator for short periods is confirmed to favor the uniform dehydration of residual tilapia skin from filleting, generating a product with satisfactory bromatological patterns for the development of fish-based by-products.

A tilápia é uma das espécies de peixe mais cultivadas no mundo, sendo comercializada principalmente na forma de filé, com isso, a quantidade de resíduos gerada com o processamento é elevada, sendo a pele de tilápia comumente descartada e não aproveitada como alimento de consumo humano. Desta forma, o objetivo desse estudo foi aproveitar peles de tilápia residuais de filetagem e realizar análises físico-química após secagem em desidratador solar afim de avaliar seu potencial para desenvolvimento de coprodutos. As peles foram coletadas no Mercado do Peixe em Teresina - PI. Foram definidos os tratamen-tos, adicionando quatro concentrações de cloreto de sódio (0,0%; 25,0%; 50,0% e 100,0%), com cinco repetições, totalizando 25 amostras. As peles foram encaminhadas para secagem no desidratador solar por 24 horas. Depois, realizou-se as análises de umidade, cinzas, proteína, lipídios, pH e atividade de água. O teor de umidade encontrado na pele em natureza foi de 57,7%, diferindo significativamente das peles de tilápia desidratadas que variaram de 9,4% a 10,6%. O teor de cinzas encontrado na pele em natureza foi de 0,17%, enquanto nas peles de tilápia desidratadas houve uma variação de 1,19% a 4,17%. A proteína bruta encontrada nas peles da tilápia em natureza foi de 41,4%, diferindo significativamente (P < 0,05) das peles submetidas ao método de desidratação solar. Com base nos resultados observados nesse estudo, conclui-se que a utilização de desidrata-dor solar em curtos períodos favorece a desidratação uniforme da pele de tilápia residual de filetagem, gerando produto com padrões bromatológicos satisfatórios para o desenvolvimento de coprodutos à base de pescado.

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El tumor sólido pseudopapilar del páncreas, conocido también como tumor de Frantz, es una enfermedad rara: neoplasia bien delimitada, de lento crecimiento, no agresiva pero maligna, habitualmente con pronóstico favorable. El tratamiento de elección es quirúrgico. Aunque algunos de ellos son agresivos a nivel local, la mayoría de los pacientes se curan con la resección completa del tumor. Se reportó el caso de una mujer de 30 años, ingresada en el Servicio de Cirugía General del Hospital Universitario Clínico Quirúrgico Comandante Faustino Pérez Hernández, con diagnóstico presuntivo clínico e imagenológico, de tumor pseudopapilar sólido del páncreas, con confirmación histológica tras la resección quirúrgica. Este infrecuente tumor debe ser considerado en el diagnóstico diferencial de los tumores pancreáticos, fundamentalmente en mujeres jóvenes(AU)

The solid pseudo-papillary carcinoma, also known as Frantz´s tumor, is a rare disease. It is a well-defined neoplasia, of low growth, non-aggressive but malignant, usually with a favorable prognosis. The elective treatment is the surgery. Although some of them are locally aggressive, most patients are healed with the complete tumor resection. The authors reported the case of a woman, aged 30 years who entered the Service of General Surgery of the University Hospital Comandante Faustino Pérez Hernández, with a presumptive clinical and imaging diagnosis of pancreas solid pseudo-papillary tumor, histologically confirmed after surgical resection. This infrequent tumor should be taken into account in the differential diagnosis of pancreatic tumors, mainly in young women(AU)

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