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Background: Establishing reference intervals (RIs) in clinical laboratories is essential, as these can vary due to inter-individual variability as well as the analytical methods used. The purpose of this study was to determine RIs for markers and ratios biochemical in apparently healthy Chilean adults. Methods: A sample of 1,143 data was selected from the Universidad Católica de Temuco, Clinical Laboratory database, La Araucanía Region, Chile, which were analysed by sex. The Tukey's Fences was used to detect outliers and the RIs were established using the non-parametric method.

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Reference intervals for physiologic parameters, crucial for assessing the health status of animals, have been documented for various crocodilian species across the globe. Nonetheless, the establishment of plasma biochemical reference intervals specific to Amazonian crocodilians remains incomplete. In an effort to address this gap, we procured blood samples from 65 black caimans (Melanosuchus niger) and 58 spectacled caimans (Caiman crocodilus) during the period of September-December 2019 within the Anavilhanas National Park in the Brazilian Amazon region We aimed to define reference intervals for 11 key plasma variables measured, namely glucose, triglycerides, total cholesterol, calcium, magnesium, sodium, potassium, albumin, total protein, uric acid, and urea. In general, the determined blood reference intervals aligned closely with those established for other crocodilian species. Some specific measurements, such as total cholesterol, sodium, and magnesium, exhibited distinct variations based on the species. Furthermore, female black caimans showcased elevated cholesterol levels compared with their male counterparts. Within the spectacled caimans, disparities related to sex were evident solely in the case of electrolytes sodium and potassium, with males demonstrating higher levels compared with females. These reference intervals not only provide data for assessing potential fluctuations in the health of wild or captive Amazonian crocodilians but also hold value for veterinary management.

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Purpose: Bibliometric analysis is a common method for evaluating current trends within a scientific field. The primary aim of this study was to define and analyze the 50 most frequently cited articles in the field of elbow surgery, both of all time and those published during the 21st century. Methods: We searched the Journal Citation Report to identify articles related to elbow surgery within academic journals. Articles were sorted by total citations. The overall top 50 articles and those published since 2000 were identified, and data were collected, including title, journal of publication, publication year, country of publication, citation density, level of evidence, article type, institution, and sex of the lead and senior authors, and inclusion on the reference list for the Orthopaedic In-Training Examination within the last 5 years. Descriptive statistics were reported, and correlation analysis was performed using Spearman test. Results: For the most-cited elbow surgery articles, "fracture" was overall the most reported topic, whereas "lateral epicondylosis" and "fracture" were equal for those published since 2000. The United States was the most represented overall and for articles published since 2000. Women comprised 1/50 (2%) of lead authors overall, increasing to 8/50 (16%) for articles published during the 21st century. Most articles in during both periods contained level IV evidence, with level I evidence appearing infrequently (4%). Six percent of the most-cited articles of all time had appeared on the reference list of the Orthopaedic In-Training Examination within the past 5 years. Conclusions: The top 50 most-cited elbow surgery articles often assess fracture and lateral epicondylosis, most commonly originating from the United States. Level IV retrospective series comprises over half of the articles on this list. Women remain underrepresented as authors. Clinical Relevance: This study provides a modern reading list for upper-extremity surgeons about impactful elbow surgery articles.

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Pinostrobin, marker compounds from Boesenbergia rotunda with various pharmacological activities, have been studied extensively, including synthesizing its derivatives, which have potent pharmacological activities. This study aims to describe research related to B. rotunda, pinostrobin, and their derivatives. Metadata information was collected from Scopus in August 2022, with three keywords searched for article titles, abstracts, and keywords. Analysis and research mapping were carried out with VOSviewer. The most widely used synonym for the plant name was "Boesenbergia rotunda", in which Norzulaani Khalid from the University of Malaya, Malaysia, mostly reported research with the keywords "Boesenbergia rotunda", "pinostrobin", and "derivative". The majority of researchers come from institutions in Southeast Asia, such as Malaysia, Thailand, and Indonesia. Interestingly, no Chinese researchers have reported studies on this topic. The journals and publishers that publish the most articles with these three keywords are Bioorganic and Medicinal Chemistry Letters and Elsevier, respectively. This information will make it easier for researchers on this topic to find partners for collaboration and determine journals to publish their research results.

La pinostrobina, compuesto de marcadores de Boesenbergia rotunda con diversas actividades farmacológicas, se ha estudiado ampliamente, incluida la síntesis de sus derivados que tienen potentes actividades farmacológicas. Este estudio tuvo como objetivo describir investigaciones relacionadas con B. rotunda, pinostrobina y sus derivados. La información de metadatos se recopiló de Scopus en agosto de 2022, con tres palabras clave buscadas para títulos de artículos, resúmenes y palabras clave. El análisis y el mapeo de la investigación se realizaron con VOSviewer. El sinónimo más utilizado para el nombre de la planta fue "Boesenbergia rotunda", en el que Norzulaani Khalid de la Universidad de Malaya, Malasia, informó principalmente sobre investigaciones con las palabras clave "Boesenbergia rotunda", "pinostrobina" y "derivado". La mayoría de los investigadores provienen de instituciones del sudeste asiático como Malasia, Tailandia e Indonesia. Curiosamente, ningún investigador chino ha informado de estudios sobre este tema. Las revistas y editoriales que más artículos publican con estas tres palabras clave son Bioorganic and Medicinal Chemistry Letters y Elsevier. Esta información facilitará a los investigadores sobre este tema encontrar colaboraciones y determinar las revistas para publicar los resultados de sus investigaciones.

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Resumen La incorporación de los gestores de referencias bibliográficas a las investigaciones se debe a sus beneficios como organizador de citas, referencias y como un recurso informático para el desarrollo de proyectos. El objetivo de este artículo es actualizar conocimientos en los últimos 5 años, sobre el uso e implicación de los Gestores de Referencias en las investigaciones. Se realizó una revisión documental que permitió consultar 133 fuentes de información asociadas a cinco grupos de documentos: I. Rol que desempeñan los gestores de referencias bibliográficas en el desarrollo de habilidades informacionales y competencias investigativas. II. Uso de los gestores como herramientas en la investigación. III. Los gestores en temas de materiales didácticos. IV. En la confección de citas y referencias y V. Para otros objetivos de investigación. Se utilizaron el Zotero, el Excel 2013 y el paquete estadístico SPSS. Se calcularon frecuencias absolutas y porcentajes, así como la Moda para los grupos conformados. Entre otras conclusiones importantes, al analizar el comportamiento de la producción científica, la Moda señala al grupo II Uso de los gestores como herramientas en la investigación, como el más frecuente dentro de los documentos estudiados, por lo que se recomienda su estudio y actualización permanente.

Abstract The incorporation of bibliographic reference managers in research is due to its benefits as an organizer of citations, references and as an informatics resource for the development of projects. The objective of this article is to update knowledge in the last 5 years on the use and implication of reference managers in research. A documentary review was carried out which allowed to consult 133 sources of information associated with five groups of documents: I. Role of bibliographic reference managers in the development of informational skills and research competencies. II. Use of managers as tools in research. III. Managers in didactic materials issues. IV. In the preparation of citations and references and V. For other research objectives. Zotero, Excel 2013 and the SPSS statistical package were used. Absolute frequencies and percentages were calculated, as well as the mode for the groups formed. Among other important conclusions, when analyzing the behavior of scientific production, Moda points out group II Use of managers as tools in research, as the most frequent within the documents studied, so its study and permanent updating is recommended.

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El índice de masa corporal (IMC) es una eficaz herramienta para detectar la sobrecarga ponderal en niños y adolescentes, asociado a la adiposidad corporal. Objetivo. Analizar la concordancia, sensibilidad y especificidad de tres referencias internacionales de IMC/edad (OMS, IOTF y CDC) para diagnosticar el exceso ponderal y conocer su precisión diagnóstica para identificar el exceso de adiposidad con relación al área grasa braquial (AGB) en población infanto juvenil de Argentina. Materiales y métodos. Se realizó un estudio multicéntrico, descriptivo-comparativo y transversal entre 2003 y 2008, en 22.658 niños y adolescentes argentinos de 4 a 13 años de edad. A partir del peso, talla, circunferencia del brazo y pliegue tricipital, se calcularon IMC y AGB. Se analizó la concordancia, sensibilidad y especificidad de referencias de IMC/edad (OMS, CDC, IOTF) y la precisión diagnóstica (curvas ROC) para identificar exceso de adiposidad, a partir del AGB, así como el punto de corte óptimo (PCO). Resultados. Las tres referencias tuvieron buena concordancia. La mayor sensibilidad correspondió a OMS y la mayor especificidad a IOTF. El área bajo la curva (ABC) fue mayor en Z-IMC/IOTF en varones y en Z-IMC/OMS en mujeres. Los PCO mostraron discrepancias, siendo mayores con OMS. Conclusión. Las tres referencias muestran similar precisión diagnóstica para detectar alta reserva calórica, con puntos de corte óptimo para las puntuaciones Z-IMC menores a 2 Z scores. Esto resulta relevante para la identificación de exceso de adiposidad en poblaciones, en relación con la implementación de políticas públicas de prevención de enfermedades crónicas no transmisibles(AU)

The body mass index (BMI) is an effective tool to detect weight overload in children and adolescents, associated with body adiposity. Objective. To analyze the concordance, sensitivity and specificity of three international BMI/age references (WHO, IOTF and CDC) to diagnose excess weight and to know their diagnostic accuracy to identify excess adiposity in relation to the brachial fat area (BFA) in Argentine child-youth population. Materials and methods. A multicenter, descriptive- comparative and cross-sectional study was carried out between 2003 and 2008 in 22.658 Argentine children and adolescents between aged 4 to 13 years. From the weight, height, arm circumference and tricipital fold, BMI and BFA were calculated. The concordance, sensitivity, and specificity of BMI / age references (WHO, IOTF, CDC,) were analyzed and the diagnostic precision (ROC curves) to identify excess adiposity, from the BFA, as well as the optimal cut-off point (OCP). Results. The three references had good agreement, the highest sensitivity corresponded to WHO and the highest specificity to IOTF. The area under the curve (AUC) was greater in Z-BMI/IOTF in men and in Z-BMI/WHO in women. The OCPs showed discrepancies, being higher with WHO. Conclusion. The three references show similar diagnostic accuracy to detect high caloric reserve, but with cut-off points for Z-BMI scores less than 2 Z scores. This is relevant for the identification of excess adiposity in populations in relation to the implementation of public policies for the prevention of chronic non-communicable diseases(AU)

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ABSTRACT Objective: Rate and compare radiographic measurements of thoracic kyphosis and lumbar lordosis using anatomical and dynamic parameters. Methods: Measurements were performed on lateral radiographs of 10 adults of both sexes without spinal disease or deformity. Thoracic kyphosis and lumbar lordosis were measured using anatomical parameters (T1-T12, T4-T12, T5-T12 and L1-S1) or dynamic parameters (cervicothoracic or thoracolumbar inflection point). Results: Thoracic kyphosis and lumbar lordosis were different in 30% of subjects. Differences in thoracic kyphosis values were observed according to the anatomical reference used for measurement. Lumbar lordosis wasn`t statistical difference considering the anatomical or dynamic reference, but in 30% of the individuals the inflection point was different from the anatomical reference. Conclusions: Thoracic kyphosis and lumbar lordosis values differ according to anatomical and dynamic references. The reference used must be considered in the measurement and interpretation of values. Level of evidence IV; Case series.

RESUMO: Objetivo: Avaliar e comparar as mensurações radiográficas da cifose torácica e lordose lombar utilizando parâmetros anatômicos e dinâmicos. Métodos: As mensurações foram realizadas nas radiografias em perfil de 10 adultos de ambos os sexos sem doença ou deformidade da coluna vertebral. A cifose torácica e a lordose lombar foram mensuradas utilizando parâmetros anatômicos (T1-T12,T4-T12, T5-T12 e L1-S1) ou dinâmicos (ponto de inflexão cervicotorácico ou toracolombar) Resultados: As referências anatômicas e dinâmicas para a identificação da cifose torácica e lordose lombar foram diferentes em 30% dos indivíduos. Foi observado diferença dos valores da cifose torácica de acordo com a referência anatômica utilizada para a mensuração. A lordose lombar não apresentou diferença estatística considerando a referência anatômica ou dinâmica, mas em 30% dos indivíduos o ponto de inflexão era diferente da referência anatômica. Conclusões: Os valores da cifose torácica e lordose lombar apresentam diferenças de acordo com as referências anatômicas e dinâmicas. A referência utilizada deve ser considerada na mensuração e interpretação dos valores. Nível de evidência IV; Série de casos.

RESUMEN: Objetivo: Calificar y comparar medidas radiográficas de cifosis torácica y lordosis lumbar utilizando parámetros anatómicos y dinámicos. Métodos: Las mediciones se realizaron en radiografías laterales de 10 adultos de ambos sexos sin enfermedad o deformidad de la columna. La cifosis torácica y la lordosis lumbar se midieron mediante parámetros anatómicos (T1-T12, T4-T12, T5-T12 y L1-S1) o dinámicos (punto de inflexión cervicotorácico o toracolumbar). Resultados: La cifosis torácica y la lordosis lumbar fueron diferentes en el 30% de los sujetos. Se observaron diferencias en los valores de cifosis torácica según la referencia anatómica utilizada para la medición. La lordosis lumbar no fue diferencia estadística considerando la referencia anatómica o dinámica, pero en el 30% de los individuos el punto de inflexión fue diferente de la referencia anatómica. Conclusiones: Los valores de cifosis torácica y lordosis lumbar difieren según referencias anatómicas y dinámicas. La referencia utilizada debe ser considerada en la medición e interpretación de los valores. Nivel de evidencia IV; Series de casos.

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Neste artigo discorremos sobre a interlocução entre as "Referências Técnicas para a Atuação de Psicólogas(os) na Educação Básica", documento publicado pelo Conselho Federal de Psicologia, e as publicações de práticas em Psicologia Escolar, considerando as contribuições da área aos processos educacionais que produzem desenvolvimento humano. Este estudo teve como objetivo realizar uma pesquisa bibliográfica sistemática no período de 2009 a 2019 visando identificar a correspondência entre as publicações de práticas de psicólogas(os) no contexto escolar e as propostas apontadas nas Referências Técnicas. O método aplicado foi de Revisão Bibliográfica Sistemática, utilizando-se dos descritores: Psicologia Escolar, Atuação do Psicólogo Escolar e Prática do Psicólogo Escolar. As bases de dados consultadas foram: SciELO, LILACS e CAPES. Concluímos que há exemplos importantes de práticas realizadas no contexto de ensino e aprendizagem que podem servir de referência para diversas intervenções e que se coadunam com as Referências Técnicas.

Este artículo discurre sobre la interlocución entre las "Referencias Técnicas para la Actuación de Psicólogas(os) en la Educación Básica", documento publicado por el Consejo Federal de Psicología, y las publicaciones sobre prácticas en Psicología Escolar, considerando los aportes de dicho campo a los procesos educativos que promueven desarrollo humano. El estudio tuvo como objetivo realizar una investigación bibliográfica sistemática en el periodo entre 2009 y 2019, para identificar cuáles han sido las prácticas de las(os) psicólogas(os) en el contexto escolar y establecer relación con las Referencias Técnicas. El método aplicado fue de Revisión Bibliográfica Sistemática, utilizándose de los descriptores: Psicología Escolar, Actuación del Psicólogo Escolar y Práctica del Psicólogo Escolar. Las bases de datos consultadas fueron: SciELO, LILACS y CAPES. Se concluye que hay ejemplos importantes de prácticas realizadas en el contexto de enseñanza y aprendizaje que pueden servir como referencia para distintas intervenciones, y que coinciden con las Referencias Técnicas.

In this article we discuss the dialogue between the "Technical References for the Performance of Psychologists in Basic Education", a document published by the Federal Council of Psychology, and the publications of practices in School Psychology, considering the contributions of the scope to the educational processes that produce human development. This study aimed to carry out a systematic literature search between 2009 to 2019 in order to identify what psychologists' practices have been in the school context and to establish a relationship with the Technical References. The method applied was Systematic Bibliographic Review, using the descriptors: School Psychology, School Psychologist's Performance and School Psychologist's Practice. The databases consulted were: SciELO, LILACS and CAPES. We conclude that there are important examples of practices carried out in the context of teaching and learning that can serve as a reference for various interventions and that are consistent with the Technical References.

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Introducción: Frecuentemente se identifican dificultades en la organización de las referencias bibliográficas por las Normas de Vancouver. Objetivo: Desarrollar la aplicación para dispositivos móviles Normas de Vancouver-APK para la organización de las referencias bibliográficas. Método: Se utilizó HTML5, CSS3, JavaScript, Java, Visual Studio Code, Android Studio y adobe Photoshop. Resultados: En este trabajo se muestra el prototipo de aplicación Normas de Vancouver-APK para dispositivos móviles, sus ventajas, la dirección electrónica donde se puede descargar, y el manual de usuario para generar y recuperar las referencias bibliográficas a través del llenado del formulario según el tipo de documento utilizado. Conclusiones: La aplicación contribuye a la organización de las referencias bibliográficas por las Normas de Vancouver de una manera más fácil, limitando la complejidad para el que lo redacta(AU)

Introduction: Difficulties are frequently identified in the organization of bibliographic references by the Vancouver Standards. Objective: To develop the Vancouver Rules-APK application for mobile devices for the organization of bibliographic references. Method: HTML5, CSS3, JavaScript, Java, Visual Studio Code, Android Studio and Adobe Photoshop were used for its construction. Results: This work shows the Vancouver Standards-APK application prototype for mobile devices, its advantages, the electronic address where it can be downloaded, and the user manual to generate and retrieve bibliographic references by filling in the form according to the type of document used. Conclusions: The application contributes to the organization of the bibliographic references by the Vancouver Standards in an easier way for the one who writes it(AU)

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Gliomas are heterogeneous, solid, and intracranial tumors that originate from glial cells. Malignant cells from the tumor undergo metabolic alterations to obtain the energy required for proliferation and the invasion of the cerebral parenchyma. The alterations in the expression of the genes related to the metabolic pathways can be detected in biopsies of gliomas of different CNS WHO grades. In this study, we evaluated the expression of 16 candidate reference genes in the HMC3 microglia cell line. Then, statistical algorithms such as BestKeeper, the comparative ΔCT method, geNorm, NormFinder, and RefFinder were applied to obtain the genes most suitable to be considered as references for measuring the levels of expression in glioma samples. The results show that PKM and TPI1 are two novel genes suitable for genic expression studies on gliomas. Finally, we analyzed the expression of genes involved in metabolic pathways in clinical samples of brain gliomas of different CNS WHO grades. RT-qPCR analysis showed that in CNS WHO grade 3 and 4 gliomas, the expression levels of HK1, PFKM, GAPDH, G6PD, PGD1, IDH1, FASN, ACACA, and ELOVL2 were higher than those of CNS WHO grade 1 and 2 glioma biopsies. Hence, our results suggest that reference genes from metabolic pathways have different expression profiles depending on the stratification of gliomas and constitute a potential model for studying the development of this type of tumor and the search for molecular targets to treat gliomas.

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ABSTRACT Objective: To analyze whether fat mass (FM) and fat-free mass (FFM) should be evaluated by chronological age and/or biological age and propose curves to classify the body composition of young Chilean soccer players. Methods: A cross-sectional descriptive study was developed. Six hundred and forty-two soccer players between 13.0 and 18.9 years of age were recruited. Body mass, height, trunk-cephalic height, and tricipital and subscapular skinfolds were evaluated. Biological maturation was determined using peak height velocity age (PHV) and the percentage of fat mass was estimated by regression equations. The reference percentiles were calculated using the LMS method. Results: The values of R2 were lower for chronological age (FM = 0.07% and FFM = 0.13%) than for biological age (FM = 0.31% and FFM = 0.50%). Eleven percentiles (p3, p5, p10, p15, p25, p50, p75, p85, p90, p95 and p97) were calculated for FFM and FM. Conclusion: Biological age (PHV) is a better predictor of FFM and FM than chronological age. The references proposed can be used to monitor the body composition of young Chilean soccer players. Level of Evidence II; Diagnostic Study .

Resumen Objetivo: Analizar si la masa grasa (MG) y la masa libre de grasa (MLG) deben ser evaluadas por la edad cronológica y/o por la edad biológica, y proponer curvas para clasificar la composición corporal de jóvenes futbolistas chilenos. Métodos: Se elaboró un estudio descriptivo transversal. Fueron reclutados 642 futbolistas entre 13,0 y 18,9 años. Fueron medidas masa corporal, estatura, altura tronco-cefálica, pliegues cutáneos tricipital y subescapular. La madurez biológica fue determinada por la edad de pico de velocidad de crecimiento (EPVC) y el porcentual de masa grasa fue estimado por ecuaciones de regresión. Los percentiles de referencia fueron calculados por el método LMS. Resultados: Los valores de R2 para edad cronológica fueron menores (MG=0,07% y MLG=0,13%) en comparación con los valores para la edad biológica (MG=0,31% y MLG=0,50%). Fueron calculados 11 percentiles (p3, p5, p10, p15, p25, p50, p75, p85, p90, p95 y p97) para la MLG y MG. Conclusión: La edad biológica (EPVC) es un predictor mejor de la MLG y de la MG que la edad cronológica. Las referencias propuestas pueden servir para monitorizar la composición corporal de jóvenes futbolistas chilenos. Nivel de evidencia II; Estudio de diagnóstico .

RESUMO Objetivo: Analisar se a massa gorda (MG) e a massa livre de gordura (MLG) devem ser avaliadas pela idade cronológica e/ou pela idade biológica, e propor curvas para classificar a composição corporal de jovens futebolistas chilenos. Métodos: Elaborou-se um estudo descritivo transversal. Foram recrutados 642 futebolistas entre 13,0 e 18,9 anos. Massa corporal, estatura, altura tronco-cefálica, dobras cutâneas tricipital e subescapular foram medidas. A maturação biológica foi determinada pela idade de pico de velocidade de crescimento (IPVC) e o percentual de massa gorda foi estimado por equações de regressão. Os percentis de referência foram calculados pelo método LMS. Resultados: Os valores de R2para idade cronológica foram menores (MG = 0,07% e MLG=0,13%) em comparação com os valores para a idade biológica (MG = 0,31% e MLG = 0,50%). Foram calculados 11 percentis (p3, p5, p10, p15, p25, p50, p75, p85, p90, p95 e p97) para a MLG e MG. Conclusão: A idade biológica (IPVC) é um preditor melhor da MLG e da MG do que a idade cronológica. As referências propostas podem servir para monitorar a composição corporal de jovens futebolistas chilenos. Nível de evidência II; Estudo de diagnóstico .

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La elaboración y la gestión de las referencias bibliográficas en el proceso de investigación es una tarea de alta importancia. Esta actividad continúa siendo una dificultad para muchos investigadores, a pesar del desarrollo informático vinculado a ella. El acceso y el uso de la información mediante Internet es una constante premisa en la investigación actual que requiere, con inmediatez para los investigadores, del avance de sus habilidades para la gestión bibliográfica, acorde con los nuevos adelantos técnicos. Los gestores bibliográficos son herramientas informáticas que ofrecen servicios automatizados para la organización bibliográfica, las cuales son conocidas a partir de otras publicaciones. Uno de los gestores más difundidos y utilizados es el EndNote, que se retomó nuevamente en esta investigación con una población de 23 doctorandos de la Universidad de las Ciencias Informáticas (UCI), con el objetivo de revelar los resultados obtenidos en la implementación de un entrenamiento de los doctorandos para el desarrollo de las habilidades de nivel avanzado. Como resultado se propusieron tres niveles de acciones para el dominio de esta herramienta que respondían al nivel de complejidad de las funcionalidades del software: básico, avanzado y experto. En el grupo de doctorandos del grupo UCI se evidencia un saber y un saber hacer en las acciones y operaciones del EndNote, superiores al diagnóstico inicial, que evidencia el desarrollo de un nivel básico a un nivel avanzado(AU)

Development and management of bibliographic references is a very important task in the research process. This activity continues to be a challenge for many researchers, despite the progress achieved in the field in terms of computer support. Access to and use of Internet-based information is a permanent premise in current research requiring immediacy in the enhancement of researchers' reference management skills, in keeping with recent technical advances. Reference managers are computer tools offering automated services for the bibliographic organization of references obtained from other publications. One of the most widely disseminated and commonly used managers is EndNote, which was revisited in the present study with a population of 23 aspiring PhDs from the Information Sciences University (UCI), with the purpose of revealing the results obtained by the implementation of a training program for the development of advanced skills intended for aspiring PhDs. As a result, three levels of actions aimed at the command of this tool were proposed: basic, advanced and expert, reflecting the degree of complexity exhibited by the functions performed by the software. The aspiring PhDs in the UCI group showed better knowledge and know-how about EndNote actions and operations than in their initial diagnosis. This was evidence of their progress from a basic to an advanced level(AU)

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Los factores genéticos y ambientales interactúan durante todo el crecimiento. La talla final adulta, el ritmo o tempo de crecimiento y maduración, así como la maduración sexual, esquelética y dental, tienen una transmisibilidad entre 41 y 71%. El estirón puberal ocurre un año antes en africanos que en europeos y los asiáticos son intermedios. Esta heterogeneidad puberal dificulta el uso de una referencia internacional en esta etapa, aunque su valor al permitir la comparabilidad entre poblaciones es indiscutible, así como el hecho que no todos los países pueden desarrollar sus propias referencias. En la Región Latinoamericana, Argentina, Cuba y Venezuela desarrollaron referencias hace muchos años y recientemente, Colombia, Ecuador y Perú. En Venezuela, se realizó el Estudio Nacional de Crecimiento y Desarrollo Humano (ENCDH) y el Estudio Longitudinal de Caracas (ELAMC) para establecer patrones de referencia, relevantes debido a la maduración más temprana y a las diferencias significativas en crecimiento y maduración con los anglosajones. Así mismo se elaboró el Atlas de Maduración Ósea del Venezolano y se han construido Curvas para uso Clínico integrando ambos estudios. Debido a la disparidad en el uso de referencias- internacionales y nacionalesse está planificando un estudio multicéntrico, denominado PRONNA, de la línea de investigación sobre Crecimiento y Desarrollo en Niños y Adolescentes (CDNNA) del Grupo Transición Alimentaria y Nutricional (grupo TAN) para la escogencia definitiva de las referencias a ser usadas(au)

Genetic and environmental factors interact during growth. Final height, tempo of growth, sexual, skeletal and dental maturation have between 41 and 71% heritability. The puberal spurt occurs one year earlier in Africans than in European descendants, Asiatic are intermediate. This pubertal heterogeneity difficult the use of an international reference during this period, although its importance in the comparability of prevalences is unique, as well as the fact that many countries are unable to develop their own references. In the Latin American Region, Argentina, Cuba and Venezuela have long--standing references, Colombia, Ecuador and Perú only recently. In Venezuela, due to the earlier maturation and differences from puberty onwards with anglosaxons, the National Growth and Development Study and the Caracas Longitudinal Study were developed in order to obtain growth charts. Both studies integrated for Clinical Use dual use charts: an Atlas for Bone Maturity Asessment is also available. Due to the multiple use of references (national as well as international) a multicenter national study-PRONNA- is being planned in order to decide which reference is most adequate. This is part of the Growth and Development Research line of study of TAN Group (Food and Nutritional Transition Group)(AU)

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While the Ophiuroidea of Peruvian waters have long been studied, there exists inconsistencies regarding taxonomy and spatial distribution records. Based on literature review and museum records, we provide an updated checklist of the ophiuroids accompanied by the first geographical distribution analysis. Peruvian waters host 36 species of Ophiuroidea (three doubtful), yet 15 previous records of species are considered invalid for the area. We recorded five new records of species for Peru: Amphiodia oerstedi, Diopederma daniana, Ophiocomella alexandri, Ophiolepis crassa, and Ophiophthalmus normani. Peruvian maritime area is divided into four areas: The Tropical Eastern Pacific area where 16 species of ophiuroids occur, the Transition Zone with 13 species, the Warm Temperate Southeastern Pacific with nine species, and the Deep Zone with 14 species. We found significant differences in species composition among areas (except among the Eastern Pacific and the Transitional Zone), and each of them is represented by particular species. According to the rarefaction curve, the inventory of ophiuroids for the country is not yet complete; therefore, we suggest performing more expeditions along the Peruvian waters focusing mainly on the deep zones which remain relatively unexplored to date.

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RESUMEN Introducción: Durante el periodo de pandemia por la COVID-19 la profesión de Enfermería ha adquirido un total protagonismo. Objetivo: Ofrecer un referente teórico en relación con los cuidados de Enfermería durante la atención a pacientes con esta enfermedad. Método: En la Universidad de Ciencias Médicas Guantánamo durante el primer semestre de 2020 se realizó una revisión bibliográfica narrativa. Se ejecutó el análisis de artículos originales y revisiones sistemáticas que incluyeron información en relación con la COVID-19 y el desempeño de Enfermería durante esta pandemia. La búsqueda se efectuó consultando las bases de datos Pubmed, Infomed, y SciELO, sin restricción de fecha, en los idiomas español e inglés. Se utilizó el buscador Google Scho lar, y las palabras clave y conectores: COVID-19 AND Nursing care; SARS-CoV-2 AND Nursing care, y los términos en español. La extracción de datos se realizó según una planilla que resumió las preguntas de interés de acuerdo al objetivo de la revisión. Resultado: Se sistematizaron referentes teóricos que sustentan el liderazgo de la profesión de Enfermería en la atención al paciente con sospecha o confirmación de esta enfermedad. Se expresan las acciones esenciales que este profesional debe dar cumplimiento durante la atención a este tipo de paciente. Conclusiones: Se revela y argumenta el protagonismo de la profesión de Enfermería durante el periodo de la citada pandemia, y se ofrece una compilación de las acciones esenciales de este personal en la atención a los pacientes con esta enfermedad.

ABSTRACT Introduction: During the COVID-19 pandemic, nursing profession has gained total prominence. Objective: To offer a theoretical reference concerning nursing care in patients tested positive for COVID-19. Method: A narrative review was conducted in the University of Medical Sciences, Guantanamo, in the first semester of the year 2020. An analysis of original articles and systematic reviews that included information related to COVID-19 and nurses´ performance during the COVID-19 pandemic was conducted. This search was carried out by consulting the following databases, Pubmed, Infomed, and SciELO, without date restriction, and in the two languages, Spanish and English. Google Scholar was the web search engine used, and the keywords and links used were: COVID-19 and Nursing care; SARS-CoV-2 and Nursing care and and their corresponding terms in Spanish. Data gathering was done according to a spread sheet that summarized the questions of interest according to the objective of the review. Results: The theoretical references that support the leadership of nurses in the care of suspected or confirmed COVID-19 patient were systematized. The essential actions that this professional must comply with during the care of this type of patient are expressed. Conclusions: the leading role of the nursing professionals during this pandemic is revealed and argumented, and it is offered a compilation of the essential actions of these personnel in the care of patients with this disease.

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RESUMEN Introducción: La aspiración de egresar un estomatólogo general suficientemente preparado para resolver los problemas de salud bucal periodontal más generales y prevalentes es una exigencia social que se revela en el actual plan de estudio de la carrera de Estomatología. Objetivo: Elaborar unos referentes teóricos de la preparación del estudiante de Estomatología en función de la educación para la salud bucal periodontal. Método: De enero a julio de 2020, en la Facultad de Estomatología de la Universidad de Ciencias Médicas Guantánamo se realizó una revisión narrativa sobre el tema a través de una búsqueda en bases de datos electrónicas (Biblioteca Virtual en Salud, LILACS, PubMed, SciELO, REDALYC, Scopus). Se sistematizaron referentes teóricos que sustentan la preparación del estudiante de Estomatología en función de la educación para la salud bucal periodontal. Conclusiones: Se evidencia la necesidad de esta preparación dada su implicación en el modo de actuación profesional para una Atención Bucal Periodontal Integral. Las bases para esta finalidad emergen de la conjugación armoniosa de referentes filosóficos, sociológicos, legales, psicológicos, pedagógicos y didácticos en función de la práctica de la profesión.

ABSTRACT Introduction: The aim to graduate a general dentist with a high standard in knowledge to solve the most general and prevalent periodontal oral health issues is a social demand that is revealed in the current study program of dentistry major. Objective: To elaborate some theoretical references concerning dentistry student preparation in terms of education for periodontal oral health. Method: From January to July 2020, at the Facultad de Estomatología in the Universidad de Ciencias Médicas Guantanamo, a narrative review on the subject was carried out through a search in electronic databases (Virtual Health Library, LILACS, PubMed, SciELO, REDALYC, Scopus). It was systematized all the theoretical references that support the preparation of the dentistry students in terms of education for periodontal oral health. Conclusions: It is evident the necessity of this type of training due to its implication in the way to the best professional performance for an integral oral care. The foundations for achieving this goal emerge from the harmonious conjugation of philosophical, sociological, legal, psychological, pedagogical and didactic referents, in accordance to the practice of the profession.

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Resumen Desde la teoría del cambio subjetivo en psicoterapia, este estudio de caso constructor de teoría examina cualitativamente el proceso de cambio de una terapia exitosa. El estudio caracteriza micro-prácticas conversacionales que aparecen en episodios de cambio (EC). Los EC son segmentos de conversación teóricamente vinculados al cambio terapéutico, dado que en ellos aparecen indicadores genéricos de cambio en tres niveles: entrada, proceso, y salida. Se exploraron aquí los 16 episodios conteniendo indicadores genéricos de proceso (nivel 2). Como resultado se describen seis supuestos terapéuticos que facilitaron el logro de autorreferencias preferidas (ARP) en los EC de proceso. Se discute cómo esta caracterización contribuye a comprender la elaboración (subjetiva) de una "teoría" sobre el propio cambio terapéutico como resultado del proceso (intersubjetivo) de clarificar y validar ARP para y con el terapeuta. En este sentido, el estudio permite dar mayor especificidad a la teoría del cambio subjetivo desde el punto de vista del proceso conversacional que con-instituye o legitima el cambio.

Abstract Drawing from the theory of subjective change in psychotherapy, this theory-building case study examines one successful therapeutic change process. The study characterizes conversational micro-practices featuring in segments of conversation theoretically linked to therapeutic change called change episodes (CE), containing three types of observable generic indicators of change: input, process, and output. For this study the 16 CE containing indicators of the second level (process) were examined. Six conversational practices involving six therapeutic assumptions are presented as a result of the study, which were consequential in discursively accomplishing preferred self-references (PSR) within CE related to process. Given that generating a "subjective theory" about the client's own change process emerges as a byproduct of conversationally clarifying PSR for and with the therapist (i.e., intersubjective validation), this study contributes further specifying the theory of subjective change.

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Objectives: The goal of this study was to develop regression equations to estimate LM with anthropometric variables and to propose percentiles for evaluating by age and sex. Methods: A cross sectional study was conducted with 2,182 Chilean students (1,347 males and 835 females). Ages ranged from 5.0 to 17.9 years old. A total body scan was carried out with the double energy X-ray anthropometry (DXA) to examine and measure lean muscle mass of the entire body. Weight, height, and the circumference of the relaxed right arm were also measured. Results: Four anthropometric equations were generated to predict lean mass for both sexes (R 2 = 83-88%, SEE = 3.7-5.0%, precision = 0.90-0.93, and accuracy = 0.99). The Lambda-mu-sigma method was used to obtain the sex-specific and age-specific percentile curves of lean mass (p3, p5, p10, p15, p25, p50, p75, p85, p90, p95, and p97). Conclusion: The four proposed equations were acceptable in terms of precision and accuracy to estimate lean mass in children and adolescents. The percentiles were created by means of anthropometric equations and real values for DXA. These are fundamental tools for monitoring LM in Chilean children and adolescents of both sexes.

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Introducción: la osteoartrosis es la más frecuente de las enfermedades articulares. Objetivo: exponer los referentes bibliográficos que actualmente se refieren a la osteoartrosis en el marco de la revisión de literatura realizada. Desarrollo: como síndrome anatomoclínico se identifica por dolor mecánico que usualmente se relaciona con rigidez y que provoca poco a poco una pérdida o mengua de la función articular. Diversos factores de riesgo se relacionan con el progreso de esta enfermedad entre los que destacan, además de la edad y el sexo femenino, la obesidad, los microtraumas repetitivos en la práctica de determinados deportes y el cumplimiento de actividades profesionales específicas. Conclusiones: el tratamiento de la osteoartrosis debería ejecutarse a nivel de medicina familiar, tanto en el componente preventivo, como en el del control y manejo conservador, instruyendo al paciente en sus cuidados y acciones diarias y operando esquemas de medicamentos, ejercicios, apoyos funcionales como rodilleras, bastones y andadores. La educación médica debe asumir este paradigma, y no solicitar acto seguido la interconsulta a la especialidad cuando el paciente no responde, sin tener en cuenta que el manejo del paciente con artrosis se encuentra distante de la prescripción farmacológica(AU)

Introduction: osteoarthrosis is the most frequent joint disease. Objective: to expose the bibliographic references that currently refer to osteoarthrosis in the framework of the literature review carried out. Development: as anatomoclinic syndrome is identified by mechanical pain that is usually related to stiffness and that gradually causes a loss or decline of joint function. Several risk factors are related to the progress of this disease, among which stand out, in addition to age and female sex, obesity, repetitive microtrauma in the practice of certain sports and compliance with specific professional activities. Conclusions: treatment of osteoarthrosis should be carried out at the level of family medicine, both in the preventive component, as well as in the control and conservative management, instructing the patient in his daily care and actions and operating medication schemes, exercises, functional supports such as knee pads, canes and walkers. The medical education must assume this paradigm, and not immediately request the interconsultation to the specialty when the patient does not respond, without taking into account that the management of the patient with osteoarthritis is distant from the pharmacological prescription(AU)

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Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA is a very versatile molecule and its abundance is tissue-dependent. RNA quantification is dependent on a reference control to estimate the abundance. Additionally, in cancer, many cellular processes are deregulated which consequently affects the gene expression profiles. In this work, we performed microarray data mining of different childhood cancers and healthy controls. We selected four genes that showed no gene expression variations (PSMB6, PGGT1B, UBQLN2 and UQCR2) and four classical reference genes (ACTB, GAPDH, RPL4 and RPS18). Gene expression was validated in 40 acute lymphoblastic leukemia samples by means of droplet digital PCR. We observed that PSMB6, PGGT1B, UBQLN2 and UQCR2 were expressed ~100 times less than ACTB, GAPDH, RPL4 and RPS18. However, we observed excellent correlations among the new reference genes (p < 0.0001). We propose that PSMB6, PGGT1B, UBQLN2 and UQCR2 are housekeeping genes with low expression in childhood cancer.

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