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As complicações associadas à COVID-19 incluem insuficiência renal, miocardite, eventos trombóticos e retinite. No entanto, outras manifestações, como a artrite reativa, também parecem estar atreladas a este vírus e precisam ser mais bem investigadas. O caso relatado se refere a uma paciente de 32 anos, do sexo feminino, na cidade do Rio de Janeiro (RJ), que desenvolveu um quadro de artrite reativa após 5 dias da manifestação de sintomas gripais. Foram realizados exames laboratoriais, GeneXpert para COVID-19 e punção do líquido sinovial. Observou-se GeneXpert positivo para COVID-19, aumento nos marcadores inflamatórios, marcadores sorológicos de autoimunidade não reagentes e cultura negativa no líquido sinovial. Esses resultados descartam artrite séptica, bem como artrite reumatoide, passando a ser considerado o quadro de artrite pós-infecciosa decorrente do SARS-CoV-2.
Complications associated with COVID-19 include renal failure, myocarditis, thrombotic events, and retinitis. However, other manifestations, such as reactive arthritis, also seem to be associated with infection and require further investigation. We report the case of a 32-year-old woman in Rio de Janeiro, RJ who developed reactive arthritis 5 days after the onset of flulike symptoms. Laboratory tests, GeneXpert for COVID-19, and synovial fluid puncture were performed. Positive GeneXpert results for COVID-19, increased inflammatory markers, non-reactive serological markers of autoimmunity, and negative culture in synovial fluid were observed. These results ruled out both septic arthritis and rheumatoid arthritis, leading to a diagnosis of postinfectious arthritis resulting from SARS-CoV-2.
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Humanos , Feminino , AdultoRESUMO
AIMS: Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS: Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h later. Disability and joint edema were assessed at the 3rd hour after LPS and at every hour up to 6 h. KEY FINDINGS: Intrathecal administration of histamine potentiated joint incapacitation and edema, while the H1R antagonist cetirizine decreased both. The H3R agonist immepip decreased both incapacitation and edema, while the H3R antagonist thioperamide had the opposite effect. The microinjection of glutamate into the ventral TMN (vTMN) caused an increase of incapacitation and articular edema, whereas the blockade of this nucleus by cobalt chloride inhibited both parameters. Intrathecal administration of cetirizine prevented the increase of incapacitation and joint edema caused by glutamate microinjection into the vTMN. Similarly, an intrathecal injection of the NKCC1 cotransporter inhibitor bumetanide prevented the effects of glutamate microinjection into the vTMN, whereas coadministration of histamine with bumetanide only inhibited the potentiation of joint edema. A microinjection of orexin B into the vTMN potentiated incapacitation and joint edema, while coadministration of the OX1/2 receptor antagonist almorexant with orexin B did not. SIGNIFICANCE: These data support the notion that TMN participates in the modulation of a peripheral inflammatory process by means of histaminergic projections to the spinal cord, and the hypothalamus may trigger TMN activation by means of glutamate and orexin.
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Artrite Experimental/fisiopatologia , Edema/patologia , Região Hipotalâmica Lateral/metabolismo , Nociceptividade/fisiologia , Medula Espinal/metabolismo , Acetamidas/farmacologia , Animais , Feminino , Histamina/administração & dosagem , Isoquinolinas/farmacologia , Orexinas/administração & dosagem , Ratos , Ratos WistarRESUMO
Resumen LA enfermedad de Poncet es una poliartritis aséptica reactiva poco frecuente que ocurre durante cualquier etapa de una infección activa pulmonar o extrapulmonar por Mycobacterium tuberculosis. Existen apenas 200 casos descritos en la bibliografía y hasta el momento permanece como diagnóstico de exclusión sin patogenia bien definida. Suele responder rápida y satisfactoriamente al tratamiento antituberculoso sin dejar secuelas. Este artículo revisa la epidemiología, patogenia, manifestación clínica, diagnóstico, tratamiento y pronóstico de la enfermedad de Poncet.
Abstract Poncet's disease is a rarely reported aseptic reactive polyarthritis associated to active pulmonary or extrapulmonary infection caused by Mycobacterium tuberculosis. There are no more than 200 cases reported in the literature and still remains as a diagnosis of exclusion with unknown pathogenesis. It quickly and remarkably resolves with antituberculous drugs, has usually a good prognosis and does not turn into chronic arthritis. This article reviews the epidemiology, pathogenesis, clinical presentation, diagnosis, treatment options and prognosis of Poncet's disease.
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Introducción: existe un debate en la actualidad acerca de si la artritis reactiva post-estreptocócica es una entidad separada o una condición en el espectro de la fiebre reumática aguda. Objetivo: revisar la literatura existente sobre el tema artritis reactiva post-estreptocócica. Desarrollo : se realizó una búsqueda bibliográfica en Medline, Pubmed, Scielo y Dialnet, buscando como palabras clave: artritis y artritis reactiva post-estreptocócica. Además de la búsqueda computadorizada se realizó una búsqueda manual. Dichas bases de datos recogen las publicaciones más importantes en el campo científico de la medicina. La búsqueda se realizó en abril del 2018, y comprendió desde el año 1989 hasta la actualidad. Utilizamos el programa Reference Manager, versión 12, para crear una base de datos con las publicaciones, categorizarlas y filtrarlas de acuerdo a su relevancia para nuestro estudio. Se recabaron un total de 45 documentos en total, de los cuales fueron descartados unos 30, debido a su nivel de generalización y escasa especificidad en el tema abordado. Conclusiones: los signos clásicos de tumefacción, eritema, calor y dolor están presentes, siendo el dolor el más importante, está presente en reposo y aumenta con los movimientos. Como en la FR, la artritis postestreptocócica es una artritis reactiva caracterizada por una infección faríngeaestreptocócica, un intervalo libre y una posterior inflamación aséptica en una o más articulaciones(AU)
Introduction: there is currently debate about whether post-streptococcal reactive arthritis is a separate entity or condition in the spectrum of acute rheumatic fever. Objective: to review the existing literature on the topic post-streptococcal reactive arthritis. Development: a bibliographic search was carried out in Medline, Pubmed, Scielo and Dialnet, searching as keywords: arthritis and post-streptococcal reactive arthritis. In addition to the computerized search, a manual search was carried out. These databases collect the most important publications in the scientific field of medicine. The search was conducted in April 2018, and ran from 1989 to the present. We use the Reference Manager program, version 12, to create a database with publications, categorize them and filter them according to their relevance to our study. A total of 45 documents were collected, of which about 30 were discarded, due to their level of generalization and lack of specificity in the topic addressed. Conclusions: the classic signs of swelling, erythema, heat and pain are present, with pain being the most important, it is present at rest and increases with movements. As in RF, post-streptococcal arthritis is a reactive arthritis characterized by a pharyngeal-streptococcal infection, a free interval and subsequent aseptic inflammation in one or more joints(AU)
Assuntos
Humanos , Febre Reumática , Infecções Estreptocócicas , Artrite ReativaRESUMO
At this time, reactive arthritis (ReA) is considered to be part of the spectrum of the spondyloarthritis, previously known as Reiter's syndrome, and refers to an infection induced systemic illness, characterized by a sterile synovitis occurring in a genetically predisposed individual, secondary to an infection localized in a distant organ/system, but also accompanied with multiple extra articular manifestations.
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Artrite Reativa/diagnóstico , Artrite Reativa/patologia , Antígeno HLA-B27 , Humanos , ProibitinasRESUMO
The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 months prior to study entry were prospectively enrolled in Guatemala City. ReA patients fulfilled the Assessment in Spondyloarthritis International Society criteria for peripheral spondyloarthropathy (SpA). Patients underwent history, examination, Achilles tendon ultrasound, and blood draw. Human leukocyte antigen (HLA) type and serum biomarkers were measured. t tests and nonparametric equivalents were used to examine the association of clinical, laboratory, and imaging factors with ReA. Patients were contacted 2 years later to assess for persistence of symptoms. Study subjects included patients with ReA (N = 32) and controls (N = 32). ReA patients were most frequently infected in April whereas controls were most frequently infected in August. Two ReA patients and two controls were HLA-B27-positive. Serum cathepsin K and C-reactive protein were higher in ReA patients compared to controls (p = 0.03 for both), while total cholesterol and low-density lipoprotein were lower (p = 0.008 and 0.045, respectively). Among those with ReA, 15 (47%) patients had continued symptoms at 2 years. These patients had a lower matrix metalloproteinase-3 level at diagnosis than patients for whom ReA resolved (p = 0.004). HLA-B27 was not associated with development of ReA in Guatemala; however, the month of infection was associated with ReA. The most striking finding was the persistence of arthritis at 2 years in nearly half of the patients.
Assuntos
Artrite Reativa/diagnóstico , Adolescente , Adulto , Artrite Reativa/etiologia , Artrite Reativa/imunologia , Biomarcadores/sangue , Estudos de Casos e Controles , Feminino , Seguimentos , Antígeno HLA-B27/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Proibitinas , Fatores de Risco , Avaliação de Sintomas , Adulto JovemRESUMO
BACKGROUND: Poncet's disease is a rare syndrome characterized by articular impairment in a form of rare tuberculid. One of the theories of its cause involves an autoimmune response induced by the intravesical administration of the Calmette-Guerin Bacillus or the treatment of bladder carcinoma. Furthermore, there may be an appearance of oligoarticular or polyarticular arthritis, beginning 1-3 months after the start of therapy. Few physicians know the disease and the literature related to that syndrome is scarce and restricted to case reports, which contributes to its under diagnosis. CASE PRESENTATION: Female patient, 64 years old, Caucasian, in whom was noticed firstly dark urine, without haematuria or dysuria. Later felt also colic pain in the hypogastric region. Microscopically, the conclusive diagnosis was a high grade non-invasive papillary urothelial carcinoma. Thereupon, the treatment of the tumour began with transurethral resection technique and intravesical instillation of Calmette-Guérin Bacillus as adjuvant treatment. Eight months after the beginning of treatment, the lingering presence of the carcinoma was identified. Nevertheless, arthritis was identified through radiographs, after an increase in the clavicle capitation, right knee and left ankle in bone scintigraphy. Coinciding with the joint manifestations, the patient developed fever and purulent urethral discharge (culture was negative). Therefore, trying to investigate the cause of the arthritis, Purified Protein Derivate was taken, with reactive results. An increase of acute phase reactants was found, with other tests resulting normal: blood chemistry, Complete Blood Count, immunology and serology. Human Leukocyte Antigen typing by polymerase chain reaction revealed the presence of A24/AX, B44, B27, BW4/BW4, DQ7 and DQ5. Consequently, Poncet's disease was the diagnostic conclusion. The treatment with intravesical Calmette-Guérin Bacillus was immediately discontinued. The patient received corticosteroids associated with etoricoxib and isoniazid for 4 months, achieving disappearance of the inflammatory joint signs in 3 months. After 6 months, no joint pain recurrence or other manifestations suggesting active disease had been seen. CONCLUSIONS: Therefore, such diagnosis should be considered when confronted with an osteoarticular clinical picture in patients treated with intravesical Calmette-Guérin Bacillus, especially patients with HLA-B27 (+) and B7 (+), as Poncet's disease is a reactive arthritis.
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Adjuvantes Imunológicos/efeitos adversos , Artrite Reativa/tratamento farmacológico , Carcinoma Papilar/diagnóstico , Tuberculose/tratamento farmacológico , Neoplasias da Bexiga Urinária/diagnóstico , Adjuvantes Imunológicos/administração & dosagem , Administração Intravesical , Corticosteroides/uso terapêutico , Artrite Reativa/induzido quimicamente , Artrite Reativa/diagnóstico , Carcinoma Papilar/patologia , Carcinoma Papilar/cirurgia , Etoricoxib , Feminino , Humanos , Isoniazida/uso terapêutico , Pessoa de Meia-Idade , Mycobacterium bovis/química , Mycobacterium bovis/imunologia , Piridinas/uso terapêutico , Sulfonas/uso terapêutico , Resultado do Tratamento , Tuberculose/induzido quimicamente , Tuberculose/diagnóstico , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/cirurgiaRESUMO
Reactive arthritis describes the relationship between the host and the environment. This leads to urogenital or gastrointestinal infections. It clinically presents with inflammatory lumbosacral pain, asymmetric oligoarthritis and enthesitis of the Achilles tendon and plantar fascia. Among the extra-articular manifestations are acute anterior uveitis, skin lesions, genital lesions, and oral ulcers, with the rarest being cardiovascular. A case is presented of a patient with a urogenital infection and cardiovascular manifestations, interpreted and managed as acute coronary syndrome. After further studies an acute myopericarditis was considered as a primary manifestation of reactive arthritis.
La artritis reactiva describe la interrelación entre el hospedero y el medio ambiente. Aparece después de infecciones urogenitales o digestivas. Clínicamente presenta dolor lumbosacro inflamatorio, oligoartritis asimétrica y entesitis del tendón de Aquiles y la fascia plantar. Entre las manifestaciones extraarticulares, se encuentran la uveítis anterior aguda, lesiones en piel, lesiones genitales y úlceras orales. Las más infrecuentes son las cardiovasculares. Describimos el caso de un paciente con infección urogenital y manifestaciones cardiovasculares interpretadas y manejadas como síndrome coronario agudo, pero que a la luz de estudios posteriores se consideró finalmente una miopericarditis aguda como manifestación primaria de una artritis reactiva.
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Humanos , Pericardite , Artrite Reativa , Espondiloartropatias , MiocarditeRESUMO
Introdução: As espondiloartropatias formam um grupo de doenças distintas com características comuns, entre elas estão a espondilite anquilosante, artrite psoriática, artrite reativa e artrite enteropática. Caracterizam-se como doenças crônicas inflamatórias, e incluem uma variedade de características clínicas e genéticas, dentre essas está a associação com o antígeno HLA-B27. Objetivos: O estudo objetivou revisar na literatura informações sobre a abordagem fisioterapêutica na dor crônica nos indivíduos portadores de espondiloartropatias. Métodos: 26 artigos foram selecionados manualmente nas línguas portuguesa e inglesa indexados nas bases de dados eletrônicos SciELO, LILACS, e Pubmed partindo dos descritores Espondiloartropatias, Espondilite Anquilosante, Artrite Reativa, Artrite Psoriásica em cruzamento com a palavra chave Fisioterapia, de acordo com os Descritores em Ciências da Saúde (DeCS). Resultados: Foram analisados 178 artigos dos quais 147 artigos foram excluídos por não se enquadrarem nos critérios de seleção e 26 preencheram os critérios de inclusão, permitindo a fundamentação teórica e problemática do assunto pesquisado. Conclusão: O diagnóstico precoce juntamente com a cinesioterapia - com ênfase à hidrocinesioterapia - demonstra redução da dor, melhora na capacidade funcional, melhora da amplitude de movimento, diminuição do quadro inflamatório e melhora da qualidade de vida.
Introduction: Spondyloarthropathies form a group of different diseases with common characteristics, among them are ankylosing spondylitis, psoriatic arthritis, reactive arthritis and arthritis enteropathic. Are characterized as chronic inflammatory diseases, including a variety of clinical and genetic characteristics, among these is the association with the HLA-B27 antigen. Objectives: The aim of this study was to review the literature about the physical therapy approach to chronic pain in patients with spondyloarthritis. Méthods: We selected 26 articles, which were manually consulted in Portuguese and English indexed in electronic databases SciELO, LILACS and PubMed starting from descriptors Espondiloartropatias, Espondilite Anquilosante, Artrite Reativa, Artrite Psoriásica crossed with keyword Fisioterapia, all according to the Descriptors in Health Sciences (DeCS). Results: We analyzed 178 articles of which 147 articles were excluded because they do not fit the selection criteria and 26 met the inclusion criteria, allowing the theoretical foundation and problems of researched subject. Conclusion: Early diagnosis of seronegative spondyloarthropathies with kinesiotherapy - with emphasis on hydrokinesiotherapy - reduced pain, improved functional capacity, improved range of movement, decreased inflammatory process and improvement of quality of life of patients.
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Humanos , Espondiloartropatias/reabilitação , Dor Crônica/reabilitação , Espondiloartropatias/complicações , Inflamação/reabilitaçãoRESUMO
BACKGROUND: Deaths due to tuberculosis have reached 2.5 million cases per year worldwide. Poncet's disease is an infrequent form of tuberculosis characterised by a clinical picture of polyarthritis. CLINICAL CASE: A 24-year-old male presented with morning stiffness, arthralgias, bilateral symmetric arthritis of the proximal interphalangeal joints, wrists, knees, ankles, and shoulders, and adenomegalies at the cervical, submandibular, left supraclavicular, axillary and inguinal levels, without fever. Laboratory results were as follows: ESR 44mm/h, C-reactive protein 4.35, normal levels of complement C3 and C4, negative rheumatoid factor and anticyclic citrullinated peptide antibodies, positive antinuclear antibodies with fine speckled pattern (1:320) and cytoplasm (1:160) pattern and negative anti-Smith, -double-stranded DNA, Sjogren's syndrome-antigen A and Sjogren's syndrome-antigen B. Histological report of cervical node tissue revealed granulomatous lesions compatible with tuberculosis. Rheumatoid arthritis and systemic lupus erythematosus were ruled out. Anti-tuberculosis agents were initiated that resolved the clinical picture. Diagnosis of Poncet's disease was confirmed. CONCLUSION: The differential diagnosis between tuberculosis and autoimmune inflammatory joint diseases is a clinical challenge.
Assuntos
Artrite Reativa/microbiologia , Tuberculose Osteoarticular , Artrite Reativa/diagnóstico , Humanos , Masculino , Doenças Reumáticas/diagnóstico , Doenças Reumáticas/microbiologia , Tuberculose Osteoarticular/diagnóstico , Adulto JovemRESUMO
Paciente masculino de 24 años de edad, con antecedente de buena salud, que inicio un cuadro de fiebre, faringitis, adenopatías cervicales y hepatoesplenomegalia; 3 días después, se acompaña de, artritis aditiva en muñeca derecha y rodilla izquierda, y tenosinovitis de los dedos de los pies que tomaron aspecto de dedos en salchicha, sin obtener respuesta favorable con 150 mg diarios indometacina más antibióticos; luego de los estudios realizados durante dos ingresos, se concluyó como una artritis reactiva por virus de Epstein Barr, lo cual se confirmo por estudios virológicos en el Instituto Pedro Kouri, con respuesta favorable a los esteroides y la azulfidina
Masculine patient of 24 years of age, with antecedent of good health, health history homeof fever, pharyngitis, cervical lymphadenopathy and hepatosplenomegaly; 3 days afterwards, accompanies of, additive arthritis in right doll and left knee, and tenosinovitis of the fingers of the feet that took appearance of fingers in sausage, without obtaining favorable answer with indomethacin at doses of 150 mg daily more antibiotics; afterwards of the studies realized during two income, concluded like a reactive arthritis by virus of Epstein Barr, which confirm by virological studies in the Pedro Kouri Institute, with favorable answer to the steroids and the azulfidine.
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La artritis postestreptocóccica es una entidad que se manifiesta por compromiso articular secundario a infección orofaríngea secundaria a Streptococcus beta hemolítico del grupo A. Se presenta el caso de un paciente de 43 años, previamente sano, que siete semanas después de un episodio de faringoamigdalitis desarrolló un cuadro oligoarticular, aditivo, no migratorio, con lesiones dermatológicas. Se documentaron títulos elevados de antiestrep-tolisina O, cumpliendo con los criterios propuestos por Ayoub y Ahmed, y se diagnosticó artritis postestreptocóccica. El paciente presentó respuesta adecuada a dosis moderadas de corticoesteroides.
Post-streptococcal reactive arthritis is an entity that includes joint involvement secondary to oropharyngeal infectious process associated with beta hemolytic group A Streptococcus. We report a clinical case of 43 year-old man, previously healthy, that seven weeks after a tonsillopharyngitis, developed an additive, non-migratory oligoarthritis, with skin lesions. High titers of antistreptolysin O antibodies are documented, with fulfillment of Ayoub and Ahmed proposed criteria for post streptococcal reactive arthritis. The patient presented adequate response to moderate doses of corticosteroids.
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La instalación del bacilo de Calmette-Guérin es un tratamiento seguro y eficaz para elcáncer superficial de vejiga. La aparición de artritis tras su administración es un raro efectosecundario.Presentamos el caso clínico de un varón de 65 anos que desarrolló oligoartritis asimétricadespués de la sexta instalación del bacilo de Calmette-Guérin, que fue resuelta tras el cesedel tratamiento y la administración de antiinflamatorios no esteroideos...
Assuntos
Humanos , Artrite Reativa , Neoplasias , Bexiga UrináriaRESUMO
KEY CLINICAL MESSAGE: Patient complained of hearing loss and tinnitus after the onset of Reiter's syndrome. Audiometry confirmed the hearing loss on the left ear; blood work showed increased erythrocyte sedimentation rate and C3 fraction of the complement. Genotyping for HLA-B27 was positive. Treatment with prednisolone did not improve the hearing levels.
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THE AUTHORS PRESENT TWO CASES OF SYPHILIS: one mimicking reactive arthritis and the other Mucha-Habermann disease. Both reports illustrate syphilis as 'the great imitator', a description given by Sir William Osler, and call attention to the strong need for awareness among physicians of all specialties, especially the younger ones, who are not used to seeing this increasingly prevalent disease, as it once was in the past.
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INTRODUÇÃO: Biomarcadores séricos, tradicionalmente associados à atividade inflamatória e mau prognóstico em doenças reumáticas, não apresentam a mesma relação nas espondiloartrites. OBJETIVO: Estabelecer uma associação entre os níveis séricos de biomarcadores com a presença de fatores associados com a atividade clínica e com o mau prognóstico nas espondiloartropatias. MÉTODOS: Sessenta e dois pacientes (13 com artrite reativa, 19 com espondilite anquilosante e 30 com espondiloartropatia indiferenciada) foram comparados a 46 controles sadios. Foram realizadas avaliações clínicas, radiológicas e laboratoriais. Os resultados foram analisados de acordo com a presença de uveíte, entesite, lombalgia inflamatória, artrite, HLA-B27 e comprometimento das articulações sacroilíacas. Os biomarcadores utilizados foram: VHS, PCRus, SAA, LBP, FSC-M e MMP-3, além da dosagem dos níveis séricos das citocinas: IL-17, IL-6, IL-1α , TNF-α , IFN-γ, e IL-23. RESULTADOS: Quarenta e três (69,4%) pacientes eram homens. A média de idades foi de 31,9 ± 9,9 anos, enquanto a idade média para o aparecimento dos sintomas foi de 26,9 ± 7,3 anos. HLA-B27 foi positivo em 26 (41,9%) dos pacientes, lombalgia inflamatória esteve presente em 42 (67,7%), artrite em 44 (71,0%) e entesite em 34 (54,8%) pacientes. Os níveis séricos de IL-17, IL-23, TNF-α , IL-6, IL-1α e PCRus foram mais elevados em pacientes com espondiloartropatia em comparação com os controles. Os valores de PCRus (P = 0,04), IL-6 (P = 0,003), IL-1α (P = 0,03), e LBP (P = 0,03) se associaram de maneira significativa com presença de HLA-B27, dor lombar inflamatória e artrite. CONCLUSÃO: O aumento dos níveis séricos de PCRus, IL-6, IL-1α e LBP apresentaram associação com fatores relacionados a atividade clínica e mau prognóstico em pacientes com espondiloartrites.
BACKGROUND: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. OBJECTIVE: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. METHODS: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, inflammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α , TNF-α , IFN-γ, and IL-23. RESULTS: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, inflammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α , IL-6, IL-1α , and US-CRP levels were significantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, inflammatory back pain, and arthritis. CONCLUSION: An increase in serum levels of US-CRP, IL-6, IL-1α , and LBP was correlated with factors associated with clinical activity and poor prognosis in spondyloarthritis.
Assuntos
Adulto , Feminino , Humanos , Espondilartrite/sangue , Espondilartrite/imunologia , Biomarcadores/sangue , PrognósticoRESUMO
Las espondiloartritis (SpA) comprenden un grupo heterogéneo de enfermedades inflamatorias articulares que comparten varias características clínicas y de laboratorio, una fuerte tendencia a la asociación familiar dada por una susceptibilidad genética relacionada con la presencia del antígeno de histocompatibilidad HLA-B27, compromiso de las entesis, afectación predominante del esqueleto axial, artritis asimétrica de grandes articulaciones en los miembros inferiores y relación con la infección como factor desencadenante de las mismas. Las SpA incluyen varios subtipos: la artropatía psoriásica (PsA), las espondiloartritis no definidas (uSpA), la artritis asociada a enfermedades inflamatorias intestinales (EII), la artritis reactiva (ReA) y la espondilitis anquilosante (EA). La característica histopatológica fundamental de las SpA es la entesitis, la cual está dada por la inflamación patológica de las entesis comprometidas, que son los sitios de inserción de los tendones, ligamentos, fascias y cápsulas articulares al hueso; así como también el sitio de unión del cartílago al hueso subcondral.
Spondyloarthritis are a heterogeneous group of inflammatory joint diseases, which share clinic and laboratory characteristics, a strong relation to hereditary factors (mainly antigen HLA-B27), enthesesitis (most commonly affecting axial skeleton), large joints asymmetric arthritis mostly in lower limbs, and its relationship with infections as a triggering factor. Spondyloarthitis include various subtypes: Psoriatic Arthropathy (PsA), Undifferentiated Spondiloarthritis (uSpA), Arthritis related to inflammatory bowel disease (IBD), Ankylosing Spondylitis (AS) and Reactive Arthritis (ReA). Fundamental histopathologic characteristic of the Spondyloarthritis is enthesitis on the sites of attachment of tendons, ligaments, joint capsules and fascias to the bone, but also over the cartilage at the subchondral bone.
Assuntos
Humanos , Espondilartrite , Entesopatia , Tendões , Predisposição Genética para Doença , Histocompatibilidade , LigamentosRESUMO
A doença de Poncet é uma condição clínica rara, caracterizada por um acometimento poliarticular em um paciente com diagnóstico de tuberculose, sem evidência de invasão direta do bacilo nas articulações, configurando uma artrite reativa. Documentamos um caso em Porto Alegre: um homem de 56 anos, com evidência de poliartrite aditiva de grandes articulações, investigada há 5 anos, sem diagnóstico definido. Ele havia sido submetido a uma nefrectomia unilateral há 5 anos, e o exame anatomopatológico do órgão revelou tuberculose renal. O teste tuberculínico atual revelou um forte reator (PPD = 20 mm). Análise do líquido sinovial não demonstrou invasão direta do bacilo. Foi instituído tratamento empírico com tuberculostáticos com remissão clínica após 2 meses. Embasados nesses dados, foi feito diagnóstico de doença de Poncet.
Poncet's disease is a rare clinical condition, characterized by polyarticular impairment in a patient diagnosed with tuberculosis, with no evidence of direct bacillary invasion of the joints, constituting reactive arthritis. We report a case of a 56-year old, white male from the city of Porto Alegre, with evidence of additive polyarthritis of the large joints, investigated for five years, and with no defined diagnosis. The patient had undergone unilateral nephrectomy five years before, and the anatomicopathological exam of the specimen revealed renal tuberculosis. The current tuberculin test was strongly reactive (PPD = 20 mm). Analysis of the synovial fluid showed no direct bacillary invasion. Tuberculostatic treatment was initiated and clinical remission occurred after two months. The diagnosis of Poncet's arthritis was established.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Artrite Reativa/diagnóstico , Tuberculose Osteoarticular/diagnósticoRESUMO
Dentro del grupo de las espondiloartritis, la artritis reactiva se define como una inflamación articular desencadenada por una infección bacteriana extra-articular. Existen pocos reportes de artritis reactiva asociada con bacteriemia simultánea causada por patógenos diversos. Brevundimonas diminuta es un bacilo Gram negativo aislado ocasionalmente de especímenes clínicos. Reportamos el caso de una paciente, sin inmunodeficiencia conocida, con artritis reactiva y bacteriemia simultánea por B. diminuta.Palabras clave: artritis reactiva, Brevundimonas diminuta, bacteriemia.
Within the group of spondyloarthritis, reactive arthritis is defined as a joint inflammation triggered by an extra-articular bacterial infection. There are few reports of reactive arthritis associated with bacteremia caused by different pathogens. Brevundimonas diminuta is a Gram-negative bacillus isolated occasionally from clinical specimens. We report a patient with reactive arthritis and concurrent B. diminuta bacteremia, without known immune deficiency.Key words: reactive arthritis, Brevundimonas diminuta, bacteremia.
Assuntos
Artrite Reativa/parasitologia , Bacteriemia/complicações , Bacteriemia/fisiopatologiaRESUMO
La espondilitis anquilosante, artritis reactiva, artritis psoriásica, artritis enteropática, espondilitis anquilosante juvenil y espondiloartropatía indife-renciada, conforman el grupo de Espóndilo artropatías seronegativas. Como síndrome clínico comparten signos y síntomas inflamatorios, compromiso articular y extra articular, HIA-B27 positivo, factor reumatoide negativo y curso crónico; debiendo ser incluidas como diagnósticos diferenciales del síndrome de dolor lumbar y cervical crónico, especialmente cuando es de tipo inflamatorio o maligno. Se realizó un estudio descriptivo, transversal y retrospectivo, elaborando una descripción clínica, diagnóstica y radiológica de pacientes incluidos en la base de datos de la unidad de reumatología de la Clínica Universitaria Bolivariana con diagnósticos de espondilitis anquilosante, espondiloanropatía indiferenciada y artritis psoriásica, atendidos entre septiembre de 2002 y julio de 2004, aplicando el formato de Espóndilo artropatías diseñado para esta investigación. Se evaluaron 27 pacientes: 55.6% hombres y 44.4% mujeres, entre 20 y 56 años. La Espóndilo artropatías serone-gativas más frecuente fue la espondilitis anquilosante (70.3%), seguida de artritis psoriásica (22.2%) y espon-diloartropatía indiferenciada (7.4%). Los síntomas más frecuentes se registraron en la región lumbar y en los talones (51.9%), rigidez artricular en la región lumbar (59.3%) y localización de la artritis en los hombros (11.1%). Los signos más frecuentes fueron Patrick y Sch6ber (62.9%).La sacroileitis bilateral y enteritis piramidal fueron los hallazgos radiológicos más frecuentes (48.1%). Para el presente estudio, la espondilítis anquilosante fue la entidad más frecuente y cursó con mayores signos y síntomas inflamatorios, predominó el compromiso del esqueleto axial, evolucionó de manera crónica y progresiva y cursó con mayor evidencia de compromiso radiológico, comparado con la anritis psoriásica y espondiloanropatía indiferenciada.
Ankylosing Spondyltis, Reactive Anhinis, Psoriasic Anhritis, Enteropatic Arthritis,youthful Ankylosing Spondylítis and Undifferentiated Spondyloanhropathies make up the group of sero-negative spondyloanhropaties. As a clinical syndrome, they share both inflammatory signs and symptoms, in-joint and out-joint involvement, positive HLA-B27, a negative rheumatoid factor and a chronic course. The physician ought to include them as differential diagnosis for chronic back pain and cervical pain, specially when the clínical picture is of inflammatory or maligntype. A descriptive, cross-sectional, retrospective study was performed, developing a description of the clinical, diagnostic and radiological issues of patients included in the Clínica...