RESUMO
Wildlife animals have been affected by human activities and the diminution of the areas needed to develop wildlife. In Colombia, artisanal and industrial mining focuses on gold extraction, which uses mercury and causes contamination in water sources. Bats may be susceptible to chemical contamination and primarily to bioaccumulated heavy metal contaminants in the food chain. The primary source of exposure is contaminated food and water ingest, followed by dermic exposition and inhalation. The objective was to evaluategenotoxic damage and mercury concentration in bats. Forty-five samples of blood and organs of bats captured in Ayapel and Majagual were collected. Erythrocytes were searched for micronuclei by peripheral blood smear. Mercury concentration in 45 liver and spleen samples was determined by atomic absorption spectroscopy (DMA80 TRICELL, Milestone Inc, Italy). Bats from four families were studied: Phyllostomidae (6 species), Molossidae (3 species), Vespertilionidae (1 species), and Emballonuridae (1 species). Mercury was found in all bat species from the different dietary guilds. Insectivores had the highest concentration of mercury in the liver (0,23 µg/g) and spleen (0,25 µg/g) and the highest number of micronuclei (260 micronuclei/10,000). The specimens captured in Majagual had the highest frequency of micronuclei (677 micronuclei/10,000), and those captured in Ayapel had the highest mercury concentration (0,833 µg/g). This is the first study in Colombia to report that bats could act as sentinels to the environment's genotoxic chemical agents. Mercury and a high frequency of micronuclei were found in the tissues of captured bats. In addition to mercury contamination, there could also be other contaminants affecting Chiroptera.
Assuntos
Quirópteros , Mercúrio , Animais , Colômbia , Dano ao DNA , Monitoramento Ambiental , Humanos , Mercúrio/análiseRESUMO
Resumen Introducción: El uso de antibióticos, enfrenta grandes problemas que deben ser resueltos en pro de la calidad de vida de los pacientes buscando un equilibrio en el costo-efectividad. Los análisis farmacoeconómicos son una herramienta útil para determinar qué fármacos deben estar disponibles en guías farmacoterapéuticas. Aunque el método de selección de fármacos varía en cada institución, el principio general es que deben ser elegidos los más efectivos al menor costo. El objetivo fue establecer el costo de los tratamientos, la evaluación de susceptibilidad y resistencia a los antibióticos en una Unidad de Cuidados Intensivos de Montería. Métodos: La muestra se integró por todos los pacientes ingresados a la UCI, que recibieron tratamiento antibiótico, durante doce meses. De las historias clínicas, se identificaron y se clasificaron los tratamientos aplicados, duración del tratamiento, costo del tratamiento por paciente, consumos por paciente de los antibióticos con el fin de estimar los costos de los antibióticos utilizados en pacientes de la UCI. Resultados: Se registraron 670 ingresos, de los cuales el 48,40% recibieron terapia antimicrobiana. Las principales causas de ingreso a la UCI fueron: evento coronario agudo (16,69%), insuficiencia respiratoria aguda (13,83%), sepsis (12,48%). Los microorganismos encontrados fueron: E. coli, K. pneumoniae, S. aureus, P. aeruginosa, S. epidermidis, A. baumanni, A. haemolyticus. Conclusión: Los sistemas estandarizados de vigilancia para el uso de antibióticos es una herramienta esencial en el uso racional y en el control de la resistencia antibacteriana.
Abstract The use of antibiotics, faces major problems that must be solved to ensure high-quality care of patients, which seeking a balance in cost-effectiveness. Pharmacoeconomics analyzes are a useful tool for determining which drugs should be available for pharmacotherapy strategies. Although the method of drug selection varies in each institution, the general principle is that the most effective ones should be chosen amongst the lowest-cost. The objective was to establish the cost of treatments, susceptibility assessment and resistance to antibiotics in an Intensive Care Unit in Montería. The sample was integrated by all the patients admitted to the ICU, who received antibiotic treatment, during twelve months. From the clinical records served, the treatments applied, duration of treatment, cost of treatment per patient, consumption per patient of the antibiotics were identified and classified to estimate the costs in relation to the therapeutic effectiveness of the antibiotics used in patients in the ICU. A total of 670 patients were registered, of whom 48,40% received antimicrobial therapy. The main causes of ICU admission were: acute coronary event (16,69%), acute respiratory failure (13,83%), sepsis (12,48%). The strains were: E. coli, K. pneumoniae, S. aureus, P. aeruginosa, S. epidermidis, A. baumanni, A. haemolyticus. Standardized surveillance systems for the use of antibiotics are an essential strategic intervention for the rational use and control antimicrobial resistance.