RESUMO

The developmental origins of breast cancer have been considered predominantly from a maternal perspective. Although accumulating evidence suggests a paternal programming effect on metabolic diseases, the potential impact of fathers' experiences on their daughters' breast cancer risk has received less attention. In this chapter, we focus on the developmental origins of breast cancer and examine the emerging evidence for a role of fathers' experiences.

Assuntos

Neoplasias da Mama/etiologia , Neoplasias da Mama/metabolismo , Suscetibilidade a Doenças , Animais , Neoplasias da Mama/patologia , Doença Crônica , Feminino , Humanos , Lactação , Exposição Materna , Herança Paterna , Gravidez , Efeitos Tardios da Exposição Pré-Natal

RESUMO

Emerging experimental evidence show that fathers' experiences during preconception can influence their daughters' risk of developing breast cancer. Here we describe detailed protocols for investigation in rats and mice of paternally mediated breast cancer risk programming effects.

Assuntos

Neoplasias da Mama/etiologia , Modelos Animais de Doenças , Suscetibilidade a Doenças , Herança Paterna , Animais , Biópsia , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Dieta , Feminino , Imuno-Histoquímica , Masculino , Glândulas Mamárias Animais/metabolismo , Neoplasias Mamárias Animais , Camundongos , Ratos , Carga Tumoral