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Recent studies highlight the strong correlation between infectious diseases and the development of neuropsychiatric disorders. In this editorial, we comment on the article "Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients" by Zhang et al, published in the recent issue of the World Journal of Psychiatry 2023; 13 (11): 903-911. Our discussion highlighted the potential consequences of anxiety, depression, and psychosis, which are all linked to bacterial, fungal, and viral infections, which are relevant to the impact of inflammation on the sequelae in mental health as those we are observing after the coronavirus disease 2019 pandemic. We focus specifically on the immune mechanisms triggered by inflammation, the primary contributor to psychiatric complications. Importantly, pathophysiological mechanisms such as organ damage, post-injury inflammation, and infection-induced endocrine alterations, including hypocortisolism or autoantibody formation, significantly contribute to the development of chronic low-grade inflammation, promoting the emergence or development of psychiatric alterations in susceptible individuals. As inflammation can have long-term effects on patients, a multidisciplinary treatment plan can avoid complications and debilitating health issues, and it is crucial to recognize and address the mental health implications.

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Introducción: La enfermedad inflamatoria pélvica aguda es una entidad frecuente en mujeres jóvenes en edad reproductiva, y constituye la causa principal de infertilidad. La búsqueda de un tratamiento antiinflamatorio eficaz y seguro que alivie el dolor, evite complicaciones y secuelas, es una prioridad para su tratamiento. Objetivo: Evaluar la eficacia y seguridad del tratamiento con Proctokinasa® en la enfermedad inflamatoria pélvica aguda grados I y II. Materiales y métodos: Se desarrolló un ensayo clínico, controlado, abierto, de enero de 2017 a enero de 2018, que incluyó 76 pacientes con diagnóstico de enfermedad inflamatoria pélvica aguda en la atención primaria de salud, quienes fueron asignadas aleatoriamente a dos grupos de tratamiento: grupo principal Proctokinasa®, que recibió una unidad/8 h por 2 días, y el grupo Piroxicam, un supositorio de 20 mg/24 h por 7 días. La antibioticoterapia oral recomendada se inició simultáneamente. Se evaluó la respuesta clínica y ecográfica al tratamiento. Los eventos adversos fueron evaluados. Resultados: Se constató respuesta clínica a partir de las 72 horas de tratamiento en más del 50 % de las pacientes en ambos grupos, y fue del 100 % de los casos para el grupo Proctokinasa® en las dos últimas evaluaciones realizadas (días 10 y 15). Se evidenció la remisión de las alteraciones ecográficas en el 96,9 % del grupo Proctokinasa®. Los eventos adversos fueron escasos y leves. Conclusiones: El empleo de Proctokinasa® resultó eficaz y seguro en el tratamiento de la enfermedad inflamatoria pélvica aguda grados I y II.

Introduction: Acute pelvic inflammatory disease is a common entity in young women of reproductive age and it is a leading cause of infertility. The search for an effective and safe anti-inflammatory treatment that relieves pain, avoids complications and sequels, it is priority for its treatment. Objective: To evaluate the efficacy and safety of the treatment with Proctokinasa® in acute pelvic inflammatory disease grades I and II. Materials and methods: An open, controlled clinical trial was carried out from January 2017 to January 2018 which included 76 patients diagnosed with acute pelvic inflammatory disease in primary health care; they were randomize assigned to two treatment groups: Proctokinasa® main group, who received one unity/8h for 2 days, and the Piroxican group, 1 suppository of 20 mg/24h per 7 days. The recommended oral antibiotic therapy was started simultaneously. Clinical and ultrasound response to treatment were evaluated. Adverse events were evaluated. Results: Clinical response was stated after 72 hours of treatment inmore than 50% of the patients in both groups, and it was 100% for the Proctokinasa® group in the last two evaluations (days 10 and 15). Remission of ultrasound alterations was evident in 96.9% of the Proctokinasa® group. Adverse events were few and mild. Conclusions: The use of Proctokinasa® was effective and safe in the treatment of acute pelvic inflammatory disease grades I and II.

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Pelvic inflammatory disease (PID) is an inflammation of the upper genital tract. PID is the leading cause of some severe sequelae in the absence of timely and accurate diagnosis and treatment. An appropriate animal model is needed to explore the underlying mechanism of PID sequelae. This study introduced an animal model of PID by vaginal injection of liquid Ureaplasma urealyticum combined with fatigue and hunger (UVF). This study was designed to test the feasibility of a rat model. A rat model was established using UVF irradiation. Levels of some inflammatory cytokines in the serum and the homogenates of the fallopian tubes were measured by ELISA, RT-PCR, and flow cytometry and compared with another rat model of Ureaplasma urealyticum liquids injected into the two uterus horns during laparotomy. Inflammatory alterations and adhesions were observed after hematoxylin and eosin (H&E) staining and detected using the Blauer scoring system. The results showed that the combined UVF and rat model caused apparent obstruction, edema, and adhesion in the fallopian tubes and connective tissues. The rat model showed upregulated CD4, CD8, and CD4/CD8 in peripheral blood mononuclear cells (PBMCs) and significantly increased levels of IL-4, IL-6, IL-10, and IL-17. UVF also enhanced the expression of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-ß, vascular endothelial growth factor (VEGF) ß, and matrix metalloproteinase (MMP)-2 (P<0.05). The UVF rat model can induce inflammatory alterations in the fallopian tubes and connective tissues, and can be used as a model of PID.

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Resumen El diagnóstico diferencial de enfermedad inflamatoria pélvica (EIP) representa un desafío, porque tiene un gran polimorfismo en su forma de presentación y, de ser sintomática, se confunde con numerosas patologías que ocasionan dolor abdominal agudo. Neisseria gonorrhoeae es uno de sus agentes etiológicos más frecuentes. Se presenta el caso de una paciente de sexo femenino con síndrome de abdomen agudo asociado a vómitos. Los estudios de imágenes (ecografía y tomografía axial computada) revelaron la presencia de líquido interasas y apéndice aumentado de tamaño. Se decidió conducta quirúrgica. Durante la misma se tomó muestra de líquido abdominal de cuyo análisis microbiológico se recuperó N. gonorrhoeae, sensible a ceftriaxona y a azitromicina. La paciente fue tratada con estos antibióticos en dosis de 1 g/día/endovenoso, con buena evolución clínica. Frente a una paciente en edad fértil con abdomen agudo es útil recordar, por sus implicancias, la posibilidad de una EIP por N. gonorrhoeae.

Abstract Differential diagnosis of pelvic inflammatory disease (PID) represents a challenge because it has a great polymorphism in its presentations and, if symptomatic, there are numerous pathologies that cause acute abdominal pain. Neisseria gonorrhoeae is one of the most frequent etiological agents. The case of a female patient with acute abdominal syndrome associated with vomiting is presented. Imaging studies (ultrasound and computed tomography) revealed the presence of fluid between the intestinal loops and an enlarged appendix. Surgical management was decided, during which a sample of abdominal liquid was taken and N. gonorrhoeae, susceptible to ceftriaxone and azithromycin, was recovered from its microbiological analysis. The patient was treated with these antibiotics at doses of 1 g/day/iv, with good clinical evolution. In the case of a patient of childbearing age suffering from acute abdomen, it is useful to remember, because of its implications, the possibility of PID due to N. gonorrhoeae.

Resumo O diagnóstico diferencial de doença inflamatória pélvica (DIP), representa um desafio, porque tem um amplo polimorfismo em sua forma de apresentação e, caso seja sintomática, confunde-se com numerosas patologias que causam dor abdominal aguda. Neisseria gonorrhoeae é um dos seus agentes etiológicos mais frequentes. É apresentado o caso de uma paciente de sexo feminino com síndrome de abdome agudo associado com vômitos. Os estudos das imagens (ultrassonografia e tomografía axial computadorizada) revelaram a existência de líquido ascítico e apêndice aumentado de tamanho. Decidiu-se o tratamento cirúrgico. Durante a prática cirúrgica foi obtida amostra do líquido abdominal de cuja análise microbiológica foi recuperada N. gonorrhoeae, sensível à ceftriaxona e à azitromicina. A paciente recebeu o tratamento com esses antibióticos em dose de 1 g/dia/intravenosa, obtendo boa evolução clínica. Diante de uma paciente em idade fértil com abdome agudo, é útil lembrar, pelas suas consequências, a possibilidade de uma DIP por N. gonorrhoeae.

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Resumen ANTECEDENTES: El absceso tubo-ovárico, como parte de la enfermedad pélvica inflamatoria, tiene características distintas en pacientes posmenopáusicas que en mujeres más jóvenes. CASO CLÍNICO: Paciente de 68 años, con antecedentes de cinco embarazos, tres partos y dos cesáreas, con vida sexual activa, diabetes mellitus tipo 2 e hipertensión arterial crónica, en control. Acudió a consulta debido a un dolor agudo en la fosa iliaca izquierda, con irradiación a la fosa iliaca derecha, acompañado de vómitos; esto disminuyó la toma pautada de antiinflamatorios no esteroideos y de los antibióticos. Con base en los reportes clínicos y de imagen se decidió la laparotomía exploradora en la que hubo hallazgos de: absceso pélvico multiseptado originado en el anexo derecho, con drenaje de material purulento de 250 cc. Se encontraron, además: síndrome adherencial severo, adenitis mesentérica, afectación del apéndice cecal con procesos inflamatorios reactivos y despulimiento del colon sigmoides, con sangrado de 500 cc. CONCLUSIONES: La enfermedad pélvica inflamatoria asociada con un absceso tubo-ovárico en una paciente posmenopáusica no es frecuente, quizá por ello a veces es infradiagosticada, lo que conduce a un aumento de la morbilidad y mortalidad.

Abstract BACKGROUND: Tubo-ovarian abscess as part of pelvic inflammatory disease has different characteristics in postmenopausal patients than in younger women. CLINICAL CASE: A 68-year-old woman with a history of five pregnancies, three deliveries and two caesarean sections, with an active sexual life, type 2 diabetes mellitus and chronic arterial hypertension under control. She presented with severe pain in the left iliac fossa with radiation to the right iliac fossa, accompanied by vomiting, which reduced the prescribed intake of non-steroidal anti-inflammatory drugs and antibiotics. Based on the clinical and imaging findings, an exploratory laparotomy was performed, which revealed the following: multiseptal pelvic abscess originating from the right adnexa with drainage of 250 cc of purulent material. There were also findings of: severe adhesive syndrome, mesenteric adenitis, involvement of the cecal appendix with reactive inflammatory processes, and sigmoid colon depulpation with bleeding of 500 cc. CONCLUSIONS: Pelvic inflammatory disease associated with a tubo-ovarian abscess in a postmenopausal patient is uncommon, perhaps because of this it is sometimes underdiagnosed, leading to increased morbidity and mortality.

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Ascites is a common complication of several conditions, but it is rare in cases of Chlamydia trachomatis infection. We report a 36-year-old patient presenting with abdominal swelling for a week prior to hospitalization. An extensive workup excluded liver or heart disease and malignancy. A computed tomography scan demonstrated massive ascites and severe thickening of peritoneal reflections. Laboratory tests showed low serum-ascites albumin gradient, high total protein, and low adenosine. Diagnostic laparoscopy revealed inflammatory signs of both fallopian tubes. The histopathological results from peritoneal biopsy were consistent with lymphoid proliferation with reactive lymphoplasmacytic infiltrate. A gynecological investigation showed a positive DNA for C. trachomatis in the cervical swab. After treatment with doxycycline, there was a complete resolution of ascites.

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RESUMEN Introducción: la apendicitis aguda es causa frecuente de dolor abdominal. Su complicación más frecuente es la infección del sitio operatorio, siendo el compromiso pélvico muy raro. Presentamos el caso de una paciente sin vida sexual activa, con una enfermedad pélvica inflamatoria como complicación posoperatoria de una apendicitis aguda. Esta ingresó por dolor abdominal, varias semanas después de una apendicetomía, sin signos de infección incisional, pero con una tomografía que reportaba un hidrosalpinx izquierdo. Evolucionó hacia el deterioro clínico a pesar de la reanimación con cristaloides y antibióticos de amplio espectro. Fue llevada a laparotomía para control del foco. Se encontró un hidrosalpinx izquierdo y necesitó de una segunda cirugía por el compromiso anexial derecho. Luego de estas intervenciones hubo recuperación. Conclusión: la enfermedad pélvica inflamatoria es una etiología poco frecuente (aunque posible) de abdomen agudo en pacientes sin vida sexual activa.

SUMMARY Introduction: Acute appendicitis is a frequent cause of abdominal pain and its most frequent complication is surgical site infection, with pelvic involvement being very rare. The following is a case of a patient with pelvic inflammatory disease as postoperative complication after appendectomy. The patient was admitted for abdominal pain several weeks after an appendectomy, without signs of incisional surgical site infection but with a CT scan that re-ported a left hydrosalpinx. The patient progresses with clinical deterioration despite resuscitation with crystalloids and broad-spectrum antibiotics. A laparotomy was performed for infection control. A left hydrosalpinx was found and needed a second surgery due to right adnexal involvement. After this she recovered. Conclusion: Pelvic inflammatory disease is a rare but possible etiology of the acute abdomen in patients who's never had sexual intercourse.

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RESUMEN Introducción: La enfermedad inflamatoria pélvica es la infección grave más frecuente en mujeres entre 16 y 25 años. La adolescencia es el periodo de mayor riesgo de aparición por la mayor incidencia de factores de riesgo relacionados con conductas sexuales inseguras. Objetivo: Determinar las características clínico epidemiológicas de las pacientes con diagnóstico de enfermedad inflamatoria pélvica tumoral. Método: Se trabajó con una población de 63 pacientes. Se conformaron dos grupos de estudio, grupo I con las adolescentes y jóvenes, y grupo II con las demás pacientes. Las variables utilizadas fueron: relaciones sexuales precoces, número de parejas sexuales, relaciones sexuales desprotegidas, uso de dispositivos intrauterinos, antecedentes de interrupción de embarazo, principales manifestaciones clínicas, resultados de complementarios y tratamiento administrado. Resultados: Se encontró que el 76,4 % de las adolescentes tenían relaciones sexuales desprotegidas, 52,9 % comenzaron las relaciones sexuales antes de los 14 años, 64,7 % refirieron antecedentes de abortos provocados, y el 100 % solicitó atención por dolor pélvico. En el 95,6 % de las pacientes se utilizó tratamiento médico. Conclusiones: En la mayoría de los casos, el cuadro clínico y los complementarios realizados fueron consistentes con la enfermedad inflamatoria pélvica tumoral; y el tratamiento utilizado fue médico.

ABSTRACT Introduction: Pelvic inflammatory disease is the most frequent serious infection in women between 16 and 25 years old. Adolescence is the period of highest risk of onset due to the higher incidence of risk factors related to unsafe sexual behaviors. Objective: To determine the clinical and epidemiological characteristics of patients diagnosed with tumoral pelvic inflammatory disease. Methods: We worked with a population of 63 patients. Two study groups were formed, group I with adolescents and young people, and group II with the other patients. The variables used were: early sexual intercourse, number of sexual partners, unprotected intercourse, use of intrauterine devices, history of pregnancy termination, main clinical manifestations, complementary results, and treatment administered. Results: It was found that 76.4% of the adolescents had unprotected sexual relations, 52.9% began sexual relations before the age of 14, 64.7% referred a history of induced abortions, and 100% requested attention for pain pelvic. Medical treatment was used in 95.6% of the patients. Conclusions: In most of the cases, the clinical and complementary symptoms performed were consistent with tumor pelvic inflammatory disease; and the treatment used was medical.

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Este trabalho buscou reunir dados essenciais sobre as etiologias de dor pélvica aguda, uma queixa constante nos serviços de emergências e ambulatórios de ginecologia, responsável por grande desconforto e impacto na qualidade de vida de pacientes mulheres. É uma condição laboriosa por causa de seu amplo espectro de causas, devendo ser abordada com cuidado e atenção pelo profissional médico, o qual deve considerar os diversos diagnósticos diferenciais, sendo a ultrassonografia o exame de maior importância para auxiliar em seu diagnóstico. As principais etiologias não obstétricas podem ser não ginecológicas e ginecológicas; essas últimas são divididas em anexiais e uterinas. Entre as causas ginecológicas, devem- -se investigar cistos ovarianos, torções anexiais, leiomiomas, doença inflamatória pélvica, abscesso tubo-ovariano, dismenorreia e complicações de dispositivos intrauterinos. A maioria das causas tem tratamento eficaz, com retorno da função do órgão e melhora da qualidade de vida, sem complicações, especialmente se diagnosticada precocemente.(AU)

The aim of this study was to gather important data on acute pelvic pain etiologies, a usual complaint in the emergency services and gynecology outpatient clinics, responsible for great discomfort and impact on quality of life in female patients. It is a laborious condition due to its wide spectrum of causes, which needs to be approached with attention by the physician, who must consider all the possible diagnoses, being the ultrasonography the most important exam to detect it. The main non-obstetric etiologies can be non-gynecological and gynecological, which are separated in adnexal and uterine causes. Among the gynecological causes, ovarian cysts, adnexal torsions, leiomyomas, pelvic inflammatory disease, ovarian tube abscess, dysmenorrhea and complications of intrauterine devices should be investigated. Most causes can be effectively treated, with return of organ function and improved quality of life, without complications, especially if diagnosed early.(AU)

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Introducción: La infertilidad se define como el no logro del embarazo posterior a 12 meses de relaciones sexuales sin protección, según la Organización Mundial de la Salud (OMS). Entre 60 a 80 millones de parejas anualmente sufren este problema. En el Perú no existen reportes actualizados que permitan conocer estas cifras y hay pocos estudios que permitan conocer las causas de esta afección. Objetivo: Determinar los factores de riesgo asociados a infertilidad en pacientes mujeres atendidas en consultorios externos en el Servicio de Ginecología del Hospital Vitarte, periodo enero 2015 a abril del 2019. Métodos: Se realizó un estudio observacional, analítico, retrospectivo de casos y controles, considerando una muestra de 82 casos y 82 controles. Se consideraron factores de riesgo clínicos, demográficos y de hábitos de consumo nocivo y, para medir la asociación, se utilizó los odds ratio crudos y ajustados, para lo cual se usó el paquete estadístico SPSS. Resultados: En base a los OR ajustados, se identificó a la dispareunia (OR:4.16, IC95% 1.56- 11.14), dismenorrea, (OR:4.22, IC95% 1.79-9.93), enfermedad pélvica infamatoria (OR:5.59, IC95% 2.11- 14.84), y el consumo de alcohol (OR:2.87, IC95% 1.10-7.49), como factores de riesgo estadísticamente significativos para el desarrollo de infertilidad. Conclusión: Los factores asociados a la infertilidad en el servicio de ginecología del Hospital Vitarte durante el periodo de enero 2015 a abril 2019 son la dispareunia, dismenorrea, el antecedente de enfermedad pélvica inflamatoria y, el consumo de alcohol.

Introduction: Infertility is defined as the failure to achieve pregnancy after 12 months of unprotected sex, according to the World Health Organization (WHO). Between 60 to 80 million couples annually suffer from this problem. In Peru there are no updated reports that allow to know these figures and there are few studies that allow to know the causes of this condition Objective: To determine the risk factors associated with infertility in female patients treated in outpatient offices in the Gynecology Service of the Vitarte Hospital, period January 2015 to April 2019. Methods: An observational, analytical, retrospective case-control study was conducted, considering a sample of 82 cases and 82 controls. Clinical, demographic and habits of harmful consumption factors were considered and, to measure the association, the crude and adjusted odds ratios were used, for which the statistical package SPSS was used. Results: Based on the adjusted OR, dyspareunia was identified (OR: 4.16, 95% CI 1.56-11.14), dysmenorrhea, (OR: 4.22, 95% CI 1.79-9.93), pelvic inflammatory disease (OR: 5.59, 95% CI 2.11-14.84), and alcohol consumption (OR: 2.87, 95% CI 1.10-7.49), as statistically significant risk factors for the development of infertility. Conclusion: The factors associated with infertility in the gynecology service of the Vitarte Hospital during the period from January 2015 to April 2019 are dyspareunia, dysmenorrhea, the history of pelvic inflammatory disease and alcohol consumption.

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El desarrollo de ascitis moderada o severa es infrecuente tras una enfermedad inflamatoria pélvica por Chlamydia trachomatis, una de las principales causas de infección de transmisión sexual a nivel mundial. Caso clínico: Paciente de 29 años que tras aborto diferido (gestación tras inseminación artificial) que inicia a las seis semanas con cuadro de dolor abdominal inespecífico y ascitis de predominio linfocitario. El diagnostico se realizo mediante PCR (Werfen®) tanto el liquido ascítico como en exudado endocervical. La paciente recibió tratamiento antibiótico con doxiciclina. Conclusión: Las enfermedades de transmisión sexual deben ser consideradas cuando se realiza un diagnóstico diferencial de una mujer sexualmente activa con dolor abdominal y ascitis, instaurar tratamiento antibiótico y evitar pruebas e intervenciones quirúrgicas innecesarias.

The development of moderate or severe ascites is infrequent after a pelvic inflammatory disease from Chlamydia trachomatis, one of the main causes of sexually transmitted infection worldwide. Clinical case: A 29-year-old patient who, after a delayed abortion (gestation after artificial insemination), started at six weeks with symptoms of non-specific abdominal pain and predominantly lymphocytic ascites. The diagnosis is made by PCR (Werfen®) both the ascitic fluid and the endocervical exudate. The patient received antibiotic treatment with doxycycline. Conclusion: Sexually transmitted diseases should be considered when making a differential diagnosis of a sexually activated woman with abdominal pain and ascites. Establishing antibiotic treatment, and avoiding unnecessary tests and surgical treatments.

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RESUMEN La imposibilidad para concebir, después de un año de relaciones sexuales sin protección, es un término aceptado como infertilidad. Entre un 15 y un 20 % de parejas en Cuba requieren algún tipo de ayuda para lograr un hijo. La laparoscopia contrastada es uno de los estudios protocolizados que se debe realizar en la búsqueda de la etiología de esa incapacidad, sobre todo cuando se sospecha una posible causa tubo-peritoneal. El síndrome de Fitz-Hugh-Curtis o perihepatitis, consiste en una inflamación de la cápsula hepática, provocada por una infección (la más frecuente: clamidias), como manifestación extrapélvica de una enfermedad inflamatoria. Se informó el hallazgo insospechado de este síndrome durante la realización de una laparoscopia contrastada, asociada a una obstrucción bilateral de las trompas, sin síntomas clínicos, que hizo sospechar de un proceso pélvico infeccioso previo, como posible factor etiológico de la dificultad para concebir.

ABSTRACT The inability to conceive after one year of unprotected intercourse is a term accepted as infertility. In Cuba 15-20% of couples require some type of help to conceive a child. Hysterosalpingography is one of the established studies that should be performed when the etiology of this inability is sought, especially when a possible tubal-peritoneal cause is suspected. Fitz-Hugh-Curtis syndrome or perihepatitis, consists of an inflammation of the liver capsule, caused by an infection (chlamydial infection is the most common), as an extrapelvic manifestation of an inflammatory disease. The unsuspected finding of this syndrome was reported during the performance of hysterosalpingography, associated with a bilateral tubal obstruction, without clinical symptoms, which led us to suspect a previous pelvic infectious process, as a possible etiological factor of the difficulty to conceive.

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OBJECTIVE: To assess the effectiveness and safety of antibiotic regimens used to treat pelvic inflammatory disease (PID). DESIGN: This is a systematic review and meta-analysis of randomised controlled trials (RCTs). Risk of bias was assessed using the criteria outlined in the Cochrane guidelines. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation. DATA SOURCES: Eight electronic databases were searched from date of inception up to July 2016. Database searches were complemented by screening of reference lists of relevant studies, trial registers, conference proceeding abstracts and grey literature. ELIGIBILITY CRITERIA: RCTs comparing the use of antibiotics with placebo or other antibiotics for the treatment of PID in women of reproductive age, either as inpatient or outpatient treatment. RESULTS: We included 37 RCTs (6348 women). The quality of evidence ranged from very low to high, the main limitations being serious risk of bias (due to poor reporting of study methods and lack of blinding), serious inconsistency and serious imprecision. There was no clear evidence of a difference in the rates of cure for mild-moderate or for severe PID for the comparisons of azithromycin versus doxycycline, quinolone versus cephalosporin, nitroimidazole versus no use of nitroimidazole, clindamycin plus aminoglycoside versus quinolone, or clindamycin plus aminoglycoside versus cephalosporin. No clear evidence of a difference between regimens in antibiotic-related adverse events leading to discontinuation of therapy was observed. CONCLUSIONS: We found no conclusive evidence that one regimen of antibiotics was safer or more effective than any other for the treatment of PID, and there was no clear evidence for the use of nitroimidazoles (metronidazole) compared with the use of other drugs with activity against anaerobes. More evidence is needed to assess treatments for women with PID, particularly comparing regimens with or without the addition of nitroimidazoles and the efficacy of azithromycin compared with doxycycline.

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RESUMEN La enfermedad inflamatoria pélvica (EIP) es un síndrome clínico que incluye todas aquellas alteraciones inflamatorias e infecciosas que comprenden los órganos de la pelvis menor. La infección es habitualmente polimicrobiana y está asociada a mujeres jóvenes con vida sexual activa, nulíparas y usuarias de dispositivo intrauterino (DIU Los abscesos tubo-ováricos son una complicación aguda o crónica, asociada a dicho proceso.). CASO CLÍNICO Presentamos el caso de una mujer de 47 años con dolor abdominal intenso, usuaria de DIU. La primera sospecha diagnóstica fue de EIP con presencia de absceso tuboovárico anexial. Sin embargo la exploración física no orientó en este sentido, por lo que se solicitó TAC abdominopélvico, en el que se informó de la posibilidad de linfangioma quístico mesentérico. Por ello, se contactó con el servicio de Cirugía General que procedió a su resección satisfactoria y sin incidencias. El estudio anatomopatológico confirmo la sospecha radiológica. CONCLUSIÓN Una adecuada exploración física es fundamental en el diagnóstico de la EIP y el absceso tuboovárico. El linfangioma quístico mesentérico puede formar parte del diagnóstico diferencial de las masas anexiales en este contexto.

ABSTRACT Pelvic inflammatory disease (PID) is a clinical syndrome involving all those inflammatory and infectious alterations affecting the minor pelvis organs. Any infection is often multibacterial and more frequent in sexually active nulliparous young women and intrauterine device (IUD) users. Tuboovarian abscesses can be an acute or chronic complication associated to that process. Our patient was a 47 year old IUD user consulting about intense abdominal pain. The initial clinical suspicion pointed at a case of PID associated to a tubo-ovarian anexial abscess. However, a physical examination did not support this suspicion and an abdominopelvian CAT scan was therefore requested, reporting a possible mesenteric cystic lymphangioma. The General Surgery service was reached for treatment, successfully excising the growth without further incident. Histological analysis confirmed the radiological diagnosis. An adequate physical examination is instrumental while diagnosing PID and tuboovarian abscesses. A mesenteric cystic lymphangioma should be included in a differential diagnosis of anexial growths in such a context

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Introducción. En las mujeres en edad fértil el dolor abdominal agudo inespecífico es una entidad frecuente, que reviste especial dificultad en el abordaje diagnóstico, especialmente por el origen gineco-obstétrico. La laparoscopia es un método diagnóstico que ofrece 100 % de sensibilidad en algunas patologías, tiempo de recuperación corto, estancia hospitalaria mínima y posibilidad de resolución en la mayoría de abdómenes agudos. Materiales y métodos. Se realizó una búsqueda retrospectiva entre los años 2013 y 2014 en el Hospital Militar Central, de pacientes de género femenino, en edad fértil, llevadas a laparoscopia diagnóstica por abdomen agudo y sospecha de patología quirúrgica. Resultados. Se identificaron 108 mujeres en edad fértil con dolor abdominal agudo y sospecha de patología quirúrgica. Se encontró que 62,07 % presentó patología quirúrgica, con una mediana de 25 años de edad. La apendicitis correspondió al 94,0 % (63/67), seguida por el plastrón apendicular en un 2,9 % (2/67) y una mediana de tiempo de 24 horas (p 5 % 5 h ­ p 95 % 96 h). Se encontró una diferencia estadísticamente significativa entre las pacientes con patología quirúrgica vs. no quirúrgica en el conteo de leucocitos, neutrófilos y proteína C reactiva. La única variable clínica con una diferencia estadísticamente significativa entre los dos grupos fue la fiebre, la cual se manifestó con mayor frecuencia en las pacientes no quirúrgicas. Conclusión. La laparoscopia diagnóstica es útil en mujeres en edad fértil con dolor abdominal agudo, leucocitosis, neutrofilia y PCR elevada, y aporta un riesgo muy bajo de morbilidad

Introduction. Nonspecific acute abdominal pain is frequent in women of childbearing age, presenting difficulty in the diagnosis due to the gyneco-obstetric origin. Laparoscopy is a diagnostic method that offers 100% sensitivity in several pathologies, with a short recovery time, brief hospital stay and the possibility of resolving most cases of acute abdomen. Materials and methods. A retrospective search was conducted at the Central Military Hospital, Bogotá, Colombia, of female patients of childbearing age who underwent diagnostic laparoscopy for acute abdomen and suspected surgical pathology in the period 2013-2014. Results. We identified 108 women of childbearing age presenting with acute abdominal pain and suspicion of surgical pathology, finding that 62.07% of the patients had a surgical pathology, with a median age of 25 years, appendicitis being 94.02% (63/67) of the cases, followed by appendicular phlegmon in 2.98% (2/67) and with a median time in 24 hours (p5% 5 hours - p95% 96 hours). A statistically significant difference was found between the patients with surgical versus non-surgical pathologies in the leukocyte count, neutrophils and CRP. The only clinical variable with a statistically significant difference between the two groups was fever, being present more frequently in the non-surgical patients. Conclusion. Diagnostic laparoscopy is useful in women of childbearing age with acute abdominal pain with leukocytosis, neutrophilia and elevated CRP, with a very low risk of morbidit

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OBJECTIVES: Our purpose was to examine the associations of female genital infections and certain comorbidities with infertility. METHODS: The Taiwan National Health Research Database was searched for women with a new diagnosis of infertility between 2000 and 2013. Women without a diagnosis of infertility served as a control group and were matched with the infertility cases by age (±3 years) and index year. They were divided into two groups: ≤40 years old and >40 years old. Univariate and multivariate conditional logistic regression models were employed to identify the risk factors associated with infertility. RESULTS: A total of 18,276 women with a new diagnosis of infertility and 73,104 matched controls (mean cohort age, 31±6.2 years) were included. According to the adjusted multivariate analysis, pelvic inflammatory disease involving the ovary, fallopian tube, pelvic cellular tissue, peritoneum (odds ratio (OR)=4.823), and uterus (OR=3.050) and cervical, vaginal, and vulvar inflammation (OR=7.788) were associated with an increased risk of infertility in women aged ≤40 years. In women aged >40 years, pelvic inflammatory disease of the ovary, fallopian tube, pelvic cellular tissue, and peritoneum (OR=6.028) and cervical, vaginal, and vulvar inflammation (OR=6.648) were associated with infertility. Obesity, lipid metabolism disorders, dysthyroidism, abortion (spontaneous or induced), bacterial vaginosis, endometritis, and tubo-ovarian abscess were associated with an increased risk of infertility according to the univariate analysis but not the multivariate analysis. CONCLUSIONS: Female genital tract infections, but not the comorbidities studied here, are associated with an increased risk of infertility.

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A infertilidade em casais frequentemente é multifatorial. Dentre elas alterações tubárias respondem por até 20% dessa causalidade, sendo a histerossalpingografia o exame de escolha para verificarem alterações em sua anatomia, orientando desde a opção por tratamentos mais conservadores até mesmo a salpingectomia com posterior fertilização in vitro. O relato de caso em questão trata de uma mulher que já se encontrava em tratamento para fertilidade há 3 anos e, antes da cirurgia definitiva, optou por buscar o tratamento homeopático como alternativa. Após repertorização chegou-se ao medicamento Sycotic co, um nosódio preparado com Entercococcus faecalis, agente que é um dos principais responsáveis por doenças inflamatórias pélvicas que, por sua vez, encontram-se na etiologia das salpingites. Após trinta dias de utilização a paciente consegue engravidar, demonstrando possivelmente que o organismo recuperou sua capacidade autopoiética (regenerativa) frente ao estímulo ocasionado pela medicação homeopática, embasando novos ensaios capazes de trazer maiores evidências da utilização da homeopatia como possibilidade no tratamento adjuvante da infertilidade. (AU)

Infertility in couples is often multifactorial. Tubal disorders account for up to 20% of causes, and hysterosalpingography is the test of choice to investigate anatomical changes, which orient the option for more conservative treatments or salpingectomy with subsequent in vitro fertilization. The present case report concerns a woman under fertility treatment for 3 years, but choose to seek homeopathic treatment before final surgery. Repertory analysis led to the selection of Sycotic co, a nosode prepared from Enterococcus faecalis, which is one of the main responsible pathogens associated with pelvic inflammatory disease, which is one of the causes of salpingitis. After 30 days of treatment, the patient became pregnant, which possibly shows that her body had regained its autopoietic (regenerative) ability against the stimulus represented by homeopathic medication. These findings support the need to perform new studies to gather further evidence of the use of homeopathy as possible adjuvant treatment for infertility. (AU)

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Streptococcus pneumoniae es un patógeno habitual en infecciones del tracto respiratorio y representa la causa más frecuente de neumonía, otitis media y sinusitis. Excepcionalmente, y de forma transitoria, puede colonizar el tracto genital inferior y ser causa de enfermedad pélvica inflamatoria y peritonitis secundaria. El objetivo es presentar un caso con el diagnóstico de absceso tubo-ovárico izquierdo con un germen poco común en esta localización. Se presenta el caso de una paciente de 52 años, histerectomizada desde hace 12 años con una inmunodepresión secundaria como factor predisponente para el desarrollo de esta complicación. Se realizó laparotomía y se realizó exéresis de la tumoración y el cultivo microbiológico del contenido de ella. Se diagnosticó una infección por Streptococcus pneumoniae. La evolución posoperatoria fue satisfactoria(AU)

Streptococcus pneumoniae is a common pathogen in respiratory tract infections and the most common cause of pneumonia, otitis media, and sinusitis. Exceptionally, and transiently, it can colonize the lower genital tract causing pelvic inflammatory disease and secondary peritonitis. The objective is to present a case with left tube-ovarian abscess diagnosis, with a rare germ at this location. The case of a 52-year-old patient is reported here. She was hysterectomized 12 years before with secondary immunosuppression as a predisposing factor for developing this complication. A laparotomy was performed and excision of the tumor and microbiological culture of the contents of the tumor were completed. Streptococcus pneumoniae was diagnosed. Postoperative evolution was satisfactory(AU)

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Resumen OBJETIVO: describir las variables sociodemográficas y clínicas relacionadas con los casos de enfermedad inflamatoria pélvica de pacientes atendidas en el Hospital Universitario de Santander, Bucaramanga, Colombia, y explorar su relación con la necesidad de cirugía. MATERIALES Y MÉTODOS: estudio retrospectivo y análisis de los expedientes de pacientes atendidas entre 2013 y 2014 en el Hospital Universitario de Santander. Análsis de datos con STATA 12.1. Evaluación entre la necesidad de cirugía y las demás variables mediante pruebas de X2 o U de Mann-Whitney. RESULTADOS: se incluyeron 212 pacientes: 136 (64.2%) hospitalizadas, de las que 35 (25.7%) requirieron intervención quirúrgica. En las pacientes hospitalizadas el régimen mayormente formulado fue clindamicina y gentamicina (55 de 136: 41.4%); en las de tratamiento ambulatorio: metronidazol y doxiciclina (21 de 76: 27.6%). Las variables significativamente asociadas con la necesidad de cirugía fueron: hallazgos ecográficos, el valor diagnóstico de los leucocitos y de PCR y las comorbilidades activas. CONCLUSIÓN: la enfermedad inflamatoria pélvica debe considerarse un diagnóstico diferencial en cualquier paciente femenina en edad fértil con dolor abdominal; los parámetros paraclínicos básicos son una aproximación útil para determinar la necesidad de cirugía en pacientes con cuadro agudo.

Abstract OBJECTIVE: to describe the socio-demographic and clinical variables related to pelvic inflammatory disease cases of patients treated in the Hospital Universitario de Santander, Bucaramanga, Colombia and explore the relationship of these variables with the need for surgery. MATERIALS AND METHODS: retrospective study and analysis of medical records of patients treated between 2013 and 2014 in the "Hospital Universitario de Santander". Data analysis was performed with STATA 12.1. Evaluation between the need for surgery and other variables using the X2 test or the Mann-Whitney U test. RESULTS: 212 patients were included: 136 (64.2%) hospitalized, 35 (25.7%) required surgical intervention. For the hospitalized patients, the main regimen was clindamycin and gentamicin (55 de 136: 41.4%); the patients with ambulatory treatment received: metronidazole and doxycycline (21 de 76: 27.6%). The variables significantly associated with the need for surgery were: ultrasound findings, the diagnostic value of white blood cells and of PCR and active comorbidities. CONCLUSION: pelvic inflammatory disease should be considered a differential diagnosis in any reproductive age female patient with abdominal pain; basic paraclinical parameters are a useful approach to determine the need for surgery in patients who present an acute picture.

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OBJECTIVE: To determine the clinical characteristics that indicate the presence of tubo-ovarian abscess (TOA) among patients with severe pelvic inflammatory disease (PID). METHODS: An observational cohort study was performed from October 2011 to March 2013. The study included all patients with a diagnosis of TOA and PID admitted to a university hospital in Mexico. A complete medical history and physical examination were performed, and laboratory studies were reviewed. A logistic regression analysis was performed on variables with statistical significance. RESULTS: Overall, 26 patients with PID and TOA (TOA group) and 26 with PID without TOA (PID group) were included in the study. Significant differences between patients with TOA and PID were found with regard to the patients' age (39.3years vs 33.1years; P=0.04), educational level (only elementary, 13 [50%] vs 5 [19%]; P=0.14), presentation with fever (23 [88%] vs 16 [62%]; P=0.025), white blood cell count (21.8×10(9)/L vs 14.9×10(9)/L; P<0.001), number of deliveries (2.2 vs 1.1; P=0.01), and presence of diarrhea (16 [62%] vs 5 [19%]; P<0.001). The triad of fever, leukocytosis, and diarrhea was positively related to the presence of TOA. CONCLUSION: The triad of fever, leukocytosis, and diarrhea should alert clinicians to the possibility of TOA formation in patients with PID.

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