RESUMO
Three sisters, born from consanguineous parents, manifested a unique Müllerian anomaly characterized by uterine hypoplasia with thin estrogen-unresponsive endometrium and primary amenorrhea, but with spontaneous tubal pregnancies. Through whole-exome sequencing followed by comprehensive genetic analysis, a missense variant was identified in the OSR1 gene. We therefore investigated OSR1/OSR1 expression in postpubertal human uteri, and the prenatal and postnatal expression pattern of Osr1/Osr1 in murine developing Müllerian ducts (MDs) and endometrium, respectively. We then investigated whether Osr1 deletion would affect MD development, using WT and genetically engineered mice. Human uterine OSR1/OSR1 expression was found primarily in the endometrium. Mouse Osr1 was expressed prenatally in MDs and Wolffian ducts (WDs), from rostral to caudal segments, in E13.5 embryos. MDs and WDs were absent on the left side and MDs were rostrally truncated on the right side of E13.5 Osr1-/- embryos. Postnatally, Osr1 was expressed in mouse uteri throughout their lifespan, peaking at postnatal days 14 and 28. Osr1 protein was present primarily in uterine luminal and glandular epithelial cells and in the epithelial cells of mouse oviducts. Through this translational approach, we demonstrated that OSR1 in humans and mice is important for MD development and endometrial receptivity and may be implicated in uterine factor infertility.
Assuntos
Infertilidade , Ductos Paramesonéfricos , Animais , Feminino , Humanos , Camundongos , Gravidez , Endométrio , Células Epiteliais , Ductos Paramesonéfricos/metabolismo , ÚteroRESUMO
Resumen: Introducción: En todo el mundo, se realizan estudios para conocer la casuística de la morbimortalidad ginecoobstétrica, y México no es la excepción: en 2009, Briones reportó las cuatro principales alteraciones que condicionan a la mortalidad en la Unidad de Cuidados Intensivos Obstétricos; y en 2011, Guerrero realizó un estudio con 333 pacientes que hubieron ingresado a la Unidad de Cuidados Intensivos del Hospital General de México. Con base en lo anterior, nosotros establecimos la siguiente pregunta de investigación: ¿cuál será la casuística de las pacientes con complicaciones de ginecoobstetricia que ingresaron a la Unidad de Cuidados Intensivos del Hospital General de Matamoros, Tamaulipas, entre 2012 y 2018?. Material y métodos: Con los datos diarios de ingresos y egresos de la Unidad de Cuidados Intensivos, se capturó cada variable, analizando cada una de ellas, mediante la forma observacional, retrospectiva, transversal y bajo la técnica de análisis estadístico. Resultados: De los 2,497 registros (n = 227), 206 fueron obstétricos complicados; 55 adolescentes estuvieron embarazadas, predominando la eclampsia. De parte de ginecología, se registraron 21 pacientes. Conclusiones: La casuística es diferente a la publicada en México. Independientemente de esto, se requiere promover los programas de apoyo de la Secretaría de Salud, con la inclusión de instituciones universitarias para que participen los jóvenes y para que cursen programas académicos relacionados con la salud, como la de médico cirujano y enfermería general.
Abstract: Introduction: Progress in the diagnosis, prevention and casuistry of disorders in pregnancy has produced a significant decrease in maternal morbidity and mortality. Research that aims to understand the number of gyneco-obstetric morbidity cases is conducted in many countries, with Mexico not being the exception. In 2009, Briones reported the four major causes that condition morbidity-mortality in a obstetric Intensive Care Unit (ICU). In 2011, Guerrero conducted a study consisting of 333 patients admitted to the Intensive Care Unit of the General Hospital of Mexico. Therefore, we aim to answer the following question: what is the number of gyneco-obstetric complicated patients that were admitted to the ICU of the General Hospital in Matamoros, Tamaulipas, during the years of 2012 to 2018?. Material and methods: With the journal of income and expenditures of the ICU, each variable is captured; each of them is analyzed; through observational, retrospective and cross-sectional forms and under the statistical analysis technique. Results: Of the 2,497 cases (n = 227), 206 were complicated obstetrics; 55 cases were adolescent pregnancies; eclampsia prevailing. There were 21 gynecology patients. Conclusions: The casuistry differs to the one published in Mexico. Regardless, it is required to increase and promote programs that support the Ministry of Health, such as the inclusion of universities, and of young people who attend health-related academic programs, such as medical surgeon and nursing; and allow an approach to secondary, preparatory or general community, to address the issues of pregnancy and complications.
Resumo: Introduçao: No mundo são realizados estudos para determinar a casuística da morbimortalidade ginecobstétrica e o México não é exceção. Em 2009, Briones relatou as quatro principais alterações que determinam a mortalidade na terapia intensiva obstétrica. Em 2011, Guerrero realizou-se um estudo com 333 pacientes que ingressaram na Unidade de Terapia Intensiva do Hospital Geral do México. Diante do exposto, temos a questão de pesquisa: qual será a casuística de pacientes ginecoobstétricas e complicadas admitidas na UTI do Hospital Geral de Matamoros Tamaulipas nos anos de 2012 a 2018?. Material e métodos: Cada variável é capturada no diário de ingressos e egressos da UCI; analisando cada um deles; através da forma observacional, retrospectiva, transversal e sob a técnica de análise estatística. Resultados: Das 2,497 (n = 227), 206 eram obstetricas complicados; 55 adolescentes gestantes; predominando a eclampsia. De ginecologia foram 21 pacientes. Conclusões: A casuística é diferente da publicada no México. Independentemente, é necessário promover os programas de apoio à Secretaria de Saúde, com a inclusão de instituições universitárias; e que participem os jovens que frequentam programas acadêmicos relacionados à saúde, como cirurgião e/ou enfermagem Geral.
RESUMO
OBJETIVE: To describe the characteristics of the scientific production of midwives in Latin American obstetrics and gynecology journals indexed to Scopus during the period 2011 to 2016. METHODS: This paper reports a descriptive bibliometric study, with intentional non-probabilistic sampling. We analyzed articles of research papers published by midwives in medical specialty journals in obstetrics and gynecology of Latin America indexed to Scopus, in the 2011 to 2016 period. RESULTS: We found eight obstetrics and gynecology journals in Latin America indexed in Scopus. There were 1,696 articles published between 2011 and 2016, of which 4.9% were authored or co-authored by midwives. Of these publications, 93.8% were related to topics of the specialty, 62.5% had midwives as corresponding authors, 64.1% of papers were in Spanish, only 3.1% were published in English, and 57.8% of midwives worked in Chile at the time of publication. In 2016, there was one-fifth the number of publications compared to 2012. CONCLUSIONS: We found little scientific production by midwives in Latin American obstetrics and gynecology journals indexed in Scopus. Strategies that encourage and allow research and scientific production by midwives are needed.
OBJETIVO: Describir las características de la producción científica de matrones en revistas latinoamericanas de obstetricia y ginecología, indizadas a Scopus durante el periodo 2011 a 2016. MÉTODOS: Estudio bibliométrico descriptivo, con muestreo intencional no probabilístico. Se analizaron artículos de trabajos de investigación publicados por matrones en revistas de especialidad médica en obstetricia y ginecología de Latinoamérica indizadas a Scopus, en el periodo comprendido entre 2011 y 2016. RESULTADOS: Se encontraron ocho revistas de obstetricia y ginecología en Latinoamérica indizadas en Scopus. Se contabilizaron 1 696 artículos publicados entre 2011 y 2016, de los cuales 4,9% los matrones fueron autores o coautores. De ese subtotal, 93,8% publicó temas propios de la especialidad; 62,5% fueron autores corresponsales; 64,1% de las publicaciones fueron en español; solo 3,1% publicó en inglés y 57,8% de matrones trabajaban en Chile al momento de la publicación. En 2016 se publicaron cinco veces menos que en 2012. CONCLUSIÓN: Se halló escasa producción científica realizada por matrones en revistas latinoamericanas de obstetricia y ginecología indizadas en Scopus. Se sugiere emplear estrategias que incentiven y permitan la investigación y producción científica en los matrones.