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The SARS-CoV-2 pandemic has affected 771 million people and caused 6.9 million confirmed deaths as of November 2023. Beyond the adversity, a crucial and less-explored chapter unfolds: adaptive sequelae. These have altered social, mental, and emotional conditions, leaving an imprint on biological systems. While some cases fully resolve the pathological process post-acute infection, others persist with symptoms, posing a challenge that underscores the need to comprehend pathophysiology from innovative perspectives. The article delves into "Long COVID" or Post-Acute COVID-19 Syndrome (PACS), where symptoms persist for ≥4 weeks irrespective of initial severity. Risk factors include a history of severe illness, in-hospital management, and intensive care. This article also explores theories, derived from various experimental models, that have demonstrated the involvement of the nervous system in coordination with the psychoneuroimmunoendocrine axes in the expression of inflammation. It is posited that PACS involves processes of peripheral and central sensitization (corticalization), facilitating dishomeostasis and the chronicity of the inflammatory process. In this context, various therapeutic strategies grounded in modulating the inflammatory reflex are reviewed, primarily through the infiltration of local anesthetics via linear and non-linear approaches. Neural therapeutic use is considered to stimulate the regulatory inflammatory circuits coordinated by the neuroimmune-endocrine system.

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Background: It has been proposed that the immunomodulatory capacity of neuraltherapeutic medicine (NTM) functions by means of stimuli to the nervous system, which influences the self-regulatory and plastic capacity of the nervous system, especially through the autonomic balance between the sympathetic and parasympathetic nervous systems. Several studies report the usefulness of NTM in inflammatory pathologies. Case presentation: A case report through a retrospective review of the medical history of an 82-year-old male patient with a diagnosis of acute SARS-CoV-2 who received a therapeutic intervention of NTM at the beginning of his hospitalization and presented satisfactory clinical evolution, with a follow-up for 18 months without post-COVID sequelae. A patient diagnosed with acute pneumonia for SARS-CoV-2, and mild ARDS, with markers of severity given by the history of COPD, advanced age, and elevation of LDH, ferritin, and CRP. On the third day of hospitalization, he presented an episode of pulmonary thromboembolism. He presented significant clinical improvement with in-hospital management for 9 days and underwent out-patient control with no post-COVID sequelae. Conclusions: NTM could be useful for the management of acute inflammatory diseases, including viral diseases such as SARS-CoV-2, in a mild or severe state of inflammation, when added to allopathic medicine, and it can improve clinical evolution and long-term sequelae. More studies are needed to validate this information.

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BACKGROUND: Inflammatory and mechanical stimuli in tooth/jaw pathologies can have far-reaching consequences via trigeminal and autonomic circuitry and can cause systemic (e.g., autoimmune) diseases and pain conditions outside the tooth/jaw region. In addition to a case report, we also describe new pathophysiological findings. CASE REPORT: We report on a patient with chronic, therapy-resistant neck pain whose cause lied in the tooth/jaw region, specifically, in wisdom teeth with space problems, and partially impacted. The tooth/jaw area itself was not painful; however, neck pain developed via the nucleus spinalis n. trigemini which extends into the cervical medulla. Surgical restoration of the wisdom teeth and subsequent neural therapy treatment of the extraction scars provided permanent pain relief. CONCLUSION: In case of therapy-resistant neck pain (among others), it is worthwhile to look for pathologies in the dental/jaw area, possibly allowing for a causal therapy.

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ABSTRACT Introduction: Poor reaction time can cause irritability, easier distractions, and interfere with normal activities that require concentration. Objective: To study the impact of simulated hypoxic training on the immune system of female middle- and long-distance runners. Methods: Observation of 50 female middle- and long-distance runners living high and training low (HiHiLo) in regard to changes in CD3+, CD4+, CD8+, NK cells and NKT cells during the process of living low and training high (LoHi). Research indicates: HiHiLo training does have a significant effect on these indicators to enhance the antioxidant capacity of the brain and nervous system. Results: Living high and training low (HiHiLo) can improve the excitability of the nervous system of long-distance endurance athletes and has a very significant impact on the stability of the nervous system. This improves cardiopulmonary function under hypoxic conditions and has a role in promoting the ability to mobilize the skeletal muscles. Conclusions: It has been proved that different forms of exercise can effectively improve the athlete's nervous response. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução: Um tempo de reação precário pode levar a irritabilidade, falta de concentração, e interferir em atividades diárias que exigem raciocínio. Objetivo: Estudar o impacto de treinamento hipóxico simulado no sistema imune de corredoras de média e longa distância. Métodos: Observação de 50 corredoras de média e longa distância que vivem em elevadas altitudes e treinam em baixas altitudes (HiHiLo) quanto a mudanças em CD3+, CD4+, CD8+, células NK e NKT, durante o processo de viver em regiões de baixa altitude e treinar em regiões de alta atitude (LoHi). A pesquisa indica que o treino HiHiLo tem um efeito significativo nesses indicadores no que diz respeito ao aumento da capacidade antioxidante do cérebro e do sistema nervoso. Resultados: O treino HiHiLo pode aumentar a excitação do sistema nervoso de atletas de resistência e longa distância, e tem um impacto muito significativo na estabilidade do sistema nervoso. Isso traz melhorias à função cardiopulmonar em condições de hipóxia e age de modo a promover a habilidade de movimentar os músculos esqueléticos. Conclusões: Foi provado que diferentes tipos de exercício podem efetivamente aprimorar a resposta nervosa de atletas. Nível de evidência II; Estudos terapêuticos - investigação de resultados de tratamento.

RESUMEN Introducción: Un tiempo de reacción precario puede causar irritabilidad, falta de concentración e interferir en actividades diarias que exigen raciocinio. Objetivo: Estudiar el impacto de entrenamiento hipóxico simulado en el sistema inmune de corredores de media y larga distancia. Métodos: Observación de 50 corredores de media y larga distancia que viven en altitudes elevadas y entrenan en altitudes bajas (HiHiLo) en relación con los cambios en las células CD3+, CD4+, CD8+, NK y NKT durante el proceso de vivir en regiones de baja altitud y entrenar en regiones de alta actitud (LoHi). La investigación indica que el entrenamiento HiHiLo tiene un efecto significativo sobre estos indicadores en lo que respecta al aumento de la capacidad antioxidante del cerebro y del sistema nervioso. Resultados: El entrenamiento HiHiLo puede aumentar la excitación del sistema nervioso de atletas de resistencia y larga distancia y tiene un impacto significativo en la estabilidad del sistema nervioso. Esto aporta mejorías en la función cardiopulmonar en condiciones de hipoxia y actúa favoreciendo en la capacidad de movimiento de los músculos esqueléticos. Conclusiones: Fue probado que diferentes tipos de ejercicio pueden efectivamente mejorar la respuesta nerviosa de atletas. Nivel de evidencia II; Estudios terapéuticos - investigación de resultados de tratamiento.

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Introducción: La efectividad de las terapias alternativas para el tratamiento de la parálisis de Bell es aún controvertida. Objetivo: Reportar la experiencia en el tratamiento de la PB mediante la administración conjunta de acupuntura y terapia neural. Métodos: Se recopiló información de 30 pacientes con parálisis de Bell, quienes recibieron una sesión semanal de acupuntura y terapia neural de manera conjunta y fueron evaluados mediante la escala House-Brackmann durante 12 semanas. Resultados: El 80 por ciento (24) de los pacientes continuaron el tratamiento hasta la semana 12 y al término de la misma ninguno alcanzó función motora normal. Apenas 6 (25 por ciento) pacientes mostraron signos de recuperación entre las semanas 6 y 12. Así, el porcentaje de pacientes con grado IV se redujo de 6 (20 por ciento) durante la evaluación inicial a 3 (12 por ciento) durante la semana 9 (p = 0,001) y el de pacientes con grado III de 12 (50 por ciento) durante la semana 9 a 9 (38 por ciento) durante la semana 12 (p = 0,663). Se evidenciaron efectos adversos en 9 (32 por ciento) pacientes, lo que incluyó hematoma en el sito de puntura y síncope, que se resolvieron sin complicaciones. Conclusiones: La administración conjunta de acupuntura y terapia neural durante al menos 6 semanas tuvo efectos modestos sobre la recuperación de pacientes con parálisis de Bell sin producir efectos adversos mayores(AU)

Introduction: The effectiveness of alternative therapies for treating Bell's palsy is still controversial. Objective: To report the experience in the treatment of Bell's palsy through joint administration of acupuncture and neural therapy. Methods: Information was collected from 30 patients with Bell's palsy, who received a weekly session of acupuncture and neural therapy jointly and were assessed using the House-Brackmann scale for 12 weeks. Results: 80 percent (24) of the patients continued treatment until week 12 and, at the end of the week, none reached normal motor function. Only 6 patients (25 percent) showed signs of recovery between weeks 6 and 12. Thus, the percentage of patients with grade IV decreased from 6 (20 percent), during the initial evaluation, to 3 (12 percent), during week 9 (p<0.001); while the percentage of patients with grade III decreased from 12 (50 percent), during week 9, to 9 (38 percent), during week 12 (p=0.663). Adverse effects were evidenced in 9 (32 percent) patients, including hematoma at the puncture site and syncope, which was solved without complications. Conclusions: Joint administration of acupuncture and neural therapy for at least six weeks had modest effects on the recovery of patients with Bell's palsy, without producing major adverse effects(AU)

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ABSTRACT Introduction: Acute stress disorder is a picture of rapid onset that follows a traumatic event. It is characterized by dissociative, intrusive, avoidance and activation symptoms that affect the quality of life of the patient. To date, there is no evidence of a relationship between altered organ function and this disorder, and there is no literature on its treatment with neural therapy on an inpatient basis. Case presentation: 53-year-old woman, who developed symptoms compatible with acute stress disorder after the resection of an intra-abdominal mass diagnosed as lymphoma. The patient was assessed by the neural therapy department, which applied procaine into specific skin zones -determined by the clinical history and physical examination-, with improvement of dissociated symptoms. Discussion: The neural therapy approach allowed identifying the relationship between the dissociative symptoms of the patient and the associated alteration in organ function, as well as applying a therapy that led to the resolution of the symptoms. Conclusions: The neural therapy approach allows for a comprehensive perspective and treatment of the patient, taking into account the close functional relationship between mind-emotions-body. This type of treatment also offers therapeutic strategies to hospitals, which can accompany the treatment established by other health specialists.

RESUMEN Introducción. El trastorno por estrés agudo es un cuadro de rápida instauración que se da luego de un evento traumático y se caracteriza por síntomas disociativos, intrusivos, de evitación y de activación que afectan la calidad de vida del paciente. A la fecha, no se ha evidenciado una relación causal orgánica de este trastorno y tampoco existe literatura sobre su intervención mediante terapia neural intrahospitalaria. Presentación del caso. Paciente femenino de 53 años quien desarrolló síntomas compatibles con un trastorno por estrés agudo posterior a la resección de una masa abdominal secundaria a un linfoma. La mujer fue valorada por el servicio de medicina neuralterapéutica, que intervino con procaína en sitios específicos de la piel -determinados por anamnesis y examen físico- con posterior mejoría de los síntomas disociativos. Discusión. El enfoque neuralterapeútico permitió, por un lado, identificar un vínculo entre los síntomas disociativos de la paciente y la alteración orgánica asociada, y, por el otro, hacer una intervención con la que se logró la resolución de tales síntomas. Conclusiones. La medicina neuralterapéutica ofrece estrategias de intervención a nivel hospitalario que pueden ir concomitantes al tratamiento instaurado por otras profesiones en el área de la salud ya que permite tener una perspectiva integral del paciente al considerar la estrecha relación funcional entre mente, emociones y cuerpo.

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La presente investigación tuvo como objetivo general evaluar el efecto de la terapia neural e infiltración paravertebral segmentaria con ozono en el dolor lumbar somático de los pacientes que asistieron a la consulta de terapia del dolor en el Hospital Dr. Pedro García Clara, Ciudad Ojeda Estado Zulia-Venezuela, en el periodo comprendido del 01 de abril al 31 de mayo del 2016. Fue un estudio prospectivo, explicativo-comparativo y el diseño fue cuasi-experimental. Se seleccionaron 60 pacientes de ambos sexos entre edades comprendidas de 18 a 60 años, se dividieron en dos grupos de 30 pacientes, al primer grupo denominado A, se le realizó terapia neural segmentaria lumbar utilizando procaína al 1% y consecutivamente se le aplicó infiltración paravertebral con ozono a una concentración de 15ug; y al grupo B, se le realizó terapia neural con lidocaína al 1% y posteriormente se le aplicó la infiltración paravertebral con ozono a una concentración de 15ug, ambos grupos con un volumen de 10mL. Para el análisis de los datos se utilizó estadística descriptiva e inferencial, específicamente la prueba t de Student para las muestras relacionadas. Resultados: indicaron que en ambas terapias, al evaluar el dolor con la escala visual análoga, se encontraron diferencias estadísticamente significativas (p<0,05), en ambos grupos. Conclusiones: no hubo diferencias estadísticamente significativas con respecto a los cambios hemodinámicos y la disminución del dolor fue significativa en ambos grupos, pero más notable en el grupo A(AU)

The present study was aimed at evaluating the overall effect of neural therapy and segmental paravertebral ozone infiltration in lumbar somatic pain patients attending the consultation of pain therapy Dr. Pedro Garcia Clara Hospital of Ciudad Ojeda Estado Zulia-Venezuela, in the period from 01 April to 31 May 2016. It was a comparative-explanatory, prospective study design was quasi-experimental, 60 patients of either sex between aged from 18 to 60 years were selected, they were divided into two groups of 30 patients, the first group called A, underwent neural therapy lumbar segmental using procaine 1% and consecutively was applied paravertebral infiltration with ozone at a concentration of 15ug; and group B, underwent neural therapy with lidocaine 1% and was subsequently applied the paravertebral infiltration with ozone at a concentration of 15ug, both groups with a volume of 10mL. For data analysis the mean, standard deviation, and inferential statistics, specifically the Student t test for related samples was used. Results: indicated that both therapies, to assess pain with visual analogue scale, statistically significant differences (p<0.05) in both groups. Conclusions: There were no statistically significant differences with respect to hemodynamic changes and pain reduction was significant in both groups, but more remarkable in group A(AU)

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Se describe el caso clínico de una paciente con gingivitis descamativa crónica, atendida en el Departamento de Periodoncia de la Clínica Estomatológica Provincial Docente "Mártires del Moncada" de Santiago de Cuba, en quien el tratamiento convencional no proporcionó resultados favorables, por lo cual se recurrió a la combinación de las terapias neural, acupuntural y periodontal y la aplicación de hipnosis, cuya combinación solucionó tan grave proceso inflamatorio, además de elevar la autoestima y la calidad de vida de la afecta.

The case report of a patient with chronic desquamative gingivitis, assisted in the Department of Periodontics of "Martires del Moncada" Teaching Provincial Stomatological Clinical in Santiago de Cuba is described, in whom the conventional treatment provided no favourable results, reason why it was decided to combine the neural, acupunctural and periodontal therapies and the hypnosis which combined could solved such a serious inflammatory process, besides raising the self-esteem and the life quality of the one affected patient.

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Introducción: La terapia neural es un tipo de medicina alternativa de origen relativamente reciente, por lo cual constituye un sistema médico complejo en construcción. Hasta el momento, no se ha realizado una síntesis conceptual que permita formular los principios teóricos que sustentan su corpus doctrinario como sistema médico complejo. Objetivo: Formular los principios teóricos que sustentan el corpus doctrinario de la terapia neural. Metodología: Se revisó la literatura de la escuela neurofisiológica inglesa, la escuela rusa pavloviana, además de trabajos de investigación en el área de terapia neural, para poder realizar la formulación de los principios con un carácter general y de este modo sustentarlos en premisas que de preferencia cumplieran con las características de inducción cualitativa, las cuales desde la lógica peirceana confieren un alto grado de veracidad y rigurosidad lógico-científica. Resultados: Se realizó una síntesis lógica de las inferencias, de las que se obtuvieron 7 enunciados con el estatuto final de principio. Conclusiones: La descripción de los principios realizada en este trabajo es un aporte para la construcción del corpus doctrinario de la terapia neural como sistema médico complejo. Salud UIS 2012; 44 (2):57-65.

Introduction: Neural therapy is a type of alternative medicine of relatively recent origin, so is a complex medical system under construction. So far, it has not made a conceptual synthesis that allows formulating the theoretical principles underpinning its doctrinal corpus as complex medical system. Objective: To develop the theoretical principles that underlines the doctrinal corpus of neural therapy. Methodology: Literature review neurophysiological school English Russian Pavlovian school, in addition to research in the area of neural therapy, in order to make the formulation of a general principles and thus sustain them in premises of preference comply with the qualitative characteristics of induction, which from Peircean logic confer a high degree of accuracy and logical-scientific rigor. Results: We performed a synthesis of logical inferences, of which 7 were obtained with the final status statements of principle. Conclusions: The description of the principles carried out in this work is a contribution to the construction of the doctrinal corpus of neural therapy as complex medical system. Salud UIS 2012; 44 (2):57-65.

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