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Background: The prevalence of intracranial neoplasms in dogs represents 2.1 to 4.0% of the cases. Brain tumors may beprimary or metastatic. The objective of this study was to describe two cases of intra encephalic neoplasia in elderly dogsreceived for necropsy by the Veterinary Oncology Service in the Federal University of Pelotas.Cases: Case 1: A 12-year-old female canine, without breed and medium size, was received for necropsy. The animal hashad behavioral changes. Macroscopic examination of the encephalus revealed asymmetry and congestion. The organs werecollected and fixed in 10% formalin. In the brain cleavage we noticed an extensive brown-gray mass with reddish areas,expansive, moderately demarcated, soft to cut and discrete hydrocephalus. Serial fragments of the brain and fragmentsof the organs were sent for processing. The slides were stained with the hematoxylin and eosin technique for histopathological analysis. At the microscopic examination, cuboidal cells were observed in the encephalus sometimes in acinar arrangements, of extensive and very limited pattern, diagnosed as ependymoma. Case 2: It is a 15-year-old, female Poodledog, with several tumors. During necropsy multiple subcutaneous nodules, mesentery, intestinal serosa, stomach and liverwere noticed. At the cut these were firm and whitish. No macroscopic changes were observed in the other organs. Fragments of organs and brain were collected and a serial section of the encephalus was performed for further processing andhistological analysis. In the histopathological analysis the masses were constituted by proliferation of sometimes roundedcells, elongated, with rounded nuclei and eosinophilic cytoplasm, allowing the diagnosis of mesothelioma. The samecell pattern was observed in other organs. In the frontal cortex of the encephalus there were small foci of cells similar tothose observed in the mesentery, as well as metastatic...(AU)

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ABSTRACT A patient had both ovaries affected by clearly demarcated colliding tumour masses of different gross appearance, histological features and immunohistochemical profiles, corresponding to bilateral collision papillary serous high-grade adenocarcinoma and fibrothecoma. Despite the applied chemotherapy, it led to a lethal outcome for the patient nearly a year after the surgery. Bilateral ovarian tumours raise the question of whether they are primary tumours or metastases. Simultaneous bilateral occurrence of surface epithelial tumours with other types of ovarian tumours is rare. Therefore, it poses a great challenge in proper differential diagnostics.

RESUMEN Una paciente tenía ambos ovarios afectados por masas tumorales en colisión, claramente demarcadas. Las mismas mostraban diferente aspecto macroscópico, y diferentes rasgos histológicos y perfiles inmunohistoquímicos, correspondientes a fibrotecomas y adenocarcinomas serosos papilares bilaterales de alto grado en colisión. A pesar de la quimioterapia aplicada, la condición condujo a un resultado fatal para la paciente, casi un año después de realizada la cirugía. Los tumores ováricos bilaterales plantean la cuestión de si se trata de tumores primarios o metástasis. La ocurrencia bilateral simultánea de tumores epiteliales superficiales con otros tipos de tumores ováricos es rara, y por tanto, plantea un gran desafío a la hora de realizar un diagnóstico diferencial adecuado.

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Background: The prevalence of intracranial neoplasms in dogs represents 2.1 to 4.0% of the cases. Brain tumors may beprimary or metastatic. The objective of this study was to describe two cases of intra encephalic neoplasia in elderly dogsreceived for necropsy by the Veterinary Oncology Service in the Federal University of Pelotas.Cases: Case 1: A 12-year-old female canine, without breed and medium size, was received for necropsy. The animal hashad behavioral changes. Macroscopic examination of the encephalus revealed asymmetry and congestion. The organs werecollected and fixed in 10% formalin. In the brain cleavage we noticed an extensive brown-gray mass with reddish areas,expansive, moderately demarcated, soft to cut and discrete hydrocephalus. Serial fragments of the brain and fragmentsof the organs were sent for processing. The slides were stained with the hematoxylin and eosin technique for histopathological analysis. At the microscopic examination, cuboidal cells were observed in the encephalus sometimes in acinar arrangements, of extensive and very limited pattern, diagnosed as ependymoma. Case 2: It is a 15-year-old, female Poodledog, with several tumors. During necropsy multiple subcutaneous nodules, mesentery, intestinal serosa, stomach and liverwere noticed. At the cut these were firm and whitish. No macroscopic changes were observed in the other organs. Fragments of organs and brain were collected and a serial section of the encephalus was performed for further processing andhistological analysis. In the histopathological analysis the masses were constituted by proliferation of sometimes roundedcells, elongated, with rounded nuclei and eosinophilic cytoplasm, allowing the diagnosis of mesothelioma. The samecell pattern was observed in other organs. In the frontal cortex of the encephalus there were small foci of cells similar tothose observed in the mesentery, as well as metastatic...

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Introducción: el cáncer en Cuba se considera un problema de salud nacional por ocupar la segunda causa de muerte del país, y el objetivo primordial de nuestro sistema de salud es prolongar en cantidad y calidad la vida del hombre. Objetivo: valorar el comportamiento de los tumores malignos y la calidad de los diagnósticos pre mortem. Método: se realizó un estudio en necropsias realizadas de forma consecutiva en el Hospital General Docente "Dr. Agostinho Neto" de Guantánamo en el período comprendido desde el último trimestre de 1993 hasta diciembre de 1999. De un total de 5359 necropsias, en 926 se diagnosticaron tumores malignos como causa básica de muerte, lo que constituyó nuestro universo de estudio. Se utilizaron los criterios de la OMS para causas de muerte, se analizaron las causas básica y directa de muerte, seleccionadas sobre la base de una correlación clínico-patológica, incluyendo, algún trastorno funcional o alteración bioquímica como causa directa de muerte. Resultados: entre los diez primeros sitios de origen, el pulmón ocupó el primer lugar, con la cuarta parte de los casos, y la próstata como segunda causa de enfermar y morir por cáncer. Como causa básica de muerte el tumor maligno representa el 89,8 por ciento, mientras que la bronconeumonía, el tromboembolismo pulmonar y el estadio terminal representaron más de la mitad de los fallecidos, en lo que la bronconeumonía, por sí sola, afecto a más de la tercera parte. Se observó un elevado porcentaje de discrepancias diagnósticas al evaluar cada caso individualmente. Conclusiones: el grupo de edades con más afectados fue el de 65-74 años, con predominio del sexo masculino. Los tumores malignos de mayor incidencia fueron los de pulmón, próstata y cuello uterino. La bronconeumonía fue la causa directa de muerte más frecuente. Existió menor porcentaje de discrepancia diagnóstica clínico-patológica para la causa básica de muerte, no así para la causa directa de muerte(AU)

Introduction: cancer in Cuba is considered a national health problem because it occupies the second cause of death in the country, and the primary objective of our health system is to prolong the quantity and quality of human life. Objective: to assess the behavior of malignant tumors and the quality of pre-mortem diagnoses. Method: a study was carried out in necropsies performed consecutively in the Teaching General Hospital "Dr. Agostinho Neto "from Guantánamo, in the period from the last quarter of 1993 to December 1999. Of a total of 5359 necropsies, in 926 malignant tumors were diagnosed as the basic cause of death, which constituted our universe of study. The WHO criteria for causes of death were used, the basic and direct causes of death were analyzed, selected on the basis of a clinical-pathological correlation, including, some functional disorder or biochemical alteration as a direct cause of death. Results: among the first ten sites of origin, the lung occupied the first place, with a quarter of the cases, and the prostate as the second cause of getting sick and dying from cancer. As a basic cause of death, the malignant tumor represents 89.8 percent, while bronchopneumonia, pulmonary thromboembolism and terminal stage represented more than half of the deceased, in which bronchopneumonia, by itself, affected more than the third part. A high percentage of diagnostic discrepancies was observed when evaluating each case individually. Conclusions: the most affected age group was 65-74 years old, with a predominance of males. The malignant tumors with the highest incidence were those of the lung, prostate and cervix. Bronchopneumonia was the most frequent direct cause of death. There was a lower percentage of clinical-pathological diagnostic discrepancy for the basic cause of death, but not for the direct cause of death(AU)

Introdução: o câncer em Cuba é considerado um problema nacional de saúde porque ocupa a segunda causa de morte no país, e o objetivo primordial de nosso sistema de saúde é prolongar a quantidade e a qualidade da vida humana. Objetivo: avaliar o comportamento dos tumores malignos e a qualidade dos diagnósticos pre-mortem. Método: foi realizado um estudo em necropsias realizadas consecutivamente no Hospital Geral de Ensino "Dr. Agostinho Neto "Guantánamo, no período desde o último trimestre de 1993 até dezembro de 1999. De um total de 5359 necropsias, 926 malignidades como causa básica de morte foram diagnosticados, o que constituiu o nosso universo de estudo. Que foram usados para critérios causas de morte, causas básicas, directos de morte, seleccionados com base numa correlação clínico-patológico, incluindo qualquer desordem funcional ou alteração bioquímica como uma causa directa da morte analisados. Resultados: entre os primeiros dez locais de origem, o pulmão ocupou o primeiro lugar, com um quarto dos casos, e a próstata como a segunda causa de adoecer e morrer de câncer. Subjacente a causa da morte como tumor maligno respondendo por 89,8 por cento, enquanto broncopneumonia, embolia pulmonar e terminais representaram mais de metade dos mortos no que broncopneumonia, sozinho, afetou mais a terceira parte. Uma alta porcentagem de discrepâncias diagnósticas foi observada ao avaliar cada caso individualmente. Conclusões: a faixa etária mais acometida foi de 65 a 74 anos, com predomínio do sexo masculino. Os tumores malignos com maior incidência foram os do pulmão, próstata e colo do útero. A broncopneumonia foi a causa direta mais frequente de morte. Houve uma menor porcentagem de discrepância diagnóstica clínico-patológica para a causa básica da morte, mas não para a causa direta da norte(AU)

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