RESUMO
AIMS: This study aims to evaluate whether there is a difference between the effects of vildagliptin and gliclazide MR (modified release) on glycemic variability (GV) in women with type 2 diabetes (T2DM) as evaluated by continuous glucose monitoring (CGM). METHODS: An open-label, randomized study was conducted in T2DM women on steady-dose metformin monotherapy which were treated with 50â¯mg vildagliptin twice daily or 60-120â¯mg of gliclazide MR once daily. CGM and GV indices calculation were performed at baseline and after 24â¯weeks. RESULTS: In total, 42 patients (age: 61.9⯱â¯5.9â¯years, baseline glycated hemoglobin (HbA1c): 7.3⯱â¯0.56) were selected and 37 completed the 24-week protocol. Vildagliptin and gliclazide MR reduced GV, as measured by the mean amplitude of glycemic excursions (MAGE, pâ¯=â¯0.007 and 0.034, respectively). The difference between the groups did not reach statistical significance. Vildagliptin also significantly decreased the standard deviation of the mean glucose (SD) and the mean of the daily differences (MODD) (pâ¯=â¯0.007 and 0.030). CONCLUSIONS: Vildagliptin and gliclazide MR similarly reduced the MAGE in women with T2DM after 24â¯weeks of treatment. Further studies are required to attest differences between vildagliptin and gliclazide MR regarding glycemic variability.