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OBJECTIVE: To explore the relationship between sociodemographic, clinical, and neurophysiological variables and health-related quality of life (HR-QOL) of patients with phantom limb pain. METHODS: This is a cross-sectional analysis of a previous clinical trial. Univariate and multivariate linear and logistic regression analyses were used to model the predictors of HR-QOL. We utilized a sequential modeling approach with increasing adjustment levels, controlling for age and sex, and other relevant clinical variables (time since amputation, level of amputation, and pain). HR-QOL was assessed by the SF-36 Health Survey and its eight subdomains. RESULTS: We analyzed baseline data from 92 patients with lower-limb amputations. They were mostly male (63%), 45.2 ± 15.6 years, with a mean time since amputation of 82.7 ± 122.4 months, and an overall SF-36 score of 55.9 ± 21.5. We found an association between intracortical facilitation in the affected hemisphere (ICF), gabapentin usage, and HR-QOL. ICF is a predictor of better HRQOL, whereas gabapentin usage was associated with a poorer HR-QOL, with the main model explaining 13.4% of the variance in the outcome. For the SF-36 subdomains, ICF was also a positive predictor for social functioning, bodily pain, and vitality, while medication usage was associated with lower scores in mental health, general health perception, bodily pain, and vitality. CONCLUSION: We found firsthand two new independent predictors of HR-QOL in individuals with PLP, namely, the neurophysiological metric ICF and gabapentin usage. These results highlight the role of the motor cortex excitability in the HR-QOL and stress the need for treatments that favor the neuroplastic adaptation after amputation, for which ICF may be used as a possible marker.
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BACKGROUND: Critical limb ischemia represents an advanced stage of peripheral arterial disease. Angioplasty improves blood flow to the limb; however, some patients progress irreversibly to lower limb amputation. Few studies have explored the predictive potential of biomarkers during postangioplasty outcomes. AIM: To evaluate the behavior of endothelial progenitor cells in patients with critical limb ischemia, in relation to their postangioplasty outcome. METHODS: Twenty patients with critical limb ischemia, candidates for angioplasty, were enrolled. Flow-mediated dilation, as well as endothelial progenitor cells (subpopulations CD45+/CD34+/CD133+/CD184+ and CD45+/CD/34+/KDR[VEGFR-2]+ estimated by flow cytometry) from blood flow close to vascular damage, were evaluated before and after angioplasty. Association with lower limb amputation during a 30-day follow-up was analyzed. RESULTS: Endothelial progenitor cells were related with flow-mediated dilation. A higher number of baseline EPCs CD45+CD34+KDR+, as well as an impaired reactivity of endothelial progenitor cells CD45+CD34+CD133+CD184+ after angioplasty, were observed in cases further undergoing major limb amputation, with a significant discrimination ability and risk (0.75, specificity 0.83 and RR 4.5 p < 0.05). CONCLUSIONS: Endothelial progenitor cells were related with endothelial dysfunction, whereas a higher baseline number of the subpopulation CD45+CD34+KDR+, as well as an impaired reactivity of subpopulation CD45+CD34+CD133+CD184+ after angioplasty, showed a predictive ability for major limb amputation in patients with critical limb ischemia.
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Células Progenitoras Endoteliais , Humanos , Isquemia Crônica Crítica de Membro , Antígenos CD34 , Angioplastia , Amputação CirúrgicaRESUMO
Background and Aim: Knowledge translation processes are necessary for improving patients' and communities' health outcomes. The aim of this study was to systematically develop evidence-based recommendations for people over 16 years of age who are in risk for or have suffered a lower limb amputation for medical reasons (vascular, diabetes mellitus) or trauma (civilian or military trauma) in order to improve function, quality of life, decrease complications and morbidity. Methods: Following the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach we developed a Clinical Practice Guideline (CPG) for lower limb amputees with funding from the Ministry of Health in Colombia and participation of a multidisciplinary group. We included patients' preferences. Based on the scope, purposes and objectives the questions were elaborated with the PECOT strategy. The evidence search was performed for each question in the main databases: Cochrane Library, Embase and PubMed, without time limit or language restriction. Teams were formed with thematic experts and clinical epidemiologists to review the clinical studies, describe the evidence, and evaluate the quality of the body of evidence with the GRADE methodology. The recommendations were made according to the judgments proposed by the GRADE working group. We conducted a stakeholder's dialogue as a mechanism for the external validation of the guideline implementation. Results: The CPG included 43 recommendations related to the diagnosis, surgical treatment, rehabilitation, prescription and adaptation of the prosthesis. They were strong in favor 37.2, weak in favor 53.5, strong against 2.3, Weak against 7.0%. Quality of evidence was high in 0, moderate in 11.6, low in 58.1, and very low 30.2%. Discussion: In 93% of the recommendations, the quality of the evidence was between low and very low. This is why it was so important to validate and discuss each recommendation with an expanded multidisciplinary group. The research group identified 25 interventions and five milestones to be prioritized in the implementation and in the stakeholder's dialogue participants identified opportunities and barriers for implementation of recommendations. Conclusion: It is necessary to develop a national policy for implementation strategies of CPG recommendations that promotes the necessary arrangements for the provision of services for diagnosis, treatment, and rehabilitation of individuals with amputations.
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Peripheral arterial disease is atherosclerotic occlusive disease of the lower extremity arteries and afflicts hundreds of millions of individuals worldwide. Its most severe manifestation is chronic limb-threatening ischemia (Petersen et al. (Science 300(5622):1140-2, 2003)), which is associated with severe pain at rest in the limbs, which progresses to necrosis, limb amputation, and/or death of the patient. Consequently, the care of these patients is considered a financial burden for both patients and health systems. Multidisciplinary endeavors are required to address this refractory disease and to find definitive solutions that lead to improved living conditions. Revascularization is the cornerstone of therapy for preventing limb amputation, and both open vascular surgery and endovascular therapy play a key role in the treatment of patients with CLI. Around one-third of these patients are not candidates for conventional surgical treatment, however, leading to higher amputation rates (approaching 20-25% at one year) with high morbidity and lower quality of life. Advances in regenerative medicine have enabled the development of cell-based therapies that promote the formation of new blood vessels. Particularly, mesenchymal stem cells (MSCs) have emerged as an attractive therapeutic agent in various diseases, including CLI, due to their role in tissue regeneration and immunomodulation. This review discusses the characteristics of MSCs, as well as their regenerative properties and their action mechanisms on CLI.
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Salvamento de Membro , Células-Tronco Mesenquimais , Isquemia Crônica Crítica de Membro , Humanos , Isquemia/terapia , Extremidade Inferior/irrigação sanguínea , Extremidade Inferior/cirurgia , Qualidade de Vida , Fatores de Risco , Resultado do TratamentoRESUMO
Resumen Objetivo: Presentar el estudio mediante el cual se construyó una ruta integral de atención en salud (RIAS) para la atención del paciente amputado de miembro inferior por causas traumática, vascular o diabetes mellitus, cuyo fin es implementar las recomendaciones de la Guía de práctica clínica del paciente amputado y garantizar la atención integral en salud de esta población en Colombia. Con la ruta se pretende orientar a los actores involucrados en la ejecución de intervenciones individuales para el diagnóstico, el tratamiento y la rehabilitación, e impactar en los desenlaces en salud y equidad de esta población. Metodología: Este estudio responde a una estrategia de mejoramiento de la atención en salud. Para esto, se revisó el Manual metodológico para la elaboración e implementación de las RIAS; se creó el grupo desarrollador de la ruta; se priorizaron y describieron las intervenciones en función del proceso continuo de atención en salud; se evaluó la práctica asistencial actual con grupos focales de pacientes y profesionales; se formularon los resultados esperados en el proceso de gestión y atención en salud (hitos), y se elaboró el diagrama de la ruta. Resultados: A partir de la Guía de práctica clínica se elaboraron 25 intervenciones individuales priorizadas y caracterizadas según el actor responsable, la población objetivo y el entorno. Para cada una de las intervenciones se presentan resultados esperados en salud, calidad de prestación de servicios, aspectos relacionados con la equidad, y la perspectiva de pacientes y actores involucrados con la atención. Se construyeron los indicadores para el seguimiento e implementación de la ruta. Conclusión: Se construyó la primera ruta integral de atención en salud del paciente con amputación de miembro inferior, de acuerdo con los lineamientos del manual del Ministerio de Salud y de la Protección Social.
Abstract Objective: Build an Integral Health Care Pathway for the care of patients with lower limb amputation due to traumatic, vascular or diabetes mellitus causes, in order to implement the recommendations of the cpg for amputee patients and guarantee comprehensive health care for this population in Colombia. Methodology: This study is a strategy to improve health care. Carried out by a review of the Methodological Manual for the Development and Implementation of Comprehensive Health Care Pathway, then the development group was created. A process of prioritization and description of required individual interventions was developed based on health care. Evaluation of current care practice with focus groups, formulation of milestones and development of the intervention diagram. Results: 25 individual interventions were prioritized and characterized according to the responsible actor, target population and environment. Expected results in health, quality of service delivery, issues related to equity, as well as the perspective of patients and actors involved with care are shown. Indicators were built for monitoring and implementation of the pathway. Conclusion: With the previous results, the first Integral Health Care Pathway for the Lower Limb Amputee Patient was developed. It intends to guide the actors involved, when executing individual interventions for the diagnosis, treatment and rehabilitation, to impact outcomes in health and equity of this group .
Resumo Objetivo: Construir uma Rota de Atenção Integral à Saúde do Paciente Amputado do Membro Inferior por causas traumáticas, vasculares ou diabetes mellitus, com a finalização de implementar as recomendações do gpc do paciente amputado e garantir a atenção integral na saúde desta población em Colômbia. Metodologia: Este estudo responde a uma estratégia para melhorar os cuidados de saúde. Foi realizada uma revisão do Manual Metodológico para o Desenvolvimento e Implementação de Rotas Integrais de Atenção à Saúde, criação do grupo de desenvolvimento da rota. Um processo de priorização e descrição das intervenções individuais necessárias foi desenvolvido com base na continuidade dos cuidados de saúde. Avaliação da prática assistencial atual com grupos focais, formulação de marcos e desenvolvimento do diagrama de intervenção. Resultados: 25 intervenções individuais foram priorizadas e caracterizadas de acordo com o ator responsável, população-alvo e ambiente. Determinação dos resultados esperados em saúde, qualidade da prestação de serviços, questões relacionadas a equidade, bem como a perspectiva de pacientes e atores envolvidos no atendimento. Foram construídos indicadores para o monitoramento e implementação da rota. Conclusão: Com os resultados anteriores, foi construída a primeira Rota de Atenção Integral à Saúde do paciente com amputação de membros inferiores por causas traumáticas e neurovasculares, com sua implementação, visando orientar os atores envolvidos na execução de intervenções individuais para a diagnóstico, tratamento e reabilitação, impactar os resultados em saúde e eqüidade dessa população.
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OBJECTIVE: The purpose of this investigation was to assess participants' self-reported satisfaction with an adjustable, immediate fit transtibial prosthetic system as compared to their conventionally fabricated prosthetic device. DESIGN: A prospective study involving a two-week single-group pre-post intervention design. SETTING: Physical medicine and rehabilitation clinic of a university hospital. PARTICIPANTS: Adults (N=27) with transtibial limb loss. INTERVENTION: Participants were fit with the iFIT prosthetic system and instructed to wear it for a two-week evaluation period. MAIN OUTCOME MEASURE: A modified PEQ scale was completed on the participant's conventional prosthetic during the initial visit and the iFIT system after the two weeks. RESULTS: Twenty-seven persons with lower limb loss were enrolled. Three were lost to follow up leaving twenty-four subjects with completed data. Three subjects had recent amputations with no conventional device for comparison. The Modified PEQ scores were significantly higher for the iFIT prosthetic in comparison to their conventional device (29.18 [SD= 4.63] vs 23.82 [SD=6.38], p <0.01). Subjects were also found to perceive significantly better temperature control with the iFIT prosthetic system (4.19 [SD= 0.68] vs 2.97 [SD=1.02], p <0.001). Subjects did not report any skin breakdown, prosthetic issues, or falls. CONCLUSION: This immediate fit, adjustable transtibial prosthesis demonstrated significantly better patient satisfaction and temperature perception compared to conventional devices. These results are consistent with previous findings and further support the efficacy of an immediate fit adjustable transtibial prosthetic system. Longer term studies in the United States and internationally are underway to assess the durability and efficacy of this new prosthesis in different populations and settings.
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BACKGROUND: The precise epidemiological evaluation of amputations is difficult. It is a serious public health and economic problem with a high death rate. The proportion of amputees with pre-amputation vascular status remains unknown. The main objective of our study was to evaluate the proportion of patients with lower limb amputation who had a pre-procedural vascular assessment. The secondary objectives were to evaluate the risk of amputation at the admission of these patients, estimate the incidence of amputations in Martinique, and to collect epidemiological data on this category of patients. MATERIAL AND METHODS: We conducted an epidemiological, retrospective, and observational study, over the year 2018 between January 01 and December 31, including all adults' patients who underwent an amputation of the lower limb at the university hospital center of Martinique. RESULTS: Among the 170 included patients, 79 (46%) patients had a major lower limb amputation. The incidence of amputations in 2018 was estimated at 48.9/100,000 inhabitants. The vascular assessment was performed for 110 (65%) patients. For the other 60 (35%) patients who did not have a vascular assessment, 53 (88%) had a severe infection. This assessment was significantly related to the amputation level: a vascular assessment was performed in 97 (70%) patients with below the knee amputation versus 13 (41%) patients with above the knee amputation (P<0.01). The WIfI classification system found a high risk of amputation for 152 (89%) of patients but also a benefit of revascularization ranked high for 138 (81%) of them. The origin of amputation was limb ischemia for 125 (68%) patients. CONCLUSION: A significant number of patients who underwent lower limb amputation did not have a pre-procedural vascular assessment. Many improvements in the health care are therefore to be implemented. The upcoming M@diCICAT project in Martinique will contribute in the improvement of patient management. The incidence of amputation in Martinique is considered high compared to other countries (French national incidence in 2003=24.8/100,000 inhabitants), and it seems to have remained stable since 2008. Our population is considered to be at high risk of amputation by the SVS-WIfI classification. This score seems adapted to anticipate the evolution of these patients and could be useful in daily practice.
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Amputação Cirúrgica/tendências , Amputados , Técnicas de Diagnóstico Cardiovascular/tendências , Hospitais Universitários , Extremidade Inferior/cirurgia , Doenças Vasculares/diagnóstico , Doenças Vasculares/cirurgia , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Incidência , Masculino , Martinica/epidemiologia , Pessoa de Meia-Idade , Admissão do Paciente , Valor Preditivo dos Testes , Indicadores de Qualidade em Assistência à Saúde , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Fatores de Tempo , Doenças Vasculares/epidemiologiaRESUMO
The calculation of symmetry in amputee gait is a valuable tool to assess the functional aspects of lower limb prostheses and how it impacts the overall gait mechanics. This paper analyzes the vertical trajectory of the body center of mass (CoM) of a group formed by transfemoral amputees and non-amputees to quantitatively compare the symmetry level of this parameter for both cases. A decomposition of the vertical CoM into discrete Fourier series (DFS) components is performed for each subject's CoM trajectory to identify the main components of each pattern. A DFS-based index is then calculated to quantify the CoM symmetry level. The obtained results show that the CoM displays different patterns along a gait cycle for each amputee, which differ from the sine-wave shape obtained in the non-amputee case. The CoM magnitude spectrum also reveals more coefficients for the amputee waveforms. The different CoM trajectories found in the studied subjects can be thought as the manifestation of developed compensatory mechanisms, which lead to gait asymmetries. The presence of odd components in the magnitude spectrum is related to the asymmetric behavior of the CoM trajectory, given the fact that this signal is an even function for a non-amputee gait. The DFS-based index reflects this fact due to the high value obtained for the non-amputee reference, in comparison to the low values for each amputee.
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Análise de Fourier , Adulto , Amputados , Membros Artificiais , Fenômenos Biomecânicos , Feminino , Marcha/fisiologia , Humanos , Masculino , Transtornos dos Movimentos/fisiopatologiaRESUMO
BACKGROUND: During the rehabilitation phase, physical exercise is a key element that requires an assessment of the best alternatives for application since the pre-prosthetic phase (PPF) for an accurate prescription. Therefore, the assessment of fitness for health (FFH) shall be included in the initial rehabilitation process. OBJECTIVE: To develop a FFH evaluation battery (Evam1) for pre-prosthetic unilateral lower-limb amputees (PPULLA). METHOD: A descriptive study of the theoretical construction and validation of a FFH evaluation battery based on a review of international literature for tests that measure amputee physical capability. RESULTS: During the scientific literature review, no batteries designed with this goal were found. We therefore designed a battery that was assembled of five tests for anthropometry, aerobic capacity, strength and flexibility. Combined leg and arm cycloergometrics, isokinetic dynamometry, and flexi test are the most reliable tests for the corresponding assessment of each component. CONCLUSIONS: PPF is of great importance, since the basic physical capabilities are altered due to long immobilization and hospitalization periods, inadequate postures, alteration of basic daily activities, and decrease in participation in sports, recreational, and work activities. This is a fundamental proposal, given that the procedures for FFH assessment of PPULLA have been rarely addressed, thus limiting the information on assessment methods, processes and/or tests established for these procedures.
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Amputação Cirúrgica/reabilitação , Amputados , Teste de Esforço , Extremidade Inferior/fisiologia , Aptidão Física , Exercício Físico , Tolerância ao Exercício , Feminino , Humanos , Masculino , EsportesRESUMO
RESUMEN El tumor de células gigantes se define como un tumor óseo benigno que invade las partes blandas localmente de forma agresiva. Se presenta una paciente con un tumor de células gigantes recidivante en el tercio distal del radio derecho, con signos de necrosis superficial e infección sobreañadidos, la cual, dada la magnitud y severidad de la lesión, requirió una amputación supracondílea de la extremidad. Presentó una evolución postoperatoria favorable, con recuperación física y psicológica(AU)
ABSTRACT Giant cell tumor is defined as a benign bone tumor that aggressively invades soft tissue locally. We present a patient with a recurrent giant cell tumor in the distal third of the right radius, showing signs of superimposed necrosis and infection, which, given the injury magnitude and severity, required supracondylar amputation of the limb. Her postoperative evolution was favorable, and this patient underwent physical and psychological recovery(AU)
RÉSUMÉ La tumeur à cellules géantes est définie comme une tumeur osseuse bénigne qui envahit agressivement les parties molles locales. Une patiente atteinte de tumeur récidivante à cellules géantes au niveau du tiers distal du radius droit, avec signes de nécrose superficielle et d'infection surajoutés, laquelle a requis une amputation supracondylienne du membre, due à la magnitude et à la sévérité de la lésion, est présentée. Elle a montré une évolution postopératoire favorable, avec une bonne récupération physique et psychologique.
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Humanos , Feminino , Adulto , Rádio (Anatomia)/cirurgia , Neoplasias Ósseas/cirurgia , Tumor de Células Gigantes do Osso/cirurgia , Amputação Cirúrgica/métodosRESUMO
INTRODUCTION: The management of severely traumatized extremity continues to be a matter of debate. Gustilo-Anderson tibial fractures III-B have a wide spectrum of variants, there are no guidelines using this classification for management. MESS has demonstrated functional and prognostic association. OBJECTIVE: To identify the pattern of decision made by surgeons for the prescription of amputations in tibial fractures exposed grade III-B Gustilo-Anderson with MESS scale. Material and methods. RESULTS: There was no association between the variables, with the application of MESS. (2 = 1.28, p = 0.2575). Surgeons of more than 10 years, increased once the possibility of matching the result of experts (OR = 2.088, 95% CI) (p = 0.0066). CONCLUSION: Academic degrees, surgical experience, and frequent clinical practice do not influence the correct application of the MESS scale. Surgeons with more than 10 years of experience have doubled the possibility of a precise decision.
INTRODUCCIÓN: El manejo de la extremidad severamente traumatizada continúa siendo materia de debate. Las fracturas de tibia III-B de Gustilo-Anderson tienen un amplio espectro de variantes, no hay guías mediante esta clasificación para un manejo. MESS ha demostrado asociación funcional y pronóstica. OBJETIVO: Identificar el patrón de decisión por parte de los cirujanos para la prescripción de amputaciones en fracturas de tibia expuesta grado IIIB Gustilo-Anderson con escala MESS. MATERIAL Y MÉTODOS: Es un estudio descriptivo, observacional, prospectivo, transversal y analítico. Se evaluaron 131 ortopedistas de un centro de referencia de patología traumática, quienes con uso de la escala MESS evaluaron 10 casos clínicos representativos de fracturas de tibia expuesta grado III-B de Gustilo-Anderson presentados en dispositivo electrónico. Se evaluó la concordancia de las decisiones entre cirujanos que laboran y expertos. Se realizó análisis inferencial mediante 2 (p 0.05) de las variables del estudio: experiencia del cirujano, postgrados académicos, práctica clínica frecuente de amputaciones, concordancia de las decisiones con escala MESS con respecto al patrón de prescripción obtenido por expertos. RESULTADOS: No se encontró asociación entre las variables con la aplicación de MESS (2 = 1.28, p = 0.2575). Los cirujanos de más de 10 años incrementaron una vez la posibilidad de coincidir con el resultado de expertos (OR = 2.088, IC 95%) (p = 0.0066). CONCLUSIÓN: Las variables como postgrados académicos, experiencia quirúrgica y práctica clínica frecuente no influyen en la correcta aplicación de la escala MESS. Los cirujanos de más de 10 años de experiencia incrementaron al doble la posibilidad de una decisión precisa.
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Amputação Cirúrgica , Fraturas Expostas , Fraturas da Tíbia , Tomada de Decisões , Fraturas Expostas/cirurgia , Humanos , Prognóstico , Estudos Retrospectivos , Tíbia , Fraturas da Tíbia/cirurgiaRESUMO
Resumen: Introducción: El manejo de la extremidad severamente traumatizada continúa siendo materia de debate. Las fracturas de tibia III-B de Gustilo-Anderson tienen un amplio espectro de variantes, no hay guías mediante esta clasificación para un manejo. MESS ha demostrado asociación funcional y pronóstica. Objetivo: Identificar el patrón de decisión por parte de los cirujanos para la prescripción de amputaciones en fracturas de tibia expuesta grado IIIB Gustilo-Anderson con escala MESS. Material y métodos: Es un estudio descriptivo, observacional, prospectivo, transversal y analítico. Se evaluaron 131 ortopedistas de un centro de referencia de patología traumática, quienes con uso de la escala MESS evaluaron 10 casos clínicos representativos de fracturas de tibia expuesta grado III-B de Gustilo-Anderson presentados en dispositivo electrónico. Se evaluó la concordancia de las decisiones entre cirujanos que laboran y expertos. Se realizó análisis inferencial mediante χ2 (p < 0.05) de las variables del estudio: experiencia del cirujano, postgrados académicos, práctica clínica frecuente de amputaciones, concordancia de las decisiones con escala MESS con respecto al patrón de prescripción obtenido por expertos. Resultados: No se encontró asociación entre las variables con la aplicación de MESS (χ2 = 1.28, p = 0.2575). Los cirujanos de más de 10 años incrementaron una vez la posibilidad de coincidir con el resultado de expertos (OR = 2.088, IC 95%) (p = 0.0066). Conclusión: Las variables como postgrados académicos, experiencia quirúrgica y práctica clínica frecuente no influyen en la correcta aplicación de la escala MESS. Los cirujanos de más de 10 años de experiencia incrementaron al doble la posibilidad de una decisión precisa.
Abstract: Introduction: The management of severely traumatized extremity continues to be a matter of debate. Gustilo-Anderson tibial fractures III-B have a wide spectrum of variants, there are no guidelines using this classification for management. MESS has demonstrated functional and prognostic association. Objective: To identify the pattern of decision made by surgeons for the prescription of amputations in tibial fractures exposed grade III-B Gustilo-Anderson with MESS scale. Material and methods: This is a descriptive, observational, prospective, transversal, analytical study. One hundred thirty-one orthopedists from a traumatic pathology referral center were evaluated, using the MESS scale to evaluate 10 representative clinical cases of Gustilo-Anderson grade III-B tibial fractures presented in an electronic device. The concordance of the decisions between working surgeons and experts was evaluated. Inferential analysis was performed using the χ2 (p < 0.05) of the study variables: surgeon experience, academic postgraduate studies, frequent clinical practice of amputations, concordance of decisions with MESS scale with respect to the prescription pattern obtained by experts. Results: There was no association between the variables, with the application of MESS. (χ2 = 1.28, p = 0.2575). Surgeons of more than 10 years, increased once the possibility of matching the result of experts (OR = 2.088, 95% CI) (p = 0.0066). Conclusion: Academic degrees, surgical experience, and frequent clinical practice do not influence the correct application of the MESS scale. Surgeons with more than 10 years of experience have doubled the possibility of a precise decision.
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Humanos , Fraturas da Tíbia/cirurgia , Fraturas Expostas/cirurgia , Amputação Cirúrgica , Prognóstico , Tíbia , Estudos Retrospectivos , Tomada de DecisõesRESUMO
We characterized physical activity (PA) and its relation to physical function and number of comorbidities in people with diabetes and transtibial amputation (AMP), people with diabetes without AMP, and nondisabled adults without diabetes or AMP. Twenty-two individuals with type 2 diabetes mellitus (DM) and transtibial amputation (DM+AMP), 11 people with DM, and 13 nondisabled participants were recruited for this cross-sectional cohort study. Measures included PA volume and intensity, a Timed Up and Go test, a 2-min walk test, and number of comorbidities. The nondisabled group performed greater amounts of PA than the DM group, who performed greater amounts of PA than the DM+AMP group. PA was related to physical function in the DM group and in the DM+AMP group, whereas no such relationship existed in the nondisabled group. PA was not related to number of comorbidities in any group. These findings suggest the ability to walk may affect overall performance of PA. Alternately, PA may alleviate walking problems. This possibility is of interest because issues with walking may be modifiable by improved levels and intensity of PA. PA's lack of relation to number of comorbidities suggests that factors beyond multiple morbidities account for group differences in PA.
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Amputação Cirúrgica , Diabetes Mellitus Tipo 2/complicações , Exercício Físico , Extremidade Inferior , Idoso , Estudos de Coortes , Comorbidade , Estudos Transversais , Diabetes Mellitus Tipo 2/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Teste de Caminhada , CaminhadaRESUMO
Little evidence exists to support the presence of differences in spatiotemporal gait parameters and ambulation ability between those individuals with traumatic and nontraumatic lower-limb amputation (LLA). We conducted an exploratory study of 81 male Veterans with unilateral amputation to quantify differences in spatiotemporal gait parameters and ambulatory mobility between Veterans with traumatic and nontraumatic LLA. Furthermore, we identified variables that significantly contributed to the explanation of variability in modified 2-min walk test distance. All participants completed the modified 2-min walk test and a spatiotemporal gait analysis using an instrumented walkway during a routine physical therapy visit. Veterans with nontraumatic LLA walked significantly shorter mean distances during a modified 2-min walk test than Veterans with traumatic LLA. Variables identified as significant contributors to modified 2-min walk test variability were amputated limb stance time, amputated limb step length, and percentage of the gait cycle spent in double support. These findings demonstrate that differences in spatiotemporal gait parameters and ambulatory mobility exist between Veterans with traumatic and nontraumatic LLA and identify important spatiotemporal parameters of gait contributing to this decline. These parameters should be considered as targets for intervention and future investigation.
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Amputação Cirúrgica , Amputados , Marcha , Teste de Caminhada , Velocidade de Caminhada , Adulto , Idoso , Amputação Traumática/fisiopatologia , Humanos , Perna (Membro) , Masculino , Pessoa de Meia-Idade , Veteranos , CaminhadaRESUMO
BACKGROUND: Many chemotherapy protocols have been reported for treatment of canine appendicular osteosarcoma (OSA), but outcome comparisons in a single population are lacking. OBJECTIVE: To evaluate the effects of protocol and dose intensity (DI) on treatment outcomes for carboplatin and doxorubicin-based chemotherapy protocols. ANIMALS: Four hundred and seventy dogs with appendicular OSA. METHODS: A retrospective cohort study was performed comprising consecutive dogs treated (1997-2012) with amputation followed by 1 of 5 chemotherapy protocols: carboplatin 300 mg/m(2) IV q21d for 4 or 6 cycles (CARBO6), doxorubicin 30 mg/m(2) IV q14d or q21d for 5 cycles, and alternating carboplatin 300 mg/m(2) IV and doxorubicin 30 mg/m(2) IV q21d for 3 cycles. Adverse events (AE) and DI were evaluated. Kaplan-Meier survival curves and Cox proportional hazards regression were used to compare disease-free interval (DFI) and survival time (ST) among protocols. RESULTS: The overall median DFI and ST were 291 days and 284 days, respectively. A lower proportion of dogs prescribed CARBO6 experienced AEs compared to other protocols (48.4% versus 60.8-75.8%; P = .001). DI was not associated with development of metastases or death. After adjustment for baseline characteristics and prognostic factors, none of the protocols provided a significant reduction in risk of development of metastases or death. CONCLUSIONS AND CLINICAL IMPORTANCE: Although choice of protocol did not result in significant differences in DFI or ST, the CARBO6 protocol resulted in a lower proportion of dogs experiencing AEs, which could be advantageous in maintaining high quality of life during treatment. DI was not a prognostic indicator in this study.
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Neoplasias Ósseas/veterinária , Carboplatina/uso terapêutico , Doenças do Cão/tratamento farmacológico , Doxorrubicina/uso terapêutico , Osteossarcoma/veterinária , Amputação Cirúrgica/veterinária , Animais , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/cirurgia , Carboplatina/administração & dosagem , Doenças do Cão/cirurgia , Cães , Doxorrubicina/administração & dosagem , Esquema de Medicação , Extremidades/cirurgia , Feminino , Masculino , Osteossarcoma/tratamento farmacológico , Osteossarcoma/cirurgia , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Introducción. Las bandas amnióticas causan un espectro muy amplio de malformaciones fetales, desde labio-paladar hendido e hidrocefalia hasta estrangulación y amputación de extremidades; presenta una prevalencia que va de 1:1,200 a 1:15,000 nacimientos. El siguiente caso clínico se reporta con el objetivo de describir los principales signos del síndrome de bandas amnióticas. Caso clínico. Madre de 21 años, primigesta, con antecedente de vulvovaginitis en el primer trimestre, sin tratamiento; control prenatal irregular sin ultrasonidos obstétricos. El embarazo culminó en cesárea a las 30 semanas por presentar oligohidramnios severo. Se obtuvo producto femenino de 1,200 g y Apgar 7-8. A la exploración física se encontró pseudosindactilia con zona de anillo uniendo a las falanges por el vértice, pie equino varo izquierdo y pierna derecha amputada desde la región tibial media terminando en punta, con escara en porción distal. Además, en estudio radiológico se observaron las falanges del segundo, tercer y cuarto dedos unidas al centro en vértice y peroné hipoplásico. Conclusiones. Los anillos de constricción, la amputación de una o más extremidades y la pseudosindactilia son signos importantes y consistentes que apoyan el diagnóstico del síndrome de bandas amnióticas, con un mal pronóstico para la función aunque bueno para la vida.
Background. Amniotic band syndrome causes a wide spectrum of congenital defects such as cleft lip, hydrocephalus, and growth restriction of limbs, with or without amputation. The condition occurs in every 1:1,200 to 1:15,000 deliveries. The objective of this report is to define the most important features of amniotic band syndrome. Case report. We report the case of a 21 -year-old female with a first pregnancy. No prenatal care or ultrasound studies were carried out, but the patient reported experiencing vaginal discharge during the first trimester. The pregnancy resulted in cesarean section at 30 gestational weeks because of severe oligohydramnios. A 1200-g female was delivered with Apgar 7-8. The newborn presented congenital amputation of the right leg and pseudosyndactyly of the left hand with a ring constriction of the third phalange of the second, third and fourth finger, a left equinovarus foot and amputation of the right leg from the middle third of the tibial region. These findings were confirmed by x-ray. Conclusions. Constriction rings, limb amputation and pseudosyndactyly are important and consistent features with the amniotic band syndrome. Functional prognosis is nonfavorable, but prognosis for life productivity is good.
RESUMO
CONTEXTO: O tratamento da isquemia crítica de membros inferiores sem leito arterial distal pode ser realizado por meio da inversão do fluxo no arco venoso do pé. OBJETIVO: O objetivo deste trabalho foi apresentar a técnica e os resultados obtidos com a arterialização do arco venoso do pé, mantendo a safena magna in situ. MÉTODOS: Dezoito pacientes, dos quais 11 com aterosclerose (AO), 6 com tromboangeíte obliterante (TO) e 1 com trombose de aneurisma de artéria poplítea (TA) foram submetidos ao método. A safena magna in situ foi anastomosada à melhor artéria doadora. O fluxo arterial derivado para o sistema venoso progride por meio da veia cujas válvulas são destruídas. As colaterais da veia safena magna são ligadas desde a anastomose até o maléolo medial, a partir do qual são preservadas. RESULTADOS: Dos pacientes, 10 (55,6 por cento) mantiveram suas extremidades, 5 com AO e 5 com TO; 7 (38,9 por cento) foram amputados, 5 com AO, 1 com TO e 1 com Ta; houve 1 óbito (5,5 por cento). CONCLUSÃO: A inversão do fluxo arterial no sistema venoso do pé deve ser considerada para salvamento de extremidade com isquemia crítica sem leito arterial distal.
BACKGROUND: Critical lower limb ischemia in the absence of a distal arterial bed can be treated by arterialization of the venous arch of the foot. OBJETIVE: The objective of this paper was to present the technique and the results of the arterialization of the venous arch of the foot with the in situ great saphenous vein. METHODS: Eighteen patients, 11 with atherosclerosis (AO), 6 with thromboangiitis obliterans (TO) and 1 with popliteal artery aneurysm thrombosis were submitted to venous arch arterialization. The in situ great saphenous vein was anastomosed to the best donor artery. Arterial flow derived from the venous system progresses through the vein whose valves were destroyed. The collateral vessels of the great saphenous vein are linked from the anastomosis to the medial malleolus and preserved from this point onward. RESULTS: Limb salvage was achieved in 10 (55.6 percent) patients, 5 with AO and 5 with TO. Seven (38.9 percent) patients were amputated, 5 with AO, 1 with TO and 1 with Ta. One (5.5 percent) patient died. CONCLUSION: Arterialization of the venous system of the foot should be considered for the salvage of limbs with critical ischemia in the absence of a distal arterial bed.
Assuntos
Humanos , Isquemia/terapia , Salvamento de Membro/enfermagem , Tromboangiite Obliterante , Veia Cava Inferior , Amputação Cirúrgica/enfermagem , Extremidade Inferior/cirurgiaRESUMO
La primera idea que tuvieron los cirujanos (1902) para evitar amputaciones por isquemia fue la de desviar el flujo arterial al sistema venoso por intermedio de una fístula arteriovenosa entre vasos adyacentes, pero con resultados inciertos. Desde entonces se han inventado las simpatecomias, las endarteriectomias y los injertos puentes o bypass y, últimamente, otros avances médicos, quirúrgicos y endovasculares. Sin embargo, en el mundo se siguen haciendo amputaciones, sobre todo en diabéticos. La arterialización de las venas del pie, basada en la vieja idea de la circulación invertida, constituye una esperanza más para estos pacientes ya condenados a la pérdida del miembro. Objetivo: Demostrar que la arterialización de las venas del pie en diabéticos con lesiones neuroisquémicas, generalmente infectadas (pie diabético), es un método eficaz y durable, aunque el puente solo funcione temporalmente. Pacientes y método: De enero de 2000 a febrero de 2009, 59 pacientes con pie diabético fueron tratados por arterialización de las venas del pie...
The first idea of surgeons (1902) to avoid amputations due to ischemia was to deviate the arterial flow to the venous system using an arteriovenous fistula between adjacent vessels; however, the results were unreliable. Since then, sympathectomies, endarterectomies and bypasses have been created, and more recently, other medical, surgical, and endovascular advances have been used. However, amputations continue to be performed worldwide mainly in diabetic patients. The arterialization of the foot veins, based on the old idea of inverted blood flow, is a new possibility for these patients who, otherwise, could lose their limbs. Objective: To demonstrate that arterialization of the foot veins in diabetic patients with neuroischemic lesions, usually infected (diabetic foot), is an effective and long-lasting method, even though the bypass only works temporally. Patients and method: From January 2000 to February 2009, 59 patients with diabetic foot were threated by means of arterialization of the foot veins. An early death was not included in the analysis. Of the 58 remaining patients, 44 were male and 14 were female. Their mean age was 71 years old: (53-91 years). Fifty-four of them were classified as being Fontaine IV and four were IIIB...
Assuntos
Humanos , Masculino , Feminino , Idoso , Amputação Cirúrgica/métodos , Complicações do Diabetes/sangue , Diabetes Mellitus/terapia , Isquemia/diagnóstico , Pé Diabético/diagnóstico , Salvamento de Membro/enfermagem , Artérias TemporaisRESUMO
O trabalho do psicólogo com pessoas amputadas é crescente, em virtude das questões de saúde da população, tais como o aumento da expectativa de vida e de comorbidades. O objetivo do artigo é apresentar uma revisão da literatura sobre os aspectos emocionais presentes na vida de pacientes submetidos à amputação de membros. Primeiramente foram descritos os tipos de amputações de membros, apontando as causas, incidência e níveis da operação no corpo; em seguida a implicação da relação médico paciente na decisão pela cirurgia; e posteriormente, buscou-se relacionar e discutir os aspectos emocionais relacionados com a amputação através pesquisas e estudos da área. Considera-se que os aspectos emocionais têm destaque no processo de amputação, porém existem lacunas a serem pesquisadas no campo da Psicologia, para o embasamento das intervenções e atuações adequadas às reais demandas nesta área.(AU)
The Psychologists work with amputees is increasing due to Public Health issues such as an increase in life expectancy and co-morbidities. The objective of this article is to present a review of the available literature related to emotional aspects associated with amputee patients. Firstly the types of limb amputations were described indicating their causes, incidence and the extent of surgery. Secondly the implications of the doctor/patient relationship on the decision to undergo surgery are considered. Finally an attempt is made to relate and discuss the emotional aspects of amputation with reference to research and studies in this area. In consideration of the fact that emotional aspects are given special attention in amputation cases, it is clear that additional psychological research is needs to provide a better basis for interventions and actions, adapting them to actual demands in this field.(AU)
Assuntos
Humanos , Amputação Cirúrgica , Adaptação Psicológica , Autonomia Pessoal , Imagem Corporal , Amputação Traumática , Psicologia , Medicina do Comportamento , Emoções ManifestasRESUMO
O trabalho do psicólogo com pessoas amputadas é crescente, em virtude das questões de saúde da população, tais como o aumento da expectativa de vida e de comorbidades. O objetivo do artigo é apresentar uma revisão da literatura sobre os aspectos emocionais presentes na vida de pacientes submetidos à amputação de membros. Primeiramente foram descritos os tipos de amputações de membros, apontando as causas, incidência e níveis da operação no corpo; em seguida a implicação da relação médico paciente na decisão pela cirurgia; e posteriormente, buscou-se relacionar e discutir os aspectos emocionais relacionados com a amputação através pesquisas e estudos da área. Considera-se que os aspectos emocionais têm destaque no processo de amputação, porém existem lacunas a serem pesquisadas no campo da Psicologia, para o embasamento das intervenções e atuações adequadas às reais demandas nesta área.
The Psychologists work with amputees is increasing due to Public Health issues such as an increase in life expectancy and co-morbidities. The objective of this article is to present a review of the available literature related to emotional aspects associated with amputee patients. Firstly the types of limb amputations were described indicating their causes, incidence and the extent of surgery. Secondly the implications of the doctor/patient relationship on the decision to undergo surgery are considered. Finally an attempt is made to relate and discuss the emotional aspects of amputation with reference to research and studies in this area. In consideration of the fact that emotional aspects are given special attention in amputation cases, it is clear that additional psychological research is needs to provide a better basis for interventions and actions, adapting them to actual demands in this field.