RESUMO

The irreproducibility in scientific research has become a critical issue. Despite the essential role of rigorous methodology in constructing a scientific article, more than half of publications, on average, are considered non-reproducible. The implications of this irreproducibility extend to reliability problems, hindering progress in technological production and resulting in substantial financial losses. In the context of laboratory animal research, this work emphasizes the importance of choosing an appropriate experimental model within the 3R's principle (Refine, Reduce, Replace). This study specifically addresses a deficiency in data specification in scientific articles, revealing inadequacies in the description of crucial details, such as environmental conditions, diet, and experimental procedures. For this purpose, 124 articles from journals with relevant impact factors were analyzed, conducting a survey of data considered important for the reproducibility of studies. Important flaws in the presentation of data were identified in most of the articles evaluated. The results of this study highlight the need to improve the description of essential information, standardizing studies, and ensuring the reproducibility of experiments in areas such as metabolism, immunity, hormones, stress, among others, to enhance the reliability and reproduction of experimental results, aligning with international guidelines such as ARRIVE and PREPARE.

RESUMO

Danio rerio (zebrafish), originating from the Asian shallow waters, is a high-rise experimental model in the scientific community for its reproductive advantage and speed; with its completely sequenced genome and great genetic similarity with humans, in addition to the care and management facilitated indoors, make zebrafish an extremely viable option for scientific research. This literature review seeks to expose and clarify the means and main parameters for the establishment of a zebrafish production, maintenance or use facility, as well as the normative resolutions and legal requirements governing the establishment of these facilities; we also meet the installation conditions necessary for the construction and implementation of the installation, its parameters for maintenance, breeding, reproduction and management of zebrafish in the animal installation.

Danio rerio (zebrafish), oriundo das águas rasas asiáticas, é um modelo experimental em grande ascensão na comunidade científica por sua vantagem e velocidade reprodutivas; com seu genoma completamente sequenciado e grande similaridade genética com o ser humano, além do cuidado e manejo facilitado em ambientes fechados, tornam o zebrafish uma opção extremamente viável para a pesquisa científica. Esta revisão bibliográfica busca expor e esclarecer os meios e principais parâmetros para o estabelecimento de uma instalação de produção, manutenção ou utilização de zebrafish, bem como as resoluções normativas e requerimentos legais que regem o estabelecimento destas instalações; também reunimos as condições de instalação necessárias para a construção e implantação da instalação, seus parâmetros para a manutenção, criação, reprodução e manejo dos peixes-zebra na instalação animal.

RESUMO

Lab animals, such as Guinea pigs (Cavia porcellus), are crucial for scientific development, as they play an important role in the development and quality control chain of vaccines and drugs distributed by the Brazilian public health system. Investigating their biological and physiological parameters is fundamental to raise and keep these animals, so the handling of the facilities that hold them can be updated whenever new information comes up, with the well-being of the animals and alignment with the 3 Rs in mind. In the search for understanding reproductive aspects of Guinea pigs, the present study had the main goal of studying puberty by means of estrous cycle analysis in short-haired Guinea pigs. Guinea pigs have a vaginal occlusive membrane that covers the vaginal orifice. Its rupture takes place gradually and naturally, moments before labor and during estrus. The present study followed 42 females as for the presentation of the vaginal occlusive membrane. Once the membranes ruptured spontaneously, a swab was collected to study vaginal cytology. Membrane rupture was observed in 39 females; six females showed membrane rupture with less than 21 days of age (17 to 21 days). Twenty-three females were characterized as being in estrus due to cytology showing a prevalence of anucleated superficial cells. One of these females was younger than 21 days old. The opening of the vaginal occlusive membrane took place most frequently in intervals between 17 and 18 days, and the membrane remained open between one and three consecutive days. It was possible to follow three cycles of membrane opening on six females. The present study showed the need to adapt handling guidelines for C. porcellus kept in research animal facilities. The early age of puberty imposes the need of separate the female daughters from their fathers at 16 days old.

RESUMO

Lab animals, such as Guinea pigs (Cavia porcellus), are crucial for scientific development, as they play an important role in the development and quality control chain of vaccines and drugs distributed by the Brazilian public health system. Investigating their biological and physiological parameters is fundamental to raise and keep these animals, so the handling of the facilities that hold them can be updated whenever new information comes up, with the well-being of the animals and alignment with the 3 Rs in mind. In the search for understanding reproductive aspects of Guinea pigs, the present study had the main goal of studying puberty by means of estrous cycle analysis in short-haired Guinea pigs. Guinea pigs have a vaginal occlusive membrane that covers the vaginal orifice. Its rupture takes place gradually and naturally, moments before labor and during estrus. The present study followed 42 females as for the presentation of the vaginal occlusive membrane. Once the membranes ruptured spontaneously, a swab was collected to study vaginal cytology. Membrane rupture was observed in 39 females; six females showed membrane rupture with less than 21 days of age (17 to 21 days). Twenty-three females were characterized as being in estrus due to cytology showing a prevalence of anucleated superficial cells. One of these females was younger than 21 days old. The opening of the vaginal occlusive membrane took place most frequently in intervals between 17 and 18 days, and the membrane remained open between one and three consecutive days. It was possible to follow three cycles of membrane opening on six females. The present study showed the need to adapt handling guidelines for C. porcellus kept in research animal facilities. The early age of puberty imposes the need of separate the female daughters from their fathers at 16 days old.(AU)

Assuntos

RESUMO

In digital curation, data are essential for actions, enabling better administrative management and greater efficiency in a sector or activity. In a research animal facility, the collection of management data associated with management systems or control sheets is the basis for ensuring quality information that subsidizes research and generates performance indicators and the needs and challenges to be transposed in the breeding and maintenance of animals. The inconsistency of data or incomplete records compromises the choices adopted in husbandry management practices or the interpretation of research results. For this reason, a survey was carried out about software available on the market that helps laboratory animal facilities with the management regarding software used in non-human primate breeding institutions (NHP) for scientific or conservation purposes. We identified 38 software that supports the handling of lab animals used in biomedical research; most of them with functionalities of environmental control (63.15%), control of animal files/tags (63.15%), and control of reproductive management (60%) and only two software related to the management of nonhuman primates kept under human care in research institutions. Regarding the tools used to manage the breeding of non-human primates in captivity in Brazilian institutions, five of the institutions questioned and reported that none currently uses software for colony management. In conclusion, there are several software for managing laboratory animals, but most of them are geared toward the management of rodent animal facilities. There is a lack of specific software on the market for use in animal facilities managing non-human primate breeding, which indicates the need for software developed to meet the management needs of animal facilities for these facilities.

Assuntos

RESUMO

A COVID-19 é uma nova coronovirose que demonstrou seu potencial pandêmico a partir de um surto observado em dezembro de 2019 na cidade de Wuhan, na China e, atualmente, já está sendo compreendida como uma síndrome de disfunção múltipla de órgãos, além dos pulmões. Até o momento, há ainda muito a se conhecer sobre o vírus, suas interações e potencial de transmissão, bem como a patogênese da doença; o desenvolvimento das candidatas a vacinas, terapias, diagnósticos mais precisos e ferramentas de controle da doença. Um dos principais desafios encontrados atualmente na pesquisa em COVID-19 é a disponibilização de modelos animais que mimetize a fisiopatogênese da doença humana. Sendo assim, este artigo objetiva fazer uma revisão não só do estado da arte em estudos pré-clínicos desenvolvidos para entendimento e enfrentamento da COVID-19 com a participação de diversos modelos animais de experimentação no aprimoramento de terapias imunes, mas também trazer à discussão a participação de espécies animais selvagens na origem da pandemia, ciclo de transmissão e manutenção da doença. De acordo com a revisão dos trabalhos publicados, foi possível observar que algumas espécies, como primatas não humanos e camundongos têm potencial de uso em múltiplas formas de experimentação, enquanto outras se limitam a um tipo de observação. Desta forma, a avaliação contínua de bons modelos animais para estudo da COVID-19 consolida a importância da investigação em animais e dos estudos pré-clínicos para solucionar esta e próximas pandemias que possam vir a ocorrer na história da saúde pública mundial.

COVID-19 is a new virus disease that demonstrated its pandemic potential from an outbreak observed in December 2019, in Wuhan, China and it is now considered as a multiple organ dysfunction syndrome, in addition to the lungs. So far, there is still much to know about the virus, its interactions and potential for transmission, as well as the pathogenesis of the disease; the development of vaccines candidates, therapies, more accurate diagnoses and disease control tools. One of the main challenges currently found in research in COVID-19 is the availability of animal models that mimic the pathophysiology of human disease. Therefore, this article aims to review not only the state of the art in preclinical studies developed to understand and confront COVID-19 with participation of several animal models of experimentation in the improvement of immune therapies, but also to bring to discussion the participation of wild animal species in the origin of the pandemic, transmission cycle and maintenance of the disease. According to this review, it was possible to observe that some species, such as non-human primates and mice, have potential for use in multiple forms of experimentation, while others are limited to one type of observation. Thus, the continuous evaluation of good animal models for COVID-19 studies consolidates the importance of animal research and preclinical studies to solve this and the next pandemics that may occur in the history of public health worldwide.

Assuntos

RESUMO

A COVID-19 é uma nova coronovirose que demonstrou seu potencial pandêmico a partir de um surto observado em dezembro de 2019 na cidade de Wuhan, na China e, atualmente, já está sendo compreendida como uma síndrome de disfunção múltipla de órgãos, além dos pulmões. Até o momento, há ainda muito a se conhecer sobre o vírus, suas interações e potencial de transmissão, bem como a patogênese da doença; o desenvolvimento das candidatas a vacinas, terapias, diagnósticos mais precisos e ferramentas de controle da doença. Um dos principais desafios encontrados atualmente na pesquisa em COVID-19 é a disponibilização de modelos animais que mimetize a fisiopatogênese da doença humana. Sendo assim, este artigo objetiva fazer uma revisão não só do estado da arte em estudos pré-clínicos desenvolvidos para entendimento e enfrentamento da COVID-19 com a participação de diversos modelos animais de experimentação no aprimoramento de terapias imunes, mas também trazer à discussão a participação de espécies animais selvagens na origem da pandemia, ciclo de transmissão e manutenção da doença. De acordo com a revisão dos trabalhos publicados, foi possível observar que algumas espécies, como primatas não humanos e camundongos têm potencial de uso em múltiplas formas de experimentação, enquanto outras se limitam a um tipo de observação. Desta forma, a avaliação contínua de bons modelos animais para estudo da COVID-19 consolida a importância da investigação em animais e dos estudos pré-clínicos para solucionar esta e próximas pandemias que possam vir a ocorrer na história da saúde pública mundial.(AU)

COVID-19 is a new virus disease that demonstrated its pandemic potential from an outbreak observed in December 2019, in Wuhan, China and it is now considered as a multiple organ dysfunction syndrome, in addition to the lungs. So far, there is still much to know about the virus, its interactions and potential for transmission, as well as the pathogenesis of the disease; the development of vaccines candidates, therapies, more accurate diagnoses and disease control tools. One of the main challenges currently found in research in COVID-19 is the availability of animal models that mimic the pathophysiology of human disease. Therefore, this article aims to review not only the state of the art in preclinical studies developed to understand and confront COVID-19 with participation of several animal models of experimentation in the improvement of immune therapies, but also to bring to discussion the participation of wild animal species in the origin of the pandemic, transmission cycle and maintenance of the disease. According to this review, it was possible to observe that some species, such as non-human primates and mice, have potential for use in multiple forms of experimentation, while others are limited to one type of observation. Thus, the continuous evaluation of good animal models for COVID-19 studies consolidates the importance of animal research and preclinical studies to solve this and the next pandemics that may occur in the history of public health worldwide.(AU)

Assuntos

RESUMO

Domestic geese are birds of zootechnical interest commonly created for ornamentation and guard in farms but are also useful for biomedical research, once they supply blood as a byproduct for laboratory analysis. The study aimed to contribute to the completion of health data available on these animals to trace a hematological profile of domestic geese that supply blood for research and provide data on the influence of periodic collections to the health of these animals. Ten Chinese geese (Anser domesticus), white and males, were kept in a research center installation. Four blood samples were performed weekly after the 1st collection, the sample with greater volume was sent to the laboratories of the Evandro Chagas Institute to be used in the arbovirus tests. The hematological evaluations observed values of packed cell volume (PCV), total number of erythrocytes (Hm), total number of leukocytes (Lc) and differential leukocyte count and the number of thrombocytes (Tb). All the animals were weighed and correlation of volume of blood collected from the animals weight was performed. No differences were found among the means obtained in the hematological values of the 1st collection and the subsequent collections demonstrating that the periodic collection in geese, when performed in obedience to the correlation between animals weight and blood volume, does not cause significant alterations in the animals hematological profile. The results of the hematological profile obtained in this study will add to the biological data of species available allowing a better health assessment of these animals in the creation of environments and in animal research facilities.

Assuntos

RESUMO

Domestic geese are birds of zootechnical interest commonly created for ornamentation and guard in farms but are also useful for biomedical research, once they supply blood as a byproduct for laboratory analysis. The study aimed to contribute to the completion of health data available on these animals to trace a hematological profile of domestic geese that supply blood for research and provide data on the influence of periodic collections to the health of these animals. Ten Chinese geese (Anser domesticus), white and males, were kept in a research center installation. Four blood samples were performed weekly after the 1st collection, the sample with greater volume was sent to the laboratories of the Evandro Chagas Institute to be used in the arbovirus tests. The hematological evaluations observed values of packed cell volume (PCV), total number of erythrocytes (Hm), total number of leukocytes (Lc) and differential leukocyte count and the number of thrombocytes (Tb). All the animals were weighed and correlation of volume of blood collected from the animals weight was performed. No differences were found among the means obtained in the hematological values of the 1st collection and the subsequent collections demonstrating that the periodic collection in geese, when performed in obedience to the correlation between animals weight and blood volume, does not cause significant alterations in the animals hematological profile. The results of the hematological profile obtained in this study will add to the biological data of species available allowing a better health assessment of these animals in the creation of environments and in animal research facilities.(AU)

Assuntos

RESUMO

Opinion studies report different points of view regarding the use of animals in research. In Brazil, few studies are dedicated to know the position of society in relation to animal experimentation. This article allowed to access and systematize the positions of high school students on the subject. For this, three discussion groups (GD) were conducted using a game tool with content focused on the Brazilian reality and covering different experiences and points of view related to laboratory animal science (LAS). The opinion of the young people was verified at the beginning and the end of the activity and the discussions throughout the game were recorded (audio and image) for content analysis. A total of 47 segments of attitudes about animal experimentation were transcribed, of which 29 were agreement (61.70%), 16 were ejection (34%) and only 2 speech segments showed an indefinite attitude (4.3%). There was a diversity of young people’s opinions about the initial positions suggested by the game. At the end of the dynamics, the positions chosen as the most representative ones involved: the importance of providing well-being to the laboratory animals; the need for monitoring and follow-up of these surveys by public agencies; investment in awareness-raising processes. The activity carried out allowed us to reflect on the theme, leading the participants to perceive the complexity of the subject. Based on this research, it will be possible to plan and carry out continuous activities for the dissemination of LAS, the development and strengthening of the area to the society and the scientific community itself.

Estudos de opinião relatam pontos de vistas distintos em relação ao uso de animais em pesquisas. No Brasil, poucos estudos dedicam-se a conhecer o posicionamento da sociedade em relação à experimentação animal. Esse artigo permitiu acessar e sistematizar os posicionamentos de jovens do Ensino Médio sobre o tema. Para isso, foram realizados três grupos de discussão (GD) utilizando uma ferramenta de jogo com conteúdo voltado à realidade brasileira e abrangendo diferentes vivências e pontos de vista relacionados à ciência em animais de laboratório (CAL). Foi verificada a opinião dos jovens no início e fim da atividade e as discussões ao longo do jogo foram filmadas e gravadas para realização de análise de conteúdo. Foram transcritos 47 segmentos de falas referentes às atitudes em relação à experimentação animal, dos quais 29 foram de apoio (61,70 %), 16 de rejeição (34 %) e apenas 2 segmentos de fala revelaram uma atitude indefinida (4,3 %). Verificou-se uma diversidade de opiniões dos jovens sobre os posicionamentos iniciais sugeridos pelo jogo. Ao final da dinâmica, os posicionamentos eleitos como os mais representativos envolveram: a importância de proporcionar bem-estar aos animais de laboratório; a necessidade de que haja fiscalização e acompanhamento dessas pesquisas pelos órgãos públicos; o investimento em processos de conscientização. A atividade realizada permitiu a reflexão sobre o tema levando os participantes a perceber a complexidade do assunto. A partir dessa pesquisa será possível planejar e desenvolver atividades continuadas de divulgação da CAL, o desenvolvimento e o fortalecimento da área perante a sociedade e a própria comunidade científica.

Assuntos

RESUMO

Opinion studies report different points of view regarding the use of animals in research. In Brazil, few studies are dedicated to know the position of society in relation to animal experimentation. This article allowed to access and systematize the positions of high school students on the subject. For this, three discussion groups (GD) were conducted using a game tool with content focused on the Brazilian reality and covering different experiences and points of view related to laboratory animal science (LAS). The opinion of the young people was verified at the beginning and the end of the activity and the discussions throughout the game were recorded (audio and image) for content analysis. A total of 47 segments of attitudes about animal experimentation were transcribed, of which 29 were agreement (61.70%), 16 were ejection (34%) and only 2 speech segments showed an indefinite attitude (4.3%). There was a diversity of young peoples opinions about the initial positions suggested by the game. At the end of the dynamics, the positions chosen as the most representative ones involved: the importance of providing well-being to the laboratory animals; the need for monitoring and follow-up of these surveys by public agencies; investment in awareness-raising processes. The activity carried out allowed us to reflect on the theme, leading the participants to perceive the complexity of the subject. Based on this research, it will be possible to plan and carry out continuous activities for the dissemination of LAS, the development and strengthening of the area to the society and the scientific community itself.(AU)

Estudos de opinião relatam pontos de vistas distintos em relação ao uso de animais em pesquisas. No Brasil, poucos estudos dedicam-se a conhecer o posicionamento da sociedade em relação à experimentação animal. Esse artigo permitiu acessar e sistematizar os posicionamentos de jovens do Ensino Médio sobre o tema. Para isso, foram realizados três grupos de discussão (GD) utilizando uma ferramenta de jogo com conteúdo voltado à realidade brasileira e abrangendo diferentes vivências e pontos de vista relacionados à ciência em animais de laboratório (CAL). Foi verificada a opinião dos jovens no início e fim da atividade e as discussões ao longo do jogo foram filmadas e gravadas para realização de análise de conteúdo. Foram transcritos 47 segmentos de falas referentes às atitudes em relação à experimentação animal, dos quais 29 foram de apoio (61,70 %), 16 de rejeição (34 %) e apenas 2 segmentos de fala revelaram uma atitude indefinida (4,3 %). Verificou-se uma diversidade de opiniões dos jovens sobre os posicionamentos iniciais sugeridos pelo jogo. Ao final da dinâmica, os posicionamentos eleitos como os mais representativos envolveram: a importância de proporcionar bem-estar aos animais de laboratório; a necessidade de que haja fiscalização e acompanhamento dessas pesquisas pelos órgãos públicos; o investimento em processos de conscientização. A atividade realizada permitiu a reflexão sobre o tema levando os participantes a perceber a complexidade do assunto. A partir dessa pesquisa será possível planejar e desenvolver atividades continuadas de divulgação da CAL, o desenvolvimento e o fortalecimento da área perante a sociedade e a própria comunidade científica.(AU)

Assuntos

RESUMO

A utilização de animais para fins científicos configura prática histórica na civilização humana, mas gera polêmica em sociedades preocupadas com proteção dos animais. No Brasil, até 2008, não havia norma ou lei que regulamentasse especificamente a experimentação animal. Este trabalho discute a utilização de animais em experimentos científicos, considerando o delineamento da Lei Arouca, por meio da leitura de artigos científicos que contemplam o histórico da experimentação no contexto mundial e brasileiro, incluindo a regulamentação do uso de animais do filo Chordata, subfilo Vertebrata, em pesquisas no Brasil. A Lei Arouca pode representar avanço na legislação brasileira quanto à utilização de animais para fins científicos, sobretudo pela criação das comissões de ética para uso de animais em instituições de pesquisa e do Conselho Nacional de Controle de Experimentação Animal, que examinam o cumprimento da legislação aplicável em projetos científicos que envolvem a utilização de animais.

The use of animals for scientific purposes is a historical procedure in human civilization, but is controversial for societies concerned with the protection of animals. In Brazil, until 2008, there was no rule or law that specifically regulated animal testing. This paper discusses the use of animals in scientific experiments, considering the Brazilian Arouca Law, through the analysis of scientific articles that consider the history of experimentation in the world and in Brazil, including the regulation of the use of animals of the phylum Chordata, subphylum Vertebrata, in Brazilian research. The Arouca Law may represent an advance in Brazilian law regarding the use of animals for scientific purposes, particularly given the creation of the Ethics Committees for Animal Use in research institutions and the National Council for Animal Experimentation Control, which examine the compliance of scientific projects involving the use of such animals to applicable law.

El uso de animales para fines científicos configura una práctica histórica en la civilización humana, pero genera controversia en las sociedades preocupadas por la protección de éstos. En Brasil, hasta 2008, no había una norma o una ley que regulara la experimentación animal. Este trabajo discute acerca del uso de animales en experimentos científicos, teniendo en cuenta los lineamientos de la Ley Arouca, a partir de la lectura de artículos científicos que abordan la historia de la experimentación animal en el mundo y en el contexto brasilero, incluyendo la regulación del uso de animales del filo Cordados, subfilo Vertebrados, en investigaciones en Brasil. La Ley Arouca puede representar un avance en la legislación brasilera con respecto al uso de estos animales para fines científicos, sobre todo por la creación de las comisiones de ética para el uso de animales (Ceua) en instituciones de investigación y del Consejo Nacional de Control de la Experimentación Animal (Concea), que son los responsables de examinar el cumplimiento de la legislación aplicable a proyectos científicos que involucran la utilización de animales.

Assuntos

RESUMO

Este artigo retrata a trajetória da Dra. Adela Rosenkranz no Brasil e outros países da América Latina. Após a instauração das políticas totalitárias nos anos sessenta, setenta e oitenta do século XX na América Latina, a Dra. Adela foi impulsionada a sair da Argentina e vir para o Brasil, como convidada por diversos professores. Naquele período, alertou as lideranças científicas sobre a qualidade inadequada dos modelos biológicos utilizados, tendo como temas a qualidade genética e sanitária dos animais de laboratório e a formação de profissionais na área. Instalada no biotério da Escola Paulista de Medicina (Unifesp), colaborou com destaque em um projeto fundamental para sua reforma e implementação. Em 1985, liderou a organização do Regional/International Scientific Meeting/I Congresso da Ciência de Animais de Laboratório no Brasil, em Águas de Lindóia - São Paulo, que contou com mais de 500 participantes nacionais e internacionais. Colaborou como consultora na modernização de inúmeros biotérios brasileiros e na implantação de Estatística Apllicáveis aos Ensaios Biológicos, tanto no Brasil como em diversos países Latino Americanos, como faz até hoje. Desde princípios dos anos 90 o empenho da Dra. Adela, em transmitir conceitos de excelência e na formação de recursos humanos em Qualidade no Uso Racional d Medicamentos e em Ciência de Animais de Laboratório, continuou pela América Latina, como consultora da OPAS (Organização Pan-Americana da Saúde), BID (Banco Interamericano de Desenvolvimento), USAID (United States Agency for International Development) e de outros organismos internacionais e nacionais, entendendo sua atividade a 14 países da America Latina. Outra honra conquistada em homenagem a sua trajetória e contribuição à Ciência Brasileira e Latinoamericana, a Academia Nacional de Farmácia do Brasil a elegeu como Acadêmia, na qualidade de Membro Honorário Estrangeiro, em julho de 2010. Este artigo representa o carinho e afeto que querem expressar todos os profissionais que tiveram oportunidade de desfrutar dos conhecimentos profundos da Ciência de Animais de Laboratório, generosamente compartilhados pela Dra Adela Rosenkranz.

This article depicts the trajectory of Dr. Adela Rosenkranz in Brazil and others Latin American countries. After the establishment of totalitarian political in the sixties, seventies and eighties of the twentieth century in Latin America, she was driven to leave Argentina and come to Brazil, as invited by several teachers. At that time, Dr. Adela alerted the scientific leaders about the poor quality of the biological models used, having as subjects the genetic quality and helth of laboratory animals and training professionals in the area. During this period Dra. Adela settled in the animal facility of the Escola Paulista de Medicina (Unifesp), where we were the leaders. She collaborated with emphasis on a central project to its reform and implementation. During this period, Dra. Adela led the organization of The Regional and International Scientific Meeting - First Congress of Laboratory Animal Science in Brazil, held in Águas de Lindóia, which was attended by over 500 national and international participants. She worked as a consultant in the modernization of many Brazilian animal facilities and the implementation of some regional networks os animal houses. In parallel, coordinated and taught courses in statistical Applicable to Biological Assays, both in Brazil and in several Latin American countries, as she still does nowadays. Since the early 90's her commitment to forward the consultant for Pan American Health Organization (PAHO), Inter-American Development Bank (IDB), United States Agency for International Development (USAID) and other international and national organizations, extending its activities to 14 countries in Latin America. In honor of her career and contribution to the Brazilian and Latin Ameican Science, the National Academy of Pharmacy of Brazil elected ger as an Academic, as Foreign Honorary Member in July 2010. This article represents the care and affection of all the professionals who had the opportunity to enjoy the deep knowledge of Laboratory Animal Science generouslu shared by Adela Rosenkranz.

Assuntos

RESUMO

Este artigo retrata a trajetória da Dra. Adela Rosenkranz no Brasil e outros países da América Latina. Após a instauração das políticas totalitárias nos anos sessenta, setenta e oitenta do século XX na América Latina, a Dra. Adela foi impulsionada a sair da Argentina e vir para o Brasil, como convidada por diversos professores. Naquele período, alertou as lideranças científicas sobre a qualidade inadequada dos modelos biológicos utilizados, tendo como temas a qualidade genética e sanitária dos animais de laboratório e a formação de profissionais na área. Instalada no biotério da Escola Paulista de Medicina (Unifesp), colaborou com destaque em um projeto fundamental para sua reforma e implementação. Em 1985, liderou a organização do Regional/International Scientific Meeting/I Congresso da Ciência de Animais de Laboratório no Brasil, em Águas de Lindóia - São Paulo, que contou com mais de 500 participantes nacionais e internacionais. Colaborou como consultora na modernização de inúmeros biotérios brasileiros e na implantação de Estatística Apllicáveis aos Ensaios Biológicos, tanto no Brasil como em diversos países Latino Americanos, como faz até hoje. Desde princípios dos anos 90 o empenho da Dra. Adela, em transmitir conceitos de excelência e na formação de recursos humanos em Qualidade no Uso Racional d Medicamentos e em Ciência de Animais de Laboratório, continuou pela América Latina, como consultora da OPAS (Organização Pan-Americana da Saúde), BID (Banco Interamericano de Desenvolvimento), USAID (United States Agency for International Development) e de outros organismos internacionais e nacionais, entendendo sua atividade a 14 países da America Latina. Outra honra conquistada em homenagem a sua trajetória e contribuição à Ciência Brasileira e Latinoamericana, a Academia Nacional de Farmácia do Brasil a elegeu como Acadêmia, na qualidade de Membro Honorário Estrangeiro, em julho de 2010. Este artigo representa o carinho e afeto que querem expressar todos os profissionais que tiveram oportunidade de desfrutar dos conhecimentos profundos da Ciência de Animais de Laboratório, generosamente compartilhados pela Dra Adela Rosenkranz.(AU)

This article depicts the trajectory of Dr. Adela Rosenkranz in Brazil and others Latin American countries. After the establishment of totalitarian political in the sixties, seventies and eighties of the twentieth century in Latin America, she was driven to leave Argentina and come to Brazil, as invited by several teachers. At that time, Dr. Adela alerted the scientific leaders about the poor quality of the biological models used, having as subjects the genetic quality and helth of laboratory animals and training professionals in the area. During this period Dra. Adela settled in the animal facility of the Escola Paulista de Medicina (Unifesp), where we were the leaders. She collaborated with emphasis on a central project to its reform and implementation. During this period, Dra. Adela led the organization of The Regional and International Scientific Meeting - First Congress of Laboratory Animal Science in Brazil, held in Águas de Lindóia, which was attended by over 500 national and international participants. She worked as a consultant in the modernization of many Brazilian animal facilities and the implementation of some regional networks os animal houses. In parallel, coordinated and taught courses in statistical Applicable to Biological Assays, both in Brazil and in several Latin American countries, as she still does nowadays. Since the early 90's her commitment to forward the consultant for Pan American Health Organization (PAHO), Inter-American Development Bank (IDB), United States Agency for International Development (USAID) and other international and national organizations, extending its activities to 14 countries in Latin America. In honor of her career and contribution to the Brazilian and Latin Ameican Science, the National Academy of Pharmacy of Brazil elected ger as an Academic, as Foreign Honorary Member in July 2010. This article represents the care and affection of all the professionals who had the opportunity to enjoy the deep knowledge of Laboratory Animal Science generouslu shared by Adela Rosenkranz. (AU)

Assuntos