RESUMO
BACKGROUND: In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions. This could also provide a new possibility for the better understanding of difference between human and chimpanzee. RESULTS: In this study, we analyzed to find molecular characteristics of human brain functions from the difference of transcriptome between human and chimpanzee's brain using the functional module-centric co-expression analysis. We performed analysis of brain disease association and systems-level connectivity of species-specific co-expressed functional modules. CONCLUSIONS: Throughout the analyses, we found human-specific functional modules and significant overlap between their genes in known brain disease genes, suggesting that human brain disorder could be mediated by the perturbation of modular activities emerged in human brain specialization. In addition, the human-specific modules having neurobiological functions exhibited higher networking than other functional modules. This finding suggests that the expression of neural functions are more connected than other functions, and the resulting high-order brain functions could be identified as a result of consolidated inter-modular gene activities. Our result also showed that the functional module based transcriptome analysis has a potential to expand molecular understanding of high-order complex functions like cognitive abilities and brain disorders.
Assuntos
Humanos , Animais , Encéfalo/metabolismo , Pan troglodytes/genética , Redes Reguladoras de Genes/genética , Transcriptoma , Vias Neurais/metabolismo , Predisposição Genética para Doença/classificação , Predisposição Genética para Doença/genética , Perfilação da Expressão Gênica/métodosRESUMO
O objetivo deste artigo é apresentar a relação da qualificação da tenepes coma participação em cursos de campo, no caso em estudo, o curso ECP2, através do me canismo das conexões assistenciais. Apresenta o mecanismo de conectividade assistencialcomo elemento de ligação entre o tenepessista, o amparador e a assistência interdimensionala ser realizada. A metodologia utilizada na pesquisa foi a análise dosregistros e das experiências pessoais da autora. Conclui-se que o investimento na conexãotenepes-ECP2 prepara e dinamiza a vivência pró-desperticidade(AU)
The objective of this article is to present the relationship of the qualification ofpenta with the participation in field courses, which in this case, the ECP2 course,through the mechanism of the assistantial connections. It presents the mechanism ofassistantial connection as the linking element between the penta practitioner, thehelper and the interdimensional assistance to be done. The methodology used in theresearch was the analysis of the registries and the author's personal experiences. Itconcludes that the investment in the connection penta-ECP2, prepares and optimizethe experience pro-intrusionfreeness(AU)
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