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1.
Arch Environ Occup Health ; 77(9): 774-777, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35040747

RESUMO

This case report describes a 61-year-old male who sought treatment for sudden symptoms of dry cough, chest pain and severe dyspnea. On admission, the patient had hypoxemia and predominantly medullary infiltrate that we could observe on his imaging exams. After hospital discharge, he presented two similar episodes, with clinical and radiological improvement with oxygen therapy alone. He denied exposure to birds, mold or chemical agents. However, the patient noticed the onset of symptoms soon after drinking chimarrão. Given the compatible clinical, radiological and laboratory history, the diagnosis of hypersensitivity pneumonitis was performed. The patient was instructed by the medical team not to consume the drink anymore, remaining asymptomatic for more than two years.


Assuntos
Alveolite Alérgica Extrínseca , Pneumonia , Alveolite Alérgica Extrínseca/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade
2.
Rev Bras Med Trab ; 19(2): 249-252, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34603422

RESUMO

Hypersensitivity pneumonia is an immune-mediated inflammation of the lung parenchyma that occurs in previously susceptible individuals, after inhalation of antigens, usually organic. In recent years, various chemical agents have been described as inducers of hypersensitivity pneumonia, including exposure to high concentrations of pesticides. The objective of the present case report was to describe a possible association of hypersensitivity pneumonia with pesticide chronic inhalation and to draw attention to the importance of early diagnosis. The patient was 72-year-old man who worked for over 30 years as a health agent fumigating pesticides in rural and urban areas. He had progressive dyspnea and cough for the past 3 years. Chest tomography demonstrated parenchymal bands, honeycombing, and diffuse air trapping. Spirometry showed a severe restrictive pattern. Surgical lung biopsy was indicated, which confirmed the diagnosis of hypersensitivity pneumonia. Due to the wide use of pesticides in Brazil, the knowledge of their association with hypersensitivity pneumonia is of great importance in warning the teams involved in health care and surveillance of these workers, providing earlier diagnoses, with better prognosis. On the contrary, late diagnoses, such as that of the case reported, have important health impacts. As a priority, preventive measures must be taken to protect exposed individuals.

3.
BMC Pulm Med ; 20(1): 299, 2020 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-33198708

RESUMO

BACKGROUND: Usual interstitial pneumonia can present with a probable pattern on high-resolution computed tomography (HRCT), but the probability of identifying usual interstitial pneumonia by surgical lung biopsy in such cases remains controversial. We aimed to determine the final clinical diagnosis in patients with a probable usual interstitial pneumonia pattern on HRCT who were subjected to surgical lung biopsy. METHODS: HRCT images were assessed and categorized by three radiologists, and tissue slides were evaluated by two pathologists, all of whom were blinded to the clinical findings. The final clinical diagnosis was accomplished via a multidisciplinary discussion. Patients with a single layer of honeycombing located outside of the lower lobes on HRCT were not excluded. RESULTS: A total of 50 patients were evaluated. The most common final clinical diagnosis was fibrotic hypersensitivity pneumonitis (38.0%) followed by idiopathic pulmonary fibrosis (24.0%), interstitial lung disease ascribed to gastroesophageal reflux disease (12.0%) and familial interstitial lung disease (10.0%). In the group without environmental exposure (n = 22), 10 patients had a final clinical diagnosis of idiopathic pulmonary fibrosis (45.5%). Irrespective of the final clinical diagnosis, by multivariate Cox analysis, patients with honeycombing, dyspnoea and fibroblastic foci on surgical lung biopsy had a high risk of death. CONCLUSIONS: The most common disease associated with a probable usual interstitial pneumonia pattern on HRCT is fibrotic hypersensitivity pneumonitis followed by idiopathic pulmonary fibrosis and interstitial lung disease ascribed to gastroesophageal reflux disease. In patients without environmental exposure, the frequencies of usual interstitial pneumonia and a final clinical diagnosis of idiopathic pulmonary fibrosis are not sufficiently high to obviate the indications for surgical lung biopsy.


Assuntos
Alveolite Alérgica Extrínseca/diagnóstico por imagem , Fibrose Pulmonar Idiopática/diagnóstico por imagem , Doenças Pulmonares Intersticiais/diagnóstico por imagem , Pulmão/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Idoso , Alveolite Alérgica Extrínseca/patologia , Biópsia/efeitos adversos , Diagnóstico Diferencial , Feminino , Humanos , Fibrose Pulmonar Idiopática/patologia , Pulmão/patologia , Doenças Pulmonares Intersticiais/patologia , Masculino , Pessoa de Meia-Idade , Probabilidade , Estudos Retrospectivos
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