RESUMO
Introducción: La retinocoroidopatía birdshot (RCB) es una uveítis posterior crónica, bilateral de origen autoinmune, con fuerte asociación al antígeno leucocitario humano HLA-A29. Objetivo: Describir un caso de RCB en Colombia. Material y métodos: Mujer caucásica de 57 años, con hallazgos clínicos y exámenes complementarios compatibles con RCB. Recibió terapia biológica durante 15 meses, con mejoría clínica significativa. Resultados y conclusiones: El tratamiento depende del estadio de la enfermedad y consiste en el uso solo de corticoesteroides o combinación con agentes inmunosupresores y biológicos, que han demostrado preservar la función visual y minimizar efectos adversos de los esteroides
Background: Birdshot Retinocoroidopathy (BRC) is a chronic, bilateral posterior uveitis of autoimmune origin, with a strong association with the human leukocyte antigen HLA-A29. Objective: To describe a BRC case in Colombia. Material and methods: A 57-year-old Caucasian woman with clinical findings and complementary tests compatible with BRC. She received biologic therapy for 15 months, with significant clinical improvement. Results and conclusions: Treatment depends on stage of disease and is about corticosteroid use, alone or combination with immunosuppressive and biological agents, which have been shown to preserve visual function and minimize adverse effects of steroids
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , ColômbiaRESUMO
OBJECTIVE: To describe the characteristics, upon presentation, of a cohort of Hispanic patients with birdshot retinochoroidopathy. METHODS: A retrospective chart review of Hispanic patients with birdshot retinochoroidopathy of was performed. The demographic and clinical characteristics were analyzed. RESULTS: Nine patients who met the research criteria for a diagnosis of birdshot retinochoroidopathy were identified and included in the analysis, all of whom were HLA-A29 positive. The median age of the cohort upon presentation was 52 years; 89% of the patients were female, and all were Hispanics. Ninety-four percent of the eyes had an initial visual acuity of 20/50 or better, while 72% had measured 20/25 or better. Sixty-one percent of the eyes had retinal vasculitis, which was bilateral in 83% of the cases. Thirty-three percent of the patients had, upon presentation, evidence of cystoid macular edema, which was always bilateral. All the eyes had the typical birdshot lesions, at presentation. CONCLUSION: Birdshot retinochoroidopathy can be found in Hispanic patients. Our study suggests that the characteristics upon presentation in Hispanics may be similar to those of Caucasian cohorts.
Assuntos
Coriorretinopatia de Birdshot/diagnóstico , Hispânico ou Latino , Adulto , Coriorretinopatia de Birdshot/etnologia , Coriorretinopatia de Birdshot/imunologia , Estudos de Coortes , Feminino , Fundo de Olho , Antígenos HLA-A , Humanos , Edema Macular/diagnóstico , Edema Macular/etnologia , Masculino , Pessoa de Meia-Idade , Porto Rico , Vasculite Retiniana/diagnóstico , Vasculite Retiniana/etnologia , Estudos Retrospectivos , Avaliação de Sintomas , Acuidade VisualRESUMO
HLA-A*29:01:08 differs from A*29:01:01:01 by a single synonymous substitution at position 519, codon 149 GCGâGCA in exon 3.