RESUMO
El síndrome de transfusión feto fetal es una complicación grave de las gestaciones gemelares monocoriales. Su etiología se debe a la transfusión crónica de sangre del feto donante, al feto receptor, a través de las anastomosis vasculares entre los territorios placentarios de ambos. El cuadro clínico característico se evidencia en ambos fetos, receptor y donante, lo cual es consecuencia directa de las alteraciones en la volemia que padece cada uno. En el feto receptor se observa un polihidramnios relacionado con la poliuria derivada de un estado de hipervolemia constante, que acaba evolucionando hacia una insuficiencia cardiaca congestiva. En el feto donante el cuadro es inverso, caracterizado por oligoamnios, oliguria, crecimiento intrauterino retardado e hipovolemia, con tasas de mortalidad sin tratamiento de entre el 80-100% de los casos, que varían en función del grado de transfusión. El diagnóstico se basa en el estudio ecográfico exhaustivo de ambos fetos, procurando un diagnóstico precoz y un estadiaje correcto, ya que el pronóstico se verá muy influenciado por la actuación temprana. El tratamiento de elección es la coagulación láser de las anastomosis vasculares por fetoscopia, que se realiza idealmente entre la semana 18 y 26 de embarazo. El pronóstico es variable, en función de la disponibilidad de terapia fetal y de la edad gestacional en el momento del diagnóstico, siendo, en general, de muy mal pronóstico sin tratamiento efectivo(AU)
Twin-twin transfusion syndrome (TTTS) is one of the most serious complications of monochorionic multiple gestations. The etiology is due to a chronic blood transfusion from de donor twin to the recipient twin trough vascular anastomoses between both placenta territories. Main clinical presentation is present in both donor and recipient fetuses, as a direct consequence of a blood volume alteration in each one. The recipient twin shows polyhydramnios related to polyuria resulting from a state of constant fluid overload, finally evolving into congestive heart failure. In the donor twin, the clinical presentation is opposite and shows oligoamnios, oliguria, intrauterine retarded growth and hypovolemia. Untreated mortality rates are between 80-100 % of all cases, which may vary depending on the severity of the transfusion. Diagnoses is based on exhausting ultrasound examination of both fetuses, securing early diagnosis and correct staging, since prognosis will be greatly influenced by early actions. Fetoscopic laser ablation is generally the definitive treatment between 16 and 26 weeks of gestation. The prognosis is variable, depending on the availability of fetal therapy and gestational age at diagnosis. It is generally very poor prognosis without effective treatment(AU)
Assuntos
Transfusão Feto-Fetal/diagnósticoRESUMO
El síndrome de transfusión feto fetal es una complicación grave de las gestaciones gemelares monocoriales. Su etiología se debe a la transfusión crónica de sangre del feto donante, al feto receptor; a través de las anastomosis vasculares entre los territorios placentarios de ambos. El cuadro clínico característico se evidencia en ambos fetos: receptor y donante, lo cual es consecuencia directa de las alteraciones en la volemia que padece cada uno. En el feto receptor, se observa un polihidramnios relacionado con la poliuria derivada de un estado de hipervolemia constante, que evoluciona hacia una insuficiencia cardiaca congestiva. En el feto donante, el cuadro es inverso; caracterizado por oligoamnios, oliguria, crecimiento intrauterino retardado e hipovolemia, con tasas de mortalidad sin tratamiento de entre 80-100 por ciento de los casos, que varían en función del grado de transfusión. El diagnóstico se basa en el estudio ecográfico exhaustivo de ambos fetos, procurando un diagnóstico precoz y un estadiaje correcto, ya que el pronóstico se verá muy influenciado por la actuación temprana. El tratamiento de elección es la coagulación láser de las anastomosis vasculares por fetoscopia, idealmente entre la semana 18 y 26 de embarazo. El pronóstico es variable, en función de la disponibilidad de terapia fetal y de la edad gestacional en el momento del diagnóstico; al ser, en general, de muy mal pronóstico sin tratamiento efectivo(AU)
Twin-twin transfusion syndrome is one of the most serious complications of monochorionic multiple gestations. Its etiology is due to a chronic blood transfusion from de donor twin to the recipient twin through the vascular anastomoses between the placental territories of both fetuses. The characteristic clinical presentation appears in both donor and recipient fetuses, as a direct consequence of altered volemia in each one. Polyhydramnios related to polyuria resulting from a state of constant hypervolemia is observed in the recipient twin, finally evolving into congestive heart failure. The clinical presentation in the donor twin is reversed and characterized by oligoamnios, oliguria, retarded intrauterine growth and hypovolemia, with untreated mortality rates ranging 80-100 percent of all cases, which may vary depending on the severity of the transfusion. The diagnosis is based on exhaustive echographic examination of both fetuses to make an early diagnosis and correct staging, since the prognosis depends very much on early action. The treatment of choice is fetoscopic laser coagulation of vascular anastomoses between 18 and 26 weeks of gestation. The prognosis is variable, depending on the availability of fetal therapy and the gestational age at diagnosis, being prognosis generally very poor without an effective treatment(AU)
Assuntos
Humanos , Feminino , Gravidez , Adulto , Transfusão Feto-Fetal/complicações , Transfusão Feto-Fetal/diagnóstico por imagem , Fetoscopia/métodos , Ultrassonografia Pré-Natal/métodos , Doenças Fetais/cirurgiaRESUMO
This study aimed to evaluate the effect of turn and type of birth on the behavior of the concentration ofglucose in Dorper lambs grazing in Piauí semiarid. 18 lambs were used in the Dorper, born aged twenty fourhours. For the evaluation of plasma concentrations of glucose, the animals were randomly distributed in shifts(day and night) and the type of birth (single and double). Blood samples were collected at 24 hours of elapsedtime after birth, soon after placed in tubes with sodium fluoride and taken to the Clinical Pathology Laboratoryof the University Veterinary Hospital - HVU, UFPI. Analysis of variance revealed a significant effect of theinteraction shift in the types of twin births (116.64 ± 6.28) on the concentration of plasma glucose. Theconclusion of this research was that the performance of twin lambs, is due to the amount of ingested colostrumdoes not depend directly on the amount of offspring or due to their own birth order.
Assuntos
Feminino , Animais , Glucose/análise , Ovinos/embriologia , Ovinos/fisiologia , Parto , SoroRESUMO
This study aimed to evaluate the effect of turn and type of birth on the behavior of the concentration ofglucose in Dorper lambs grazing in Piauí semiarid. 18 lambs were used in the Dorper, born aged twenty fourhours. For the evaluation of plasma concentrations of glucose, the animals were randomly distributed in shifts(day and night) and the type of birth (single and double). Blood samples were collected at 24 hours of elapsedtime after birth, soon after placed in tubes with sodium fluoride and taken to the Clinical Pathology Laboratoryof the University Veterinary Hospital - HVU, UFPI. Analysis of variance revealed a significant effect of theinteraction shift in the types of twin births (116.64 ± 6.28) on the concentration of plasma glucose. Theconclusion of this research was that the performance of twin lambs, is due to the amount of ingested colostrumdoes not depend directly on the amount of offspring or due to their own birth order.(AU)
Assuntos
Animais , Feminino , Ovinos/embriologia , Ovinos/fisiologia , Parto , Glucose/análise , SoroRESUMO
The endothelin is a potent vasoconstricor that possess angiogenic, mitogenic and neurotrophical functions. In this study we aimed to quantify the Endothelin-1 (ET-1) levels in chorionic placental villi and amnion of placentae of twins childbirths whose women were submitted to an assisted pregnancy and spontaneal fecundation. Were collected 08 placental samples. After the placental delivery the samples had been placed in liquid nitrogen and later in a -80ºC until the Enzyme-Linked Immunosorbent Assay (ELISA) technique. The concentration levels of ET-1 in samples of chorionic villi in twins placentae varied from 0,52 to 0,70 fmol/ml, while in chorionic villi single gestation varied from 0,47 to 0,86 fmol/ml. The same determination in samples of amnion of twins placentae varied from 0,65 to 1,16 fmol/ml, while in single gestation varied from 0,65 to 1,04 fmol/ml. These findings suggests that in the chorionic villi the levels of ET-1 didn"t vary between twins and single gestation. In the amnion the levels of ET-1 are higher in twins than in single gestation, suggesting that the amnion is the source of ET-1 in the amniotic fluid.
A endotelina é um peptídeo vasoconstrictor potente que possui funções angiogênicas, mitogênicas e neurotróficas. Neste estudo procurou-se quantificar os níveis de Endotelina -1 (ET-1) em vilos coriônicos placentários e no âmnio de placentas de fetos gemelares, cujas mães submeteram-se à reprodução assistida e fecundação espontânea. Foram colhidas oito amostras de placentas, que após o delivramento placentário, foram colocadas em nitrogênio líquido e, posteriormente, congeladas e mantidas à -80ºC até o processamento por ensaio imunoenzimático (ELISA). Os níveis de concentração de ET-1 em amostras de vilos coriônicos de placentas de fetos gemelares variaram de 0,52 a 0,70fmol/ml, enquanto que de fetos únicos variou de 0,47 a 0,86fmol/ml. A mesma determinação em amostras de âmnio de placentas de gemelares variou de 0,61 a 1,16 fmol/ml, enquanto que de fetos únicos variou de 0,65 a 1,04fmol/ml. Estes achados indicam que em vilos coriônicos, os níveis de concentração de ET-1 não variaram entre gemelares e fetos únicos. No âmnio, os níveis de ET-1 são mais elevados em gemelares que em fetos únicos, dados que sugerem que o âmnio é a principal fonte de ET-1 presente no líquido amniótico.
RESUMO
In the present work, we developed several extensive experiments with Pollwart (Ideal) and Corriedale sheep flocks, at the Posto de Ovinos e Caprinos de Itapetininga, Instituto de Zootecnia, Secretaria da Agricultura do Estado de Sao Paulo, with the aim of investigating the effects of the preweaning mortality and the birth and weaning weight for twin and single lambs. The preweaning mortality among twin lambs was higher than that observed among single lambs. The weights at birth and at weaning were significantly higher for single than for twin lambs in both races.
Foram comparados a mortalidade pré-desmame e os pesos ao nascer e ao desmame (105 dias) de cordeiros das raças Ideal e Corriedale de parto simples e gemelar. De um total de 279 cordeiros ideal de parto simples ocorreram 30 óbitos (10,8%) enquanto que em 132 gêmeos foram verificados 34 óbitos (25,8%). De um total de 124 cordeiros corriedale de parto simples ocorreram 9 óbitos (7,3%) e de 28 gêmeos, 7 óbitos (25,0%). As diferenças de mortalidade entre cordeiros de parto simples e gêmeos foram significativas (P 0,01) para ambas as raças. O peso ao nascer dos cordeiros da raça Ideal de parto simples foi 3,75 kg e o de gêmeos 2,89 kg (P 0,01), enquanto que o peso ao desmame foi de 19,21 kg para os de parto simples e 13,34 kg para gêmeos (P 0,01). Para a raça Corriedale o peso ao nascer foi de 4,00 kg para os de parto simples e 2,96 kg para gêmeos (P 0,01) e ao desmame verificou-se um peso de 19,52 kg para os de parto simples e 15,43 kg para gêmeos (P 0,01).
RESUMO
In the present work, we developed several extensive experiments with Pollwart (Ideal) and Corriedale sheep flocks, at the Posto de Ovinos e Caprinos de Itapetininga, Instituto de Zootecnia, Secretaria da Agricultura do Estado de Sao Paulo, with the aim of investigating the effects of the preweaning mortality and the birth and weaning weight for twin and single lambs. The preweaning mortality among twin lambs was higher than that observed among single lambs. The weights at birth and at weaning were significantly higher for single than for twin lambs in both races.
Foram comparados a mortalidade pré-desmame e os pesos ao nascer e ao desmame (105 dias) de cordeiros das raças Ideal e Corriedale de parto simples e gemelar. De um total de 279 cordeiros ideal de parto simples ocorreram 30 óbitos (10,8%) enquanto que em 132 gêmeos foram verificados 34 óbitos (25,8%). De um total de 124 cordeiros corriedale de parto simples ocorreram 9 óbitos (7,3%) e de 28 gêmeos, 7 óbitos (25,0%). As diferenças de mortalidade entre cordeiros de parto simples e gêmeos foram significativas (P 0,01) para ambas as raças. O peso ao nascer dos cordeiros da raça Ideal de parto simples foi 3,75 kg e o de gêmeos 2,89 kg (P 0,01), enquanto que o peso ao desmame foi de 19,21 kg para os de parto simples e 13,34 kg para gêmeos (P 0,01). Para a raça Corriedale o peso ao nascer foi de 4,00 kg para os de parto simples e 2,96 kg para gêmeos (P 0,01) e ao desmame verificou-se um peso de 19,52 kg para os de parto simples e 15,43 kg para gêmeos (P 0,01).