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1.
Environ Toxicol ; 39(3): 1822-1835, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38083805

RESUMO

Glyphosate-based herbicides (GBH) have been commonly used in agriculture to inhibit weed growth and increase yields. However, due to the high solubility of these herbicides in water, they can reach aquatic environments, by infiltration, erosion, and/or lixiviation, affecting non target organisms. Thus, this study aimed to characterize the toxicity of GBH Roundup WG® (RWG®) during the embryonic and larval development of Danio rerio. Embryos (3 hours post fertilization, hpf-until hatching) and larvae (3 days post fertilization, dpf to 6 dpf) were exposed to concentrations of 0.065 and 6.5 mg L-1 . They were evaluated for survival, hatching, spontaneous movements, heartbeat, morphology, and morphometry by in vivo photographs in microscope, cell proliferation and apoptosis by immunohistochemistry, and exploratory behavior and phototropism by video recording. Our results showed an increase in embryo and larvae mortality in those exposed to 0.065 mg L-1 , as well as a reduction in spontaneous embryo movements. The larval heartbeats showed a decrease at 4 dpf in the group exposed to 0.065 mg L-1 and an increase at 5 and 6 dpf in both exposed groups. Cell proliferation was reduced in both groups exposed in embryos and only in the 0.065 mg L-1 group in larvae, while cell death increased in embryos exposed to 6.5 mg L-1 . These results demonstrated the toxic effect of low concentrations of the herbicide RWG® during embryonic and larval development of non target organisms, as well as the importance of constantly reviewing acceptable limits for exposure in natural environments.


Assuntos
Herbicidas , Perciformes , Poluentes Químicos da Água , Animais , Glifosato , Herbicidas/toxicidade , Peixe-Zebra , Glicina/toxicidade , Embrião não Mamífero , Larva , Poluentes Químicos da Água/toxicidade , Desenvolvimento Embrionário
2.
Front Psychol ; 14: 1253654, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37908820

RESUMO

Introduction: Creativity is a recognized quality in various areas, including sports. Within the training processes, various modifications to objectives, game configurations, rules, among other factors, can be considered to favor creative solutions to the tactical problems inherent to soccer. This systematic review aimed to identify the impact of the number of players on the emergence of creative movements in small-sided soccer games, emphasizing deliberate practice. Methods: A systematic review of Scopus, PubMed, Scielo, PsycInfo, SportDiscus and Lilacs databases was performed according to PRISMA guidelines. Eligibility criteria were defined based on the elements of population, context and concept. Only full articles published in scientific journals written in English were included. No period restriction was applied. Results: Five papers were included and the results of studies indicate greater number of actions, variability, and creativity in small-sided games compared to formal soccer matches. When comparing different small-sided game formats, 5 v 5 showed higher values in terms of total number of actions compared to 7 v 7, and the absolute number of original and creative actions tended to decrease as the game format increased. Imbalanced small-sided games format can promote increased exploratory behavior. Structural manipulation in goal positioning in 5 v 5 games may also influence the originality of tactical behaviors, while the use of different ball types in 4 v 4 games appears to decrease fluency values. In 6 v 6 games, fluency and versatility are negatively impacted. Conclusion: Reduced game formats with fewer players and in smaller field dimensions provide more suggestive environment for exploratory behavior, variability and original and creative actions. The protocol was registered on the Open Science Framework (OSF) on 2 December 2022 (DOI: 10.17605/OSF.IO/VN6YZ). Systematic review registration: [https://osf.io/jmf4k/].

3.
Front Psychol ; 14: 1278774, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37965660

RESUMO

Introduction: The onset of manual reaching allows the expansion of the infant's interaction with the environment. When born preterm, infants become vulnerable to problems in the development of reaching. However, it is still unknown whether there are differences in reaching according to the degree of prematurity. Objective: This study aimed to explore the differences in reaching acquisition and behavior between late preterm and very preterm infants, as well as whether age and clinical variables influence the results. Method: This is an exploratory, comparative, observational study. In total, 24 infants were included soon after reaching onset; 12 infants were born late preterm (35.55 ± 0.67 gestational weeks) and 12 very preterm (30.60 ± 0.05 gestational weeks). Infants were placed in a baby seat, and a toy was placed at a reachable distance for 2 min. Reaching behavior was the primary variable; birth weight and length of hospital stay were secondary variables. Results: The age of reaching onset was higher in the very preterm group. The proportion of reaches with grasping was higher in the late preterm group. These differences were affected by the lower birth weight and longer length of hospital stay in the very preterm group. The proportions of proximal and distal adjustments did not differ between groups. Conclusion: Very preterm infants presented disadvantages in the acquisition time and the number of reaches with grasping, but not in the proportions of proximal and distal adjustments of reaching, relative to late preterm infants. Group differences were influenced by clinical variables.

4.
Cir Cir ; 2023 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-37770074

RESUMO

Foreign bodies in the bladder can occur by self-insertion, and patients often hide the symptoms owing to embarrassment. The foreign bodies act as a nidus for calculus formation when not detected for a long time. Foreign bodies can declare symptoms such as frequency, dysuria, nocturia, hematuria, urethrorrhagia, obstruction, or retention. This case spotlights self-inserted intravesical neodymium magnetic spheres clumped and calcified due to delayed presentation which were removed by open cystotomy after a cystoscopic failure.


Los cuerpos extraños en la vejiga pueden ocurrir por autoinserción y los pacientes a menudo ocultan los síntomas por vergüenza. Los cuerpos extraños actúan como un nido para la formación de cálculos cuando no se detectan durante mucho tiempo. Los cuerpos extraños pueden manifestar síntomas como polaquiuria, disuria, nicturia, hematuria, uretrorragia, obstrucción o retención. Este caso destaca esferas magnéticas de neodimio intravesicales autoinsertadas, agrupadas y calcificadas debido a una presentación tardía que se extrajeron mediante cistotomía abierta después de una falla cistoscópica.

5.
Pharmacol Biochem Behav ; 230: 173618, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37595803

RESUMO

Substance dependence is a disorder that alters the functioning of the nervous system due to frequent abuse of drugs. The role of dopamine in the addictive effect of psychostimulants is well known; however, the involvement of the noradrenergic system is still unclear and poorly understood, though drugs like cocaine and amphetamines are known to exert significant activity on this system. The drug modafinil (MOD) has no proven addictive effect. It promotes wakefulness by acting mainly on the dopaminergic system and, to a lesser degree, the noradrenergic (NOR) system. Atomoxetine (ATX) is a non-stimulant drug that acts only on the NOR system, enhancing its activity. The aims of the present study were to analyze the effect of co-activating the DA and NOR systems (with MOD and ATX, respectively) on motor activity and exploratory behavior, and to examine the possible emergence of rewarding properties of MOD and an MOD+ATX mixture. Male Wistar rats at postnatal day 60 were treated chronically (16 days) with either monotherapy with 2ATX, 4ATX, or 60MOD mg/kg, two combinations of these substances -60MOD + 2ATX and 60MOD + 4ATX- or a vehicle. The rats co-administered with 60MOD + 4ATX reduced the rearing behavior frequency induced by MOD, but this behavior was sensitized by self-administration of the MOD+ATX mixture after chronic treatment. The rats pre-treated with 60MOD + 4ATX showed higher self-administration of MOD and greater activity on an operant task to obtain the MOD+ATX mixture. In addition, the 60MOD, 2ATX, and 60MOD + 2ATX groups showed sensitization of exploratory behavior after ingesting the mixture. Results suggest that the noradrenergic system enhances the incentive value of MOD and a MOD+ATX mixture, while also playing an important role in the sensitization of exploratory behavior.


Assuntos
Comportamento Exploratório , Motivação , Masculino , Animais , Ratos , Ratos Wistar , Modafinila/farmacologia , Cloridrato de Atomoxetina/farmacologia , Dopamina
6.
Front Endocrinol (Lausanne) ; 14: 1062211, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36817576

RESUMO

Introduction: Vasopressin (AVP) and oxytocin (OXT) are neuropeptides produced by magnocellular neurons (MCNs) of the hypothalamus and secreted through neurohypophysis to defend mammals against dehydration. It was recently demonstrated that MCNs also project to limbic structures, modulating several behavioral responses. Methods and Results: We found that 24 h of water deprivation (WD) or salt loading (SL) did not change exploration or anxiety-like behaviors in the elevated plus maze (EPM) test. However, rats deprived of water for 48 h showed reduced exploration of open field and the closed arms of EPM, indicating hypoactivity during night time. We evaluated mRNA expression of glutamate decarboxylase 1 (Gad1), vesicular glutamate transporter 2 (Slc17a6), AVP (Avpr1a) and OXT (Oxtr) receptors in the lateral habenula (LHb), basolateral (BLA) and central (CeA) amygdala after 48 h of WD or SL. WD, but not SL, increased Oxtr mRNA expression in the CeA. Bilateral pharmacological inhibition of OXTR function in the CeA with the OXTR antagonist L-371,257 was performed to evaluate its possible role in regulating the EPM exploration or water intake induced by WD. The blockade of OXTR in the CeA did not reverse the hypoactivity response in the EPM, nor did it change water intake induced in 48-h water-deprived rats. Discussion: We found that WD modulates exploratory activity in rats, but this response is not mediated by oxytocin receptor signaling to the CeA, despite the upregulated Oxtr mRNA expression in that structure after WD for 48 h.


Assuntos
Núcleo Central da Amígdala , Ratos , Animais , Núcleo Central da Amígdala/metabolismo , Ocitocina/metabolismo , Receptores de Ocitocina/metabolismo , Desidratação , Privação de Água , Água , RNA Mensageiro , Mamíferos/metabolismo
7.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;56: e12902, 2023. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1520465

RESUMO

There are several studies in the literature showing that male and female rats explore novel environments and exhibit different exploration patterns when submitted to different apparatuses. In general, female rats spend more time moving and exploring the apparatuses than males do. A previous study showed that male woodlice (Armadillidium vulgare) explore novel environments in a very similar way to male rats (Rattus norvegicus) when tested in apparatuses analogous to the open-field test and light/dark box. Since that study was conducted only with male rats and woodlice, and since they exhibited very similar patterns of behavior, the present experiment aimed at investigating whether male and female woodlice explore novel environments with different behavioral patterns. Female and male woodlice were tested in the open-field and in the dry/moist box. Results obtained in the open-field test showed that both males and females remained longer in the corners than along the walls and avoided staying in the center. However, females remained longer along the walls and less in the corners. In the dry/moist box, there were no significant differences between the sexes: both females and males remained significantly longer in the moist compartment.

8.
Front Pharmacol ; 13: 841826, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35444550

RESUMO

Atrazine and Diuron are widely used herbicides. The use of pesticides contaminates the aquatic environment, threatening biodiversity and non-target organisms such as fish. In this study, we investigated the effects of acute exposure for 96 h hours to atrazine and diuron commercial formulations in zebrafish (Danio rerio, wild-type AB) embryos and larvae and adult stages. We observed a significant concentration-dependent survival decrease and hatching delays in animals exposed to both herbicides and in the frequency of malformations compared to the control groups. Morphological defects included cardiac edema, tail reduction, and head malformation. At 7 days post-fertilization (dpf), atrazine exposure resulted in a reduction in the head length at 2, 2.5, and 5 mg/L and increased the ocular distance at 1, 2, 2.5, and 5 mg/L atrazine when compared to controls. At the same age, diuron increased the ocular distance in animals exposed to diuron (1.0 and 1.5 mg/L) and no effects were observed on the head length. We also evaluated a behavioral repertoire in larvae at 7 dpf, and there were no significant differences in distance traveled, mean speed, time in movement, and thigmotaxis for atrazine and diuron when animals were individually placed in a new environment. The cognitive ability of the larvae was tested at 7 dpf for avoidance and optomotor responses, and neither atrazine nor diuron had significant impacts when treated groups were compared to their corresponding controls. Adults' behavior was evaluated 7 and 8 days after the end of the acute herbicide exposure. Exploration of a new environment and associated anxiety-like parameters, social interaction, and aggressiveness were not altered. Our results highlight the need for further studies on the sublethal effects of both herbicides and the consideration of the effects of commercial formulas vs. isolated active ingredients. It also emphasizes the need to take sublethal effects into consideration when establishing the environmental limits of residues.

9.
Front Pharmacol ; 13: 833227, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35126165

RESUMO

Zebrafish is a prominent vertebrate model, with many of its advantages related to its development, life cycle, and translational ability. While a great number of behavioral phenotypes and tasks to evaluate them are available, longitudinal studies across zebrafish life stages are scarce and made challenging because of the differences between protocols and endpoints assessed at each life stage. In this mini review, we highlight the relevance that longitudinal studies could have for neurobehavioral pharmacology using this model. We also present possible strategies to standardize behavior endpoints in domains related to human diseases throughout the life cycle, especially between larvae and adult fish. Furthermore, we discuss the remaining difficulties of these analyses and explore future advances needed to bridge this knowledge gap.

10.
J Exp Child Psychol ; 216: 105335, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-34974330

RESUMO

There is growing interest in teaching computer science and programming skills in schools. Here we investigated the efficacy of peer tutoring, which is known to be a useful educational resource in other domains but never before has been examined in such a core aspect of applied logical thinking in children. We compared (a) how children (N = 42, age range = 7 years 1 month to 8 years 4 months) learn computer programming from an adult versus learning from a peer and (b) the effect of teaching a peer versus simply revising what has been learned. Our results indicate that children taught by a peer showed comparable overall performance-a combination of accuracy and response times-to their classmates taught by an adult. However, there was a speed-accuracy trade-off, and peer-taught children showed more exploratory behavior, with shorter response times at the expense of lower accuracy. In contrast, no tutor effects (i.e., resulting from teaching a peer) were found. Thus, our results provide empirical evidence in support of peer tutoring as a way to help teach computer programming to children. This could contribute to the promotion of a widespread understanding of how computers operate and how to shape them, which is essential to our values of democracy, plurality, and freedom.


Assuntos
Comportamento Exploratório , Grupo Associado , Adulto , Criança , Computadores , Humanos , Lactente , Estudantes , Ensino
11.
J Neurosci Methods ; 366: 109429, 2022 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-34852253

RESUMO

BACKGROUND: Reduced locomotion with repeated exposure to a novel environment is often used as a measure of the basic adaptive learning process of habituation. While this is a well-established and reliable measure of habituation, it is not useful for the investigation of neurobiological changes before and after habituation because of the uncontrolled differential activity levels in a novel versus habituated environment. In this study we report a behavioral method that uses spontaneous locomotion to measure habituation, in which the total spontaneous locomotion in an initially novel environment does not change with repeated testing but, the ratio of central to peripheral activity does change and is indicative of habituation. The test sessions are brief (5 min) and the locomotion is measured in 2 separate zones. The peripheral zone comprises 8/9 of the test arena and the central zone 1/9 of the arena. RESULTS/COMPARISON WITH EXISTING METHODS: In contrast to methods that use between-session reductions in locomotion to assess habituation, this method employs brief test sessions in which overall activity between sessions does not change, but the distribution of locomotion in the periphery versus the central zone of the arena does change. The brevity of the test session also enables us to utilize post-trial drug treatment protocols to impact memory consolidation. CONCLUSIONS: The progressive change in the central/peripheral activity ratio with repeated testing can be determined independently of total activity and provides a habituation acquisition function that permits the measurement of neurobiological changes without the complication of effects related to changes in locomotor activity per se. The present report also presents evidence that this method can be used with post-trial drug treatment protocols to study the learning and memory effects of the post-trial treatments without the use of explicit rewards and punishments.


Assuntos
Habituação Psicofisiológica , Locomoção , Aprendizagem
12.
Nutr Neurosci ; 25(5): 976-989, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-33034271

RESUMO

BACKGROUND: Early-life adversity impacts on the offspring's brain development and is associated with a higher risk of developing age-associated diseases. In particular, perinatal protein malnutrition appears to be one of the most critical nutritional deficiencies affecting the individual's health and survival, but little is known about its effects on the persistence of behavioral alterations throughout life. Thus, the aim of the present study was to investigate how perinatal protein malnutrition impacts on age-related changes in the neuromuscular, cognitive and behavioral functions throughout life in a mouse model. METHODS: One group of CF-1 dams received a normal-protein diet (NP: 20% casein) during gestation and lactation, whereas another group received a low-protein diet (LP: 10% casein). The offspring of both groups were analyzed by means of several behavioral tests at four different ages (young: 6-10 weeks old, mature: 22-26 weeks old, middle age: 39-43 weeks old, and old: 55-59 weeks old). RESULTS: Regarding neuromuscular functions, LP mice showed an early deterioration in muscular strength and a reduction in the body weight throughout life. Regarding behavior, while NP mice showed an age-related reduction of exploratory behavior, LP mice showed a constantly low level of this behavior, as well as high anxiety-like behavior, which remained at high levels throughout life. Regarding cognitive functions, LP mice showed deteriorated working memory at middle age. Finally, LP mice died 3.4 times earlier than NP mice. Analysis of the sex-related vulnerability showed that females and males were equally affected by perinatal protein malnutrition throughout life. CONCLUSION: Our results demonstrate that perinatal protein malnutrition induces enduring and age-related impairment behaviors, which culminate in higher death risk, affecting males and females equally.


Assuntos
Desnutrição , Efeitos Tardios da Exposição Pré-Natal , Animais , Caseínas , Dieta com Restrição de Proteínas/efeitos adversos , Modelos Animais de Doenças , Feminino , Humanos , Lactação , Masculino , Desnutrição/complicações , Desnutrição/metabolismo , Fenômenos Fisiológicos da Nutrição Materna , Camundongos , Gravidez , Efeitos Tardios da Exposição Pré-Natal/metabolismo
13.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;55: e11979, 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1374711

RESUMO

Bidirectional selection is a procedure in which an arbitrary characteristic is chosen as a selection criterion and animals exhibiting more of this characteristic are bred in one group and animals exhibiting less are bred in another group. The procedure is repeated along generations until the selected characteristic becomes stable, resulting in two strains that are opposite in relation to the chosen characteristic. The present study aimed at selectively breeding rats exhibiting either a high or a low tendency to socialize by using the proximity test. We tested male and female Wistar rats in a square open field with a communicating birdcage, separated by a grid, containing a co-specific rat and coupled on the outside. Subjects that remained more time in front of the birdcage, interacting with the co-specific rat were bred in a group considered of high sociability (SOC+). Likewise, subjects that remained little time in front of the birdcage, with little interaction with the co-specific rat, were bred in a second group considered of low sociability (SOC-). By the 10th generation, the bidirectional selection resulted in SOC+ rats that spent a large amount of time in front of the cage sniffing and rearing in interaction with the co-specific rat and spent less time in the corners, exploring and grooming. It also resulted in SOC- rats that spent a small amount of time in front of the cage sniffing and rearing in interaction with the co-specific rat and spent more time in the corners and used most of their time grooming.

14.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;55: e11892, 2022. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1360237

RESUMO

The elevated gradient of aversion (EGA) is an apparatus for investigating the exploratory behavior of rats in 3-min sessions, consisting of three different sections of the same size: tunnel, closed arm, and open arm. Factorial analyses have defined three factors: exploration, impulsivity, and self-protection. In general, male rats are placed in the tunnel end and tend to hesitate leaving this starting point. Then, they hesitate leaving the tunnel and entering the closed arm, which they explore and tend to avoid entering the open arm or even just stick their head in and not enter it at all. Since females were not used for this test and are reported to be more explorative than male rats, the present work aimed to compare the behavior of male and female rats in the EGA. Thirty male and 34 female Wistar rats were submitted to 3-min sessions in the EGA. In general, results indicated that females were different from males: they explored more (Factor 1 - Exploration), are more impulsive (Factor 2 - Impulsivity), and are less anxious/fearful (Factor 3 - Self-protection). These results confirmed the results of other studies obtained with other apparatuses and show that females exhibit higher locomotion than males and are less anxious/fearful.

15.
Edumecentro ; 14: e1758, 2022.
Artigo em Espanhol | LILACS | ID: biblio-1404578

RESUMO

RESUMEN Los premios LURAP, creados por la American Physiological Society, constituyen una iniciativa establecida en Cuba y otros países que tienen miembros en esa sociedad. Ellos pueden nominar anualmente un estudiante de la carrera de Medicina para este premio. El Laboratorio Central de Líquido Cefalorraquídeo es una entidad de ciencia, técnica e innovación que pertenece a la Facultad "Miguel Enríquez" de la Universidad de Ciencias Médicas de la Habana; se distingue por su producción científica, allí los alumnos constituyen una parte importante de los logros investigativos que exhibe esta entidad de ciencia y técnica, a lo cual ha contribuido el estímulo que representa obtener el premio LURAP (Local Undergraduate Research Award in Physiology) que otorga internacionalmente la mencionada sociedad.


ABSTRACT The LURAP awards, created by the American Physiological Society, constitute an initiative established in Cuba and other countries that have members in that society. They can annually nominate a medical student for this award. The Central Laboratory of Cerebrospinal Fluid is an entity of science, technique and innovation that belongs to the "Miguel Enríquez" Faculty of Havana University of Medical Sciences; it´s distinguished by its scientific production, there the students constitute an important part of the research achievements exhibited by this science and technique entity, to which the encouragement represented by obtaining the LURAP (Local Undergraduate Research Award in Physiology) award has contributed. It´s internationally granted by the aforementioned company.


Assuntos
Academias e Institutos , Pesquisa , Educação Médica , Comportamento Exploratório
16.
Brain Struct Funct ; 225(9): 2799-2813, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33128125

RESUMO

Temporal lobe epilepsy is the most common form of intractable epilepsy in adults. More than 30% of individuals with epilepsy have persistent seizures and have drug-resistant epilepsy. Based on our previous findings, treatment with bone marrow mononuclear cells (BMMC) could interfere with early and chronic phase epilepsy in rats and in clinical settings. In this pilocarpine-induced epilepsy model, animals were randomly assigned to two groups: control (Con) and epileptic pre-treatment (Ep-pre-t). The latter had status epilepticus (SE) induced through pilocarpine intraperitoneal injection. Later, seizure frequency was assessed using a video-monitoring system. Ep-pre-t was further divided into epileptic treated with saline (Ep-Veh) and epileptic treated with BMMC (Ep-BMMC) after an intravenous treatment with BMMC was done on day 22 after SE. Analysis of neurobehavioral parameters revealed that Ep-BMMC had significantly lower frequency of spontaneous recurrent seizures (SRS) in comparison to Ep-pre-t and Ep-Veh groups. Hippocampus-dependent spatial and non-spatial learning and memory were markedly impaired in epileptic rats, a deficit that was robustly recovered by treatment with BMMC. Moreover, long-term potentiation-induced synaptic remodeling present in epileptic rats was restored by BMMC. In addition, BMMC was able to reduce abnormal mossy fiber sprouting in the dentate gyrus. Molecular analysis in hippocampal tissue revealed that BMMC treatment down-regulates the release of inflammatory cytokine tumor necrosis factor-α (TNF-α) and Allograft inflammatory factor-1 (AIF-1) as well as the Rho subfamily of small GTPases [Ras homolog gene family member A (RhoA) and Ras-related C3 botulinum toxin substrate 1 (Rac)]. Collectively, delayed BMMC treatment showed positive effects when intravenously infused into chronic epileptic rats.


Assuntos
Transplante de Medula Óssea , Cognição , Encefalite/fisiopatologia , Epilepsia/fisiopatologia , Epilepsia/psicologia , Nucleotídeos de Guanina/antagonistas & inibidores , Recuperação de Função Fisiológica , Animais , Comportamento Animal , Transplante de Medula Óssea/métodos , Modelos Animais de Doenças , Epilepsia/terapia , Infusões Intravenosas , Potenciação de Longa Duração , Masculino , Ratos Wistar
17.
Edumecentro ; 12(1): 185-201, ene.-mar. 2020. graf
Artigo em Espanhol | LILACS | ID: biblio-1090006

RESUMO

RESUMEN Introducción: la investigación resulta un proceso complejo si las personas que la realizan son maestros noveles que intentan dar solución a problemas identificados en su práctica pedagógica. Objetivo: analizar desde una mirada problematizadora y dialéctica el proceso investigativo tomando como referencia "los seis humildes sirvientes" de Rudyard Kipling. Métodos: se presenta el resultado de la experiencia de las autoras obtenido a través de su participación en eventos, discusiones, debates científicos, asesoría de tesis de maestrías y tribunales en defensa de doctorados. Se consultaron textos de Rudyard Kipling (1865-1936), de donde se seleccionó el analizado, artículos elaborados por las autoras y publicados en revistas internacionales; además de otras fuentes impresas y digitalizadas de pertinencia con el tema, utilizando buscadores reconocidos. Desarrollo: se enfatiza en la necesidad de enfrentar el proceso investigativo desde el inicio con una actitud cuestionadora que encamine un proceso de problematización desde la práctica y la teoría. Las autoras se apoyan en las seis preguntas básicas formuladas por Kipling quien, aunque no las formuló con el propósito de orientar el trabajo de investigación, les atribuyó un valor inapreciable en la adquisición del conocimiento y han sido utilizadas con este fin por diversos autores en disímiles ramas y especialidades. Conclusiones: se demostró la eficacia de aplicar "los seis humildes sirvientes" del escritor inglés Rudyard Kipling (1865-1936) al vincularlos con categorías específicas de la investigación y su utilidad para emprender este difícil proceso, sobre todo dirigido a maestros noveles que intentan dar solución a problemas identificados en su práctica pedagógica pero sin experiencia como investigadores.


ABSTRACT Background: researching is a complex process if the people who carry it out are new teachers who try to solve problems identified in their pedagogical practice. Objective: to analyze the researching process from a problem-solving and dialectical perspective, taking as reference "the six humble servants" of Rudyard Kipling. Methods: the result of the experience of the authors obtained through their participation in events, discussions, scientific debates, advice on master´s thesis and examining boards in defense of doctorates is presented. Texts by Rudyard Kipling (1865-1936) were consulted, from which the analyzed one was selected, articles prepared by the authors and published in international journals; In addition to other printed and electronic sources of relevance to the subject, using recognized search engines. Development: the need to face the researching process from the beginning is emphasized with a questioning attitude that guides a problem-solving process from practice and theory. The authors rely on the six basic questions asked by Kipling who, although he did not ask them for the purpose of guiding the research work, he attributed them an invaluable value in the acquisition of knowledge and they have been used for this purpose by various authors in dissimilar branches and specialties. Conclusions: the effectiveness of applying "the six humble servants" of the English writer Rudyard Kipling (1865-1936) was demonstrated by linking them to specific categories of research and their usefulness to undertake this difficult process, especially aimed at novice teachers trying to give solution to problems identified in their pedagogical practice but without experience as researchers.


Assuntos
Pesquisa , Projetos de Pesquisa , Educação Médica , Comportamento Exploratório , Aprendizagem
18.
Paidéia (Ribeirão Preto, Online) ; 30: e3021, 2020. tab, graf
Artigo em Inglês | Index Psicologia - Periódicos, LILACS | ID: biblio-1135424

RESUMO

Abstract The relationship between physical stimulus and perception is fundamental to understand aesthetic appreciation. This study aimed to examine how the properties of sculptures influence their artistic appreciation. Thirteen participants touched altered sculptures from the series Bichos de Lygia Clark. Participants indicated their perceptions for each stimulus using Semantic Differential Scales (7-point Likert scale): Complexity, Irregularity, Amount of pieces, Interest and Pleasingness. The duration of manipulation was recorded. The results showed that sculptures perceived as having more pieces were the ones judged to have a high level of Complexity and Irregularity. Sculptures evaluated as demonstrating a high level of Complexity and Irregularity were considered more interesting, although less pleasant. Participants tended to spend more time exploring the more complex sculptures. The results indicate that the amount of informational content, represented by the amount of pieces present in the sculpture, can influence the way it is perceived and affect its hedonic value.


Resumo A relação entre estímulo físico e percepção é fundamental para entender a apreciação estética. Este estudo teve como objetivo examinar como propriedades de esculturas influenciam suas apreciações artísticas. Treze participantes tocaram esculturas alteradas da série Bichos de Lygia Clark. Os participantes indicaram suas percepções para cada estímulo usando Escalas de Diferencial Semântico (tipo Likert - 7 pontos): Complexidade, Irregularidade, Quantidade de peças, Interesse e Agradabilidade. A duração da manipulação foi registrada. Os resultados mostraram que esculturas julgadas como tendo maior quantidade de peças foram julgadas como tendo alto nível de Complexidade e Irregularidade. Esculturas avaliadas como demonstrando um alto nível de Complexidade e Irregularidade foram consideradas mais interessantes, embora menos agradáveis. Os participantes tenderam a gastar mais tempo explorando as esculturas mais complexas. Os resultados indicam que a quantidade de conteúdo informacional, representado pela quantidade de peças presente na escultura, pode influenciar o modo como ela é percebida e afetar seu valor hedônico.


Resumen La relación entre el estímulo físico y la percepción es esencial para comprender la apreciación estética. Este estudio tuvo como objetivo examinar cómo las propiedades de las esculturas influyen en su apreciación artística. Trece participantes tocaron esculturas alteradas de la serie Bichos de Lygia Clark. Los participantes manifestaron sus percepciones para cada estímulo utilizando Escalas de Diferencial Semántico (de tipo Likert - 7 puntos): Complejidad, Irregularidad, Cantidad de piezas, Interés y Satisfacción. Se registró la duración de la manipulación. Los resultados apuntaron que las esculturas consideradas con más cantidad de piezas tenían un alto grado de Complejidad e Irregularidad. Las esculturas evaluadas con un alto grado de Complejidad e Irregularidad se consideraron más interesantes, aunque menos agradables. Los participantes tendían a pasar más tiempo explorando las esculturas más complejas. Los resultados indican que la cantidad de contenido informativo, representado por la cantidad de piezas presentes en la escultura, puede influir en la forma de percibirla y afectar su valor hedónico.


Assuntos
Percepção , Arte , Escultura , Diferencial Semântico , Publicações Seriadas , Pesos e Medidas , Sistema Único de Saúde , Afeto , Estética , Comportamento Exploratório
19.
Artigo em Inglês | MEDLINE | ID: mdl-30906255

RESUMO

Objectives: In artwork appreciation situations, individuals often show altered time perception. We tested the hypothesis that Parkinson's disease (PD) patients present movement patterns that have an impact on the time perception of artwork manipulation time. We predicted that, compared to healthy controls (non-PD), differences in the exploratory behavior of patients would evoke alteration of artwork manipulation time perception. Methods: Ten PD patients and 10 non-PD participants manipulated two reproductions of artwork with different complexity levels from the series "Bichos" by Lygia Clark. Subsequently, participants performed a verbal estimation regarding the temporal duration of their manipulations. The exploratory behavior was analyzed. Results: All participants overestimated the artwork manipulation time. However, PD patients, regardless of the artwork's level of complexity, showed shorter manipulation time and minor time overestimation compared to the non-PD participants. PD patients touched the artworks more often, especially the more complex artworks, than the non-PD participants; in contrast, PD patients moved the artworks less often, particularly the less complex artwork. Conclusion: PD patients showed an altered perception of artwork manipulation time. This suggests that exploratory behavior influenced temporal estimation. Besides, it is likely that PD patients had presented a decreased ability to manage attention during the task, which interfered in the cognitive reconstruction of its duration. Considered altogether, these appointments indicate that, as a result of cognitive and motor deficits, PD patients showed impairment in temporal information processing. The exploratory behavior facilitated the understanding of these results and processes in terms of motor-timing operations of the basal ganglia-thalamocortical system.

20.
R. Ci. agrovet. ; 18(3): 346-351, 2019. graf, tab
Artigo em Português | VETINDEX | ID: vti-25805

RESUMO

O enriquecimento ambiental constitui no aperfeiçoamento das instalações na forma de estímulos ambientais necessários para alcançar o bem-estar dos animais nas condições psíquico, fisiológico e melhor qualidade de vida. Nos últimos anos, o bem-estar animal vem se tornando um dos maiores desafios para os modernos sistemas de produção. A pressão da sociedade e do mercado internacional para que os sistemas de produção respeitem o bem-estar animal, aumenta a necessidade de pesquisas que possam gerar conhecimentos sobre possíveis formas de se produzir suínos garantindo a lucratividade do sistema em combinação com a manutenção da qualidade de vida dos mesmos. Sendo assim, objetivou-se com este estudo avaliar o comportamento de leitões na fase de creche submetidos a enriquecimento ambiental. Foram utilizados 12 suínos na fase de creche, distribuídos em dois tratamentos, com presença e ausência de enriquecimento ambiental. Para avaliação das variáveis comportamentais foram observadas as seguintes características: em pé, deitado, explorando, cheirando, bebendo, comendo, ócio, fuçando, defecando, urinando, sentado, andando, vocalizando, mordendo, brincando e brigando. As observações foram realizadas a cada 10 minutos durante seis dias. Houve diferença significativa (p<0,05) para os comportamentos brincando, comendo e mordendo em relação aos tratamentos avaliados. Não houve diferença significativa (p>0,05) para o comportamento brigando em relação aos tratamentos, dias e animais. O comportamento dos animais foi influenciado pela presença do enriquecimento ambiental, em que o mesmo proporcionou a diminuição de alguns comportamentos indesejáveis nos sistemas de produção.(AU)


Environmental enrichment consists of the enhancement of facilities by means of the necessary environmental stimuli to achieve animal welfare in psychical, physiological, and to improve quality of life conditions. In recent years welfare has been turning into one of the biggest challenges for modern production systems. There is a great pressure from civil society and international market claiming for production systems to respect animal welfare. This increases the need for studies that generate knowledge on how to raise pigs in order to ensure the profitability of the system and the maintenance of the quality of life for these animals. Therefore, the aim of this study was to evaluate the behavior of piglets in nursery phase subjected to environmental enrichment. A total of 12 pigs in the nursery phase were distributed into two treatments (with and without environmental enrichment). The following behaviors were evaluated: standing, laying, exploring, smelling, drinking, eating, idling, digging, defecating, urinating, sitting, walking, vocalizing, biting, playing, and fighting. Piglet behavior was recorded every 10 minutes during six days. Significant differences (p<0.05) between treatments were found for playing, eating and biting. No significant differences (p>0.05) were found for fighting behavior regarding the treatments, days and animals. Animal behavior was affected by the presence of environmental enrichment, which decreased some undesirable behaviors in production systems.(AU)


Assuntos
Animais , Suínos/crescimento & desenvolvimento , Bem-Estar do Animal , Abrigo para Animais , Comportamento Animal
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