RESUMO
Los tumores de próstata representan la neoplasia maligna más frecuente en el varón. Mientras que las lesiones epiteliales son frecuentes, las neoplasias de origen mesenquimal representan entre 1 y 2 porciento de las neoplasias malignas prostáticas. Son poco conocidas, sobre todo las de origen estromal. Se presenta el caso de un varón de 77 años de edad, con un sarcoma del estroma prostático al que se le realiza una exéresis parcial. El tumor ocupa prácticamente la totalidad de la cavidad pélvico-abdominal, con un diámetro de 35 cm y un peso de 3 800 g. Histológicamente se concluyó, como sarcoma prostático aunque en el transoperatorio no se encontró un nexo evidente con este órgano. El comportamiento clínico de estos tumores, basado en los escasos casos descritos en la literatura, es prácticamente desconocido y su diagnóstico preoperatorio difícil. Este paciente se presentó con pérdida de peso, sin dolor, hematuria, ni síntomas obstructivos(AU)
Prostate tumors represent the most frequent malignancy in men. Epithelial lesions are frequent, whereas malignancies of mesenchymal origin represent only 1-2 percent of all prostatic malignacies. They are little known, mostly those of stromal origin. A case of a 77 year- old man with prostatic stromal sarcoma is presented to whom partial exeresis is performed. The tumor practically occupies the totality of the pelvic abdominal cavity, and it had a diameter of 35 cm and a weight of 3 800 g. Histologically, it was recognized as prostatic sarcoma although an evident link with this organ was not found during the transoperatory. The clinical behavior of these tumors, based on the little cases described in the literature, is practically unknown and its preoperative diagnosis becomes difficult. The patient presented with weight loss, he had no pain, hematuria, or obstructive symptoms(AU)
Assuntos
Humanos , Masculino , Idoso , Neoplasias da Próstata/cirurgia , Sarcoma do Estroma Endometrial/cirurgiaRESUMO
Los tumores de próstata representan la neoplasia maligna más frecuente en el varón. Mientras que las lesiones epiteliales son frecuentes, las neoplasias de origen mesenquimal representan entre 1 y 2 porciento de las neoplasias malignas prostáticas. Son poco conocidas, sobre todo las de origen estromal. Se presenta el caso de un varón de 77 años de edad, con un sarcoma del estroma prostático al que se le realiza una exéresis parcial. El tumor ocupa prácticamente la totalidad de la cavidad pélvico-abdominal, con un diámetro de 35 cm y un peso de 3 800 g. Histológicamente se concluyó, como sarcoma prostático aunque en el transoperatorio no se encontró un nexo evidente con este órgano. El comportamiento clínico de estos tumores, basado en los escasos casos descritos en la literatura, es prácticamente desconocido y su diagnóstico preoperatorio difícil. Este paciente se presentó con pérdida de peso, sin dolor, hematuria, ni síntomas obstructivos(AU)
Prostate tumors represent the most frequent malignancy in men. Epithelial lesions are frequent, whereas malignancies of mesenchymal origin represent only 1-2 percent of all prostatic malignacies. They are little known, mostly those of stromal origin. A case of a 77 year- old man with prostatic stromal sarcoma is presented to whom partial exeresis is performed. The tumor practically occupies the totality of the pelvic abdominal cavity, and it had a diameter of 35 cm and a weight of 3 800 g. Histologically, it was recognized as prostatic sarcoma although an evident link with this organ was not found during the transoperatory. The clinical behavior of these tumors, based on the little cases described in the literature, is practically unknown and its preoperative diagnosis becomes difficult. The patient presented with weight loss, he had no pain, hematuria, or obstructive symptoms(AU)
Assuntos
Humanos , Masculino , Idoso , Neoplasias da Próstata/cirurgia , Sarcoma do Estroma Endometrial/cirurgiaRESUMO
O sistema endócrino é uma complexa rede de glândulas e hormônios que regulam muitas das funções do corpo, incluindo crescimento, desenvolvimento e maturação, como as vias de ação de muitos órgãos. A próstata é um importante alvo dos hormônios e sua maturidade funcional e seu desenvolvimento são influenciados pelos níveis de esteroides. O presente grupo de pesquisa tem estudado os potenciais efeitos dos agentes esteroides sobre a próstata masculina e feminina do gerbilo da Mongólia (Meriones unguiculatus), utilizando métodos morfológicos e imuno-histoquímicos. Os resultados têm revelado a próstata do gerbilo da Mongólia como uma importante ferramenta para estudos da ação dos hormônios esteroides e seus antagonistas.
The endocrine system is a complex network of glands and hormones that regulates many of the body's functions; including growth, development and maturation, as well as the way several organs operate. The prostate is an important target of hormones and its functional maturity and development are influenced by steroids levels. Our research group has been evaluating the potential effects of the steroidal agents on the Mongolian gerbil (Meriones unguiculatus) male and female prostate using different morphological and immunohistochemical methods. Our results have revealed the Mongolian gerbil prostate as an important tool for the morphofunctional studies of steroid hormones and its antagonist actions.