RESUMO
BACKGROUND: Since early 2015, a large epidemic of Zika Virus (ZIKV) is spreading across South and Central America. An association between congenital neurological malformations (mainly microcephaly), other neurological manifestations such as Guillain-Barrè Syndrome, and ZIKV infection is suspected. CASE PRESENTATION: Three confirmed cases of ZIKV in travelers returning from Brazil between May 2015 and January 2016 are described. All patients had mild symptoms with no neurological complications. CONCLUSIONS: An increasing awareness among clinicians about this emerging disease is advisable, both for the need to provide correct additional information to the patients and to travelers, with a special focus on pregnant women, and for the presence of the competent vector in Southern Europe.
Assuntos
Viagem , Infecção por Zika virus/epidemiologia , Zika virus , Adulto , Idoso , Brasil/epidemiologia , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Gravidez , Infecção por Zika virus/patologiaRESUMO
We describe the dynamics of Zika virus (ZIKV) infection in a man in his early 40s who developed fever and rash after returning from Haiti to Italy, in January 2016. Follow-up laboratory testing demonstrated detectable ZIKV RNA in plasma up to day 9 after symptom onset and in urine and saliva up to days 15 and 47, respectively. Notably, persistent shedding of ZIKV RNA was demonstrated in semen, still detectable at 181 days after onset.
Assuntos
Febre/virologia , RNA Viral/sangue , Saliva/virologia , Sêmen/química , Eliminação de Partículas Virais , Infecção por Zika virus/diagnóstico , Zika virus/isolamento & purificação , Adulto , Anticorpos Antivirais/sangue , Exantema/virologia , Haiti , Humanos , Imunoglobulina M/sangue , Itália , RNA Viral/genética , RNA Viral/urina , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Sêmen/virologia , Análise do Sêmen , Análise de Sequência de RNA , Viagem , Urina/virologia , Carga Viral , Zika virus/genética , Infecção por Zika virus/sangue , Infecção por Zika virus/virologiaRESUMO
We report two cases of Guillain-Barré syndrome who had concomitant Zika virus viruria. This viruria persisted for longer than 15 days after symptom onset. The cases occurred on Martinique in January 2016, at the beginning of the Zika virus outbreak. Awareness of this possible neurological complication of ZikV infection is needed.