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ABSTRACT Purpose: To assess the effects of the preoperative application of artificial tears combined with recombinant bovine basic fibroblast growth factor on the ocular surface function and inflammatory factor levels after operation in cataract patients complicated with dry eyes. Methods: A total of 118 cataract patients (118 eyes) complicated with dry eyes treated from February 2019 to February2020 were assigned to control and observation groups (n=59 eyes/group) using a random number table. One week before the operation, the control group was administered 0.1% sodium hyaluronate eye drops (artificial tears), based on which the observation group received Beifushu eye drops (recombinant bovine basic fibroblast growth factor), both 6 times daily for 1 week. A comparison was made between the scores of clinical symptoms and the indices of ocular surface function, inflammatory factors in tears, and oxidative stress indices before and after the operation. The ocular surface function was evaluated by an ocular surface disease index questionnaire, tear film breakup-time assay, Schirmer's I test, and corneal fluorescein stain test. The inflammatory factors in tears were measured. Results: No significant differences were noted in the general data and clinical symptom score, ocular surface disease index, tear film breakup-time, Schirmer's I test score, fluorescein stain score, interleukin-6, tumor necrosis factor-alpha, malondialdehyde, superoxide dismutase, lipid peroxide, and total antioxidant capacity before treatment between the 2 groups (p>0.05). After treatment, the clinical symptom score, ocular surface disease index, fluorescein stain score, tumor necrosis factor-alpha, interleukin-6, malondial-dehyde and lipid peroxide declined significantly, and tear film breakup-time, Schirmer's I test score, superoxide dismutase, and total antioxidant capacity increased in both the groups. The improvements in the clinical symptom score as well as in the indices of ocular surface function, inflammatory factors, and oxidative stress were more prominent in the observation group than in the control group (p<0.05). Conclusions: Artificial tears combined with recombinant bovine basic fibroblast growth factor before operation. significantly improved the ocular surface function, reduced inflammatory factors in tears, and alleviated dry eye symptoms after operation in cataract patients.

RESUMO Objetivo: Avaliar os efeitos da aplicação pré-operatória de lágrimas artificiais combinadas com o fator de crescimento de fibroblastos básicos bovinos recombinantes na função da superfície ocular e níveis de fator inflamatório após cirurgia em pacientes com catarata complicada com olhos secos. Métodos: Um total de 118 pacientes com catarata complicada com olhos secos (118 olhos), tratados entre fevereiro de 2019 e fevereiro de 2020, foram divididos em grupos de controle e de observação (n=59, 59 olhos) usando uma tabela de números aleatórios. Uma semana antes da cirurgia, o grupo controle recebeu colírio de hialuronato de sódio a 0,1% (lágrimas artificiais), enquanto o grupo de observação recebeu colírio Beifushu (fator de crescimento de fibroblastos básicos bovinos recombinantes), ambos, seis vezes ao dia, por uma semana. Antes do tratamento e um mês após a cirurgia, os escores de sintomas clínicos, índices de função da superfície ocular, níveis de fatores inflamatórios nas lágrimas e índices de estresse oxidativo foram comparados. A função da superfície ocular foi avaliada pelo questionário do índice de doença da superfície ocular, ensaio de tempo de ruptura do filme lacrimal, teste I de Schirmer e teste de coloração por fluoresceína da córnea. Os níveis de fatores inflamatórios nas lágrimas foram medidos. Resultados: Não houve diferenças significativas nos dados gerais e no escore de sintomas clínicos, índice de doença da superfície ocular, tempo de ruptura do filme lacrimal, escore do teste I de Schirmer, pontuação do teste de coloração por fluoresceína da córnea, interleucina-6, fator de necrose tumoral alfa, malondialdeído, superóxido dismutase, peróxido lipídico e capacidade antioxidante total antes do tratamento entre os dois grupos (p>0,05). Após o tratamento, o escore de sintomas clínicos, índice de doença da superfície ocular, escore do teste de coloração por fluoresceína da córnea, fator de necrose tumoral alfa, interleucina-6, malondialdeído e peróxido lipídico diminuíram significativamente, e o tempo de ruptura do filme lacrimal, escore do teste I de Schirmer, superóxido dismutase e a capacidade antioxidante total aumentou em ambos os grupos. As melhorias no escore de sintomas clínicos, bem como os índices de função da superfície ocular, fatores inflamatórios e estresse oxidativo foram mais proeminentes no grupo de observação do que no grupo controle (p<0,05). Conclusões: Lágrimas artificiais combinadas com fator de crescimento de fibroblastos básicos recombinantes antes da cirurgia melhoram notavelmente a função da superfície ocular, diminuem os níveis de fatores inflamatórios nas lágrimas e aliviam os sintomas de olho seco após a cirurgia em pacientes com catarata complicada com olhos secos.

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Purpose: To determine the prevalence of SARS-CoV-2 in tear samples and to investigate whether it correlates with ocular findings and patients' prognosis in Brazil. Methods: Tears were collected using Schirmer strips (SS) and conjunctival swabs (CS) from patients hospitalized with laboratory-confirmed SARS-CoV-2 infection. Samples were analyzed using qRT-PCR. Demographic and clinical data, ocular symptoms, and Schirmer tests (ST) were collected from patients. Charlson Comorbidity Index (CCI) was used to rate comorbidities, and patients were monitored until hospital discharge or death. Results: There were 61 hospitalized patients, 33 of which were diagnosed with COVID-19. Within the confirmed COVID-19 patients, SARS-CoV-2 was detected in 18.2% (n = 6) of CS and 12.1% (n = 4) of SS samples. Subjective and objective parameters for dry eye syndrome (e.g., ST COVID-19: 8.3 ± 6.4mm, non-COVID-19: 8.9 ± 6.6mm, p > 0.05) were comparable between COVID-19 (n = 33) and non-COVID-19 patients (n = 28). Among the 16 COVID-19 patients exhibiting ocular symptoms, only tearing was reported significantly more frequently when tear samples were positive for SARS-CoV-2 (p < 0.05). Strikingly, patients whose tears tested positive for SARS-CoV-2 had significantly inferior CCI (pos.: 34.0 ± 31.8%, neg.: 67.6 ± 36.4%, p < 0.05) and higher mortality rates (pos.: 50.0%, neg.: 7.4%, p < 0.01). Conclusions: SARS-CoV-2 was detected with a prevalence of 18.2% on the ocular surface. Decreased CCI and increased mortality rate in the positive tear group suggests that viral detection may relate to prognosis and highlight the need of personal protective measures for healthcare professionals. Most of the patients, regardless of COVID-19 diagnosis, had low tear production and eye discomfort, possibly pointing to the need for artificial tear use during hospitalization.

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Purpose: To determine the prevalence of SARS-CoV-2 in tear samples and to investigate whether it correlates with ocular findings and patients' prognosis in Brazil. Methods: Tears were collected using Schirmer strips (SS) and conjunctival swabs (CS) from patients hospitalized with laboratory-confirmed SARS-CoV-2 infection. Samples were analyzed using qRT-PCR. Demographic and clinical data, ocular symptoms, and Schirmer tests (ST) were collected from patients. Charlson Comorbidity Index (CCI) was used to rate comorbidities, and patients were monitored until hospital discharge or death. Results: There were 61 hospitalized patients, 33 of which were diagnosed with COVID-19. Within the confirmed COVID-19 patients, SARS-CoV-2 was detected in 18.2% (n = 6) of CS and 12.1% (n = 4) of SS samples. Subjective and objective parameters for dry eye syndrome (e.g., ST COVID-19: 8.3 ± 6.4mm, non-COVID-19: 8.9 ± 6.6mm, p > 0.05) were comparable between COVID-19 (n = 33) and non-COVID-19 patients (n = 28). Among the 16 COVID-19 patients exhibiting ocular symptoms, only tearing was reported significantly more frequently when tear samples were positive for SARS-CoV-2 (p < 0.05). Strikingly, patients whose tears tested positive for SARS-CoV-2 had significantly inferior CCI (pos.: 34.0 ± 31.8%, neg.: 67.6 ± 36.4%, p < 0.05) and higher mortality rates (pos.: 50.0%, neg.: 7.4%, p < 0.01). Conclusions: SARS-CoV-2 was detected with a prevalence of 18.2% on the ocular surface. Decreased CCI and increased mortality rate in the positive tear group suggests that viral detection may relate to prognosis and highlight the need of personal protective measures for healthcare professionals. Most of the patients, regardless of COVID-19 diagnosis, had low tear production and eye discomfort, possibly pointing to the need for artificial tear use during hospitalization.

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Objetivo: describir el comportamiento del síndrome de ojo seco en pacientes diabéticos de un área de salud. Métodos: se realizó un estudio observacional descriptivo transversal. La muestra la conformaron 134 pacientes diabéticos que asistieron a la consulta del Policlínico Mario Muñoz, de septiembre de 2013 a febrero de 2014. Se estudiaron variables sociodemográficas, así como síntomas, signos y gravedad del ojo seco. Se aplicaron métodos de estadística descriptiva para variables cualitativas. Para el procesamiento y análisis de la información se confeccionó una base de datos en el programa estadístico Microsoft Excel 2003. Resultados: el 88,8 por ciento de los pacientes tenían más de 50 años. Predominó el grupo de 60-69 años y el sexo femenino a razón de 97:37 por cada 2,6 mujeres diagnosticadas con diabetes mellitus. Se diagnosticó un hombre. Predominó la diabetes mellitus tipo 2 (97,8 por ciento) y de ellos 74,7 por ciento presentaron ojo seco. También predominaron los pacientes con sintomatología de ojo seco (38 por ciento) y menos de 5 años de evolución de la diabetes (57,4 por ciento). La visión borrosa resultó el síntoma más frecuente (62,7 por ciento) y la inyección conjuntival el signo (54,9 por ciento). El ojo seco leve predominó en el 98 por ciento de los casos. Conclusiones: la diabetes mellitus es un problema de salud real. Las personas diabéticas presentan con frecuencia daño de la superficie ocular y síndrome de ojo seco, por lo que deben visitar al oftalmólogo periódicamente(AU)

Objective: to describe the behavior of the dry eye syndrome in diabetic patients from a health area. Method: a cross-sectional, descriptive and observational study was carried out. The sample was made up by 134 diabetic patients who had been seen at "Mario Muñoz" Policlinics from September 2013 to February 2014. Sociodemographic variables as well as symptoms, signs and severity of the dry eye syndrome were all studied. Summary statistic methods were applied in qualitative variables. For data processing and information, a database according to Microsoft Excel statistical program 2003 was developed. Results: in the sample, 88.8 percent of the patients were older than 50 years, prevailing the 60-69 year-old group and females at a ratio of 97:37, that is, 2.6 women were diagnosed with diabetes mellitus per one man. Diabetes mellitus type 2 prevailed (97.8 percent) and from this figure, 74.7 percent presented with dry eye. Likewise, patients with dry eye symptoms (38 percent) and less than 5 years of diabetes progression (57.4 percent) were also predominant. Blurred vision was the most frequent symptom (62.7 percent) and the conjunctival injection the most common sign (54.9 percent). Mild dry eye syndrome prevailed in 98 percent of cases. Conclusions: diabetes mellitus is a real health problem. Diabetic people frequently present damage of the ocular surface and dry eye syndrome, therefore, they should go systematically to the ophthalmologist's(AU)

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Objetivo: describir el comportamiento del síndrome de ojo seco en pacientes diabéticos de un área de salud. Métodos: se realizó un estudio observacional descriptivo transversal. La muestra la conformaron 134 pacientes diabéticos que asistieron a la consulta del Policlínico Mario Muñoz, de septiembre de 2013 a febrero de 2014. Se estudiaron variables sociodemográficas, así como síntomas, signos y gravedad del ojo seco. Se aplicaron métodos de estadística descriptiva para variables cualitativas. Para el procesamiento y análisis de la información se confeccionó una base de datos en el programa estadístico Microsoft Excel 2003. Resultados: el 88,8 por ciento de los pacientes tenían más de 50 años. Predominó el grupo de 60-69 años y el sexo femenino a razón de 97:37 por cada 2,6 mujeres diagnosticadas con diabetes mellitus. Se diagnosticó un hombre. Predominó la diabetes mellitus tipo 2 (97,8 por ciento) y de ellos 74,7 por ciento presentaron ojo seco. También predominaron los pacientes con sintomatología de ojo seco (38 por ciento) y menos de 5 años de evolución de la diabetes (57,4 por ciento). La visión borrosa resultó el síntoma más frecuente (62,7 por ciento) y la inyección conjuntival el signo (54,9 por ciento). El ojo seco leve predominó en el 98 por ciento de los casos. Conclusiones: la diabetes mellitus es un problema de salud real. Las personas diabéticas presentan con frecuencia daño de la superficie ocular y síndrome de ojo seco, por lo que deben visitar al oftalmólogo periódicamente(AU)

Objective: to describe the behavior of the dry eye syndrome in diabetic patients from a health area. Method: a cross-sectional, descriptive and observational study was carried out. The sample was made up by 134 diabetic patients who had been seen at "Mario Muñoz" Policlinics from September 2013 to February 2014. Sociodemographic variables as well as symptoms, signs and severity of the dry eye syndrome were all studied. Summary statistic methods were applied in qualitative variables. For data processing and information, a database according to Microsoft Excel statistical program 2003 was developed. Results: in the sample, 88.8 percent of the patients were older than 50 years, prevailing the 60-69 year-old group and females at a ratio of 97:37, that is, 2.6 women were diagnosed with diabetes mellitus per one man. Diabetes mellitus type 2 prevailed (97.8 percent) and from this figure, 74.7 percent presented with dry eye. Likewise, patients with dry eye symptoms (38 percent) and less than 5 years of diabetes progression (57.4 percent) were also predominant. Blurred vision was the most frequent symptom (62.7 percent) and the conjunctival injection the most common sign (54.9 percent). Mild dry eye syndrome prevailed in 98 percent of cases. Conclusions: diabetes mellitus is a real health problem. Diabetic people frequently present damage of the ocular surface and dry eye syndrome, therefore, they should go systematically to the ophthalmologist's(AU)

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El ordenador, si no se utiliza adecuadamente, produce trastornos en la salud. La causa de estas alteraciones está relacionada con factores ergonómicos visuales del entorno de trabajo y la exacerbación de problemas visuales ya existentes. Objetivo: describir características clínicas del síndrome de visión de la computadora en trabajadores de dos bancos metropolitanos de un área de salud.Métodos: se realizó un estudio descriptivo transversal. La muestra la conformaron 40 trabajadores que refirieron sintomatología asociada al uso del ordenador y que cumplieron los criterios de inclusión. Se estudiaron las variables: edad, sexo, síntomas, signos biomicroscópicos, afecciones oculares asociadas y tipo de defecto refractivo.Resultados: el 82,5 por ciento de los pacientes tenían más de 30 años, con edad media de 41,7 años. Por cada 12,3 mujeres diagnosticadas con síndrome de visión de la computadora se diagnosticó un hombre. Ojo rojo intermitente y visión borrosa resultaron los síntomas más frecuente y la inyección conjuntival el signo. Las afecciones oculares más frecuentes fueron las ametropías con 87,5 por ciento y ojo seco con 57,5 por ciento. Dentro de las ametropías predominó el astigmatismo con 43 por ciento de casos. Conclusiones: el síndrome de visión de la computadora es un problema de salud real en la actualidad. Las personas que pasan muchas horas frente al ordenador generalmente presentan antecedentes de afecciones oculares como ametropías y ojo seco, por lo que deben asistir al oftalmólogo(AU)

The computer, if not properly used, may cause health disorders. The cause is already related with visual ergonomic factors of the work environment and the exacerbation of already existing visual problems. Objective: to describe the clinical characteristics of the computer vision syndrome in employees from two metropolitan banks in a health area. Method: a cross-sectional descriptive study was carried out. The sample made up of 40 workers who had symptoms associated to the use of computer and met the inclusion criteria. The study variables were age, sex, symptoms, biomicroscopy signs, other eye pathologies and type of refractive defect. Results: in the study group, 82,5 percent of the patients were older than 30 years old, being the mean age of 41,7 years. One man per 12,3 women was diagnosed with the computer vision syndrome. Intermittent red eye and blurred vision were the most frequent symptoms and the conjunctival injection was the sign. The most frequent ocular pathologies turned to be the ametropia with 87,5 percent and dry eye with 57,5 percent of cases. Astigmatism prevailed in 43 percent of the group. Conclusions: the computer vision syndrome is a real health problem at the present time people that spend many hours working with computer generally show eye alterations as ametropia and dry eye, and they should go to the ophthalmologist(AU)

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El ordenador, si no se utiliza adecuadamente, produce trastornos en la salud. La causa de estas alteraciones está relacionada con factores ergonómicos visuales del entorno de trabajo y la exacerbación de problemas visuales ya existentes. Objetivo: describir características clínicas del síndrome de visión de la computadora en trabajadores de dos bancos metropolitanos de un área de salud. Métodos: se realizó un estudio descriptivo transversal. La muestra la conformaron 40 trabajadores que refirieron sintomatología asociada al uso del ordenador y que cumplieron los criterios de inclusión. Se estudiaron las variables: edad, sexo, síntomas, signos biomicroscópicos, afecciones oculares asociadas y tipo de defecto refractivo. Resultados: el 82,5 por ciento de los pacientes tenían más de 30 años, con edad media de 41,7 años. Por cada 12,3 mujeres diagnosticadas con síndrome de visión de la computadora se diagnosticó un hombre. Ojo rojo intermitente y visión borrosa resultaron los síntomas más frecuente y la inyección conjuntival el signo. Las afecciones oculares más frecuentes fueron las ametropías con 87,5 por ciento y ojo seco con 57,5 por ciento. Dentro de las ametropías predominó el astigmatismo con 43 por ciento de casos. Conclusiones: el síndrome de visión de la computadora es un problema de salud real en la actualidad. Las personas que pasan muchas horas frente al ordenador generalmente presentan antecedentes de afecciones oculares como ametropías y ojo seco, por lo que deben asistir al oftalmólogo(AU)

The computer, if not properly used, may cause health disorders. The cause is already related with visual ergonomic factors of the work environment and the exacerbation of already existing visual problems. Objective: to describe the clinical characteristics of the computer vision syndrome in employees from two metropolitan banks in a health area. Method: a cross-sectional descriptive study was carried out. The sample made up of 40 workers who had symptoms associated to the use of computer and met the inclusion criteria. The study variables were age, sex, symptoms, biomicroscopy signs, other eye pathologies and type of refractive defect. Results: in the study group, 82,5 percent of the patients were older than 30 years old, being the mean age of 41,7 years. One man per 12,3 women was diagnosed with the computer vision syndrome. Intermittent red eye and blurred vision were the most frequent symptoms and the conjunctival injection was the sign. The most frequent ocular pathologies turned to be the ametropia with 87,5 percent and dry eye with 57,5 percent of cases. Astigmatism prevailed in 43 percent of the group. Conclusions: the computer vision syndrome is a real health problem at the present time people that spend many hours working with computer generally show eye alterations as ametropia and dry eye, and they should go to the ophthalmologist(AU)

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Introducción: la Blefaritis se define como inflamación bilateral crónica de los bordes palpebrales. Produce alteraciones de bordes palpebrales, glándulas de Meibomio, córnea, conjuntiva y película lagrimal, dando lugar a complicaciones. Tiene especial importancia debido a su elevada incidencia y al daño que produce sobre la superficie ocular. Objetivo: evidenciar manifestaciones clínicas y complicaciones oftalmológicas en paciente con Blefaritis mixta. Presentación del caso: paciente masculino de 82 años, raza negra con antecedentes patológicos personales de salud, acude por aumento de volumen del párpado inferior de ojo izquierdo desde hace 2 años acompañado de secreción y lagrimeo, sin tratamiento previo. El examen oftalmológico evidencia párpado inferior invertido, pestañas que contactan con la conjuntiva. Bordes palpebrales inflamados, con costras y telangiectasias, dilatación de los orificios de las glándulas de Meibomio. Lesiones tumorales en número de 3 que varían entre 2 y 4 mm, duras e indoloras en tarso inferior. Inyección conjuntival moderada y secreción espumosa. Prueba de Shirmer I 9 mm y tiempo de ruptura de película lagrimal 5 segundos. Se diagnosticó Blefaritis mixta complicada con múltiples chalazión, entropión y queratoconjuntivitis seca. Se indicó, previo consentimiento del paciente, tratamiento con tetraciclina, prednisolona, lágrimas artificiales y tratamiento quirúrgico de múltiples chalazión, y se logró la desaparición del entropión. Se realizó el diagnóstico diferencial con carcinoma de glándulas sebáceas, penfigoide cicatrizal y síndrome de Stevens-Johnson. Conclusiones: la Blefaritis es causa importante de morbilidad ocular debido a los cambios que ocasiona sobre la anatomía de los párpados y película lagrimal con el consecuente daño a la superficie ocular(AU)

Introduction: the Blepharitis is defined like a chronic inflammation of the eyelids borders. It produces alterations of eyelids borders, Meibomio glands, and cornea, conjunctive and lachrymal film, giving place to complications. It has special importance due to their high incidence. Objective: evidencing clinical manifestations and ophthalmologic complications in patient with mixed Blepharitis. Case Presentation: a male patient of 82 years, black race with antecedents of health consults because an increase of volume of the lower left lid of eye for 2 years accompanied by secretion and shed tears, without previously treatment. The ophthalmologic exam evidences reversed lower lid, lashes that contact with the conjunctive. We observed a palpable border with a blush eyelid and scabs, telangiectasias, dilation of the holes of Meibomio glands, tumor injuries in number of 3 with a size between 2 and 4 mm, hard and painless lower plate, moderate conjunctival injection, and scarce foamy secretion. The Schirmers test I 9 mm and plate break down up to 5 seconds. It was diagnosed complicated mixed Blepharitis with multiple chalazion, entropion and dry keratoconjunctivitis. Previous informed consent treatment was indicated withtetracycline, prednisolone, artificial tears and surgical treatment of multiple chalazion, being achieved the disappearance of the entropion. It was carried out the differential diagnosis with carcinoma of sebaceous glands, cicatricial pemphigus and Stevens-Johnson´s syndrome. Conclusions: the Blepharitis is an important cause of ocular morbidity due to the changes produced on the anatomy of the lids and lachrymal film with the consequent damage to the ocular surface(AU)

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Introducción: la infección inicial por el virus de la varicela-zoster produce una enfermedad exantemática aguda (varicela). Meses después se desarrolla el Herpes Zoster por reactivación del virus endógeno latente. El área inervada por el nervio trigémino es la segunda en cuanto a frecuencia de afectación. Cuando la enfermedad afecta la primera división de este, recibe el nombre de Herpes Zoster Oftálmico y tiene especial importancia debido al peligro que implica para el ojo.Objetivo: evidenciar manifestaciones clínicas, complicaciones y secuelas oftalmológicas en un paciente con diagnóstico de Herpes Zoster oftálmico.Presentación del caso: paciente masculino de 75 años con antecedentes personales de varicela en la infancia, acude a consulta por lagrimeo, fotofobia y edema palpebral en ojo derecho, acompañado de lesiones vesiculares y costras en piel de la frente y nariz. El examen oftalmológico evidencia inyección cilio-conjuntival intensa, lesiones dendríticas en la córnea, precipitados queráticos en endotelio corneal y Signo de Hutchinson positivo. Se diagnosticó Herpes Zoster oftálmico complicado con uveítis anterior aguda que dejó como secuela queratitis neurotrófica y queratoconjuntivitis seca. Se indicó, previo consentimiento informado del paciente, tratamiento con Aciclovir, prednisolona, homatropina, lágrimas artificiales y vitaminoterapia. Se realizó el diagnóstico diferencial con enfermedades que afectan piel y mucosas, en especial la conjuntiva, con lesiones vesículo-ampollar, como penfigoide cicatrizal, Síndrome de Stevens-Johnson, queratitis por herpes simple, entre otros. Conclusiones: el Herpes Zoster oftálmico es causa importante de morbilidad ocular debido a secuelas como queratitis neurotrófica y queratoconjuntivitis seca, con el consecuente daño a la superficie ocular(AU)

Introduction: the initial infection by the virus of the varicella-zoster produces an exanthematous acute illness (varicella). A few months later the herpes zoster is developed because of a reactivation of the latent endogenous virus. The area innervated by the trigeminal nerve is the second taking in consideration its frequency. When the illness affects the first branch of the nerve, receives the name ophthalmic herpes zoster and it is very important because it is very dangerous for the eye. Objective: to show the clinical manifestations evidence, complications and ophthalmic sequels in a patient with an ophthalmic herpes zoster diagnosis. Case Presentation: a male patient of 75 years old with personal medical records of varicella in the childhood, he goes to outpatient service because of lacrimation, photophobia and great palpebral edema in his right eye, accompanied by clear watery vesicles and scabs in skin of the forehead and nose. The ophthalmic exam evidences severe ciliary and conjunctival injection, dendritic keratitis, corneal endothelial plaques and positive Hutchinson's sign. It was diagnosed as complicated herpes zoster ophthalmicus with acute uveitis that left as a sequel a neurotropic keratitis and dry eyes. It was indicated, previous information to the patient, treatment with acyclovir, prednisolone, homatropin, artificial tears and multivitamins. It was carried out the differential diagnosis with illnesses that affect skin and mucous, especially the conjunctive one, with lesions to blister as cicatrizal pemphigoid, Stevens-Johnson syndrome and herpes simplex keratitis. Conclusions: the herpes zoster ophthalmicus is an important cause of ocular morbidity due to the sequels like the neurotropic keratitis and dry eyes, with the consequent damage to the ocular surface(AU)

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