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ABSTRACT OBJECTIVE To describe drug consumption and the co-occurrence use of more than one illegal drug as well as associated factors in freshmen at a public university in Southern Brazil. METHODS Cross-sectional study with census of students entering undergraduate courses in 2017. A total of 1,788 university students answered questions about illicit drug use. For analysis, ordinal logistic regression was used. RESULTS Marijuana was the most consumed drug (lifetime: 42.1%; 30-day use: 22.7%), followed by hallucinogens (lifetime: 13.1%, 30-day use: 2.8%). Rates for lifetime use of 0, 1 and 2 or more drugs were 56.2%, 23.3% and 20.4%, respectively, and were associated with men (OR = 2.2; 95%CI:1.4-3.5), being at least 23 years old (OR = 2.7; 95%CI: 1.4-5.1), under 18 years old first experimentation with drugs (OR = 2.3; 95%CI: 1.3-3.9) and living with friends (OR = 2.0; 95%CI: 1.2-3.4). Rates for 30-day use of 0, 1 and 2 or more drugs were 76.8%; 18.1% and 5.1%, respectively, and were associated with being single, separated or widowed (OR = 3.2; 95%CI: 1.4-7.0), lower socioeconomic classes (OR = 0.3; 95%CI: 0.1-1.1; p = 0.001), under 18 years old first experimentation with drugs (OR = 1.8; 95%CI: 1.1-2.9) and living with friends (OR = 1.8 95%CI: 1.2-2.8). CONCLUSION Results indicate that students are at greater risk of illicit drug-related health problems. Thus, a better understanding of this consumption should be pursued, as well as the development of a prevention plan.

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Resumo Introdução O presente estudo teve por objetivo identificar o quantitativo de estudantes em uma instituição de ensino superior no interior paulista que vivenciam o envolvimento com o álcool, o tabaco e ou outras substâncias, e avaliar a ocorrência e nível de dependência nos mesmos. Materiais e Métodos Trata-se de extrato de uma pesquisa de levantamento, exploratória, descritiva, de abordagem quantitativa, realizada com 416 estudantes universitários. A coleta de dados se deu no decorrer do 3º trimestre de 2017, com aplicação de questionário semiestruturado, elaborado pelos autores e Questionário para Triagem do Uso de Álcool, Tabaco e Outras Substâncias. Os dados foram analisados com uso de análise estatística descritiva, teste de Qui-Quadrado de Pearson e de acordo com as instruções para aplicação do instrumento selecionado. A pesquisa foi submetida e aprovada pelo Comitê de Ética em Pesquisa. Resultados Os índices gerais de envolvimento e o tipo de drogas são: 140 (30%) para derivados do tabaco, 303 (66%) para bebidas alcoólicas, 89 (19%) para maconha, 32 (7%) para cocaína/crack, 24 (5%) para anfetaminas ou êxtase, 30 (7%) para inalantes, 45 (10%) para hipnóticos/sedativos, 36 (8%) para alucinógenos, e nove (2%) para opióides. Discussão Houve envolvimento com todos os tipos de substâncias, associado a romantização quanto ao uso das mesmas no ambiente universitário e facilidade de acesso. Conclusões O envolvimento de universitários com álcool, tabaco e outras substâncias é real e intenso. Além do envolvimento, o risco para dependência dessas substâncias se caracteriza como grande problema social e de saúde.

Abstract Introduction This study aimed to identify the number of students from a higher education institution into the interior of São Paulo state who experienced their entry into alcohol, tobacco and other substances in order to evaluate the occurrence and dependency level on them. Materials and Methods An extract of a compiling, exploratory, descriptive study under a quantitative approach was conducted in 416 undergraduate students. The data were collected over the third quarter of 2017 by applying a semi-structured questionnaire prepared by the authors in addition to the Triage Questionnaire for Alcohol, Tobacco and other Drugs Use. A descriptive statistical analysis was conducted for data analysis as well as a Pearson' chi-squared test, according to the instructions for the application of the selected instrument. This study was received and approved by the Research Ethics Committee. Results The general rates for entry and drug type are 140 (30%) for tobacco derivatives, 303 (66%) for alcohol beverages, 89 (19%) for marijuana, 32 (7%) for cocaine/crack, 24 (5%) for amphetamines or ecstasy, 30 (7%) for inhalant drugs, 45 (10%) for hypnotics/sedatives, 36 (8%) for hallucinogens and 9 (2%) for opioids. Discussion Students showed to be involved in all types of substances which is linked to flexibility in relation to their use in the university environment and their easy access. Conclusions Undergraduate students have a real and intense relationship with alcohol, tobacco and other drugs. In addition to this relationship, the risk of addiction to these substances is presented as a major social and healthcare problem.

Resumen Introducción El presente estudio tuvo como objetivo identificar la cantidad de estudiantes en una institución de educación superior en el interior paulista que experimentan su incursión en el alcohol, el tabaco y otras sustancias, y evaluar así la ocurrencia y el nivel de dependencia de los mismos. Materiales y Métodos Se trata de un extracto de un estudio de levantamiento, exploratorio, descriptivo, de enfoque cuantitativo, realizado con 416 estudiantes universitarios. Los datos fueron recolectados en el transcurso del 3º trimestre de 2017, mediante la aplicación de un cuestionario semi-estructurado, elaborado por los autores y del Cuestionario para Triaje de Uso de Alcohol, Tabaco y otras Sustancias. Los datos fueron analizados a través de un análisis estadístico descriptivo, la prueba de Qui-Cuadrado de Pearson y de acuerdo con las instrucciones para la aplicación del instrumento seleccionado. El estudio fue recibido y aprobado por el Comité de Ética en Investigación. Resultados Los índices generales de incursión y el tipo de drogas son: 140 (30%) para derivados del cigarrillo, 303 (66%) para bebidas alcohólicas, 89 (19%) para marihuana, 32 (7%) para cocaína/crack, 24 (5%) para anfetaminas o éxtasis, 30 (7%) para drogas inhaladas, 45 (10%) para hipnóticos/sedantes, 36 (8%) para alucinógenos, y nueve (2%) para opioides. Discusión Los estudiantes demostraron haber estado involucrados con todos los tipos de sustancias, lo que se asocia a la flexibilización con respecto al uso de las mismas en el ambiente universitario y a la facilidad de acceso. Conclusiones La relación de los universitarios con el alcohol, el cigarrillo y otras sustancias es real e intensa. Además de esa relación, el riesgo de adicción a estas sustancias se configura como un gran problema social y de salud.

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ABSTRACT Objective: this study will present insights on the situation in the surveyed sample as it relates to attitudes towards persons who abuse alcohol by age and gender and would constitute a platform upon which further research can be conducted by researchers in the drug field. Method: this cross-sectional study examines the profile of a sample of residents in the Electoral District of Woodbrook, Port-of-Spain, Trinidad and Tobago. The sample consisted of 121 respondents. Results: alcohol was the most abused drug (85.2%), followed by marijuana (86%), cocaine (69%) and cocaine derivative (41.8%). The prevailing attitude towards persons who abused alcohol was ambivalence (64.8%); this was followed to a lesser extent by an attitude of negativity (34.4%), and the least significant attitude among respondents was premised on positivity (.8%). Respondents also held a negative attitude towards those who abused cocaine and marijuana. Conclusion: the high level of ambivalence towards alcohol use may be intertwined with the social acceptability and high usage of this drug reported from among those surveyed in the Electoral District of Woodbrook.

RESUMO Objetivo: este estudo apresentará insights sobre a situação na amostra pesquisada no que se refere a atitudes em relação às pessoas que abusam de álcool por idade e sexo e que constituiria uma plataforma sobre a qual mais pesquisas podem ser conduzidas por pesquisadores no campo das drogas. Método: transversal que examina o perfil de uma amostra de residentes no Distrito Eleitoral de Woodbrook, Port of Spain, Trinidad e Tobago. A amostra foi composta por 121 respondentes. Resultados: o álcool foi a droga mais utilizada (85,2%), seguido pela maconha (86%), cocaína (69%) e derivado de cocaína (41,8%). A atitude predominante em relação às pessoas que abusaram do álcool foi a ambivalência (64,8%); isso foi seguido em menor medida por uma atitude de negatividade (34,4%), e a atitude menos significativa entre os entrevistados foi baseada na positividade (0,8%). Os entrevistados também mantiveram uma atitude negativa em relação àqueles que abusaram de cocaína e maconha. Conclusão: o alto nível de ambivalência em relação ao uso de álcool pode estar interligado com a aceitabilidade social e alto uso dessa droga relatada entre os entrevistados no Distrito Eleitoral de Woodbrook.

RESUMEN Objetivo: este estudio presentará un informe sobre la situación en la muestra investigada en lo que se refiere a actitudes hacia las personas que hacen uso excesivo de alcohol por edad y sexo, y que constituiría una plataforma sobre la cual los investigadores pueden conducir más investigaciones en el campo de las drogas. Método: transversal que examina el perfil de una muestra de residentes en el Distrito Electoral de Woodbrook, Puerto de España, Trinidad y Tobago. La muestra estuvo compuesta por 121 participantes. Resultados: el alcohol fue la droga más utilizada (85,2%), seguida por la marihuana (86%), cocaína (69%) y derivado de la cocaína (41,8%). La actitud predominante en relación a las personas que hicieron uso excesivo de alcohol fue la ambivalencia (64,8%), seguido en menor medida por una actitud negativa (34,4%), y la actitud menos significativa entre los entrevistados se basó en la positividad (0,8%). Los entrevistados también mantuvieron una actitud negativa hacia los que hacen uso excesivo de la cocaína y marihuana. Conclusión: el alto nivel de ambivalencia en relación al uso de alcohol puede estar interconectado con la aceptabilidad social y el uso excesivo de esta droga mencionada entre los entrevistados en el Distrito Electoral de Woodbrook.

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Background: Low availability of medicines in health services, self-medication, inadequate use of medicines, and inadequate dispensing practices in pharmacies are frequent problems in Peru. We aimed to evaluate how frequent the purchase of medications without medical prescription is in Peru, and which factors are associated with this practice. Methods: We conducted a secondary analysis of the 2016 ENSUSALUD national survey data. Purchase of one or more medicines that require a prescription was measured as a dichotomous variable. Crude and adjusted prevalence ratios (PR) and their 95% confidence intervals (95% CI) were calculated using Poisson regressions model with robust variance to assess the association of purchasing of medicines that require prescriptions with sociodemographic factors. Results: There were 3858 participants in the dataset. The prevalence of purchasing medications without prescriptions was 47.2%. History of having previously consumed the same medication (31.6%), and the delay in receiving an appointment at health facilities (26.9%) were the main reasons to buy medications without a prescription. Regarding the recommendation of the medication purchased, the advice of the pharmacy, and remembering a previous old prescription, were the most frequent reasons (38.3%, and 25.9%, respectively). On the multivariable analysis, users that buy medications without prescription were more likely to be of aged 25-44; reside in the Jungle  and Highlands regions; and self-consumption of the purchase. Individuals with Seguro Integral de Salud (Comprehensive Health Insurance) were less likely to buy medications without prescription. Conclusions: There is a high prevalence of prescription requiring medication being bought without one from pharmacies in Peru. It is necessary to include the evaluation of consumer patterns to develop strategies with the aim to regulate the consumption of prescription drugs in the Peruvian population.

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This study aimed to test seeking behavior caused by alcohol and the drug effects on learning in the zebrafish, Danio rerio. Three treatments were conducted: acute, chronic and withdrawal, using 0.10%, 0.25%, and 1.00% alcohol and control (0.00%) (vol/vol.%). For the drug seeking behavior, we used a place preference paradigm (shuttle box tank) before and after alcohol exposure in acute (single exposure) and chronic (7 days) treatments. We observed a change in the basal preference due to the association with alcohol only for 0.25% and 1.00% doses in both acute and chronic offering, indicating an alcohol-seeking behavior after the drug exposure. For the learning task, two treatments were tested: chronic alcohol exposure (26 days including the learning period) and alcohol withdrawal (15 days of alcohol exposure before the learning period). During the learning period, fish received light stimulus followed by food in a pre-defined area of the tank for 8 consecutive days. The low dose group (0.10%) learned the task by the 3rd day both in chronic and withdrawal treatments. The higher doses (0.25% and 1.00%) caused a learning impairment in the chronic treatment group, while fish from the alcohol withdrawal treatment displayed learning on the final testing day. Therefore, we suggest that high alcohol doses impair learning and cause drug seeking behavior, even after drug exposure cessation, while low doses positively affect learning and do not cause seeking behavior. Given our results we propose that the zebrafish is a promising model for identifying active compounds, antibodies or genes which modulate the alcohol dual effects: learning improvement and reinforcing behavior.

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RESUMO Este estudo teve por objetivo investigar o tratamento e a reabilitação de usuários do CAPS -AD de Caxias do Sul (RS), Brasil, sob a perspectiva dos profissionais do serviço. Trata-se de uma pesquisa qualitativa, realizada com profissionais de nível superior, no período compreendido entre setembro e novembro de 2011. A coleta de dados foi realizada por meio de entrevistas semiestruturadas. Para a análise de dados, foi utilizada a análise de conteúdo, na modalidade temática, proposta por Minayo. Os resultados apontam para a importância do vínculo entre equipe e usuários; a construção de projetos terapêuticos singulares, que contemplem as necessidades e habilidades do sujeito; o papel da família no contexto do uso e abuso de substâncias psicoativas; e a importância da motivação para o tratamento e a reabilitação.

ABSTRACT This study aimed at investigating the treatment and rehabilitation of users of the Psychosocial Care Center Alcohol and Other Drugs (CAPS -AD) in Caxias do Sul (RS), Brazil from the perspective of professionals who work in this unit. This qualitative research was carried out with professionals who have a college degree, from September to November 2011. Semi-structured interviews were used for data collection. Content analysis, based on themes, proposed by Minayo, was used for the data analysis. Results show the importance of the development of bonds between the team and the users, the construction of specific therapeutic projects to meet the subjects' needs and abilities, the family's role in the context of addiction to psychoactive substances and the motivation for treatment and rehabilitation.

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CONTEXTO: Os ambientes recreativos noturnos têm conquistado, na atualidade, um protagonismo crescente na vida juvenil, determinando estilos de vida, normalizando o consumo recreativo de álcool/drogas e a adoção de outros comportamentos de risco. OBJETIVO: Delinear o perfil dos jovens portugueses que frequentam ambientes recreativos noturnos e determinar a prevalência de comportamentos violentos relacionados com variáveis sociodemográficas, consumo de álcool e drogas e envolvimento nas atividades recreativas noturnas. METODOLOGIA: Entrevista de 1346 jovens (idade média = 22,49 anos) frequentadores de ambientes recreativos noturnos, de ambos os sexos, em 10 cidades portuguesas, utilizando uma variação da Respondent-driven sampling, entre 2007 e 2010. RESULTADOS: Verificou-se que existe uma relação positiva entre comportamentos violentos, consumo de álcool e drogas e a participação dos jovens na vida recreativa noturna. Conclusões: Sugere-se que a implementação de medidas preventivas neste contexto atenda às características dos jovens apresentadas neste estudo como preditoras de comportamentos violentos.

BACKGROUND: The night time recreational environments have currently gained an important role in the juvenile life, determining life styles, standardizing the recreational consumption of alcohol and drugs, as well as the adoption of associated risk behaviours. OBJECTIVES: To characterize the profile of Portuguese young people attending nightlife recreational environments and determine the prevalence of violent behaviors based on sociodemographic variables, alcohol consumption and drug use, and engagement in recreational nightlife activities. METHODOLOGY: Interview applied to 1346 young people who used to go to nighttime recreational environments, both sexes, into 10 Portuguese cities, between 2007 and 2010, using the respondent-driven sampling. RESULTS: It was notified the existence of a positive relation among violent behaviours, alcohol consumption and drug use, and young people's engagement in recreational nightlife.Conclusions: It is suggested that preventive actions should be implemented in recreational environments, to meet the characteristics of young people presented in this study as predictors of violent behaviors.

ANTECEDENTES: Los entornos recreativos nocturnos han conquistado, en la actualidad, una importancia creciente en la vida juvenil, determinando los estilos de vida, normalizando el consumo recreativo de alcohol/drogas y la practica de otros comportamientos de riesgo. OBJETIVO: Delinear el perfil de los jóvenes portugueses que frequentan ambientes recreativos nocturnos y determinar la prevalencia de conductas violentas en relación con variables sociodemográficas, consumo de alcohol y drogas y envolvimiento en las actividades recreacionales nocturnas. METODOLOGÍA: Entrevista con 1346 jóvenes (edad media = 22,49 años) frecuentadores de ambientes recreativos nocturnos, de ambos sexos, en 10 ciudades portuguesas, mediante el uso de una variación de la Respondent-Driven Sampling entre 2007 y 2010.Resultados: Se constató una relación positiva entre comportamiento violento, consumo de alcohol y drogas y la participación de los jóvenes en la vida recreativa nocturna. CONCLUSIÓN: Se sugiere que la implementación de medidas preventivas en este contexto atienda a las características de los jóvenes presentados en este estudio, como predictoras de la conducta violenta.

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Por ser o lazer, momento de vivências onde há possibilidade de liberação das tensões cotidianas e ao mesmo tempo, espaço criativo e questionador, surge a possibilidade de identificar a presença da droga neste espaço/tempo, como instrumento viabilizador destas atitudes. A presença das drogas nas mais diversas sociedades, comumente abordada através da perspectiva fisiológica e psicológica, não parece considerar o importante aspecto deste fenômeno, enquanto manifestação social e cultural. Através do olhar biopsicossocial, faz-se possível reavaliar tanto usuários quanto o próprio uso da droga e tentar encontrar, mais do que respostas, um panorama desta presença em nossa cultura.

To be the leisure, time of experiences where have the possibility of the release of daily tensions and at the same time, space creative and inquisitive, the possibility of identifying the presence of drugs in this space/time arises, as an instrument enabler of these processes. The presence of drugs in various societies, commonly addressed by physiological and psychological perspective, does not seem to consider the important aspect of this phenomenon, while social and cultural manifestation. Through the biopsychosocial look, it is possible to reassess both users and the own use of drugs, trying to find more than answers, an overview of this presence in our culture.

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