RESUMO
The saturated LPC18:0 and unsaturated LPC18:1 lysophosphatidylcholines have important roles in inflammation and immunity and are interesting targets for immunotherapy. The synthetic cationic lipid DODAB has been successfully employed in delivery systems, and would be a suitable carrier for those lysophosphatidylcholines. Here, assemblies of DODAB and LPC18:0 or LPC18:1 were characterized by Differential Scanning Calorimetry (DSC) and Electron Paramagnetic Resonance (EPR) spectroscopy. LPC18:0 increased the DODAB gel-fluid transition enthalpy and rigidified both phases. In contrast, LPC18:1 caused a decrease in the DODAB gel-fluid transition temperature and cooperativity, associated with two populations with distinct rigidities in the gel phase. In the fluid phase, LPC18:1 increased the surface order but, differently from LPC18:0, did not affect viscosity at the membrane core. The impact of the different acyl chains of LPC18:0 and 18:1 on structure and thermotropic behavior should be considered when developing applications using mixed DODAB membranes.
Assuntos
Lisofosfatidilcolinas , Compostos de Amônio Quaternário , Termodinâmica , Temperatura de Transição , Compostos de Amônio Quaternário/química , Varredura Diferencial de Calorimetria , Bicamadas Lipídicas/químicaRESUMO
O sentimento de ciúme é um tema frequente nas sessões de psicoterapia, pois traz muito sofrimento tanto para quem o sente quanto para quem é vítima de uma pessoa ciumenta. Neste artigo procura-se enquadrar este doloroso sentimento na teoria psicodramática, utilizando-se fundamentalmente dos conceitos da Matriz de Identidade e do duplovínculo.(AU)
The feeling of envy is a frequent issue raised in psychotherapy sessions, as it causes suffering for those who feel envious as well as those on the receiving end of someone elses envy. This article aims to fit this painful feeling into the psychodrama theory, relying mainly on the concepts of the matrix of identity and the double-bond.(AU)