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Background: Brazil has a larger number of adolescent offenders, but studies evaluating their oral health are still limited. Objective: Assess the association between salivary flow and caries experience in youngsters deprived of liberty. Methodology: Sixty-eight male adolescents in conflict with the law, aged between 15 and 19 years, from a Socio-Educational Assistance Center in Brazil participated in the present study. They answered a structured questionnaire, and oral examination was performed by the Decayed, Missing, and Filled Teeth (DMFT) index. The salivary flow rate was obtained using the mechanically stimulated total saliva method. Adjusted Poisson regression was used for the association with total DMFT and its decayed component, using the salivary flow (continuous fashion) or the hyposalivation (≤1 ml/min) as independent variables. Results: Participants were divided into two groups, those who did not have any decayed teeth at the moment of the examination (n = 39) and those who had at least one decayed tooth (n = 29). Moreover, two groups were formed based on the DMFT: those who had DMFT = 0 (n = 20) and those who had DMFT≥1 (n = 48). In the multivariate analysis, hyposalivation was associated with DMFT≥1 (p = 0.048), but when the salivary flow was included, no significant association with DMFT index was identified (p = 0.178). Conversely, the presence of at least one decayed tooth was significantly associated with the salivary flow (p = 0.004), but not with hyposalivation (p = 0.091). Conclusions: Institutionalized adolescents who present hyposalivation or low salivary flow are associated with DMFT≥1 index or presence of at least one decayed tooth, respectively.

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Introducción: La Organización Mundial de la Salud define a la caries dental como un problema de salud mundial que afecta entre el 60 al 90% de la población. Se considera una enfermedad transmisible de origen multifactorial, que evoluciona de manera progresiva hasta ocasionar la destrucción de los tejidos duros. Objetivo: Determinar la relación entre dientes cariados, perdidos y obturados, y la limitación para socializar en escolares de Ecuador. Métodos: Se realizó un estudio descriptivo de tipo correlacional sobre una población de 154 escolares de 12 años de la parroquia el Batán, de Cuenca-Ecuador (2016); para el análisis estadístico los datos fueron ingresados al programa SPSS, donde se efectuó estadística descriptiva para cada una de las variables y la limitación para socializar. Resultados: Se logró constatar que la población objeto presentó un índice de CPOD muy bajo (32,5 %), de igual forma se evidenció que el 62,7% no presentó limitación a la hora de socializar. En cuanto a la correlación entre ambas variables, se mostró una asociación positiva con un nivel de significancia de p=0,002. Una de las principales limitaciones del estudio fue el escaso contacto con los participantes. Se recomienda, efectuar investigaciones epidemiológicas longitudinales con la finalidad de observar la variación del coeficiente de correlación de las variables en fases de pretratamiento y de postratamiento. Conclusión: Al finalizar el estudio, se demostró que existe correlación estadística entre el índice CPOD y la limitación en el desempeño socializar en los escolares de 12 años de la parroquia el Batán.

Introduction: the World Health Organization defines dental caries as a global health problem that affects between 60 and 90% of the population. It is considered a communicable disease of multifactorial origin, which evolves progressively until it causes the destruction of hard tissues. Objective: to determine the relationship between decayed, missing and filled teeth and the limitation to socialize in schoolchildren from Ecuador. Methods: a descriptive correlational study was carried out on a population of 154 schoolchildren aged 12 years from the El Batán parish, Cuenca-Ecuador (2016); data was entered into the SPSS program for the statistical analysis, where descriptive statistics were performed for each of the variables and for the limitation to socialize. Results: it was possible to verify that the target population had a very low DMFT index (32.5%); in the same way it was evidenced that 62.7% did not have limitations when socializing. A positive association, with a significance level of p=0.002, was shown regarding the correlation between both variables. One of the main limitations of the study was the limited contact with the participants. We recommend to carry out longitudinal epidemiological investigations in order to observe the variation of the correlation coefficient of the variables in the pre-treatment and post-treatment phases. Conclusion: we showed, at the end of the study, that there is a statistical correlation between the DMFT index and the limitation in socializing performance in 12-year-old schoolchildren from the El Batán parish.

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OBJECTIVE: To identify the prevalence of dental caries in pregnant women in the Colombian population and its association with the medical history and social determinants, based on data from the fourth National Oral Health Survey (ENSAB IV). MATERIALS AND METHODS: A total of 1,047 pregnant women from different areas of Colombia were evaluated. A dental evaluation was performed using a flat oral mirror and blunt-tipped probe (World Health Organization, 2007). For diagnosis of the dental condition, the DMFT index was used. A negative binomial regression analysis was performed to evaluate the association between social determinants and the DMFT index. RESULTS: The results of this national study show a 59% prevalence of caries in this population. Regarding the experience of caries, 89.9% of pregnant women showed having had caries. CONCLUSIONS: The results of this national study on pregnant women show a high prevalence of dental caries. The women's level of education is an important factor associated with dental caries and filled teeth, so the role of oral health education and dental check-ups are important. CLINICAL RELEVANCE: The findings of this study show the oral health situation of pregnant women, with a high prevalence of dental caries. This leads to the development and strengthening of oral health education strategies that empower pregnant women in their care. In addition, dental checkups during pregnancy should be implemented and reinforced to prevent and treat oral pathologies and thus prevent complications during this stage.

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This research study examined how the use of dimethylformamide (DMF) as an inhibitor affects the propylene polymerization process when using a Ziegler-Natta catalyst. Several experiments were carried out using TiCl4/MgCl2 as a catalyst, aluminum trialkyl as a cocatalyst, and different amounts of DMF. Then, we analyzed how DMF influences other aspects of the process, such as catalyst activity, molecular weight, and the number of branches in the polymer chains obtained, using experimental and computational methods. The results revealed that as the DMF/Ti ratio increases, the catalyst activity decreases. From a concentration of 5.11 ppm of DMF, a decrease in catalyst activity was observed, ranging from 45 TM/Kg to 44 TM/Kg. When the DMF concentration was increased to 40.23 ppm, the catalyst activity decreased to 43 TM/Kg, and with 75.32 ppm, it dropped even further to 39 TM/Kg. The highest concentration of DMF evaluated, 89.92 ppm, resulted in a catalyst productivity of 36.5 TM/Kg and lost productivity of 22%. In addition, significant changes in the polymer's melt flow index (MFI) were noted as the DMF concentration increased. When 89.92 ppm of DMF was added, the MFI loss was 75%, indicating a higher flowability of the polymer. In this study, it was found that dimethylformamide (DMF) exhibits a strong affinity for the titanium center of a Ziegler-Natta (ZN) catalyst, with an adsorption energy (Ead) of approximately -46.157 kcal/mol, indicating a robust interaction. This affinity is significantly higher compared to propylene, which has an Ead of approximately -5.2 kcal/mol. The study also revealed that the energy gap between the highest occupied molecular orbital (HOMO) of DMF and the lowest unoccupied molecular orbital (SOMO) of the Ziegler-Natta (ZN) catalyst is energetically favorable, with a value of approximately 0.311 eV.

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Digital microfluidics (DMF) is a versatile lab-on-a-chip platform that allows integration with several types of sensors and detection techniques, including colorimetric sensors. Here, we propose, for the first time, the integration of DMF chips into a mini studio containing a 3D-printed holder with previously fixed UV-LEDs to promote sample degradation on the chip surface before a complete analytical procedure involving reagent mixture, colorimetric reaction, and detection through a webcam integrated on the equipment. As a proof-of-concept, the feasibility of the integrated system was successfully through the indirect analysis of S-nitrosocysteine (CySNO) in biological samples. For this purpose, UV-LEDs were explored to perform the photolytic cleavage of CySNO, thus generating nitrite and subproducts directly on DMF chip. Nitrite was then colorimetrically detected based on a modified Griess reaction, in which reagents were prepared through a programable movement of droplets on DMF devices. The assembling and the experimental parameters were optimized, and the proposed integration exhibited a satisfactory correlation with the results acquired using a desktop scanner. Under the optimal experimental conditions, the obtained CySNO degradation to nitrite was 96%. Considering the analytical parameters, the proposed approach revealed linear behavior in the CySNO concentration range between 12.5 and 400 µmol L-1 and a limit of detection equal to 2.8 µmol L-1. Synthetic serum and human plasma samples were successfully analyzed, and the achieved results did not statistically differ from the data recorded by spectrophotometry at the confidence level of 95%, thus indicating the huge potential of the integration between DMF and mini studio to promote complete analysis of lowmolecular weight compounds.

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This study aims to investigate whether the trajectory of dental caries in the life course is associated with rs307355 (TAS1R3) and rs35874116 (TAS1R2) and if there is an epistatic association between rs307355 (TAS1R3) and rs35874116 (TAS1R2). A representative sample of all 5,914 births from the 1982 Pelotas birth cohort was prospectively investigated, and the decayed, missing, and filled teeth (DMF-T) components were assessed at ages 15 (n = 888), 24 (n = 720), and 31 (n = 539) y. Group-based trajectory modeling was used to identify groups with similar trajectories of DMF-T components in the life course. Genetic material was collected, and rs307355 (TAS1R3) and rs35874116 (TAS1R2) were genotyped. Ethnicity was evaluated using ADMIXTURE. Generalized multifactor dimensionality reduction software was used to investigate epistatic interactions. Considering rs307355 (TAS1R3) in the additive effect, the genotype TT was associated with the high decayed trajectory group (odds ratio [OR] = 4.52; 95% confidence interval [CI], 1.15-17.74) and the high missing trajectory group (OR = 3.35; 95% CI, 1.09-10.26). In the dominant effect, the genotype CT/TT was associated with the high decayed trajectory group (OR = 1.64; 95% CI, 1.14-2.35). Allele T was associated with an increased odds of 64% (OR = 1.64; 95% CI, 1.20-2.25) for the decayed component and 41% (OR = 1.41; 95% CI, 1.04-1.92) for the missing component. No associations were observed between rs307355 (TAS1R3) and the filled component. rs35874116 (TAS1R2) was not associated with DMF-T components. Positive epistatic interactions were observed involving rs307355 (TAS1R3) and rs35874116 (TAS1R2) with the decayed component (OR = 1.72; 95% CI, 1.04-2.84). Thus, rs307355 (TAS1R3) genotypes and alleles seem positively associated with the trajectory of decayed and missing components in the life course. Epistatic interaction between rs307355 and rs35874116 may increase the decayed caries trajectory.

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OBJECTIVE: To assess the prevalence and associated factors of self-reported halitosis in institutionalized adolescents in a city in southern Brazil. METHODS: This cross-sectional study involved male institutionalized adolescents, aged 15-19 years old, at the Socio-Educational Assistance Center in the city of Passo Fundo, Brazil. Data collection was performed by a research team composed of two interviewers, two clinical examiners of oral health and two examiners of salivary flow. A structured questionnaire was applied, which included demographical, socioeconomical, general health behaviour, presence of health problems and oral health self-perception variables. Decayed, Missing, Filled Index was used for the clinical examination. The salivary flow collection was performed using the mechanically stimulated total saliva method, in which only the liquid component was measured. RESULTS: The prevalence of self-reported halitosis in this sample was 51.5% (n = 35). In the final multivariate analysis, halitosis was significantly associated with the non-white racial group (prevalence ratio [RP]:1.703; 95% confidence interval [95%CI]:1.101-2.634), use of crack (RP:1.857; 95%CI:1.270-2.714) and number of decayed teeth (PR: 1.123; 95%CI:1.008-1.252). The use of alcohol and access to dental care in the last 12 months were not significantly associated with self-reported halitosis. CONCLUSION: It was concluded that non-white and crack-user youngsters had a high occurrence of self-reported halitosis. Higher rates of dental caries are also associated with halitosis.

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Dysregulated microglia and astrocytes have been associated with progressive neurodegeneration in multiple sclerosis (MS), highlighting the need for strategies that additionally target intrinsic inflammation in the central nervous system (CNS). The objective of the present study was to investigate the glial response in experimental autoimmune encephalomyelitis (EAE)-induced mice treated with a combination of dimethyl fumarate (DMF) and pregabalin (PGB). For that, 28 C57BL/6J mice were randomly assigned to the five experimental groups: naïve, EAE, EAE-DMF, EAE-PGB, and EAE-DMF + PGB. Pharmacological treatments were initiated with the beginning of clinical signs, and all animals were euthanized at 28 dpi for the lumbar spinal cord evaluation. The results demonstrated a stronger attenuation of the clinical presentation by the combined approach. DMF alone promoted the downregulation of Iba-1 (microglia/macrophages marker) in the ventral horn compared with the non-treated EAE animals (P < 0.05). PGB treatment was associated with reduced Iba-1 immunofluorescence in both the dorsal (P < 0.05) and ventral horn (P < 0.05) compared to EAE vehicle-treated counterparts. However, the combined approach reduced the Iba-1 marker in the dorsal (P < 0.05) and ventral (P < 0.01) horns compared to non-treated EAE animals and further reduced Iba-1 in the ventral horn compared to each drug-alone approach (P < 0.05). In addition, the combination of DMF and PGB reduced activated astrocytes (GFAP) in both the dorsal and ventral horns of the spinal cord to a naïve-like level and upregulated Nrf-2 expression. Taken together, the data herein suggest robust attenuation of the glial response in EAE mice treated with DMF and PGB.

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RESUMEN Introducción. La caries dental y las enfermedades gingivales son las patologías más comunes en la población mundial y se ha demostrado que las prácticas de higiene oral pueden controlarlas y prevenirlas Objetivo. Diseñar una estrategia educativa de prevención de enfermedades bucales e implementar en forma piloto en el personal de limpieza de la Universidad del Pacífico en Paraguay. Metodología. Estudio de intervención cuasiexperimental en el personal de limpieza de la Universidad del Pacífico en el periodo 2021. Se registraron índices CPOD y de O´Leary para establecer diagnóstico. Cada paciente recibió elementos de higiene bucal y semanalmente recibía mensajes, fotos y videos motivadores vía WhatsApp. Resultados. Participaron 13 individuos de entre 21 y 48 años, 69% del sexo femenino. Se realizaron 6 talleres con insumos para cada participante. El 49% de los participantes logró el objetivo de llegar al 20% del índice de O´Leary y el 40% de ellos reducir el 50% el índice Caries y el 100% de los que completaron los talleres resolvió la gingivitis. De 6 talleres realizados, 3 participantes acudieron al 100% de las actividades Conclusión. El cepillado dental bajo supervisión e instrucciones sencillas disminuye el Índice de O´Leary y controla la gingivitis. El uso de teléfonos celulares para realizar seguimiento y dar motivación constante compartiendo mensajes recordatorios, reflexiones positivas, imágenes de sonrisas agradables y videos demostrativos, evidenció ser altamente efectivo promover la constancia de los cuidados de salud bucal, sin embargo, no hubo impacto sobre la cantidad de caries activas presentes.

ABSTRACT Introduction. Dental caries and periodontal disease are the most common oral pathologies affecting the global population and it is proven that a good oral hygiene practices can control and prevent them. Objective. to design an educative strategy to prevent oral diseases and experimentally implement it with the cleaning workers of the Universidad del Pacífico in Paraguay. Methodology. Interventional quasi-experimental study with the cleaning workers at Universidad del Pacífico in 2021. DMF and O´Leary Indexes were measured to stablish diagnosis. Each patient received oral hygiene supplies in every control meeting. They also received weekly messages, photos, videos via WhatsApp. Results. 13 people between 21 to 48 years old participated in this study. 69% of them were female. 6 workshops were conducted where each individual received hygiene supplies. 49% of the participants achieved the goal of reducing to 20% or less in the O´Leary Index and 40% reduced their Decay Index to 50% and all the individuals who suffered initially from gingivitis were no longer affected by it at the end of the study. Out of 6 workshops, only 3 people participated in all of them. Conclusion. Supervised tooth brushing can help diminishing O´Leary index and controls gingivitis. It was proven that the use of cell phones to communicate with the participants with texting, photos or videos to promote the strategy and to rise the spirit was very helpful, nonetheless there were no impact over the amount of tooth decays.

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RESUMEN: Las enfermedades que afectan la salud bucodental en Chile son de alta prevalencia, severidad y afectan la calidad de vida de las personas. El Estado chileno ha implementado políticas públicas destinadas a mejorar la salud bucodent al, que benefician principalmente a niños y embarazadas. El trabajo consistió en un estudio observacional analítico. Se analizaron los índices COPD y ceod de las edades: 2, 4, 6 y 12 años, obtenidos de los Registros Estadísticos Mensuales (REM) de los años 2008-2017 (n=3.415.720). Análisis de datos: Excel 2011, EPIDAT 4.2 y SPSS; pruebas de Chi cuadrado y T-student (IC 95% y p<0,05). Disminución en prevalencia y severidad de caries durante los 10 años en estudio (p <0,05). Disminución estadísticamente significativa en la prevalencia y severidad de caries posterior a la implementación del programa que beneficia a los niños de 6 años. En cuanto a los programas Salud Oral Integral para la embarazada y Sembrando Sonrisas, solo tuvieron una disminución estadísticamente significativa en la severidad de caries. Se pudo observar impacto positivo de todas las políticas públicas estudiadas principalmente en la severidad de caries a lo largo de los años en estudio. No se pueden hacer comparaciones estadísticas con estudios previos por presentar metodologías muy disimiles con el presente. Se debe destacar la relevancia de un correcto registro de los índices en el REM. Es necesario realizar vigilancia epidemiológica según las metodologías y tiempos indicados para evaluar que papel ha jugado la prevención y promoción planteada en los objetivos estratégicos de la década que recién terminó.

ABSTRACT: Diseases affecting oral health in Chile are highly prevalent, severe and affect people's quality of life. The Chilean State has implemented public policies aimed at improving oral health, mainly benefiting children and pregnant women. This was an analytical observational study. DMF index for primary and permanent theeth were analyzed for ages: 2, 4, 6 and 12 years, obtained from the Monthly Statistical Records (MSR) for the years 2008-2017 (n=3.415.720). Data analysis: Excel 2011, EPIDAT 4.2 and SPSS; Chi-square and T-student tests (95% CI and p<0.05). Decrease in caries prevalence and severity during the 10 years under study (p<0.05). Statistically significant decrease in the prevalence and severity of caries after the implementation of the program benefiting 6-year-old children. As for the Oral Health Program for Pregnant Women and Sowing Smiles programs, they only had a statistically significant decrease in the severity of caries. A positive impact of all the public policies studied was observed, mainly in the severity of caries over the years under study. Statistical comparisons with previous studies cannot be made because they present very dissimilar methodologies. The relevance of a correct recording of the indices in the MSR should be emphasized. It is necessary to carry out epidemiological surveillance according to the methodologies and times indicated in order to evaluate the role played by prevention and promotion as set out in the strategic objectives of the decade that has just ended.

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RESUMEN De acuerdo a la literatura, los pacientes hospitalizados con trastornos mentales (TM), tienen mayor riesgo a desarrollar caries y enfermedad periodontal que la población general, asociado a la dificultad motora para hacerse una adecuada higiene oral, a los efectos adversos que ocasionan los medicamentos para el control de los síntomas psiquiátricos y a la falta de cuidado oral y atención clínica. El objetivo era realizar una revisión sistemática de la literatura sobre el estado de salud oral de pacientes hospitalizados con TM. Se hizo una búsqueda sistemática de la literatura en PubMed, de acuerdo con la metodología de la declaración PRISMA, a través de los descriptores en salud MeSh "Dental Caries" y "Mental Disorders" a febrero de 2017. De acuerdo a los diferentes filtros que fueron aplicados, se obtuvieron 14 artículos que describieron el estado de salud oral -mediante el índice COP-D (dientes con caries, dientes con restauraciones, dientes perdidos y dientes con extracción mandatoria)- de pacientes hospitalizados con TM. Se debe promover el reconocimiento de la importancia de la salud oral por parte de los profesionales de la salud, cuidadores y familiares; se debe explorar la cavidad oral para determinar el estado de salud además de instruir a los pacientes y personal de apoyo en higiene oral; las instituciones de salud mental deben establecer un programa de intervención para eliminar focos infecciosos orales y luego implementar un programa preventivo multidisciplinario para mantener la salud oral de acuerdo al diagnóstico del TM.

ABSTRACT According to the literature, hospitalized patients with mental disorders have a higher risk of developing cavities and periodontal disease than the general population, associated with the motor difficulty to perform adequate oral hygiene, to the adverse effects caused by drugs for the control of psychiatric symptoms, as well as the lack of oral care and clinical care. The aim was to carry out a systematic review of the literature on the oral health status of hospitalized patients with mental disorders (MD). A systematic search of the literature was carried out in PubMed, according to the PRISMA statement methodology, through the MeSh health descriptors "Dental Caries" and "Mental Disorders" in February 2017. According to the different filters that were applied, 14 articles describing the oral health status were obtained - through the DMF-T index (teeth with cavities, teeth with restorations, missing teeth and teeth with necessary extraction)- of hospitalized patients with MD. The recognition of the importance of oral health by health professionals, carers and family members should be promoted; the oral cavity should be explored to determine the state of health in addition to instructing patients and support personnel in oral hygiene; mental health institutions should establish an intervention programme to eliminate oral infectious sites and then implement a multidisciplinary preventive programme to maintain oral health according to the MD diagnosis.

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According to the literature, hospitalised patients with mental disorders have a higher risk of developing cavities and periodontal disease than the general population, associated with the motor difficulty to perform adequate oral hygiene, to the adverse effects caused by drugs for the control of psychiatric symptoms, as well as the lack of oral care and clinical care. The aim was to carry out a systematic review of the literature on the oral health status of hospitalised patients with mental disorders (MD). A systematic search of the literature was carried out in PubMed, according to the PRISMA statement methodology, through the MeSh health descriptors "Dental Caries" and "Mental Disorders" in February 2017. According to the different filters that were applied, 14 articles describing the oral health status were obtained-through the DMF-T index (teeth with cavities, teeth with restorations, missing teeth and teeth with necessary extraction)-of hospitalised patients with MD. The recognition of the importance of oral health by health professionals, carers and family members should be promoted; the oral cavity should be explored to determine the state of health in addition to instructing patients and support personnel in oral hygiene; mental health institutions should establish an intervention programme to eliminate oral infectious sites and then implement a multidisciplinary preventive programme to maintain oral health according to the MD diagnosis.

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RATIONALE: The FDA-approved Dimethyl Fumarate (DMF) as an oral drug for Multiple Sclerosis (MS) treatment based on its immunomodulatory activities. However, it also caused severe adverse effects mainly related to the gastrointestinal system. OBJECTIVE: Investigated the potential effects of solid lipid nanoparticles (SLNs) containing DMF, administered by inhalation on the clinical signs, central nervous system (CNS) inflammatory response, and lung function changes in mice with experimental autoimmune encephalomyelitis (EAE). MATERIALS AND METHODS: EAE was induced using MOG35-55 peptide in female C57BL/6J mice and the mice were treated via inhalation with DMF-encapsulated SLN (CTRL/SLN/DMF and EAE/SLN/DMF), empty SLN (CTRL/SLN and EAE/SLN), or saline solution (CTRL/saline and EAE/saline), every 72 h during 21 days. RESULTS: After 21 days post-induction, EAE mice treated with DMF-loaded SLN, when compared with EAE/saline and EAE/SLN, showed decreased clinical score and weight loss, reduction in brain and spinal cord injury and inflammation, also related to the increased influx of Foxp3+ cells into the spinal cord and lung tissues. Moreover, our data revealed that EAE mice showed signs of respiratory disease, marked by increased vascular permeability, leukocyte influx, production of TNF-α and IL-17, perivascular and peribronchial inflammation, with pulmonary mechanical dysfunction associated with loss of respiratory volumes and elasticity, which DMF-encapsulated reverted in SLN nebulization. CONCLUSION: Our study suggests that inhalation of DMF-encapsulated SLN is an effective therapeutic protocol that reduces not only the CNS inflammatory process and disability progression, characteristic of EAE disease, but also protects mice from lung inflammation and pulmonary dysfunction.

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Abstract Objective: To explore the clinical pattern, host factors, and presentation of Streptococcus mutans related to caries incidence among children and adults visiting Universitas Airlangga dental clinic. Material and Methods: This was an observational study with a cross-sectional approach with 50 patients in each group of carious children (6-12 years) and adults (18-35 years). Dental decay samples were taken by sterile excavator, put in a BHI's transport medium, and directly incubated overnight at 37 ºC. The next day, they were sub-cultured microbiologically in Tryptone Yeast Cystine Sucrose Bacitracin (TYCSB) selective medium. Bacterial species and serogroups were examined by PCR. All patient's data were collected from medical records and direct observation. Results: Caries were mostly media type in both children and adults. Oral hygiene (OHIS) in children was higher than in adults but not significantly different according to their DMFT. The highest scores for decay, missed and filled teeth were 16, 8 and 7, with an average of 6.82, 1.22 and 0.63, considered quite high. Conclusion: The prevalence of S. mutans was higher in children's caries than in adults, but among the adult patients the co-incidence of S. mutans and S. sobrinus was associated with higher DMFT. The mutans serotypes e, f, and d were more prevalent among children than adults.

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Objetivo. Evaluar indicadores de salud oral en niños y adolescentes con parálisis cerebral en Lima-Perú. Métodos. Estudio observacional, descriptivo y transversal de una muestra de 171 pacientes de dos centros de referencia nacional especializados, periodo 2012- 2013, que cumplieron los criterios de inclusión. Para los índices de higiene oral (IHO) de Greene & Vermillion, índice de dientes cariados, perdidos y obturados (CPOD) y análisis de maloclusión dentaria (MD) se evaluaron 126 niños (6,0-11,9 años) y 45 adolescentes (12,0-19,0 años). Resultados. El IHO fue de 2,55 (malo) en el 91,8%, IHO regular en el 8,2% y ninguno mostró IHO bueno, observándose el mismo comportamiento en ambos grupos etarios. La prevalencia de caries fue 100% y CPOD de 4,55 ±1,56; los niños registraron CPOD de 4,52 ±1,537 y los adolescentes CPOD de 4,64 ±1,626. El 74,3% mostró MD, los niños evidenciaron MD en el 69,8% y los adolescentes mostraron 86,7%. En los niños, se observó relación molar (RM) Clase I derecha en el 42,1% e izquierda en el 44,4%; los adolescentes evidenciaron RM Clase III derecha en el 42,2% e izquierda en el 37,8%. Para los niños, el overbite (OB) no fue registrable en el 33,3% y normal en el 29,4%; en adolescentes, se registró OB normal en el 40%. Se observó con mayor frecuencia línea media dentaria desviada hacia el lado izquierdo. Conclusiones. En la mayoría de niños y adolescentes con parálisis cerebral de centros especializados se encontró alto índice de caries CPOD, mala higiene oral y presencia de maloclusiones.

Objective. To evaluate oral health indicators in children and adolescents with cerebral palsy in Lima-Peru. Methods. An observational, descriptive and cross-sectional study of a sample of 171 patients from two specialized national referral centers for the 2012- 2013 period who met the inclusion criteria. For the Greene & Vermillion oral hygiene index (OHI), decayed, missing and filled teeth (DMFT) and the dental malocclusion (DM) analysis, 126 children (6.0-11.9 years-old) and 45 adolescents (12.0-19.0 years- old) were evaluated. Results. The OHI was 2.55 (poor hygiene) in the 91.8%, regular OHI in the 8.2% and no one showed a good IHO, observing the same behavior in both age groups. The prevalence of caries was 100% and the DMFT was 4.55 ± 1.56; the children registered a DMFT of 4.52 ± 1.537 and the adolescents 4.64 ± 1.626. The DM was present in 74.3%; the children showed a 69,8% of DM and the adolescents showed 86.7%. In children, a right class I molar relationship (MR) was observed in 42.1% and a left MR in 44.4%; the adolescents showed right Class III in 42.2% and left in 37.8%. In children, the overbite (OB) was not registered in the 33.3% of the cases and it was normal in the 29.4%; the adolescents registered a normal OB in 40%. It was more frequently observed a deviation of the dental midline to the left. Conclusions. In most children and adolescents with cerebral palsy from specialized centers, a high index of DMFT caries, poor oral hygiene and the presence of malocclusions were found.

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Studies have shown that domestic waste collectors are exposed to toxicants including infectious pathogens, which may be linked to their oral health conditions. This cross-sectional study evaluated the dental caries and its associated factors among domestic waste collectors. A total of 301 adult men who worked for a waste collection corporation were included; 171 men worked in direct contact with domestic solid waste and 130 did not. Sociodemographic data, working, and medical history were assessed. The decayed, missing, and filled permanent teeth (DMFT) index was examined. Logistic regression analysis was used to identify factors associated with dental status with a significance level of 5%. The overall mean DMFT score was 8.36±5.64. The mean DMFT, missing teeth (MT), and filled teeth (FT) were significantly higher in workers who did not have any direct contact with waste (p≤0.04). In the logistic analysis, DMFT ≥8 was only associated with older age (OR=8.41 [95% confidence interval (95%CI), 5.01-14.12], p<0.001). Decayed teeth (DT) ≥2 was associated with no previous oral hygiene instruction (OR=2.70 [1.50-4.81], p=0.001) and no daily dental flossing (OR=4.26 [1.92-9.43], p<0.001). MT ≥9 was associated with lower education level (OR=3.33 [1.57-7.10], p= 0.002). FT≥3 had a negative association with low income (OR= 0.42 [0.25-0.70], p<0.001) and no daily flossing (OR=0.42 [0.23-0.76], p=0.004). In conclusion, occupational exposure to domestic solid waste was not associated with poor dental status. Instead, age, education, income level, and oral hygiene were associated with dental health status. Missing teeth constituted the major component of the DMFT index. Therefore, prevention and oral rehabilitation programs are necessary to improve dental health.

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Introduction: Oral diseases affect some 3.9 billion people worldwide, the most prevalent are dental caries, gingivitis, and periodontitis. Untreated dental caries lesions affect 35% of the population. Objective: To determine the level of severity of dental caries lesions in adults treated at public dental services in the cities of Asunción and Pirayú, Paraguay, in 2 017. Material and Methods: Sociodemographic and clinical variables of oral health status were evaluated by means of a cross-sectional study using consecutive sampling. Two dentists were calibrated to perform the oral examination. Caries experience was evaluated using the DMF-T index. The Chi square test and Fisher's exact test were applied, with a confidence level of 95%. Results:333 subjects with a mean age of 35 years participated in the study, 77.2% were females, and 64.0% did not have access to private health care services. The DMF-T index was 11.43 (SD=6.7); 12.6% obtained a very low level, 35.7% low level, 41.7% had a medium level, and 9.9% had a high level in the DMF-T index. The DMF-T index was significantly higher in females (p=0.001), in the age range of 50 to 59 years (p<0.001), in those who did not have access to private health services (p=0.008), in those who reported a negative self-evaluation of their oral health (p=0.04), in those with a normal molar ratio (p=0.023) and a very severe aesthetic index (p<0 . 0 01). Conclusion: The general level of severity of global caries was medium and associated with sociodemographic and clinical variables.

Introducción: Las enfermedades orales afectan a 3,9 billones de personas a nivel mundial, siendo las más prevalentes la caries dental, la gingivitis y periodontitis; afectando al 35% de la población las lesiones de caries dental no tratadas. Objetivo: Determinar el nivel de severidad de lesiones de caries dental en adultos que acuden a servicios odontológicos públicos en las ciudades de Asunción y Pirayú, en el Paraguay, en el año 2017. Material y Métodos: Estudio transversal donde se evaluaron variables sociodemográficas y clínicas del estado de salud oral. El muestreo fue de casos consecutivos. Dos odontólogos fueron calibrados para realizar el examen oral. La experiencia de caries fue evaluada mediante el índice CPO-D. Se aplicaron las pruebas Chi cuadrado y Test exacto de Fisher, con un nivel de confianza del 95%. Resultados: Participaron del estudio 333 sujetos, con edad promedio de 35 años, el 77,2% mujeres y el 64,0% no tenía acceso a servicios de salud privado. El índice CPO-D fue de 11,43 (DE = 6,7). El 12,6% obtuvo un nivel muy bajo, el 35,7% nivel bajo, el 41,7% tuvo nivel medio y el 9,9% nivel alto del CPO-D, siendo significativamente más elevado en mujeres (p= 0, 0 01), en la edad de 50 a 59 años (p<0,001), en aquellos que no cuentan con acceso a servicios de salud privado (p=0,008), los que relataron una autoevaluación negativa de su salud bucal (p=0,04), los que tenían una relación molar normal (p=0,023) e índice de estética muy grave (p<0, 0 01). Conclusión: El nivel general de severidad de caries global fue medio, se asoció con variables sociodemográficas y clínicas.

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Resumo Objetivo Avaliar a prevalência da cárie dentária e da deficiência visual nos escolares do ensino fundamental da rede pública de ensino de Barreirinha-AM e verificar os fatores associados a estas condições. Método Estudo transversal, com 1.828 estudantes entre 06 e 17 anos, da rede pública de ensino, Barreirinha. A avaliação da cárie dentária seguiu as recomendações da Organização Mundial da Saúde utilizando os critérios estabelecidos para as condições dentárias, tanto para dentes decíduos, quanto para permanentes: cariados, perdidos e obturados. O índice Significant Caries Index mediu a severidade da cárie dentária nos indivíduos mais afetados com a doença. Realizou-se avaliação para acuidade visual e analisou-se idade, sexo e escola. Resultados Evidenciou-se elevada prevalência de cárie dentária, desigualdade em sua distribuição e associação entre esta doença e sexo (p = 0,005). A prevalência de dificuldades visuais entre os escolares foi baixa. Conclusão e implicações para prática O estudo sugere carência de tratamento odontológico restaurador e elevada prevalência de cárie dentária, evidenciando a necessidade de planejamento e desenvolvimento de ações de promoção de saúde bucal, com o intuito de minimizar os agravos provocados pela doença.

Resumen Objetivo Evaluar la prevalencia de caries dentales y discapacidad visual en estudiantes de la enseñanza primaria del sistema escolar público de Barreirinha-AM, y verificar los factores asociados con estas condiciones. Método Estudio transversal realizado con 1.828 estudiantes entre 06 y 17 años, de escuelas públicas de Barreirinha-AM. La evaluación de las caries dentales siguió las recomendaciones de la Organización Mundial de la Salud, utilizando los criterios establecidos para las condiciones dentales, tanto para dientes temporales como permanentes: cariados, perdidos y obturados. El índice Significant Caries Index midió la gravedad de la carie dental en las personas más afectadas por la enfermedad. Se realizó la evaluación para agudeza visual y se analizó edad, sexo y nivel educativo. Resultados Hubo alta prevalencia de carie dental, desigualdad en su distribución y asociación entre esta enfermedad y el sexo (p = 0,005). La prevalencia de dificultades visuales entre los estudiantes fue baja. Conclusión e implicaciones para la práctica El estudio sugiere una carencia de tratamiento dental restaurador y una alta prevalencia de caries dentales, evidenciando la necesidad de planificación y desarrollo de acciones de promoción a la salud bucal, con el fin de minimizar los problemas ocasionados por la enfermedad.

Abstract Objective To evaluate the prevalence of dental caries and visual acuity deficiency in elementary school students of the public school system in the municipality of Barreirinha- AM and check the factors associated with these conditions. Method Cross-sectional study with 1,828 students aged 6 to 17 in the public school system of the municipality-of Barreirinha-AM. The dental cavity evaluation followed the recommendations of the World Health Organization using the established criteria for dental conditions, for deciduous as for permanent teeth: decayed, missing and filled. The Significant Caries Index was used to measure the dental caries severity in the individuals most affected by this disease. Visual acuity was assessed and age, sex and school were analyzed. Results It became evident high prevalence of dental cavities, inequality in its distribution, and relation between this disease and gender (p=0.005). The visual deficit frequency was low among the students. Conclusion and implications for practice The study indicates a lack of dental restoration treatment and high dental cavity prevalence, highlighting the need for planning and development of oral health promotion actions, with the purpose of minimizing the aggravations caused by the disease.

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Abstract Objective: To compare the estimates obtained, considering or not the weighting data. Material and Methods: Secondary data from the Oral Health Survey of the State of São Paulo (SBSP2015) was used for calculation of mean estimates, standard errors of the mean and confidence intervals (CI) for the DMFT index and components (decayed, lost and filled), in the age group of 35-44 years. Multiple logistic regression models were estimated, considering or not the weighting from the sampling plan (p<0.05). Results: It was observed that the estimates of the DMFT index and the carious component did not vary much when the design was considered or not (1.1% and 2.0%, respectively). However, the data referring to the lost and filled component showed greater differences between the values of the means. The averages fluctuated up and down by up to 6.7% for weighted versus unweighted analyses. The standard error was underestimated in the unweighted analysis and the confidence interval showed variations. Differences between the regression models obtained by the weighted and unweighted analysis of the data were detected. Conclusion: Although weighted and unweighted models presented differences of less than 10% in estimates of the mean, confidence intervals, as well as statistical inferences, were different. Thus, weighting should be applied in the population base data analysis collected by sampling with complex designs.

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ABSTRACT OBJECTIVE The objective was to analyze the role of health literacy (HL) as a factor associated with tooth loss among users of the Brazilian Health System with chronic non-communicable diseases. METHODS The cross-sectional analytical study was conducted with adult and elderly users chosen at ten Family Health Clinics in a draw in the town of Piracicaba, São Paulo State, Brazil. A questionnaire was applied with sociodemographic data (sex, age, skin color and education), behavioral data (brushing and flossing), determinants in health (type of dental health services and how often) and clinical data (pain). Mouth conditions were collected by intraoral examination of visible dental biofilm and community Pediodontal Index. The systemic clinical conditions (blood glucose, glycated hemoglobin and blood pressure) were extracted from the medical records. The explanatory variable was HL (low, medium and high), measured with the Health Literacy Scale (HLS-14). RESULTS The outcome was tooth loss measured by the index of decayed, missing and filled teeth. Logistic regression was performed using a conceptual model for HL (p < 0.05). For the 238 subjects, the mean age was 62.7 years (± 10.55). Tooth loss was associated with HL in regression models adjusted by type of dental service, dental frequency, and dental floss. In the final model, the factors associated with tooth loss are older age (OR = 1,12; 95%CI: 1,07-1,17), a lower education (OR = 3,43; 95%CI: 1,17-10,10), irregular use of dental floss (OR = 4,58; 95%CI: 1.75 in-7,31), irregular use of dental services (n = 2,60; 95% 1,32-5,12), periodontal pocket (> 4 mm) (n = 0,31; 95%CI: 0,01-0,08), having visible dental biofilm (OR = 7,23; 95%CI: 3,19-16,41) and a higher level of blood sugar (glucose) (n = 1,98; 95%CI: 1.00-3,92). CONCLUSIONS tooth loss was associated with HL when adjusted by health behaviors; when sociodemographic variables and clinical conditions were included, it was less significant. In the final model, behaviors, determinants in health and clinical conditions were risk indicators of tooth loss, showing the multifactorial nature of this phenomenon.

RESUMO OBJETIVO O objetivo foi analisar o papel da Literacia em Saúde (LS) como fator associado às perdas dentárias entre usuários do Sistema Único de Saúde com doenças crônicas não transmissíveis. MÉTODOS O estudo transversal e analítico foi conduzido com usuários adultos e idosos selecionados em dez Unidades de Saúde da Família sorteadas, em Piracicaba - SP, Brasil. Foi aplicado um questionário com dados sociodemográficos (sexo, idade, cor da pele e escolaridade), comportamentais (escovação e uso de fio dental), determinantes em saúde (tipo e frequência de uso de serviço de saúde médico e odontológico) e clínica (dor). As condições bucais foram coletadas por exame intrabucal do biofilme dental visível e Índice Pediodontal Comunitário. As condições clínicas sistêmicas (glicemia, hemoglobina glicada e pressóricas) foram extraídas dos prontuários. A variável explanatória foi a LS (baixa, média e alta), medida pelo Health Literacy Scale (HLS-14). RESULTADOS O desfecho foi à perda dentária medida pelo Índice de dentes permanentes cariados, perdidos e obturados. Foi realizada regressão logística com uso de um modelo conceitual para a LS (p < 0,05). Para os 238 indivíduos, a média de idade foi 62,7 anos (± 10,55). A perda dentária esteve associada à LS nos modelos de regressão ajustados por tipo de serviço odontológico, frequência odontológica e uso de fio dental. No modelo final, a perda dentária teve como fatores associados a maior idade (OR = 1,12; IC95% 1,07-1,17), menor escolaridade (OR = 3,43; IC95% 1,17-10,10), ao uso irregular de fio dental (OR = 4,58; IC95% 1,75-7,31), uso irregular do serviço odontológico (OR = 2,60; IC95% 1,32-5,12), bolsa periodontal (> 4mm) (OR = 0,31; IC95% 0,01-0,08), ter biofilme dental visível (OR = 7,23; IC95% 3,19-16,41) e maior índice de glicemia (OR = 1,98; IC95% 1,00-3,92). CONCLUSÕES A perda dentária esteve associada à LS quando ajustada por comportamentos em saúde, a partir da inclusão das variáveis sociodemográficas e condições clínicas ela perdeu a significância. No modelo final, comportamentos, determinantes em saúde e condições clínicas foram indicadores de risco da perda dentária, demonstrando a multifatorialidade envolvida neste fenômeno.

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