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BACKGROUND: Emerging evidence suggests that poor dietary quality is an important risk factor for disability. However, few studies have compared adherence to dietary patterns with disability and none among Puerto Rican adults. OBJECTIVES: This study was designed to examine relationships between 3 dietary patterns-including Dietary Approaches to Stop Hypertension (DASH), Mediterranean dietary score (MeDS), and Healthy Eating Index (HEI)-2010-and â¼6-y incidence of activities of daily living (ADL) and instrumental activities of daily living (IADL) disability and to assess potential mediation by handgrip strength. METHODS: Data are from the Boston Puerto Rican Health Study, a longitudinal cohort of Puerto Rican adults aged 45-75 y (N = 1502). Adherence to dietary pattern variables were derived from food frequency questionnaire (FFQ) data averaged at baseline and â¼2 y. Handgrip strength was assessed at baseline. Cox proportional hazards models were used to assess longitudinal associations between DASH, MeDS, and HEI-2010 and incident â¼6-y ADL (and subscales) and IADL disability. Mediation by handgrip strength was also tested. RESULTS: Participants with higher adherence DASH had lower risk of ADL, ADL mobility, and ADL manual dexterity disabilities (hazards ratio [HR]: 0.96; 95% confidence interval [CI]: 0.91, 0.98; HR: 0.96; 95% CI: 0.92, 0.99; and HR: 0.95; 95% CI: 0.92, 0.98, respectively). Higher adherence to MeDS was associated with lower risk of ADL and ADL mobility disabilities (HR: 0.89; 95% CI: 0.81, 0.98; HR: 0.90; 95% CI: 0.82, 1.00), and higher adherence to HEI with lower risk of ADL manual dexterity (HR: 0.98; 95% CI: 0.97, 0.99) in fully adjusted models. Only DASH tended to be associated with IADL (HR: 0.97; 95% CI: 0.94, 1.00). Baseline handgrip strength was a mediator between HEI and ADL manual dexterity (23.7% of the indirect effect was explained through handgrip strength). CONCLUSIONS: Higher adherence to a healthy diet pattern may decrease risk of disability and may be an important prevention strategy for ADL and IADL disability associated with aging.
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Atividades Cotidianas , Dieta Saudável , Dieta Mediterrânea , Abordagens Dietéticas para Conter a Hipertensão , Força da Mão , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Boston/epidemiologia , Pessoas com Deficiência , Hispânico ou Latino , Estudos Longitudinais , Cooperação do Paciente , Porto Rico/etnologia , Fatores de RiscoRESUMO
INTRODUCTION: Nutritional management plays a crucial role in treating patients with type 2 diabetes (T2D), working to prevent and control the progression of chronic non-communicable diseases. OBJECTIVES: To evaluate the effects of individualized nutritional interventions on weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglycerides (TGs), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR)} over 12 months and subsequently at follow-up (15 months). METHODS: This longitudinal experimental study (without randomization and blinding) enrolled 84 sedentary participants with T2D (both sexes, aged 18-80 years). They were divided into a control group of 40 participants who received only medical consultations, and an intervention group of 44 participants who received the same medical care along with a nutritional assessment. Consultations occurred quarterly from August 2020 to November 2022 (first-twelfth month), with six to nine patients per session. Subsequently, a follow-up was conducted from December 2022 to November 2023, during which the intervention group had only medical care (during the 12th-15th months). Personalized dietary planning was inspired by the Mediterranean/DASH diets adapted to Brazilian foods and socioeconomic cultures. STATISTICAL ANALYSIS: Normal variables were compared between groups for each time point and also within each group across different time points using a two-way ANOVA (repeated measures for intragroup) followed by the Sídák post hoc test. Non-normal variables were compared between groups for each time point using Kruskal-Wallis followed by the Dunn post hoc test, and within each group across different time points using Friedman followed by the Dunn post hoc test. Data with a Gaussian distribution were presented as mean ± standard deviation (SD), and data with a non-Gaussian distribution were presented as median ± interquartile range (IQR). For all cases, α < 0.05 and p < 0.05 were adopted. RESULTS: In the intervention group, significant reductions were observed between the first and twelfth month for all parameters (p < 0.05), (except for TC), along with an increase in HDL-C (p = 0.0105). Conversely, in the control group, there was a significant increase in HbA1c, weight, BMI, FBG, and WHR (p < 0.05) between the first and twelfth months. Regarding the comparison between groups, there was a significant difference for all analyzed parameters (p < 0.05) from the first to the twelfth month. In the follow-up, differences were also observed (p < 0.05), except for BMI (p > 0.05). CONCLUSION: The individualized nutritional intervention improved eating habits, anthropometric, biochemical, and cardiovascular markers in T2D over 12 months, with sustained results during follow-up. The dietary plan inspired by the Mediterranean and DASH diets demonstrated good adaptation to the Brazilian food culture and the patients' socioeconomic contexts. Consistent monitoring and personalized nutritional management are essential for optimizing long-term outcomes. However, more clinical trials are necessary in order to optimize the level of evidence for longitudinal interventions.
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Glicemia , Diabetes Mellitus Tipo 2 , Controle Glicêmico , Humanos , Diabetes Mellitus Tipo 2/dietoterapia , Diabetes Mellitus Tipo 2/sangue , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , Idoso , Controle Glicêmico/métodos , Estudos Longitudinais , Glicemia/metabolismo , Fatores de Risco de Doenças Cardíacas , Hemoglobinas Glicadas/metabolismo , Doenças Cardiovasculares/prevenção & controle , Idoso de 80 Anos ou mais , Adulto Jovem , Índice de Massa Corporal , Adolescente , Pressão Sanguínea , Biomarcadores/sangue , Relação Cintura-Quadril , Circunferência da Cintura , Terapia Nutricional/métodosRESUMO
BACKGROUND: Increased serum urate (SU) and hyperuricemia (HU) are associated with chronic noncommunicable diseases and mortality. SU concentrations are affected by several factors, including diet, and are expected to rise with age. We investigated whether the Dietary Approaches to Stop Hypertension (DASH) diet alter this trend. OBJECTIVE: The objective was to assess whether adherence to the DASH diet predicts a longitudinal change in SU concentrations and risk of HU in 8 y of follow-up. METHODS: Longitudinal analyses using baseline (2008-2010, aged 35-74 y), second (2012-2014), and third (2016-2018) visits data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The inclusion criteria were having complete food frequency questionnaire (FFQ) and urinary sodium measurement, in addition to having SU measurement at the 1st visit and at least 1 of the 2 follow-up visits. For the HU incidence analyses, participants had also to be free from HU at baseline. The final samples included 12575 individuals for the SU change analyses and 10549 for the HU incidence analyses. Adherence to DASH diet was assessed as continuous value. HU was defined as SU>6.8 mg/dL and/or urate-lowering therapy use. Mixed-effect linear and Poisson regressions (incidence rate ratio [IRR] and 95% confidence interval [CI]) were used in the analyses, adjusted for confounders. RESULTS: The mean age was 51.4 (8.7) y, and 55.4% were females. SU means (standard deviation) were 5.4 (1.4) at 1st visit, 5.2 (1.4) at 2nd visit, and 5.1(1.3) mg/dL at 3rd visit. The HU incidence rate was 8.87 per 1000 person-y. Each additional point in adherence to the DASH diet accelerated SU decline (P< 0.01) and lowered the incidence of HU by 4.3% (IRR: 0.957; 95% CI: 0.938,0.977) in adjusted model. CONCLUSION: The present study findings reinforce the importance of encouraging the DASH diet as a healthy dietary pattern to control and reduce the SU concentrations and risk of HU.
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Abordagens Dietéticas para Conter a Hipertensão , Hipertensão , Hiperuricemia , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Masculino , Estudos Longitudinais , Ácido Úrico , Brasil/epidemiologia , Hipertensão/epidemiologia , DietaRESUMO
Background: The Disability of the Arm, Shoulder and Hand (DASH) questionnaire assesses the impact of upper extremity disorders on quality of life. However, its use in the Mexican population has not been formally validated. Objective: To conduct a cultural adaptation and validation of the DASH questionnaire to evaluate the perspective of patients with neurogenic disorders of the upper extremity regarding the impact on their quality of life. Method: We performed an adaptation of the Spanish version of the DASH questionnaire to the Mexican vocabulary and applied it to 478 volunteers. Ceiling effect, floor effect, item-total correlation, descriptive statistics of items and total score, internal consistency, precision, cross-sectional and longitudinal validity were estimated by comparing healthy controls and affected individuals with different disability levels. Results: Our DASH questionnaire version was equivalent to those previously approved and showed homogeneity of the items with respect to the total value of the questionnaire (Cronbach's alpha > 0.96). In addition, it showed an accuracy of 7.25 points and the crosssectional and longitudinal validity was documented with significant differences between groups and subgroups with distinct disability levels. Conclusions: The DASH questionnaire can be used with a high level of confidence in the Mexican population.
Antecedentes: El cuestionario de discapacidad de brazo, hombro y mano (DASH, Disabilities of the Arm, Shoulder and Hand) mide el impacto de patologías del miembro superior en la calidad de vida. Sin embargo, su uso en la población mexicana no ha sido formalmente validado. Objetivo: Realizar la adaptación cultural y validación del cuestionario DASH para conocer la perspectiva de pacientes con trastornos neurogénicos del miembro superior respecto al impacto en su calidad de vida. Método: Se realizó una adaptación al vocabulario mexicano de la versión española del cuestionario DASH y se aplicó en 478 voluntarios. Se estimaron el efecto techo, el efecto suelo, la correlación ítem-total, las medidas de tendencia central de ítems y el puntaje total, la consistencia interna, la precisión y la validez transversal y longitudinal mediante la comparación de individuos sanos y enfermos con diferente nivel de discapacidad. Resultados: Nuestra versión del cuestionario DASH resultó equivalente a las previamente aprobadas y mostró homogeneidad de los ítems respecto al valor total del cuestionario (alfa de Cronbach > 0.96). Además, tuvo una precisión de 7.25 puntos y se documentó la validez transversal y longitudinal con diferencias significativas entre grupos y subgrupos con diferente nivel de discapacidad. Conclusiones: El cuestionario DASH puede ser empleado con un nivel de confianza alto en la población mexicana.
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Preeclampsia (PE) affects up to five times more women with pre-existing diabetes mellitus (PDM) than women without it. The present study aimed to identify the effect of the DASH diet on PE incidence (primary outcome) and blood pressure, glycated haemoglobin (GH), serum lipids, glutathione peroxidase (GP), C-reactive protein (CRP - secondary outcomes) in pregnant with PDM. This randomised, controlled, single-blind trial studied sixty-eight pregnant women with PDM throughout prenatal care until delivery (18 weeks) at a public maternity hospital, Brazil. The standard diet group (SDG) received a diet containing 45-65 % carbohydrates, 15-20 % protein and 25-30 % lipids. The DASH diet group (DDG) received the adapted DASH diet with a similar macronutrient distribution, but with a higher concentration of fibres, unsaturated fats, calcium, magnesium and potassium as well as lower saturated fat. Student's t, Mann-Whitney U and the Chi-square tests were used to compare outcomes. PE incidence was 22â 9 % in the SDG and 12â 1 % in the DDG (P = 0â 25). GP levels significantly increased in the DDG (intra-group analysis; mean difference = 1588 [CI 181, 2994], P = 0â 03) and tended to be different from the variation in the SDG (mean difference = -29â 5 [CI -1305; 1â 365]; v. DDG: 1588 [CI 181; 2994], P = 0â 09). GH levels decreased significantly and similarly between groups (SDG: -0â 61 [CI -0â 26, -0â 96], P = 0â 00) v. DDG: -1â 1 [CI -0â 57, -1â 62], P = 0â 00). There was no evidence of a difference in PE incidence at the end of the intervention between the two diets. The DASH diet seems to favour PE-related biochemical markers.
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Abordagens Dietéticas para Conter a Hipertensão , Pré-Eclâmpsia , Gravidez em Diabéticas , Humanos , Feminino , Gravidez , Pré-Eclâmpsia/epidemiologia , Pré-Eclâmpsia/prevenção & controle , Gravidez em Diabéticas/dietoterapia , Diabetes Mellitus , Brasil , Adulto , Pressão Sanguínea , Hemoglobinas Glicadas/análise , Lipídeos/sangue , Glutationa Peroxidase/análise , Proteína C-Reativa/análiseRESUMO
Introducción: La hipertensión arterial es una enfermedad crónica que aumenta el riesgo de presencia de complicaciones sistémicas, especialmente en el aparato cardiovascular. En ocasiones la enfermedad se presenta de forma asintomática, retrasando su diagnóstico, control y aumentando el riesgo de complicaciones. Mantener hábitos y estilos de vida saludables constituyen la primera estrategia de prevención y tratamiento de esta afección. Objetivo: Aplicar una intervención nutricional, basado en la implementación de la dieta DASH, para mejorar el estado nutricional y controlar las cifras de tensión arterial. Métodos: Investigación aplicada, con diseño cuasiexperimental, descriptivo y correlacional consistente en la aplicación de una intervención nutricional basada en la dieta DASH. El universo estuvo integrado por 54 personas que acudieron a consulta de nutrición con la finalidad de disminuir su peso corporal, la muestra quedó constituida por 48 pacientes. Se aplicó la prueba de McNemar y ANOVA para verificar cambios en las variables tensión arterial, índice de masa corporal y circunferencia de la cintura. Resultados: Al inicio de la intervención predominaron los pacientes con cifras de tensión arterial normal alta (50,00 %), obesidad (58,33 %) y riesgo muy elevado según circunferencia de la cintura (66,67%). Después de finalizada la intervención predominaron los pacientes con tensión arterial óptima (66.67 %), sobrepeso (58,33 %) y riesgo muy elevado (50,00 %). Conclusión: La intervención nutricional aplicada, basada en la implementación de la dieta DASH contribuyó al mejoramiento del estado nutricional y al control de las cifras de TA.
Introduction: Hypertension is a chronic disease that increases the risk of systemic complications, especially in the cardiovascular system. Sometimes the disease is asymptomatic, delaying its diagnosis, control and increasing the risk of complications. Maintaining healthy habits and lifestyles are the first prevention and treatment strategy for this condition. Objective: Apply a nutritional intervention, based on the implementation of the DASH diet, to improve nutritional status and control blood pressure figures. Methods: Applied research, with a quasi-experimental, descriptive and correlational design consisting of the application of a nutritional intervention based on the DASH diet. The universe was made up of 54 people who attended a nutrition consultation in order to reduce their body weight, the sample was made up of 48 patients. The McNemar test and ANOVA were applied to verify changes in the variables blood pressure, body mass index and waist circumference. Results: At the beginning of the intervention, patients with high normal blood pressure figures (50.00 %), obesity (58.33 %) and very high risk according to waist circumference (66.67 %) predominated. After the intervention, patients with optimal blood pressure (66.67 %), overweight (58.33 %) and very high risk (50.00 %) predominated. Conclusion: The applied nutritional intervention, based on the implementation of the DASH diet, contributed to the improvement of the nutritional status and the control of the BP figures.
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Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbimortality. Dietetic, phenotypic, and genotypic factors influencing HDP were analyzed during a nutrigenetic trial in Rio de Janeiro, Brazil (2016-2020). Pregnant women with pregestational diabetes mellitus (n = 70) were randomly assigned to a traditional or DASH diet group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured during prenatal visits and HDP were diagnosed using international criteria. Phenotypic data were obtained from medical records and personal interviews. Genotyping for FTO and ADRB2 polymorphisms used RT-PCR. Linear mixed-effect models and time-to-event analyses were performed. The variables with significant effect on the risk for progression to HDP were: black skin color (adjusted hazard ratio [aHR] 8.63, p = 0.01), preeclampsia in previous pregnancy (aHR 11.66, p < 0.01), SBP ≥ 114 mmHg in the third trimester (aHR 5.56, p 0.04), DBP ≥ 70 mmHg in the first trimester (aHR 70.15, p = 0.03), mean blood pressure > 100 mmHg (aHR 18.42, p = 0.03), and HbA1c ≥ 6.41% in the third trimester (aHR 4.76, p = 0.03). Dietetic and genotypic features had no significant effect on the outcome, although there was limited statistical power to test both.
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Introducción: La escala de discapacidades del brazo, el hombro y la mano se utiliza para evaluar los miembros superiores como unidad funcional. Este instrumento se encuentra certificado en diferentes idiomas y permite el estudio de diversas patologías especialmente osteomusculares. Objetivo: Consolidar procesos de validación realizados a la escala DASH en idioma español. Métodos: Se realizó una búsqueda bibliográfica en las bases de datos PubMed, Clinical Key, SciELO, Science Direct, Epistemonikos y Google. Se incluyeron los artículos publicados hasta el 31 de agosto de 2020 sin restringir la fecha de inicio. Desarrollo: En la revisión se incluyeron un total de siete estudios, seis de ellos validaron la versión completa de la escala DASH y uno la versión corta, a partir de los siguientes tipos de validación: contenido, de criterio, de constructo, longitudinal y convergente. Fue utilizada en pacientes con manejo quirúrgico, población con cáncer de mama, patologías osteomusculares y pacientes sanos. Esta escala permite evaluar la evolución y efectividad del tratamiento para determinar el impacto de la enfermedad sobre las estructuras y la función del miembro superior. Conclusión: Se recomienda el uso de la escala DASH para evaluar los miembros superiores porque ha evidenciado buenos resultados de validez y fiabilidad; además es un instrumento útil y de bajo costo que permite su implementación en países con escasos recursos o poca inversión en el sistema de salud.
Introduction: The scale of disabilities of the arm, shoulder and hand is used to evaluate the upper limbs as a functional unit. This instrument is certified in different languages and allows the study of various pathologies, especially musculoskeletal diseases. Objective: To consolidate validation processes implemented to the DASH scale in Spanish. Methods: A literature search was performed in the databases PubMed, Clinical Key, SciELO, Science Direct, Epistemonikos and Google. Articles published up to 31 August 2020 were included without restricting the start date. Development: A total of seven studies were included in the review, six of them validated the full version of the DASH scale and one the short version, based on the following types of validation: content, criterion, construct, longitudinal and convergent. It was used in patients with surgical management, population with breast cancer, musculoskeletal pathologies and healthy patients. This scale allows evaluating the evolution and effectiveness of the treatment to determine the impact of the disease on the structures and function of the upper limb. Conclusion: The use of the DASH scale is recommended to evaluate the upper limbs because it has shown good results of validity and reliability. It is also a useful and low-cost instrument that allows its implementation in countries with scarce resources or little investment in the health system.
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BACKGROUND AND AIMS: To evaluate the effect of lifestyle modification by adopting a DASH diet, with and without physical activity guidance, on blood pressure, glycemic control, lipid profile, weight, and body composition in older patients with type 2 diabetes mellitus (T2DM) and hypertension. METHODS AND RESULTS: For this randomized clinical trial, we recruited patients aged 60 years or older with T2DM and uncontrolled hypertension. One group (DASH) received only DASH dietary guidance, while the other group (DASHPED) received dietary guidance and encouragement to walk with a pedometer. Outcomes of interest were (1) blood pressure, (2) physical activity, (3) weight, body mass index (BMI), and body composition, and (4) biochemical variables. Measurements were taken at baseline and 16 weeks after the intervention. We included 35 patients in the analysis. At the end of the study, the DASHPED group had an mean increase in physical activity of 1721 steps/day. Both groups displayed significantly reduced weight, BMI, and waking diastolic pressures on ambulatory blood pressure monitoring after the intervention. A trend of reduced sleeping diastolic pressure was found in the DASHPED group. Changes in weight, BMI, muscle mass, body fat, waist-hip ratio, glycemic control, lipid profile, and insulin sensitivity did not differ between the groups. CONCLUSION: There was no difference in outcomes between the group that only dieted and the group that also performed increased physical activity, despite a significant increase in exercise. This reinforces the importance of dietary changes in immediate blood pressure control.
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Improving dietary patterns is a cornerstone of the non-pharmacological management of hypertension. Evidence about the adherence to healthy dietary patterns at the population level is scarce. We aimed to analyze the adherence to the Dietary Approaches to Stop Hypertension (DASH) diet among Mexican men and women by hypertension status. We used data from the 2012 Mexican National Health and Nutrition Survey (n = 2560). Using self-reported diagnosis of hypertension and blood pressure measurements, we identified participants without, with undiagnosed, and diagnosed hypertension. We calculated DASH scores (total and dietary components) based on a single 24-hour recall and analyzed differences in adherence across hypertension status using sex-specific multivariable Poisson regression models. Overall, regardless of hypertension status, adherence to the DASH score was low, with 35% of men and 38% of women with diagnosed hypertension adhering to recommended guidelines; lower adherence was observed in men (21.8%) and women (27.2%) with undiagnosed hypertension, and with no hypertension (26.8% in men, 26.3% in women). In multivariable models for men, the prevalence of adherence to the total DASH diet was 29% lower in undiagnosed adults versus adults without hypertension (RP 0.71; 95%CI 0.50,0.99). Specifically, adherence to fruits, total dairy, and animal protein was lower in undiagnosed men. Among women, the adherence to the DASH diet was similar across hypertension status in multivariable models. Mexican adults had low adherence to DASH, regardless of hypertension status. Strategies to improve adherence to DASH are needed, focusing in patients with hypertension but also as a preventive measure for the population.
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Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (n = 41) or DASH diet (n = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of Medicine guidelines. Genotyping was performed using real-time PCR. Time-to-event analysis was performed to investigate risk factors for progression to excessive GWG. Regardless the type of diet, AT carriers of rs9939609 (FTO) and AA carriers of rs1042713 (ADRB2) had higher risk of earlier exceeding GWG compared to TT (aHR 2.44; CI 95% 1.03-5.78; p = 0.04) and GG (aHR 3.91; CI 95% 1.12-13.70; p = 0.03) genotypes, respectively, as the AG carriers for FTO haplotype rs9939609:rs17817449 compared to TT carriers (aHR 1.79; CI 95% 1.04-3.06; p = 0.02).
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Diabetes Mellitus , Ganho de Peso na Gestação , Gravidez em Diabéticas , Dioxigenase FTO Dependente de alfa-Cetoglutarato/genética , Feminino , Ganho de Peso na Gestação/genética , Humanos , Recém-Nascido , Nutrigenômica , Polimorfismo Genético , Gravidez , Gestantes , Receptores Adrenérgicos beta 2/genética , Fatores de Risco , Estados Unidos , Aumento de Peso/genéticaRESUMO
Video streaming currently dominates global Internet traffic. Live streaming broadcasts events in real-time, with very different characteristics compared to video-on-demand (VoD), being more sensitive to variations in delay, jitter, and packet loss. The use of adaptive streaming techniques over HTTP is massively deployed on the Internet, adapting the video quality to instantaneous condition of the network. Dynamic Adaptive Streaming over HTTP (DASH) is the most popular adaptive streaming technology. In DASH, the client probes the network quality and adjusts the quality of requested video segment according to the bandwidth fluctuations. Therefore, DASH is an over-the-top application using unmanaged networks to distribute content in the best possible quality. In order to maintain a seamless playback, VoD applications commonly use a large reception buffer. However, in live streaming, the use of large buffers is not allowed because of the induced delay. Active Queue Management (AQM) arises as an alternative to control the congestion in router's queue, pressing the traffic sources to reduce their transmission rate when it detects incipient congestion. In this article, we evaluate the performance of recent AQM strategies for real-time adaptive video streaming. Furthermore, we propose a new AQM algorithm to improve the user-perceived video quality. The results show that the proposed method achieves better performance than competing AQM algorithms and improves the video quality in terms of average peak signal-to-noise ratio while keeping the fairness among concurrent flows.
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INTRODUCTION: Background: adherence to Dietary Approach to Stop Hypertension (DASH) has demonstrated to be effective in lowering blood pressure and other cardiovascular risk markers in different populations, but has never been evaluated in the Mexican population. Objective: to assess adherence to the DASH dietary pattern by using an adapted DASH adequacy index (DASH-AI), and to evaluate its association with cardiovascular risk markers in an adult Mexican population. Methods: we conducted a cross-sectional analysis of data of 1,490 adults aged 20-50 years. Diet was assessed with a Food Frequency Questionnaire and sodium intake by 24-hour urinary sodium excretion; the DASH-AI score was calculated based on the DASH nutrient targets. Multivariable linear and logistic regression analyses were performed to estimate the association between the DASH-AI score and cardiovascular risk markers (body mass index [BMI], waist circumferences, systolic (SBP) and diastolic blood pressure (DBP), glucose, triglycerides, total cholesterol, and high- and low-density lipoproteins). Results: we observed an association of the DASH-AI score with BMI, WC and DBP in the linear (BMI, ï¢: -0.55, 95 % CI: -0.77, -0.33; WC, ï¢: -1.66, 95 % CI: -2.19, -1.13; DBP, ï¢: -0.65, 95 % CI: -1.07, -0.24), and logistic (BMI > 25 kg/m2, OR: 0.82, 95 % CI: 0.74, 0.93; elevated WC, OR: 0.72, 95 % CI: 0.64, 0.81; DBP, OR: 0.83, 95 % CI: 0.72, 0 .95) models. Conclusion: compliance to the DASH-style diet was inversely associated with BMI, WC and DBP in this Mexican population. Promoting adherence to this dietary pattern in the context of Mexican diet is needed to improve cardiovascular health in this population.
INTRODUCCIÓN: Antecedentes: la adherencia al patrón de alimentación DASH ha mostrado ser eficaz para reducir la presión arterial y los marcadores de riesgo cardiovascular en diferentes poblaciones, pero nunca en la mexicana. Objetivo: evaluar la adherencia al patrón de alimentación DASH mediante un índice adapatado a los lineamientos DASH (DASH-AI) y evaluar su asociación con marcadores de riesgo. Métodos: análisis transversal de datos de 1490 adultos de entre 20 y 50 años de edad. La ingesta dietética se evaluó utilizando un cuestionario de frecuencia de consumo de alimentos y el sodio a través de la excresión urinaria en 24 horas; la puntuación DASH-AI se calculó de acuerdo con la adherencia a las recomendaciones DASH. Se realizaron modelos logísticos y lineales para estimar la asociación entre el puntaje DASH-AI y los marcadores de riesgo cardiovascular (índice de masa corporal [IMC], circunferencia de cintura (CC), presión arterial sistólica (PAS) y diastólica (PAD), glucosa, triglicéridos, colesterol total, lipoproteínas de alta y baja densidad). Resultados: observamos una asociación del DASH-AI con el IMC, la CC y la PAD en los modelos lineales (IMC ï¢: -0,55, IC del 95 %: -0,77, -0,33; CC ï¢: -1,66, IC del 95 %: -2,19, -1,33; PAD, ï¢: -0,65, IC del 95 %: -1,07, -0,24) y logístico (IMC > 25 kg/m2, OR: 0,82, IC del 95 %: 0,74, 0,93; CC elevado, OR: 0,72; IC del 95 %: 0,64, 0,81; PAD, OR: 0,83, IC del 95 %: 0,72, 0,95). Conclusión: la adherencia a la dieta DASH se asoció inversamente con el IMC, la CC y la PAD en la población estudiada. Es necesario promover la adherencia a este patrón dietético para mejorar la salud cardiovascular.
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Abordagens Dietéticas para Conter a Hipertensão , Hipertensão , Adulto , Pressão Sanguínea , Estudos Transversais , Dieta , Humanos , Hipertensão/epidemiologia , Pessoa de Meia-Idade , Adulto JovemRESUMO
Most chronic modern non-transmissible diseases seem to begin as the result of low-grade inflammation extending over prolonged periods of time. The importance of diet as a source of many pro-inflammatory compounds that could create and sustain such a low-grade inflammatory state cannot be ignored, particularly since we are constantly exposed to them during the day. The focus of this review is on specific components of the diet associated with inflammation, specifically advanced glycation end products (AGEs) that form during thermal processing of food. AGEs are also generated in the body in normal physiology and are widely recognized as increased in diabetes, but many people are unaware of the potential importance of exogenous AGEs ingested in food. We review experimental models, epidemiologic data, and small clinical trials that suggest an important association between dietary intake of these compounds and development of an inflammatory and pro-oxidative state that is conducive to chronic diseases. We compare dietary intake of AGEs with other widely known dietary patterns, such as the Mediterranean and the Dietary Approaches to Stop Hypertension (DASH) diets, as well as the Dietary Inflammation Index (DII). Finally, we delineate in detail the pathophysiological mechanisms induced by dietary AGEs, both direct (i.e., non-receptor-mediated) and indirect (receptor-mediated).
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Dieta/estatística & dados numéricos , Produtos Finais de Glicação Avançada/análise , Inflamação , Humanos , Inflamação/sangue , Inflamação/metabolismoRESUMO
Quality of service (QoS) requirements for live streaming are most required for video-on-demand (VoD), where they are more sensitive to variations in delay, jitter, and packet loss. Dynamic Adaptive Streaming over HTTP (DASH) is the most popular technology for live streaming and VoD, where it has been massively deployed on the Internet. DASH is an over-the-top application using unmanaged networks to distribute content with the best possible quality. Widely, it uses large reception buffers in order to keep a seamless playback for VoD applications. However, the use of large buffers in live streaming services is not allowed because of the induced delay. Hence, network congestion caused by insufficient queues could decrease the user-perceived video quality. Active Queue Management (AQM) arises as an alternative to control the congestion in a router's queue, pressing the TCP traffic sources to reduce their transmission rate when it detects incipient congestion. As a consequence, the DASH client tends to decrease the quality of the streamed video. In this article, we evaluate the performance of recent AQM strategies for real-time adaptive video streaming and propose a new AQM algorithm using Long Short-Term Memory (LSTM) neural networks to improve the user-perceived video quality. The LSTM forecast the trend of queue delay to allow earlier packet discard in order to avoid the network congestion. The results show that the proposed method outperforms the competing AQM algorithms, mainly in scenarios where there are congested networks.
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PURPOSE: Patient-reported outcome measures assess health status and treatment outcomes in orthopedic care, but they may burden patients with lengthy questionnaires. Predictive models using machine learning, known as computerized adaptive testing (CAT), offer a potential solution. This study evaluates the ability of CAT to improve efficiency of the 30-item Disabilities of the Arm, Shoulder, and Hand (DASH) and 11-item QuickDASH questionnaires. METHODS: A total of 2,860 DASH and 27,355 QuickDASH respondents were included in the analysis. The CAT system was retrospectively applied to each set of patient responses stored on the instrument to calculate a CAT-specific score for all DASH and QuickDASH entries. The accuracy of the CAT scores, viewed in the context of the minimal clinically important difference for both patient-reported outcome measures (DASH, 12; QuickDASH, 9), was determined through descriptive statistics, Pearson correlation coefficient, intraclass correlation coefficient, and distribution of scores and score differences. RESULTS: The CAT model required an average of 15.3 questions to be answered for the DASH and 5.8 questions for the QuickDASH, representing a 49% and 47% decrease in question burden, respectively. Mean CAT score was the same for DASH and 0.1 points lower for QuickDASH with similar SDs (DASH, 12.9 ± 19.8 vs 12.9 ± 19.9; QuickDASH, 32.7 ± 24.7 vs 32.6 ± 24.6). Pearson coefficients (DASH, 0.99; QuickDASH, 0.98) and intraclass correlation coefficients (DASH, 1.0; QuickDASH, 0.98) indicated strong agreement between scores. The difference between the CAT and full score was less than the minimal clinically important difference in 99% of cases for DASH and approximately 95% of cases for QuickDASH. CONCLUSIONS: The application of CAT to DASH and QuickDASH surveys demonstrated an ability to lessen the response burden with negligible effect on score integrity. CLINICAL RELEVANCE: In the case of DASH and QuickDASH, CAT is an appropriate alternative to full questionnaire implementation for patient outcome score collection.
Assuntos
Avaliação da Deficiência , Ombro , Humanos , Medidas de Resultados Relatados pelo Paciente , Reprodutibilidade dos Testes , Estudos Retrospectivos , Inquéritos e QuestionáriosRESUMO
BACKGROUND: The prevalence of metabolic syndrome is higher among minority populations, including individuals of Mexican ethnic descent. Whether alignment to healthy dietary patterns is associated with lower risk of metabolic syndrome in this population is largely unknown. OBJECTIVE: To prospectively evaluate the associations between a priori diet quality scores and risk of metabolic syndrome and its components among postmenopausal women of Mexican ethnic descent. METHODS: A total of 334 women of Mexican ethnic descent who participated in the Women's Health Initiative (WHI) observational study without metabolic syndrome or diabetes at baseline (1993-1998) were included. Baseline diets were scored with the Alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), the Healthy Eating Index (HEI-2010), the Mediterranean Diet Score (MDS), and the traditional Mexican Diet (MexD) score. Multivariable linear and logistic regression models were used to test the associations between baseline diet quality and risk of metabolic syndrome and its individual components at follow-up (2012-2013). RESULTS: Approximately 16% of women met the criteria for metabolic syndrome at follow-up. None of the diet quality indices were associated with risk of metabolic syndrome. However, higher vs lower DASH scores were associated with lower waist circumference (85.2 vs 88.0âcm) and glucose concentrations (90.0 vs 95.1âmg/dL), and higher HDL cholesterol (62.6 vs 59.0âmg/dL), while higher vs lower HEI-2010 scores were associated with lower waist circumference (83.9 vs 88.1âcm), triglycerides (103 vs 117âmg/dL) and glucose concentrations (89.5 vs 94.4âmg/dL), and higher HDL cholesterol levels (63.9 vs 58.5âmg/dL). CONCLUSIONS: Diet quality was not associated with risk of metabolic syndrome in this population. However, the results suggest that alignment to DASH and HEI-2010 recommendations may be beneficial for reducing some individual components of metabolic syndrome among postmenopausal women of Mexican descent.
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Carpometacarpal joint dislocations are uncommon hand injuries. These dislocations are usually misdiagnosed due to their non-specific clinical signs and tend to be difficult to identify in simple X-rays. We report our experience in the management of carpometacarpal bone dislocations at a specialized hand surgery center. Patients with carpometacarpal dislocations seen at the emergency department between 2013 and 2017 were included. All patients were treated with either closed reduction and percutaneous pinning (CRPP) or open reduction and internal fixation (ORIF). Postoperative functional assessment was performed at 6 and 18 months using the Disabilities of the Arm, Shoulder, and Hand (DASH) score. Eleven patients were included, 8 (72%) were managed with CRPP and the rest required ORIF (28%). For the functional outcome, we found an average DASH score of 27.9 at the 6 months threshold and of 1.5 at the 18 months threshold. Carpometacarpal dislocations are uncommon and easy to misdiagnose; the hand surgeon should have a high clinical suspicion in patients who sustained high-energy trauma, and imaging studies should be thoroughly evaluated. Closed reduction and percutaneous pinning is a safe and effective treatment option, with long-term good functional results.
Les dislocations des articulations carpométacarpiennes sont des blessures peu courantes de la main. Elles sont généralement mal diagnostiquées en raison de leurs signes cliniques non spécifiques et ont tendance à être difficiles à dépister au moyen d'une simple radiographie. Les auteurs rendent compte de leur expérience dans la prise en charge des dislocations des os carpométacarpiens dans un centre spécialisé de chirurgie de la main. Les patients atteints d'une dislocation carpométacarpienne vus à l'urgence entre 2013 et 2017 étaient inclus dans l'étude. Tous les patients ont subi une réduction fermée et un embrochage percutané (RFEP) ou une réduction ouverte et une fixation interne (ROFI). L'évaluation fonctionnelle postopératoire a eu lieu au bout de six et 18 mois au moyen du score d'incapacité du bras, de l'épaule et de la main (DASH). Onze patients ont participé : huit (72 %) ont subi une RFEP et les autres ont dû subir une ROFI (28 %). Le score DASH moyen du résultat fonctionnel s'établissait à 27,9 au seuil de six mois et à 1,5 à celui de 18 mois. Puisque les dislocations carpométacarpiennes sont rares et faciles à mal diagnostiquer, le chirurgien de la main devrait en présumer la possibilité chez les patients victimes d'un traumatisme de forte énergie, et les études d'imagerie devraient faire l'objet d'une évaluation approfondie. La RFEP est une possibilité de traitement sécuritaire et efficace qui donne de bons résultats fonctionnels à long terme.
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Abstract Recent epidemiological studies have shown that dietary patterns may have a more persistent impact on the risk of stone formation than single nutrients of the diet. Dietary Approaches to Stop Hypertension (DASH), a low-sodium and fruits/vegetables-rich diet, has been associated with a lower risk of nephrolithiasis, due to altered urinary biochemistry. This observational study aimed to investigate whether the dietary pattern of stone formers (SF) resembled a DASH-diet and its influence on urinary lithogenic parameters. Anthropometric data, fasting serum sample, 24-h urine samples, and a 3-day food intake record under an unrestricted diet were obtained from 222 SF and compared with 136 non-SF subjects (controls). The DASH-diet food portions were determined from the food records whereas intakes of sodium chloride (NaCl) and protein (protein equivalent of nitrogen appearance, PNA) were estimated from 24-hr urinary sodium and urea. A dietary profile close to a DASH-diet was not observed in any of the groups. NaCl intake and PNA were significantly higher in SF versus non-SF (12.0 ± 5.2 v.s. 10.1 ± 3.4 g/day, p = 0.01 and 1.8 ± 0.1 v.s. 1.4 ± 0.1 g/kg/day, p = 0.03). SF exhibited a positive correlation of NaCl intake and PNA with urinary calcium, oxalate and uric acid, and of PNA with urinary sodium. SF consumed more vegetables and legumes, but less fruits and low-fat dairy items than non-SF. The present series presented a dietary profile characterized by low calcium and high salt and protein contents, not reflecting an ideal DASH-style diet pattern.
Resumo Estudos epidemiológicos recentes mostraram que os padrões alimentares podem ter um impacto mais persistente sobre o risco de formação de cálculos do que apenas os nutrientes da dieta. A dieta DASH (Dietary Approaches to Stop Hypertension), uma dieta pobre em sódio e rica em frutas/vegetais, tem sido associada a um menor risco de nefrolitíase, devido às alterações metabólicas urinárias. Este estudo observacional teve como objetivo investigar se o padrão alimentar de pacientes litiásicos (Lit) se assemelhava a uma dieta estilo DASH e sua influência nos parâmetros litogênicos urinários. Dados antropométricos, amostra de soro em jejum, amostras de urina de 24 horas e um registro de ingestão alimentar de 3 dias sob dieta irrestrita foram obtidos de 222 Lit e comparados com 136 indivíduos não-Lit (controles). As porções de alimentos do padrão de dieta DASH foram determinadas a partir dos registros alimentares, enquanto a ingestão de cloreto de sódio (NaCl) e proteína (Equivalente Protéico do Aparecimento de Nitrogênio Urinário, PNA) foram estimadas a partir da uréia e sódio urinários de 24 horas. Um perfil alimentar próximo a uma dieta estilo DASH não foi observado em nenhum dos grupos. A ingestão de NaCl e PNA foram significativamente maiores nos Lit versus não-Lit (12,0 ± 5,2 v.s. 10,1 ± 3,4 g/dia, p = 0,01 e 1,8 ± 0,1 v.s. 1,4 ± 0,1 g/kg/dia, p = 0,03). Os Lit exibiram uma correlação positiva entre a ingestão de NaCl e PNA com cálcio, oxalato e ácido urinários, e de PNA com sódio urinário. Os Lit consumiram mais vegetais e leguminosas, mas menos frutas e lácteos com teor reduzido de gordura do que os não-Lit. A presente série apresentou um padrão alimentar caracterizado por reduzido consumo de cálcio e elevado em sal e proteínas, não refletindo um padrão ideal de dieta DASH.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Cálculos Renais , Dieta Hipossódica , Hipertensão , Verduras , Dieta , FrutasRESUMO
PURPOSE: The main objective of this study was to evaluate the Quick-Disabilities of the Arm, Shoulder and Hand Score (DASH) score as the main early (90 days) outcome in a prospective multicenter observational Latin American study on isolated humeral shaft fractures. METHODS: From December 2015 to April 2017, in six Latin American countries, patients 18 years or older with a closed, isolated nonpathological 12A, 12B, or 12C AO/OTA (Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association) fractures were included. The 90 (±10)-day Quick-DASH score was used to compare the results of the different treatments. The secondary outcomes were patient treatment satisfaction, shoulder and elbow range of motion, and radiographic evaluation. RESULTS: A total of 92 patients successfully completed the Quick-DASH questionnaire. Surgical treatments resulted in better outcomes than nonsurgical treatment, but only minimally invasive plate osteosynthesis produced significantly lower Quick-DASH scores than nonsurgical treatment (p < 0.05). There were strong correlations between patient self-evaluation and the Quick-DASH score (p < 0.0005) but not between the Quick-DASH score and radiographic fracture healing. No significant difference was found between the treatments regarding the rate of return to work, but the medical center had a significant influence on treatment choice (p < 0.0005). CONCLUSION: The high correlation between Quick-DASH score and patient satisfaction and functional outcome indicates that the Quick-DASH questionnaire is a suitable tool for evaluating adult humeral shaft fracture outcomes. Patients with a Quick-DASH score below 15 could be considered recovered, and patients with a Quick-DASH score above 40 could be considered not yet recovered. Quick-DASH scores were not significantly associated with radiographic fracture healing.