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Abstract Objective To evaluate the expulsion and continuation rates of the copper intrauterine device (IUD) inserted in the immediate postpartum period in a Brazilian public university hospital. Materials and Methods In the present cohort study, we included women who received immediate postpartum IUD at vaginal delivery or cesarean s March 2018 to December 2019. Clinical data and the findings of transvaginal ultrasound (US) scans performed 6-weeks postpartum were collected. The expulsion and continuation rates were assessed 6-months postpartum using data from the electronic medical records or by telephone contact. The primary outcome was the proportion of IUDs expelled at 6 months. For the statistical analysis, we used the Student t-test, the Poisson distribution, and the Chi-squared test. Results There were 3,728 births in the period, and 352 IUD insertions were performed, totaling a rate of 9.4%. At 6 weeks postpartum, the IUD was properly positioned in 65.1% of the cases, in 10.8% there was partial expulsion, and in 8.5% it had been completely expelled. At 6 months postpartum, information was obtained from 234 women, 74.4% of whom used IUD, with an overall expulsion rate of 25.6%. The expulsion rate was higher after vaginal delivery when compared with cesarean section (68.4% versus 31.6% respectively; p = 0.031). There were no differences in terms of age, parity, gestational age, final body mass index, and newborn weight. Conclusion Despite the low insertion rate of copper IUDs in the postpartum period and a higher expulsion rate, the rate of long-term continuation of intrauterine contraception was high, indicating that it is a useful intervention to prevent unwanted pregnancies and to reduce short-interval birth.
Resumo Objetivo Avaliar as taxas de expulsão e continuação do dispositivo intrauterino (DIU) de cobre inserido no pós-parto imediato em um hospital universitário brasileiro. Materiais e Métodos Neste estudo de corte transversal, foram incluídas parturientes submetidas à inserção de DIU de cobre no pós-parto imediato entre março de 2018 e dezembro de 2019. Foram coletados dados clínicos e da ultrassonografia (US) transvaginal realizada após seis semanas. As taxas de expulsão e de continuação foram avaliadas após seis meses por meio de dados do prontuário ou por contato telefônico. O resultado principal foi a proporção de DIUs expelidos em seis meses. Para análise estatística, utilizaram-se o teste t de Student, a distribuição de Poisson, e o teste do Qui quadrado. Resultados Houve 3,728 nascimentos no período, e foram inseridos 352 DIUs, em uma taxa de 9,4%. Com 6 semanas, o DIU estava bem posicionado em 65,1% dos casos, em 10,8%, houve expulsão parcial, e, em 8,5%, fora totalmente expelido. Aos 6 meses de pós-parto, foram obtidas informações de 234 mulheres, 74,4% das quais usavam DIU, com uma taxa de expulsão geral de 25,6%. A taxa de expulsão foi maior após o parto vaginal do que após cesariana (68,4% versus 31,6%, respectivamente; p = 0,031). Não houve diferenças quanto à idade, paridade, idade gestacional, índice de massa corpórea final, e peso do recém-nascido. Conclusão Apesar da baixa taxa de inserção e alta taxa de expulsão, a taxa de continuação em longo prazo da contracepção intrauterina com DIU de cobre foi elevada, o que indica que se trata de intervenção útil para prevenir gestações indesejadas em curto intervalo de tempo.
Assuntos
Humanos , Feminino , AnticoncepçãoRESUMO
This study aimed to evaluate copper sulfate solutions at 5% and 10% concentrations in footbaths from three dairy farms (A, B and C) with free stall and compost barn production systems, located in the municipality of Arapoti, Parana, Brazil. Farms A, B and C were composed of 537, 88 and 208 lactating cows, respectively, all conditioned to the use of a footbath. Every seven days, before and after the passage of each batch of cows through the footbath, samples of the solution were collected for the evaluation of pH, temperature, and the volume of the solution measured. Farms A and C had higher pH alkalinization due to the greater number of batch passages, from the third batch onwards, and also a reduction in the volume of the solution. It is concluded that the volume varied both with the number of animals that passed through the footbath and with the deposition of organic matter in the solution. The concentration of 10% copper sulfate solution was not able to inhibit pH changes. Furthermore, there was no standardization in the dimensions of the footbaths on the farms.
Objetivou-se avaliar as soluções de sulfato de cobre nas concentrações de 5% e 10%, em pedilúvios de três propriedades leiteiras (A, B e C), com sistemas de produção "free stall" e "compost barn", localizadas no município de Arapoti, Paraná, Brasil. As propriedades A, B e C eram compostas por 537, 88 e 208 vacas em lactação, respectivamente, todas condicionadas ao uso do pedilúvio. A cada sete dias, antes e após a passagem de cada lote de vacas pelo pedilúvio, foram colhidas amostras da solução para a avaliação do pH, da temperatura e do volume. As propriedades A e C tiveram alcalinização maior do pH devido ao maior número de passagem de lotes, a partir do terceiro lote, com redução também do volume da solução. Conclui-se que o volume variou tanto com o número de animais que passaram pelo pedilúvio quanto com a deposição de matéria orgânica na solução. A concentração da solução de sulfato de cobre a 10% não foi capaz de inibir as alterações de pH. Além disso, não houve padronização das dimensões dos pedilúvios nas fazendas.
Assuntos
Animais , Bovinos , Bovinos/lesões , Sulfato de CobreRESUMO
A biosorbent composed of non-viable Pseudomonas putida trapped in agar beads was able to remove Cu2+ and Zn2+ from solutions containing one or both metals. The process in batch followed pseudo second-order kinetics, with adsorption capacities of 0.255 mg Cu2+/g and 0.170 mg Zn2+/g according to the Langmuir isotherm. These values were up to ten times lower for beads without biomass. The metals became bound to OH, CH2, CO, COC and COP groups, with the last three being provided by the biomass, which highlights its importance. Adsorption values for single-metal solutions filtered in a fixed-bed column were 0.152 mg Cu2+/g and 0.117 mg Zn2+/g, but decreased to 0.075 and 0.058, respectively, with mixed-metal solutions (1:1 ratio). In 10:1-ratio solutions, the metal in greater proportion was better adsorbed. Under all conditions, removal percentage was â¼60 %. The column could be reused throughout ten absorption/desorption cycles without significant alterations in adsorption capacity.
Assuntos
Cobre , Poluentes Químicos da Água , Adsorção , Biomassa , Concentração de Íons de Hidrogênio , Íons , Cinética , Soluções , Poluentes Químicos da Água/análise , ZincoRESUMO
Resumo Fundamento Os dados mais utilizados como referência de aptidão cardiorrespiratória (ACR) são os de Cooper, que utiliza valores calculados de captação máxima de oxigênio (VO2máx). Objetivo Desenvolver valores de ACR a partir do teste cardiopulmonar de exercício (TCPE) em uma população brasileira com alto nível socioeconômico e livre de cardiopatia estrutural. Os resultados dos testes de VO2max foram comparados aos dados de Cooper e do FRIEND Registry. Métodos Foram utilizados neste estudo dados de TCPE de indivíduos consecutivos entre 1º de janeiro de 2000 e 31 de maio de 2016. Os critérios de inclusão foram: VO2máx pré-definido. Foi construído um gráfico de ACR de acordo com os percentuais do VO2máx: muito ruim (≤20%), ruim (20-40%), regular (40-60%), boa (60-80%), excelente (80-90%), e superior (≥90%). A correlação Kappa foi usada para analisar nossos dados em comparação aos dados dos outros dois bancos de dados. Os testes estatísticos com p<0,005 foram considerados significativos. Resultados A coorte final incluiu 18.186 testes: 12.552 homens, 5.634 mulheres (7 a 84 anos). A resposta mais recorrente foi "boa" (20,2%). Houve diferença média de peso, altura, índice de massa corporal (IMC) e idade no gráfico da ACR. Houve correlação inversa entre VO2máx e idade, peso e IMC. Usando uma regressão linear e essas variáveis, uma equação preditiva foi desenvolvida para o VO2máx. Nossas descobertas diferiram das dos outros bancos de dados. Conclusão Desenvolvemos uma classificação para a ACR e encontramos valores mais altos em todas as faixas de classificação de capacidade funcional, em contraste com os dados de Cooper e do FRIEND Registry. Nossos achados oferecem uma interpretação mais precisa da ACR nessa grande amostra populacional brasileira, quando comparados aos padrões anteriores, com base no VO2máx estimado. (Arq Bras Cardiol. 2020; 115(3):468-477)
Abstract Background The most widely used data for cardiorespiratory fitness (CRF) referrals are from the Cooper Clinic, which uses calculated maximal oxygen uptake (VO2max) values. Objective To develop CRF values from cardiopulmonary exercise testing (CPX) in a Brazilian population with high socioeconomic level and free of structural heart disease. VO2max testing results were compared with the Cooper Clinic and FRIEND Registry data. Methods CPX data from consecutive individuals between January 1,2000, and May 31,2016 were used in this study. Inclusion criteria were: VO2max by a pre-specified definition. We built a CRF chart according to VO2max percentiles: very poor (≤20%), poor (20-40%), fair (40-60%), good (60-80%), excellent (80-90%), and superior (≥90%). Kappa correlation was used to analyze our data in comparison with that of the other two databases. Statistical tests with p<0.005 were considered significant. Results Final cohort included 18,186 tests: 12,552 men, 5,634 women (7-84 years). The most recurrent response was "good" (20.2%). There was a mean difference in weight, height, body mass index (BMI), and age in the CRF chart. An inverse correlation existed between VO2max and age, weight, and BMI. Using a linear regression and these variables, a predictive equation was developed for VO2max. Our findings differed from that of the other databases. Conclusion We developed a classification for CRF and found higher values in all classification ranges of functional capacity in contrast to the Cooper Clinic and FRIEND Registry. Our findings offer a more accurate interpretation of ACR in this large Brazilian population sample when compared to previous standards based on the estimated VO2max. (Arq Bras Cardiol. 2020; 115(3):468-477)
Assuntos
Exercício Físico , Aptidão Física , Resistência Física , Estilo de Vida Saudável , Treino Aeróbico , Atividade MotoraRESUMO
BACKGROUND: Minimum cardiorespiratory fitness (CRF) has been recommended for firefighters due to job requirements. Thus, it is important to identify accurate and readily available methods to assess CRF in this population. Non-exercise CRF estimates (NEx-CRF) have been proposed but this approach requires validation in this population. OBJECTIVE: To evaluate the accuracy of a NEx-CRF, as compared to a field maximum exercise test, among career military firefighters of both genders using a comprehensive agreement analysis. METHODS: We evaluated the accuracy of a NEx-CRF estimate compared to the Cooper 12âmin running test among 702 males and 106 female firefighters. RESULTS: Cooper and NEx-CRF tests yielded similar CRF in both genders (differences <1.8±4.7âml/kg-1.min-1; effect size <0.34). However, NEx-CRF underestimated Cooper-derived CRF among the fittest firefighters. NEx-CRF showed moderate to high sensitivity/specificity to detect fit or unfit firefighters (71.9% among men and 100% among women). Among men, the NEx-CRF method correctly identified most firefighters with less than 11 METs or greater than 13 METs, but showed lower precision to discriminate those with CRF between 11-13 METs. CONCLUSIONS: The NEx-CRF method to estimate firefighters' CRF may be considered as an alternative method when an exercise-based method is not available or may be used to identify those who require more traditional testing (CRF 11-13 METs).
Assuntos
Aptidão Cardiorrespiratória , Teste de Esforço , Bombeiros , Militares , Feminino , Humanos , MasculinoRESUMO
The present work reports the degradation of 4-nitrophenol using BiVO4/CuO hybrid material synthesized by the precipitation of BiVO4 in the presence of CuO. Morphological and structural characterizations were performed using X-ray diffraction and scanning electronic microscopy coupled to energy dispersive X-ray spectroscopy. Through the calculation of the Kubelka-Munk function applied to diffuse reflectance spectrophotometry data, the hybrid material presented absorption edge of 1.85 eV. The formation of p-n heterojunction between BiVO4 and CuO renders the hybrid material suitable for the construction of a photoanode employed in hydroxyl radical generation. UV-vis spectrophotometry and high-performance liquid chromatography experiments were performed in order to monitor the degradation of 4-nitrophenol and the formation of secondary products. Additional information regarding the hybrid material was obtained through ion chromatography and total organic carbon analyses. The application of BiVO4/CuO-based photocatalyzer led to a 50.2% decrease in total organic carbon after the degradation of 4-nitrophenol. Based on the results obtained in the study, BiVO4/CuO has proved to be a promising material suitable for the removal of recalcitrant compounds in water treatment plants.
RESUMO
Fusarium oxysporum f. sp. lycopersici is a phytopathogenic fungus that causes vascular wilt in tomato plants. In this work we analyze the influence of metal salts such as iron and copper sulphate, as well as that of bathophenanthrolinedisulfonic acid (iron chelator) and bathocuproinedisulfonic acid (copper chelator) on the activity of laccases in the intra (IF) and extracellular fractions (EF) of the wild-type and the non-pathogenic mutant strain (rho1::hyg) of F. oxysporum. The results show that laccase activity in the IF fraction of the wild and mutant strain increased with the addition of iron chelator (53.4 and 114.32%; respectively). With copper, it is observed that there is an inhibition of the activity with the addition of CuSO4 for the EF of the wild and mutant strain (reduction of 82 and 62.6%; respectively) and for the IF of the mutant strain (54.8%). With the copper chelator a less laccase activity in the IF of the mutant strain was observed (reduction of 53.9%). The results obtained suggest a different regulation of intracellular laccases in the mutant strain compared with the wild type in presence of CuSO4 and copper chelator which may be due to the mutation in the rho gene.
Assuntos
Cobre/metabolismo , Proteínas Fúngicas/metabolismo , Fusarium/enzimologia , Ferro/metabolismo , Lacase/metabolismo , Proteínas Fúngicas/química , Proteínas Fúngicas/genética , Fusarium/química , Fusarium/genética , Lacase/química , Lacase/genética , Solanum lycopersicum/microbiologia , Doenças das Plantas/microbiologiaRESUMO
Laccase production in saline conditions is still poorly studied. The aim of the present study was to investigate the production of laccase in two different types of bioreactors by the marine-derived basidiomycete Peniophora sp. CBMAI 1063. The highest laccase activity and productivity were obtained in the Stirred Tank (ST) bioreactor, while the highest biomass concentration in Air-lift (AL) bioreactor. The main laccase produced was purified by ion exchange and size exclusion chromatography and appeared to be monomeric with molecular weight of approximately 55 kDa. The optimum oxidation activity was obtained at pH 5.0. The thermal stability of the enzyme ranged from 30 to 50 °C (120 min). The Far-UV Circular Dichroism revealed the presence of high ß-sheet and low α-helical conformation in the protein structure. Additional experiments carried out in flask scale showed that the marine-derived fungus was able to produce laccase only in the presence of artificial seawater and copper sulfate. Results from the present study confirmed the fungal adaptation to marine conditions and its potential for being used in saline environments and/or processes.
Assuntos
Organismos Aquáticos/metabolismo , Basidiomycota/metabolismo , Reatores Biológicos/microbiologia , Meios de Cultura/química , Lacase/metabolismo , Solução Salina/metabolismo , Organismos Aquáticos/crescimento & desenvolvimento , Basidiomycota/crescimento & desenvolvimento , Cromatografia em Gel , Cromatografia por Troca Iônica , Dicroísmo Circular , Sulfato de Cobre/metabolismo , Estabilidade Enzimática , Concentração de Íons de Hidrogênio , Lacase/química , Lacase/isolamento & purificação , Peso Molecular , Oxirredução , Estrutura Secundária de Proteína , TemperaturaRESUMO
Objetivos: Este relato descreve um distúrbio genético raro, denominado de Síndrome de Wilson, herdado em caráter autossômico recessivo, com sintomas muito facilmente confundidos com outras doenças. A causa básica responsável pelas manifestações clínicas é o acúmulo de cobre em diversos compartimentos do organismo humano, especialmente em locais como fígado, cérebro, rins e córneas, devido a mutações no gene ATP7B que codifica a Cu+2 ATPase, uma proteína transportadora de cobre que está localizada no complexo de Golgi dos hepatócitos. As alterações hepáticas podem se apresentar como hepatite crônica, cirrose e, mais raramente, hepatite fulminante. As alterações neurológicas são variáveis, predominando os sintomas extrapiramidais, tremores, distonia, disartria, alterações de humor, sintomas psiquiátricos e, se não tratada, diminuição progressiva da capacidade intelectual. Uma das características mais extraordinárias dessa síndrome é a grande variabilidade de manifestações fenotípicas em pacientes que possuem a mesma mutação. No diagnóstico da doença de Wilson são analisados diversos parâmetros bioquímicos, sendo eles: ceruloplasmina sérica, cobre sérico, excreção urinária de cobre e concentração hepática de cobre. Além disso, realiza-se exame oftalmológico com a observação de anéis de Kayser Fleischer. A fim de complementar e facilitar o diagnóstico podem ser realizados estudos genéticos, visto que muitas vezes os sintomas e alterações laboratoriais podem estar associados a outras doenças. O tratamento baseia-se no uso de drogas quelantes do cobre. A Dpenicilamina é a droga de escolha, apesar do risco de piora neurológica em até 50% dos pacientes e dos diversos efeitos colaterais associados ao seu uso. Trientina e tetratiomolibdato são drogas alternativas, sendo a última escolhida para indivíduos com sintomas neurológicos. O zinco tem indicação em assintomáticos ou em terapia de manutenção. O tratamento precoce evita graves complicações. Relato de caso: Paciente de 14 anos de idade, natural de Poço Fundo-MG, procurou atendimento médico por apresentar episódios frequentes de paralisia facial, principalmente na região mandibular, que levava à disfagia e disfonia, além de irritabilidade e anormalidades na marcha. Foi submetida ao exame de ressonância magnética que mostrou "alteração de sinal simétrica nos corpos estriados bilateralmente, com sinais de edema dos putâmens e núcleos caudados, e atrofia dos globos pálidos. Diante do histórico familiar para a síndrome de Wilson, foi realizado o diagnóstico diferencial, por meio da concentração de sérica de ceruloplasmina e cobre sérico e urinário, que mostraram alterações típicas da síndrome de Wilson e a biomicroscopia ocular que constatou a presença do anel de Kayser-Fleischer. Conclusões: Ainda há um longo caminho a ser seguido no que se diz respeito ao diagnóstico precoce da Síndrome de Wilson. Nesse caso, a paciente não apresentou hepatopatia pregressa. Isso mostra que a doença nem sempre se apresenta da forma esperada, e reflete a dificuldade de estabelecer um diagnóstico precoce que possa impedir o surgimento dos primeiros sintomas. Todos os portadores da síndrome de Wilson necessitam de atendimento multidisciplinar, (AU)
Objectives: This report describes a rare genetic disorder, called Wilson's Disease, inherited in an autosomal recessive form, with symptoms very easily confused with other diseases. The underlying cause of the clinical manifestations is the accumulation of copper in various compartments of the human body, especially in places such as liver, brain, kidneys and corneas, due to mutations in the ATP7B gene encoding Cu + 2 ATPase, a copper carrier protein which is located in the Golgi complex of hepatocytes. Liver changes may present as chronic hepatitis, cirrhosis and, more rarely, fulminant hepatitis. Neurological changes are variable, predominantly extrapyramidal symptoms, tremors, dystonia, dysarthria, mood changes, and psychiatric symptoms, if not treated, progressive decrease in intellectual capacity. One of the most extraordinary characteristics of this syndrome is the great variability of phenotypic manifestations in patients who have the same mutation. In the diagnosis of Wilson's disease, several biochemical parameters are analyzed: serum ceruloplasmin, serum copper, urinary excretion of copper and hepatic copper concentration. In addition, an ophthalmologic examination is performed with Kayser-Fleischer rings observation. In order to complement and facilitate the diagnosis, genetic studies can be performed, since the symptoms and laboratory abnormalities can often be associated with other diseases. Treatment is based on the use of copper chelating drugs. D-penicillamine is the drug of choice, despite the risk of neurological worsening in up to 50% of patients and the various side effects associated with its use. Trientin and tetrathiomolybdate are alternative drugs, the latter being chosen for individuals with neurological symptoms. Zinc is indicated for asymptomatic or maintenance therapy. Early treatment prevents serious complications. Case report: A 14-year-old patient from Poço Fundo-MG sought medical attention because of frequent episodes of facial paralysis, especially in the mandibular region, leading to dysphagia and dysphonia, as well as irritability and gait abnormalities. She underwent magnetic resonance imaging (MRI), which showed "symmetrical signal changes in the bilaterally striatum, with signs of edema of the caudate nuclei and caudate nuclei, and atrophy of the pale globes." In view of the family history of Wilson's syndrome, a differential diagnosis was performed, by serum concentration of ceruloplasmin and serum and urinary copper, which showed typical changes in Wilson's syndrome and ocular biomicroscopy, which verified the presence of the Kayser-Fleischer ring. The patient did not present previous liver disease, showing that the disease does not always present as expected, and reflects the difficulty in establishing an early diagnosis that may prevent the emergence of the first symptoms. All patients with Wilson's syndrome require multidisciplinary care since it is a disease that can significantly affect various organs and systems (AU)
Assuntos
Humanos , Feminino , Adolescente , Penicilamina , Cobre , Degeneração HepatolenticularRESUMO
ABSTRACT Fusarium oxysporum f. sp. lycopersici is a phytopathogenic fungus that causes vascular wilt in tomato plants. In this work we analyze the influence of metal salts such as iron and copper sulphate, as well as that of bathophenanthrolinedisulfonic acid (iron chelator) and bathocuproinedisulfonic acid (copper chelator) on the activity of laccases in the intra (IF) and extracellular fractions (EF) of the wild-type and the non-pathogenic mutant strain (rho1::hyg) of F. oxysporum. The results show that laccase activity in the IF fraction of the wild and mutant strain increased with the addition of iron chelator (53.4 and 114.32%; respectively). With copper, it is observed that there is an inhibition of the activity with the addition of CuSO4 for the EF of the wild and mutant strain (reduction of 82 and 62.6%; respectively) and for the IF of the mutant strain (54.8%). With the copper chelator a less laccase activity in the IF of the mutant strain was observed (reduction of 53.9%). The results obtained suggest a different regulation of intracellular laccases in the mutant strain compared with the wild type in presence of CuSO4 and copper chelator which may be due to the mutation in the rho gene.
Assuntos
Proteínas Fúngicas/metabolismo , Cobre/metabolismo , Lacase/metabolismo , Fusarium/enzimologia , Ferro/metabolismo , Doenças das Plantas/microbiologia , Proteínas Fúngicas/genética , Proteínas Fúngicas/química , Solanum lycopersicum/microbiologia , Lacase/genética , Lacase/química , Fusarium/genética , Fusarium/químicaRESUMO
ABSTRACT Fusarium oxysporum f. sp. lycopersici is a phytopathogenic fungus that causes vascular wilt in tomato plants. In this work we analyze the influence of metal salts such as iron and copper sulphate, as well as that of bathophenanthrolinedisulfonic acid (iron chelator) and bathocuproinedisulfonic acid (copper chelator) on the activity of laccases in the intra (IF) and extracellular fractions (EF) of the wild-type and the non-pathogenic mutant strain (rho1::hyg) of F. oxysporum. The results show that laccase activity in the IF fraction of the wild and mutant strain increased with the addition of iron chelator (53.4 and 114.32%; respectively). With copper, it is observed that there is an inhibition of the activity with the addition of CuSO4 for the EF of the wild and mutant strain (reduction of 82 and 62.6%; respectively) and for the IF of the mutant strain (54.8%). With the copper chelator a less laccase activity in the IF of the mutant strain was observed (reduction of 53.9%). The results obtained suggest a different regulation of intracellular laccases in the mutant strain compared with the wild type in presence of CuSO4 and copper chelator which may be due to the mutation in the rho gene.
RESUMO
Fusarium oxysporum f. sp. lycopersici is a phytopathogenic fungus that causes vascular wilt in tomato plants. In this work we analyze the influence of metal salts such as iron and copper sulphate, as well as that of bathophenanthrolinedisulfonic acid (iron chelator) and bathocuproinedisulfonic acid (copper chelator) on the activity of laccases in the intra (IF) and extracellular fractions (EF) of the wild-type and the non-pathogenic mutant strain (rho1::hyg) of F. oxysporum. The results show that laccase activity in the IF fraction of the wild and mutant strain increased with the addition of iron chelator (53.4 and 114.32%; respectively). With copper, it is observed that there is an inhibition of the activity with the addition of CuSO4 for the EF of the wild and mutant strain (reduction of 82 and 62.6%; respectively) and for the IF of the mutant strain (54.8%). With the copper chelator a less laccase activity in the IF of the mutant strain was observed (reduction of 53.9%). The results obtained suggest a different regulation of intracellular laccases in the mutant strain compared with the wild type in presence of CuSO4 and copper chelator which may be due to the mutation in the rho gene.(AU)
RESUMO
Introdução: É necessário que os militares mantenham um condicionamento físico que os capacite ao desempenho de suas funções. Por questões de testes rotineiros e ou por detecção de estado de saúde, investigar parâmetros de condicionamento físico se faz necessário. Objetivo: Identificar se existe correlação entre o Índice de massa corporal e o desempenho de militares no teste de Cooper. Métodos: Pesquisa original do tipo descritiva por correlação entre dados, com corte transversal. A amostra foi composta por 32 policiais do serviço administrativo do Batalhão de Ações com Cães da Policia Militar do estado do Rio de Janeiro, voluntários, com 39,84±3,08 anos de idade, todos do sexo masculino. Foi feita a medição de massa corporal e estatura dos policiais, a fim de obter o Índice de Massa Corporal (IMC), além disso, foi aplicado testes de Cooper (12 minutos). Resultados: Os valores de IMC foram 27,02 ± 3,14 e Cooper 2479,06 ± 270,73m. Com a realização desses testes foi verificado correlação moderada entre ambos. A correlação foi feita através do coeficiente de Pearson que resultou r=-0,52 e um nível de significância de 0,002. Conclusão: Os policiais apresentaram maior frequência de sobrepeso, porém tal fator parece não influenciar no nível de aptidão física destes indivíduos, uma vez que a maior parte da amostra teve bom desempenho no teste de Cooper(AU)
Introducción: Es necesario que los militares mantengan un condicionamiento físico que los capacite para el desempeño de sus trabajos. Por motivos de pruebas rutinarias y / o por detección de estado de salud, investigar parámetros de acondicionamiento físico se hace necesario. Objetivo: identificar si existe una correlación entre el índice de masa corporal y el rendimiento militar en la prueba de Cooper. Métodos: estudio original de tipo descriptivo por correlación entre datos, con corte transversal. Se incluyeron 32 agentes hombres del Departamento Administrativo del batallón de acciones con los perros de la policía militar del estado de Río de Janeiro, con 39,84 ± 3,08 años de edad. Se encontró la altura y el peso de los sujetos para obtener el Índice de Masa Corporal (IMC), además, se aplicó la prueba de Cooper (12 minutos). Resultados: los valores de IMC fueron 27,02 ± 3,14 y Cooper 2479,06 ± 270,73m. Con la realización de estas pruebas se encontró correlación moderada entre ambos. La correlación se realizó mediante el coeficiente de Pearson r = -0,52 dado y un nivel de significación de 0,002. Conclusiones: la mayoría de los agentes de policía mostraron sobrepeso, pero este factor no influyó en el nivel de forma física de estas personas, ya que la mayoría de la muestra tuvo un buen rendimiento en la prueba de Cooper(AU)
Introduction: It is necessary for the military to maintain a physical condition that enables them to perform their jobs. For reasons of routine testing and / or detection of health status, investigating physical fitness parameters is necessary. Objective: This study aimed to Identify if there is a correlation between the index body mass and the cooper test and the performance of militaries in the cooper test. Methods: Original research of the descriptive type by correlation between data, with cross-section. The sample was composed for 32 policies of the administrative service of the Action's Battallion with dogs of the military police of the Rio de Janeiro state, with voluntaries with 39,84 ±3,08 years old, all of male. It was made the measurement of the corporal mass and the height of the policies to obtain the index body mass, and it was applied the cooper test (12 minutes). Results: The BMI values were 27.02 ± 3.14 and Cooper 2479.06 ± 270.73m. With the tests a moderate influence of BMI was observed in the outcome of the Cooper test. The correlation was made with the Pearson's coefficient that result r=-0,52 and a significance level of 0,002. Conclusions: The police had higher frequency of overweight, however this factor apparently not influence the physical aptitude of this men, once the bigger part of the sample had a good performance in the cooper test(AU)
Assuntos
Humanos , Masculino , Adulto , Resistência Física , Índice de Massa Corporal , Condicionamento Físico Humano/métodos , Militares , Epidemiologia Descritiva , Estudos Transversais , Correlação de DadosRESUMO
PURPOSE : This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS: The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. RESULTS: Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin[70.1 ng/mL (CI95% 55.8-84.5) vs.53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations [120 µg/dL(CI95% 114-126) vs. 106 µg/dL(CI95% 98-114), p<0.01] and the Cu/Zn ratio [1.59 (CI95% 1.48-1.71)vs. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. CONCLUSION: These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Zinco/sangue , Neoplasias Colorretais/sangue , Adenocarcinoma/sangue , Estado Nutricional , Cobre/sangue , Período Perioperatório , Valores de Referência , Composição Corporal , Ensaio de Imunoadsorção Enzimática , Biomarcadores/sangue , Índice de Massa Corporal , Estudos de Casos e Controles , Fatores de Risco , Estatísticas não Paramétricas , Complexo Antígeno L1 Leucocitário/sangue , Desnutrição , Ingestão de Alimentos , Inflamação/sangueRESUMO
PURPOSE : This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS: The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. RESULTS: Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin[70.1 ng/mL (CI95% 55.8-84.5) vs.53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations [120 µg/dL(CI95% 114-126) vs. 106 µg/dL(CI95% 98-114), p 0.01] and the Cu/Zn ratio [1.59 (CI95% 1.48-1.71)vs. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. CONCLUSION: These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.(AU)
Assuntos
Humanos , Masculino , Feminino , Idoso , Neoplasias Colorretais , Avaliação Nutricional , Cobre/sangue , Zinco/sangue , Inflamação , Antropometria/métodos , Doenças Inflamatórias IntestinaisRESUMO
The effect of competition of Cu(II) and Ni(II) on the kinetic stability of Cr(III) complexed with natural organic matter (NOM) was characterized using EDTA exchange with single-stage tangential-flow ultrafiltration. For a water sample from Serra de Itabaiana, 3% of spiked Cr(III) was exchanged, while for a sample from the Itapanhaú River, 7, 10, 10, and 21% was exchanged in experiments using Cr(III) alone and in combination with Cu(II), Ni(II), or Cu(II) + Ni(II), respectively. Times required to reach exchange equilibrium with EDTA were less than 360 min. The influence of competition from Ni(II) and Cu(II) on the availability of complexed Cr(III) was low, demonstrating preference of the ligand sites for Cr(III). This was correlated with sample humification, as confirmed by EPR and (13)C NMR analyses. Exchange efficiency was in the order Cu > Ni > Cr, and the process could be readily described by first order kinetics, with average rate constants of 0.35-0.37 h(-1).
Assuntos
Cátions/química , Ácido Edético/química , Metais Pesados/química , Poluentes Químicos da Água/química , Cromo/química , Cobre/química , Humanos , Troca Iônica , Cinética , Ligantes , Níquel/química , Termodinâmica , UltrafiltraçãoRESUMO
La translocación de dispositivo intrauterino (DIU) es poco frecuente, con afección a órganos vecinos como el recto-sigmoide, la vejiga y el ovario; luego de la perforación uterina por migración de DIU se justifica su inmediata extracción de la cavidad abdominal. Presentamos el caso clínico de una mujer de 38 años de edad, que cursó con una perforación parcial de dispositivo intrauterino que causó dolor pélvico en la mujer.
Translocation of an intrauterine device (IUD), is slightly frequent, affecting neighboring organs like the rectal sigmoid, bladder and ovaries. After uterine perforation, because of IUD migration, immediate removal of the abdominal cavity is justified. We present a case of a 38 year-old woman who had a partial perforation by an intrauterine device causing pelvic pain.
Assuntos
Humanos , Feminino , Adulto , Migração de Dispositivo Intrauterino/etiologia , ÚteroRESUMO
No Maranhão, dentre as bebidasalcoólicas produzidas, destaca-se atiquira, uma bebida destilada de origemindígena, com alto teor de álcooletílico, produzida artesanalmente, apartir da mandioca, em cerca de 13municípios. O objetivo deste trabalhofoi caracterizar físico-quimicamenteas tiquiras oriundas dos municípiosmaranhenses de Barreirinhas e UrbanoSantos e comercializadas em São Luís. As amostras foram adquiridasno comércio informal da cidade,levadas ao Laboratório de Bromatologiado Programa de Controle deQualidade de Alimentos e Água daUniversidade Federal do Maranhão(PCQA-UFMA) e efetuadas as análisesfísico-químicas em triplicata(resíduo seco, teor alcoólico, acidezvolátil, densidade e pH), seguindo-seos métodos analíticos do InstitutoAdolfo Lutz (2005). A determinaçãode cobre foi realizada por espectrofotometriade absorção atômica dechama. Os resultados obtidos para aacidez volátil permitiram observar queas amostras de tiquiras de Barreirinhase a de coloração violeta oriunda deUrbano Santos, estavam imprópriaspara consumo e, apenas a tiquiraincolor do município de Urbano Santos,apresentou acidez volátil dentrodos parâmetros estabelecidos peloMinistério da Agricultura, Pecuáriae Abastecimento. As determinaçõespara o teor de cobre total apresentaram teores fora dos padrões especificados pela legislação nacional, sendo consideradasimpróprias para o consumo. (AU)
In Maranhão, among the alcoholicbeverages produced there isthe "tiquira", a liquor of indigenousorigin, with high levels of ethanolproduced from cassava handmade inabout 13 municipalities. The objectiveof this study was to characterize thephysical-chemical tiquira rum comingfrom the municipalities of Maranhão,Barreirinhas and Urbano Santos andsold in São Luís. The samples wereacquired in informal trade of the city,brought to Bromatology Laboratory ofPrograma de Controle de Qualidadede Alimentos e Água of the UniversidadeFederal do Maranhão (PCQA-UFMA)and made the physical andchemical analysis in triplicate (dry,alcohol content, volatile acidity, densityand pH) followed by the analyticalmethods of the Instituto Adolfo Luz (2005). The determination of copperwas carried out by atomic absorptionspectrophotometry and jlame. The resultsobtained for the volatile aciditywas possible to observe that samplesof ticks and Barreirinhas violet stainingcoming from Urbano Santos wereunfit for consumption, and only the cityof tiquira rum colorless, volatile acidityUrbano Santos presented withinthe parameters established by theMinistério da Agricultura, Pecuária eAbastecimento. Measurements for thecontent of total copper levels showedoff the standards set by national legislation,being considered unfit forconsumption. (AU)
Assuntos
Bebidas Alcoólicas , Manihot , BrasilRESUMO
The aim of this work was to determine serum copper levels, aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) activity in purebred show sheep fed concentrate and field sheep raised on natural pastures of Rio Grande do Sul, the southernmost State of Brazil. Blood samples of 120 show sheep and 110 field raised animals were collected independently of age, sex and breed. Mean serum levels of copper found on purebred and field sheep were 66.14 ± 9.76 and 62.01 ± 16.36 µg/dl (P<0.0357), respectively. AST activity was higher in show sheep than in field animals (85.01 ± 40.02 vs. 65.58 ± 16.19 IU, P<0.0001). GGT activity levels found were 41.02 ± 10.61 and 41.91 ± 9.49 IU, with no significant differences between groups. It is concluded that serum copper levels of purebred show sheep group were within international reference values for the species, whereas in the grass grazed group, the level of this mineral was bellow the lower limit in several individuals. Enhanced AST serum activity in blood samples of show sheep examined appear to be related to copper liver levels detected in these animals.
O objetivo desse trabalho foi identificar as concentrações séricas de cobre enzimas aspartatoaminotransferase (AST) e gamaglutamiltransferase (GGT), tanto em ovinos preparados para exposição e alimentados com concentrados como criados a campo, a fim de contribuir para a formação de valores de referência e auxiliar no prognóstico da saúde desses animais. Colheram-se 120 amostras de sangue de animais de exposição e 110 de animais de campo, independente de sexo, raça e idade. Os níveis séricos médios de cobre, AST e GGT dos animais de exposição e a campo foram iguais a 66,14 ± 9,76 e 62,01 ± 16,36 µg/kg (P<0,0357); 85,01 ± 40,02 e 65,58 ± 16,19 UI (P<0,0001); 41,02 10,61 e 41,91 ± 9,49 UI (P>0.05), respectivamente. Em conclusão, a concentração de cobre em ovinos preparados para exposição mostraram-se dentro dos valores de referência e as de alguns animais mantidos a campo abaixo do intervalo fisiológico. Os níveis séricos de AST aumentados no grupo exposição parecem estar relacionados com o acúmulo hepático de cobre.
Assuntos
Animais , Aspartato Aminotransferases/análise , Ovinos/sangue , Cobre/sangue , Intoxicação por Metais Pesados/veterinária , gama-Glutamiltransferase/análiseRESUMO
Se propone un protocolo de manejo para la patología herniaria en el Servicio de Cirugía General del Hospital Dr. Teodoro Maldonado Carbo de Guayaquil, cuyo propósito es unificar criterios para el manejo de esta patología tan frecuente en nuestro medio; siendo el objetivo principal disminuir las recurrencias, que fluctúan entre 4 y 6% según las estadísticas mundiales; independientemente de las variables atribuibles al equipo quirúrgico y evaluación exacta de cada caso.Como conclusiones podemos mencionar que la causa principal de recidiva es la tensión en la línea de sutura y que la técnica de Shouldice es la apropiada cuando existe defecto de la pared posterior. Este artículo resume una propuesta para el manejo de esta patología muy frecuente como resultado de la experiencia en este servicio.
We intend to propose a protocol for handling a hernial pathology in the Service of General Surgery of the Hospital of the I.E.S.S of Guayaquil. Our purpose is to unify criteria for the handling of this pathology that is very frequent in our society. Our main objective is to lower recurrences that are between 4 and 6% according to world statistics independent from variables such as surgery equipment and the evaluation of each case.As a conclusion the main cause of recurrence is the suture line tension. We also want to conclude that the Shouldice technique should be used when there is a defect on the posterior wall. This article summarizes a proposal of the handling of this pathology that is very frequent at our service.