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OBJECTIVE: To map explicit screening tools to identify potentially inappropriate medication (PIMs), and the characteristics and limitations of these tools. Including PIMs-interactions, therapeutic alternatives and the clinical management of PIMs. METHODS: A systematic scoping review was conducted in PubMed and Scopus (until May 2021). The number of PIMs listed as essential drugs was identified in Model List of Essential Medicines by the World Health Organization (WHO) and National List of Essential Medicines (Brazil). In addition to reporting the therapeutic alternatives and clinical management proposed by explicit screening tools to identify PIMs, we suggested our own alternatives for the PIMs most frequently reported. RESULTS: Fifty-eight tools reported 614 PIMs and 747 PIMs-interactions. Limited overlap between the tools was observed: 123 (69.1%) of 178 therapeutic alternatives proposed by the tools were considered inappropriate by other tools, and 222 (36.1%) of the 614 PIMs identified were named as being inappropriate only once. Only 21 tools were developed by a Delphi panel technique associated with systematic review. The PIMs listed as essential medication in Brazil and by the WHO were 30.6% and 23.3% of the total reported, respectively. For the most-cited PIMs, such as non-steroidal anti-inflammatory drugs, tricyclic antidepressants and benzodiazepines, we suggested the use of non-opioid and opioid analgesics; agomelatine, bupropion or moclobemide; and melatonin, respectively. CONCLUSIONS: The next stages in the development of explicit screening tools to identify PIMs include achieving more consensus between them and improving their applicability across countries. Further, it is recommended that tools include PIMs risks and advice on therapeutic alternatives.
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Prescrição Inadequada , Lista de Medicamentos Potencialmente Inapropriados , Brasil , Consenso , Humanos , Prescrição Inadequada/prevenção & controleRESUMO
Percutaneous procedures through femoral access in patients with inferior vena cava (IVC) filter may be at risk of complications. We evaluated the feasibility and safety of left atrial appendage closure (LAAC) through femoral access in patients previously implanted with IVC filter. We described the WatchmanTM device implantation in two patients with formal contraindication for oral anticoagulation. First patient had a GreenfieldTM filter and the second one an OpteaseTM filter, and in this patient an attempt to withdrawal the filter immediately before the LAAC procedure failed. A femoral approach was performed in both patients using a 14 Fr sheath. Before crossing IVC filters, venographies did not detect any thrombus. All steps of IVC filter crossing were performed under fluoroscopic guidance. No immediate or intrahospital complications related to the procedure occurred. Herein, we presented two cases of successful LAAC closure with Watchman device in patients with two different kinds of IVC filters.
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Fibrilação Atrial , Filtros de Veia Cava , Átrios do CoraçãoRESUMO
Cisplatin is the standard of treatment for squamous cell carcinoma of the head and neck (SCCHN) that has demonstrated efficacy, either in locally advanced disease when combined with radiotherapy at high doses, or in metastatic/recurrent disease when combined with other agents. However, the usual toxicities related to cisplatin, such as neurotoxicity, nephrotoxicity, ototoxicity, and hematologic toxicities, especially when high doses have been administered, have important implications in the patients' quality of life. The decision to administer cisplatin depends on several patient factors, such as age, performance status, weight loss, comorbidities, previous toxicities, chronic viral infection, or even the current SARS-CoV-2 pandemic. In order to establish recommendations for the management of patients with SCCHN, a group of experts in medical and radiation oncology from Spain and Latin-American discussed how to identify patients who are not candidates for cisplatin to offer them the most suitable therapeutic alternative.
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Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms. Here, its safety and efficacy were evaluated among AIS patients with a previous history of cerebral hemorrhage. Patients who arrived at the hospital within 4.5 h of initial stroke symptoms and who were treated with tPA intravenous thrombolysis or conventional therapies were analyzed. The 90-day modified Rankin scale (90-d mRS) was used alongside mortality and incidence of symptomatic intracerebral hemorrhage (SICH) rates to evaluate the curative effect of these therapies. Among 1,694 AIS patients, 805 patients were treated with intravenous thrombolysis, including patients with (n=793) or without (n=12) a history of cerebral hemorrhage, and the rate of incidence of SICH significantly differed between them (8.3 vs 4.3%, P=0.039). No significant difference was found in 90-d mRS measurements (41.7 vs 43.6%, P=0.530) and 90-d mortality rates (8.3 vs 6.5%, P=0.946). A total of 76 AIS patients with a history of cerebral hemorrhage received tPA thrombolytic therapy (n=12) or conventional therapy (n=64), and a significant difference was noted in the 90-d mRS scores between the two groups (41.7 vs 23.4%, P=0.029), while no significant difference was found in SICH measurements (8.3 vs 4.6%, P=0.610) and 90-d mortality rates (8.3 vs 9.4%, P=0.227). A history of cerebral hemorrhage is not an absolute contraindication for thrombolytic therapy; tPA intravenous thrombolysis does not increase SICH measurements and mortality rates in patients with a history of cerebral hemorrhage, and they may benefit from thrombolytic therapy.
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Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Isquemia Encefálica/tratamento farmacológico , Ativador de Plasminogênio Tecidual/administração & dosagem , Hemorragias Intracranianas/etiologia , Fibrinolíticos/administração & dosagem , Terapia Trombolítica/métodos , Isquemia Encefálica/complicações , Resultado do Tratamento , Administração IntravenosaRESUMO
Resumen OBJETIVO Identificar las amenazas a la seguridad de la paciente en la práctica de la conducción del trabajo de parto con oxitocina y las repercusiones maternas y perinatales en un hospital público de tercer nivel de Lima, Perú. MATERIALES Y MÉTODOS Estudio cuantitativo, descriptivo, retrospectivo y transversal efectuado en pacientes embarazadas atendidas en un hospital público, de tercer nivel, de Lima, Perú, a quienes se indicó conducción del parto con oxitocina. Los datos se tabularon en Excel y SPSS v21. El análisis univariado incluyó frecuencia y porcentaje para las variables cualitativas; se emplearon medidas de tendencia central, dispersión y desviación estándar para variables cuantitativas. RESULTADOS Se revisaron 112 historias clínicas de pacientes sin alteraciones en el trabajo de parto a quienes se indicó conducción con oxitocina (29.5%; n = 33). La principal vía de término fue el parto vaginal (73.2%; n = 82) y del grupo con cesárea el motivo más común fue la desproporción céfalo pélvica (56.7%; n = 17). Se observaron complicaciones obstétricas en 25% (n = 28), de este grupo la principal fue la hemorragia posparto (46.4%; n = 13). El peso de los recién nacidos fue 3401 ± 394 gramos, 93.7 y 96.4% obtuvieron un Apgar entre 10 a 7 al primero y quinto minutos, respectivamente. CONCLUSIONES Las amenazas identificadas a la seguridad de la paciente fueron: conducción del parto con oxitocina en quienes no tenían alteraciones en el trabajo de parto y en quienes tuvieron desproporción céfalo-pélvica, a pesar de que es una contraindicación para el procedimiento.
Abstract OBJECTIVE Identify the threats to the safety of the patient in the practice of conducting labor with oxytocin and maternal and perinatal outcomes in a public tertiary hospital in Lima, during 2016. MATERIALS AND METHODS Quantitative, descriptive, retrospective and cross-sectional. A total 112 pregnants' medical histories were review who underwent augmentation of labour with oxytocin. Inclusion criteria's: term gestation, hospitalization with a 4 cm dilatation, fetuses in cephalic presentation. Exclusion criteria's: patients with previous or intercurrent pathologies to pregnancy. RESULT The augmentation with oxytocin made in pregnant women without alterations in labor (29.5%; n = 33). The main type childbirth was vaginal delivery (73.2%; n = 82) and of the group that underwent cesarean section, the most usual reason was cephalopelvic disproportion (56.7%; n = 17). Obstetric complications were observed (25%; n = 28), of this group the main was postpartum hemorrhage (46.4%; n = 13). The weight of the newborns oscillated between 3401 ± 394 g, 93.7% and 96.4% obtained an Apgar 10 to 7 at the 1st and 5th minute respectively. CONCLUSIONS The threats to the safety of the patient identified were the practice of augmentation of labor with oxytocin in pregnant women without alterations in labor and in pregnant women with cephalopelvic disproportion, although it is a contraindication to the procedure.
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OBJECTIVE: There is little research on factors associated with alcohol consumption among Puerto Ricans living in the USA; thus the aim of the present study was to examine alcohol intake patterns, and factors associated with drinking categories, in a cohort of Puerto Rican adults in Massachusetts. DESIGN: Cross-sectional study. Descriptive and polytomous logistic regression analyses were used to identify factors associated with drinking patterns, stratified by gender. SETTING: Greater Boston area, MA, USA. SUBJECTS: Puerto Rican adults (n 1292), aged 45-75 years. RESULTS: Eight per cent of men and 39% of women were lifetime abstainers; 40% of men and 25% of women were former drinkers; 31 % of men and 27% of women were moderate drinkers; and 21% of men and 8% of women were heavy drinkers. Thirty-five per cent of participants reported drinking alcohol while taking medications with alcohol contraindications. After multivariable adjustment, young men were less likely than older men to be moderate drinkers. Among women, higher BMI, age, lower income and lower psychological acculturation were associated with abstention; age and lower perceived emotional support were associated with increased likelihood of former drinking; and women without v. with diabetes were more likely to be heavy drinkers. CONCLUSIONS: High prevalence of chronic disease, heavy drinking and alcohol use while taking medications with alcohol contraindications suggest an urgent need for better screening and interventions tailored to this rapidly growing Hispanic national subgroup. As heavy drinking appears to increase with acculturation for women, public health initiatives are needed to support appropriate alcohol use.
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Envelhecimento , Consumo de Bebidas Alcoólicas/epidemiologia , Alcoolismo/epidemiologia , Saúde da População Urbana , Aculturação , Idoso , Consumo de Bebidas Alcoólicas/etnologia , Consumo de Bebidas Alcoólicas/psicologia , Bebidas Alcoólicas/efeitos adversos , Alcoolismo/etnologia , Alcoolismo/psicologia , Boston/epidemiologia , Estudos de Coortes , Contraindicações , Estudos Transversais , Etanol , Feminino , Interações Alimento-Droga , Inquéritos Epidemiológicos , Hispânico ou Latino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Prevalência , Porto Rico/etnologia , Risco , Fatores Sexuais , Saúde da População Urbana/etnologiaRESUMO
KEY CLINICAL MESSAGE: Pharmaceutical excipients need careful observation as they play a significant role in treatment outcomes. It is imperative for a physician to collect complete patient profile before prescribing new medications for current treatment. We present a case report on the significance of pharmaceutical excipients in prescribed medicines.
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Determining the indications and contraindications for psychoanalytic treatment seems crucial to achieve therapeutic success and improve treatment effectiveness. In reviewing the classic literature on the topic, aspects such as age, diagnosis, motivation for treatment, present moment in life, ability to gain insight, psychic suffering when seeking treatment, defensive behaviors, and frustration tolerance are clearly analyzed by therapists/analysts when indicating psychoanalytic treatments. However, traditionally, most criteria underlying such indications date back to a time when the therapeutic relationship was viewed merely as a therapist treating a patient, with no regard to the therapeutic relationship itself. The goal of this article was to critically review the relevance and current adequacy of indications for psychoanalytic treatment, in view of advancements in knowledge on the analytic field. Considering cases that do not evolve as expected according to the indications, patients who are better suited to certain therapists, and therapist-patient pairs that modify their interaction over the course of treatment, the main question remains on how to identify the necessary elements in evaluating a candidate patient for psychoanalytic treatment, as well as the significant elements of therapeutic action
Determinar critérios de indicação e contraindicação para tratamentos psicanalíticos parece um ponto técnico crucial para a obtenção de sucesso terapêutico e a elevação de seus índices de efetividade. Na revisão da literatura clássica sobre o tema, percebe-se que a idade, o diagnóstico do paciente, a motivação para tratamento, o momento de vida, a capacidade de insight, o sofrimento psíquico apresentado no momento da busca de tratamento, o estilo defensivo e a tolerância à frustração são alguns dos pontos analisados pelos terapeutas/analistas para indicar tratamentos psicanalíticos. Contudo, classicamente, tais indicações provêm de um período em que a relação terapêutica era vista meramente como um terapeuta atendendo um paciente, sem levar em conta a relação terapêutica propriamente dita. O objetivo deste artigo foi revisar criticamente a relevância e pertinência atual das indicações para tratamento psicanalítico, tendo em vista a evolução dos conhecimentos sobre o campo analítico. Considerando casos que não evoluem da maneira esperada segundo as indicações, pacientes que se adaptam melhor a determinados terapeutas e duplas que modificam sua interação ao longo do tempo de tratamento, a principal questão continua sendo como identificar quais seriam os elementos necessários na avaliação de um paciente candidato a tratamento psicanalítico, bem como os elementos significativos da ação terapêutica
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Humanos , Psicanálise , Técnicas e Procedimentos Diagnósticos , Psicanálise/métodos , Terapia Psicanalítica/métodosRESUMO
Introdução: Trabalhar os aspectos sociais que podem comprometer a adesão ao tratamento pós-transplante é um dos cuidados da equipe do Programa de Transplante Hepático Infantil (PTHI) do Hospital de Clínicas de Porto Alegre. O serviço social possui um protocolo de avaliação e trabalha em parceria com a rede de apoio do paciente pediátrico, otimizando a sua entrada em lista de espera para transplante hepático após o equacionamento dos principais problemas sociais. Objetivo: Traçar o perfil sociocultural dos pacientes atendidos e mostrar a intervenção do serviço social nas principais contra-indicações sociais para o transplante. Método: Foi realizada pesquisa documental nos protocolos de avaliação utilizados para avaliar 22 famílias de crianças candidatas ao transplante, encaminhadas ao serviço social no período de janeiro de 2006 a janeiro de 2007. Resultados: Os resultados mostram que 81,8% das famílias apresentam baixa renda. Contudo, o trabalho desenvolvido pela assistente social junto a essas famílias viabilizou que 90,9% das crianças tivessem seus nomes incluídos nas listas para transplante hepático. Conclusão: A partir dos resultados, torna-se evidente a necessidade do olhar social sobre a questão dos transplantes de órgãos, considerando a complexidade do procedimento e o perfil das famílias atendidas. Trabalhar em parceria com a rede social de apoio do paciente é fundamental para o trabalho social junto a famílias de baixa renda, que somam a essa condição a ausência de saúde e a indicação de transplante.
Background: To find solutions for the social problems that could hinder compliance with posttransplant treatment is one of the concerns of the Program of Pediatric Hepatic Transplant (PTHI) from Hospital de Clínicas of Porto Alegre. The social service team uses an evaluation protocol and works along with a support network for pediatric patients, optimizing their inclusion on the waiting list for hepatic transplant after evaluation of the main social problems. Objective: To provide information on the sociocultural profile of the families and to present the intervention of the social service team on the main social contraindication for transplant. Methods: The protocols used to evaluate 22 families of young candidates for transplant who were referred to social service between January 2006 and January 2007 were reviewed. Results: The results showed that despite the low income of 81.8% of the families, the work done by the social service team enabled 90.0% of the children to be included on the waiting list for hepatic transplant. Conclusion: Based on the results, the need of a social intervention on the aspects related to organ transplantation becomes evident, considering the complexity of the procedure and the profile of the families. Working in partnership with a social support network is vital for the social work involving low-income families who, in addition to the economic difficulties, have to deal with poor health and transplant indication.