RESUMO
To assess the effects of Cimicifuga racemosa (L.) Nutt on climacteric symptoms and sexual function in women receiving tamoxifen after breast cancer treatment. A prospective study of women treated at the Mastology Outpatient Clinic of the Department of Obstetrics and Gynecology of the Santa Casa de Sao Paulo School of Medical Science of the hospital was conducted between 2018 and 2021. Patients diagnosed with breast cancer that underwent surgical, radiotherapy and chemotherapy treatment more than one year prior, receiving tamoxifen, exhibited climacteric symptoms and were sexually active were selected. Total of 34 women were recruited and during outpatient visits completed sociodemographic questionnaire, Blatt-Kupperman Index (KI) and Female Sexual Function Index (FSFI). The group showed improvements in climacteric symptoms (p<.001) and sexual function (p=.011) after the 6-month follow-up. Cimicifuga racemosa (L.) Nutt promoted improvements in climacteric symptoms and sexual function in women surgically treated for breast cancer. Clinical Trials.gov ID: NCT02467686.Impact StatementWhat is already known on this subject? The medications used for the treatment of breast cancer can lead to important complaints of vasomotor manifestations with a negative impact on the success of their treatment, and cases have been described until their interruption. Cimicifuga racemosa (L.) Nutt. is described in several works as a therapy to alleviate these symptoms. Numerous works in the literature present climatic symptoms and sexual function with a selective approach to the themes.What do the results of this study add? Our study evaluated a group of women who were treated for breast cancer after menopause taking into account the following aspects: climacteric symptoms and sexual function. When we reviewed the literature, we did not find, so far, work similar to ours.What are the implications of these findings for clinical practice and/or further research? In clinical practice, assessing vasomotor symptoms and sexual response of breast cancer patients can contribute towards improving the lives of this patient group. Prescribing Cimicifuga racemosa (L.) Nutt in cases with climacteric complaints and poor sexual response can relieve distress and promote better health and life status for these women. Although the present investigation has generated important data on female breast cancer survivors, there are limitations regarding the number of participants. We recommend further clinical research with expansion of the sample studied and the results presented.
Assuntos
Neoplasias da Mama , Cimicifuga , Feminino , Humanos , Tamoxifeno/efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Fitoterapia , Estudos Prospectivos , Brasil , Extratos Vegetais/efeitos adversos , MenopausaRESUMO
Abstract Objective To determine if there is a correlation between body mass index (BMI) and climacteric symptoms in postmenopausal women. Methods The study sample was composed of 109 postmenopausal women with a mean age of 57 ± 8 years, mean body mass index (BMI) of 30 ± 6 kg/m2, and 8 ± 8 years after menopause. For the assessment of the climacteric symptoms, the Blatt-Kupperman Index (BKI), the Menopause Rating Scale (MRS), and the Cervantes Scale (CS) were used. Data analysis was performed through the Chi-squared test, analysis of variance (ANOVA) with the Bonferroni post hoc test, and multiple linear regression. The level of significance adopted was of p < 0.05. The statistical analyses were performed using the Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY, United States) software, version 26.0. Results The multiple linear regression showed a positive association (p<0.01) between BMI values and menopause symptoms when adjusted for age and time after menopause in the 3 questionnaires used (BKI: B = 0.432; CS: B = 304; and MRS: B = 302). Regarding symptom scores, the obese women had higher mean scores (p<0.05) when compared to eutrophic women (BKI = 28 ± 10 and 20 ± 10; and MRS = 20 ± 10 and 13±7, respectively). In the Chi-squared analysis, 28% of obese women had severe symptoms and 46% had moderate symptoms, while only 1% and 46% of eutrophic women had these same symptoms. Conclusion There is an association between BMI and climacteric symptoms, and overweight or obese women have more intense and moderate symptoms than eutrophic women.
Resumo Objetivo Verificar se há correlação entre o índice de massa corporal e os sintomas do climatério em mulheres na pós-menopausa. Métodos Participaram do estudo 109 mulheres na pós-menopausa, com idade média de 57± 8 anos, índice de massa corporal (IMC) médio de 30± 6kg/m2 e 8± 8 anos após a menopausa. Para a avaliação dos sintomas climatéricos, foram utilizados os questionários específicos para essa população: Índice de Kupperman-Blatt (IKB), Menopause Rating Scale (MRS), e Escala de Cervantes (EC). A análise dos dados foi realizada por meio do teste do chi-quadrado, análise de variância (analysis of variance, ANOVA, em inglês) com o teste post hoc de Bonferroni e regressão linear múltipla. O nível de significância adotado foi p<0,05. Todas as análises estatísticas foram realizadas no programa Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY, Estados Unidos), versão 26.0. Resultados A regressão linear múltipla mostrou associação positiva (p < 0,01) entre os valores do IMC e os sintomas do climatério quando ajustados pela idade e pelo tempo após a menopausa nos 3 questionários utilizados (IKB: B = 0,432; CE: B = 304; e MRS: B = 302). Quanto às pontuações dos sintomas, as mulheres com obesidade apresentaram médias maiores (p < 0,05) quando comparadas às mulheres eutróficas (IKB = 28 ± 10 e 20 ± 10; e MRS = 20± 10 e 13 ±7). Na análise pelo chi-quadrado 28% das mulheres obesas apresentaram sintomas graves, e 46%, moderados, ao passo que apenas 1% e 46% das eutrópicas apresentavam esses mesmos sintomas. Conclusão Há uma associação entre IMC e sintomas climatéricos, e mulheres com sobrepeso ou obesidade apresentam sintomas mais intensos e moderados do que mulheres eutróficas.
Assuntos
Humanos , Feminino , Climatério , Menopausa , ObesidadeRESUMO
OBJECTIVE: The purpose of the current study was to evaluate the modulation of Calcitonin gene-related peptide (CGRP) associated to the efficacy of Electroacupuncture (EA) in the reduction of climacteric symptoms. METHODS: Nine women between 51 and 59 years old with climacteric syndrome in menopause or perimenopause were included. Patients with hormone replacement therapy, psychiatric treatment with antidepressants, or acupuncture treatment in the last 3 months were excluded. A 4 Hz EA treatment was performed at acupoints Shenshu (BL-23), Pishu (BL-20), Guanyuan (REN-4), Taixi (KID-3), Fuliu (KID-7), Sanyinjiao (SP-6) and Neiguan (P-6) points. Women were treated two times a week for five consecutive weeks for a total treatment of 10 sessions. The menopause rating scale (MRS) was used to evaluate symptoms reduction and CGRP gene expression was measured before and after 10 EA session. RESULTS: The results shown that climacteric symptoms diminish significantly after EA therapy. CGRP gene expression was down-regulated, evidencing a decrease of 5-fold after EA therapy respect to the initial condition. CONCLUSION: EA treatment was associated with improvement in patients with climacteric syndrome and may be related to modulation of CGRP levels.
Assuntos
Terapia por Acupuntura , Climatério , Eletroacupuntura , Pontos de Acupuntura , Peptídeo Relacionado com Gene de Calcitonina , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
PURPOSE: The aim of this study is to compare climacteric symptomatology and sociodemographic conditions and their effect on quality of life in two populations: Monterrey (Mexico) and Madrid (Spain). METHODS: 469 women from Monterrey (mean age 50.5 + 4.3 years) and 452 (mean age 51.7 + 3.7 years) from Madrid participated in the study. Descriptive analyses of sociodemographic and clinics characteristics of the sample were performed. A cross-sectional design and a regression analysis were performed to establish the sociodemographic and clinical variables that would be used as predictors of quality of life. Data was collected using the Menopause-Specific Quality of Life, MENQOL, the Menopause Rating Scale (MRS), the Hospital Anxiety and Depression Scale (HADS), the Quality of Life Scale for Women Aged From 45 to 64 (QLS), and a sociodemographic and clinical interview designed ad hoc. RESULTS: Approximately 60% of both Spanish and Mexican women present symptoms during climacteric that impairs their quality of life. Spanish women suffer more intense symptoms and for a longer period of time than Mexican women, with the exception of anxiety. Mexican women report better quality of life than Spanish women and it is moderated by educational, socioeconomical, and marital status. Women's knowledge about menopause is also related to a better quality of life. CONCLUSIONS: Our study confirms the differences in climacteric symptomatology between populations and the impact of educational level and knowledge about menopause as predictors of a better quality of life in climacteric women.
Assuntos
Ansiedade/epidemiologia , Climatério/psicologia , Depressão/epidemiologia , Menopausa/psicologia , Adulto , Estudos Transversais , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , México/epidemiologia , Pessoa de Meia-Idade , Qualidade de Vida , Fatores Socioeconômicos , Espanha/epidemiologia , Inquéritos e QuestionáriosRESUMO
For 15 years, the Collaborative Group for Research of the Climacteric in Latin America (REDLINC) has been conducting research on several topics including age of menopause, metabolic syndrome, quality of life and climacteric symptoms, sexual dysfunction, poor quality of sleep and insomnia, and use of menopausal hormone therapy (MHT) in the general population and among gynecologists. Examples of data to have emerged for this region include the age of menopause (49 years), a high prevalence of metabolic syndrome (42.9%), and a new waist circumference cut-off value for the Latin American population (88 cm). Sexual dysfunction, poor quality of life, and sleep disorders have a prevalence of over 50%, with obesity and sedentary lifestyles affected importantly. MHT use is still low (12.5%), lack of prescription the most important reason for not using it, and gynecologists use MHT for themselves but do not recommend it often to their patients. The prevalence of alternative therapy use, recommended by physicians, is high.
Assuntos
Terapia de Reposição Hormonal/estatística & dados numéricos , Menopausa/fisiologia , Menopausa/psicologia , Feminino , Humanos , América Latina/epidemiologia , Síndrome Metabólica/epidemiologia , Obesidade/epidemiologia , Prevalência , Qualidade de Vida , Comportamento Sedentário , Sono , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Circunferência da CinturaRESUMO
BACKGROUND: Exercise and supplementation with isoflavones are therapies used to prevent and treat climacteric symptoms. AIM: To verify the effects of 10 weeks of combined aerobic and resistance training and isoflavone supplementation on climacteric symptoms in postmenopausal women. METHODS: A randomised, double-blind, controlled clinical trial was performed. A total of 32 postmenopausal women, aged 54.4 ± 5.4 years, with a body mass index of 26.6 ± 3.0 kg/m2 and 5.6 ± 4.6 years after menopause, were randomly assigned to groups: placebo and exercise (PLA + EXE, n = 15) or 100 mg of isoflavone and exercise (ISO + EXE, n = 17). At the beginning and after 10 weeks of aerobic + resistance (20 min each, moderate intensity) training, climacteric symptoms were evaluated using the Blatt-Kupperman Menopausal Index, Cervantes Scale and Menopause Rating Scale. ANCOVA was used for analysis between groups and at different times, with the covariate adjusted by the pre-value. The level of significance considered was p < 0.05. RESULTS: A reduction in climacteric symptoms was observed in both groups, without differences between the interventions. The reductions were 45% and 50% for the Blatt-Kupperman Menopausal Index, 41% and 52% for the MRS and 39% and 39% for the Cervantes Scale in the ISO + EXE and PLA + EXE groups, respectively. In the descriptive analysis of the Blatt-Kupperman Menopausal Index values, there was an increase in the absence of symptoms from 48-77% in the ISO + EXE group and 24-58% in the PLA + EXE group. CONCLUSIONS: A period of 10 weeks of combined training was effective in improving climacteric symptoms in post-menopausal women. However, isoflavone supplementation did not promote additional effects in improving symptoms.
Assuntos
Climatério , Transtorno Depressivo/prevenção & controle , Exercício Físico , Qualidade de Vida , Treinamento Resistido , Distúrbios do Início e da Manutenção do Sono/prevenção & controle , Vertigem/prevenção & controle , Brasil , Climatério/psicologia , Terapia Combinada , Transtorno Depressivo/etiologia , Transtorno Depressivo/fisiopatologia , Transtorno Depressivo/psicologia , Suplementos Nutricionais , Método Duplo-Cego , Exercício Físico/psicologia , Feminino , Seguimentos , Humanos , Isoflavonas/uso terapêutico , Pessoa de Meia-Idade , Fitoestrógenos/uso terapêutico , Pós-Menopausa , Autorrelato , Índice de Gravidade de Doença , Distúrbios do Início e da Manutenção do Sono/etiologia , Distúrbios do Início e da Manutenção do Sono/fisiopatologia , Distúrbios do Início e da Manutenção do Sono/psicologia , Vertigem/etiologia , Vertigem/fisiopatologia , Vertigem/psicologiaRESUMO
OBJECTIVES: To investigate women's subjective experiences in the climacteric transition, especially the impact of self-concept, quality of life and depression on the severity of climacteric symptoms. METHOD: Non-experimental, cross-sectional study, purpose sampling. To analyze the results, we proposed a three-way interaction, in which the direct effect of depression on the severity of climacteric symptoms would be buffered by perceived sexual quality of life, and mediated by self-concept. RESULTS: As hypothesized, depression significantly predicted self-concept, which in turn mediated the severity of climacteric symptoms. In a second stage of the model, sexual quality of life moderated the direct effect of depression on climacteric symptoms, such that women with a better sexual quality of life would perceive less severity of climacteric symptoms than those with a less favorable sexual quality of life. Physical quality of life did not significantly buffer the direct effect of depression on climacteric symptoms, nor did vasomotor or psychosocial quality of life. CONCLUSIONS: Our study confirmed the impact of subjective factors such as satisfaction, self-concept, and quality of life on climacteric symptoms; specifically, we observed the moderating effect of the sexual quality of life on the previously established correlation between depression and aggravation of climacteric symptoms.
Assuntos
Transtorno Depressivo/psicologia , Menopausa/psicologia , Autoimagem , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Qualidade de Vida , Índice de Gravidade de DoençaRESUMO
BACKGROUND: Sleep disturbances and pain are assumed to be reciprocally linked. Insomnia and pain are central symptoms of the postmenopausal period and are closely related. Insomnia affects quality of life, increases pain sensitivity, the risk of pain-related disability, and other health problems. OBJECTIVE: To investigate whether insomnia influences aspects of pain (pain intensity and the effect of pain on daily function) in postmenopausal women, and to evaluate the objective sleep pattern of insomniacs with pain. METHODS: Fifty-seven women completed questionnaires about insomnia, climacteric symptoms, and pain. Polysomnography data were collected as well as their medical history. Patients were allocated into three groups: control, subthreshold insomnia, and insomnia. Pain intensity, climacteric symptoms and objective sleep pattern were compared between groups. RESULTS: Postmenopausal women with insomnia had statistically significant higher pain interference in their activities (e.g. relationships with other people, enjoyment of life and sleep) than controls, and had more severe climacteric symptoms. There were no statistically significant differences in pain intensity and objective sleep pattern between groups. CONCLUSIONS: Insomnia status affected climacteric symptoms and pain interference, but not pain intensity in postmenopausal women. Women with insomnia had higher rates of climacteric symptoms than those without insomnia or those with subthreshold insomnia. No changes in objective sleep pattern were found.
Assuntos
Dor Crônica/psicologia , Pós-Menopausa/psicologia , Distúrbios do Início e da Manutenção do Sono/psicologia , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Medição da Dor , Inquéritos e QuestionáriosRESUMO
Introducción: la expresión clínica del síndrome climatérico se asocia con el estilo de vida de la mujer. Factores socioculturales, ambientales y laborales influyen en la calidad de vida.Objetivo: identificar la relación entre la percepción de la sintomatología del síndrome climatérico y el estilo de vida en las mujeres de mediana edad estudiadas.Métodos: se realizó una investigación descriptiva, de corte transversal, con un diseño no experimental en el consultorio 17 del Policlínico "Luis A. Turcios Lima", del municipio 10 de Octubre, desde el 1ro de junio de 2014 hasta el 31 de mayo de 2015. Se entrevistaron 91 mujeres entre 40 y 59 años. Se aplicó la encuesta para medir la intensidad del síndrome climatérico y la encuesta para el estudio del estilo de vida.Resultados: en la percepción de los síntomas climatéricos, la cuarta parte eran asintomáticas y los síntomas leves fueron percibidos en 37,4 por ciento de las pacientes. Casi la totalidad de las mujeres que tenían un estilo de vida saludable, eran asintomáticas o su percepción de los síntomas era leve; 42,8 por ciento presentó síntomas moderados o intensos. En el área de salud, predominaron las mujeres entre 55 y 59 años de piel blanca, universitarias y trabajadoras.Conclusiones: un estilo de vida no saludable se relaciona con el síndrome climatérico de intensidad moderada o intensa. Las condiciones físicas inadecuadas, la autoestima baja y no disponer de tiempo libre; se relacionaron con una mayor intensidad del síndrome climatérico(AU)
Introduction: the clinical expression of the climacteric syndrome is associated with the lifestyles of women. Sociocultural, environmental and occupational factors influence the quality of life.Objective: identify the relationship between perception of climacteric symptoms and lifestyle in the middle-aged women studied.Methods: a descriptive cross-sectional non-experimental study was conducted at Consultation Office 17 of Luis A. Turcios Lima Polyclinic, in the municipality of 10 de Octubre, from 1 June 2014 to 31 May 2015. Interviews were conducted with 91 women aged 40-59. Two surveys were applied: one to gauge the intensity of the climacteric syndrome and the other to study lifestyle.Results: with respect to perception of climacteric symptoms, one fourth of the patients were asymptomatic. Mild symptoms were perceived by 37.4 percent. Almost all the women who had a healthy lifestyle were either asymptomatic or their perception of symptoms was mild; 42.8 percent had either moderate or intense symptoms. In the health area there was a predominance of white women of the 55-59 age group who were workers and university graduates.Conclusions: an unhealthy lifestyle is associated with a climacteric syndrome of moderate to high intensity. Inadequate physical conditions, a low self-esteem and lack of free time are related to a greater intensity of the climacteric syndrome(AU)
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Climatério , Estilo de VidaRESUMO
Introducción: la expresión clínica del síndrome climatérico se asocia con el estilo de vida de la mujer. Factores socioculturales, ambientales y laborales influyen en la calidad de vida. Objetivo: identificar la relación entre la percepción de la sintomatología del síndrome climatérico y el estilo de vida en las mujeres de mediana edad estudiadas. Métodos: se realizó una investigación descriptiva, de corte transversal, con un diseño no experimental en el consultorio 17 del Policlínico Luis A. Turcios Lima, del municipio 10 de Octubre, desde el 1ro de junio de 2014 hasta el 31 de mayo de 2015. Se entrevistaron 91 mujeres entre 40 y 59 años. Se aplicó la encuesta para medir la intensidad del síndrome climatérico y la encuesta para el estudio del estilo de vida. Resultados: en la percepción de los síntomas climatéricos, la cuarta parte eran asintomáticas y los síntomas leves fueron percibidos en 37,4 por ciento de las pacientes. Casi la totalidad de las mujeres que tenían un estilo de vida saludable, eran asintomáticas o su percepción de los síntomas era leve; 42,8 por ciento presentó síntomas moderados o intensos. En el área de salud, predominaron las mujeres entre 55 y 59 años de piel blanca, universitarias y trabajadoras. Conclusiones: un estilo de vida no saludable se relaciona con el síndrome climatérico de intensidad moderada o intensa. Las condiciones físicas inadecuadas, la autoestima baja y no disponer de tiempo libre; se relacionaron con una mayor intensidad del síndrome climatérico(AU)
Introduction: the clinical expression of the climacteric syndrome is associated with the lifestyles of women. Sociocultural, environmental and occupational factors influence the quality of life. Objective: identify the relationship between perception of climacteric symptoms and lifestyle in the middle-aged women studied. Methods: a descriptive cross-sectional non-experimental study was conducted at Consultation Office 17 of Luis A. Turcios Lima Polyclinic, in the municipality of 10 de Octubre, from 1 June 2014 to 31 May 2015. Interviews were conducted with 91 women aged 40-59. Two surveys were applied: one to gauge the intensity of the climacteric syndrome and the other to study lifestyle. Results: with respect to perception of climacteric symptoms, one fourth of the patients were asymptomatic. Mild symptoms were perceived by 37.4 percent. Almost all the women who had a healthy lifestyle were either asymptomatic or their perception of symptoms was mild; 42.8 percent had either moderate or intense symptoms. In the health area there was a predominance of white women of the 55-59 age group who were workers and university graduates. Conclusions: an unhealthy lifestyle is associated with a climacteric syndrome of moderate to high intensity. Inadequate physical conditions, a low self-esteem and lack of free time are related to a greater intensity of the climacteric syndrome(AU)
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Climatério/psicologia , Serviços de Saúde da Mulher , Estilo de Vida , Percepção Social , Epidemiologia Descritiva , Estudos Transversais , Anos de Vida Ajustados por Qualidade de VidaRESUMO
Every woman experiences the menopause transition period in a very individual way. Menopause symptoms and management are greatly influenced by socioeconomic status in addition to genetic background and medical history. Because of their very unique cultural heritage and often holistic view of health and well-being, menopause symptoms and management might differ greatly in aboriginals compared to non-aboriginals. Our aim was to investigate the extent and scope of the current literature in describing the menopause experience of aboriginal women. Our systematic literature review included nine health-related databases using the keywords 'menopause' and 'climacteric symptoms' in combination with various keywords describing aboriginal populations. Data were collected from selected articles and descriptive analysis was applied. Twenty-eight relevant articles were included in our analysis. These articles represent data from 12 countries and aboriginal groups from at least eight distinctive geographical regions. Knowledge of menopause and symptom experience vary greatly among study groups. The average age of menopause onset appears earlier in most aboriginal groups, often attributed to malnutrition and a harsher lifestyle. This literature review highlights a need for further research of the menopause transition period among aboriginal women to fully explore understanding and treatment of menopause symptoms and ultimately advance an important dialogue about women's health care.
Assuntos
Conhecimentos, Atitudes e Prática em Saúde/etnologia , Menopausa/etnologia , Saúde da Mulher/etnologia , Adulto , Austrália/etnologia , Bolívia/etnologia , Canadá/etnologia , Colômbia/etnologia , Feminino , Guatemala/etnologia , Serviços de Saúde do Indígena , Humanos , Índia/etnologia , Malásia/etnologia , México/etnologia , Pessoa de Meia-Idade , Nova Zelândia/etnologia , Peru/etnologia , Grupos Populacionais , Classe Social , Taiwan/etnologia , Estados Unidos/etnologiaRESUMO
BACKGROUND: Latin-American women present a greater severity of climacteric symptoms than women from other parts of the world. Previous studies suggest that this could be due to either its Amerindian crossbreeding or the altitude in which a huge proportion of the Latin-American population lives. OBJECTIVE: To answer this question, climacteric symptoms between Peruvian women ("Hispanic-Mestizas" and "Quechuas") living in similar altitude (around 3000 MASL) were compared. METHOD: This is a cross sectional descriptive study of healthy women of 40-59 years of age living in Departamento de El Cusco, Peru. Using the MRS questionnaire climacteric symptoms were assessed in 395 "Hispanic-Mestizas" (Quechua-Spaniard breeding) and 376 pure "Quechuas". RESULTS: The "Quechuas" compared with "Hispanic-Mestizas" have comparable similar age, but less: obesity, schooling years, cigarette smoking, use of hormonal therapy, diabetes and hypertension; and a greater: proportion of postmenopausal women and number of children. "Quechuas" showed a greater prevalence in ten of the eleven symptoms evaluated by the MRS scale, except for insomnia. The total MRS score was 14.54±7.51 vs. 9.87±6.26 (p<0.0001), respectively. As a consequence of this, 46.5% of the "Quechuas" had a deteriorated quality of life due to severe climacteric symptomatology, compared to only 14.2% of "Hispanic-Mestizas" women (p<0.0001). After adjusting for confounding variables menopause was associated with increased risk of severe menopausal symptoms (OR: 5.86, 95% CI: 3.93-8.75), followed by lack of partner (OR: 3.52, 95% CI: 1.91-6.48), arterial hypertension (OR: 2.62, 95% CI: 1.28-5.39) and Quechua being (OR: 2.38, 95% CI: 1.27-4.45). CONCLUSIONS: Peruvian "Quechuas" women have severer climacteric symptoms than the Peruvian "Hispanic-Mestizas" who live in a comparable altitude. This could suggest that the ethnicity could be one of the factors that could explain the augmented symptoms in Latin-American climacteric woman.
Assuntos
Climatério/etnologia , Indígenas Sul-Americanos , Adulto , Altitude , Climatério/fisiologia , Climatério/psicologia , Estudos Transversais , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Peru , Qualidade de Vida/psicologia , Inquéritos e QuestionáriosRESUMO
Introducción: la mayoría de los estudios sobre la sintomatología de la menopausia se han realizado entre mujeres caucásicas de la cultura occidental, lo que lleva a la inquietud de si sus hallazgos son aplicables a mujeres de otros grupos étnicos/raciales. Hay un creciente interés en estudiar el papel de la etnia/raza en los síntomas de la menopausia. Objetivo: revisar la literatura, identificando estudios que comparen los síntomas menopáusicos en diferentes etnias/razas. Materiales y métodos: se realizó una búsqueda electrónica en PubMed, Cochrane y SciELO con las palabras clave "menopause", "ethnicity" y "race". Se incluyeron estudios que compararan la presentación de síntomas climatéricos en diferentes etnias. Debido a la dificultad para la comparación de los resultados, no se incluyeron estudios realizados en una sola población étnica. Resultados: se identificaron 55 estudios, de los cuales 19 cumplieron con los criterios de inclusión. La prevalencia de los síntomas menopáusicos difirió entre los grupos étnicos y se observaron contrastes en la percepción y la experiencia de la menopausia entre las culturas. Conclusión: los resultados de estos estudios no apoyan un único síndrome menopáusico. El entendimiento de las diferencias entre los grupos étnicos puede mejorar la calidad de la atención en salud que se le brinda a la mujer y promover estilos de vida que contribuyan a disminuir su incidencia y severidad y mejorar la calidad de vida de la mujer.
Introduction: most studies about the symptomatology of menopause have been done on Caucasian females living in western culture, leading to worry about whether their findings are really applicable to females from other ethnic/ racial groups. There is growing interest in studying the role of ethnic groups/race in the symptoms of menopause. Objective: reviewing the literature identifying studies comparing menopausal symptoms in different ethnic groups/races. Materials and methods: PubMed, Cochrane and SciELO databases were searched using the key words "menopause", "ethnicity", "race". Studies were included which compared the presentation of climacteric symptoms in different ethnic groups; studies carried out on a single ethnic population were not included due to the subsequent difficulty in comparing results. Results: 55 studies were identified, of which 19 fulfilled the inclusion criteria. The prevalence of menopausal symptoms differed between ethnic groups and differences were observed concerning the perception and experience of menopause amongst cultures. Conclusion: the results of these studies did not support a single menopausal syndrome. Understanding the differences between ethnic groups could improve the quality of healthcare attention being provided for females and promote lifestyles contributing towards reducing the symptoms' incidence and severity, thereby improving females' quality of life.
Assuntos
Humanos , Feminino , Climatério , Grupos Raciais , Etnicidade , MenopausaRESUMO
Objetivos: Avaliar a eficácia e tolerabilidade da associação transdérmica de estradiol e noretisterona, em regime combinado contínuo, em mulheres na pós-menopausa. Casuística e Métodos: Foram estudadas 40 pacientes, com média etária de 56,7 anos em estudo prospectivo, aberto e não comparativo. As pacientes receberam a associação de estradiol e noretisterona em regime combinado contínuo pelo período de seis meses, seguidos de extensão por período de mais um ano. Avaliaram-se os sintomas menopausais por meio do índice de Kupperman, além de parâmetros clínicos e ultra-sonográficos (peso, pressão arterial, espessura endometrial) e aspectos relacionados aos eventos adversos e às manifestações cutâneas, através de exame dermatológico. Resultados: Houve melhora global dos sintomas menopausais avaliados pelo índice de Kupperman. A análise detalhada dos sintomas moderados e graves demonstrou melhora significativa dos fogachos, sudorese, parestesia, fadiga, irritabilidade e psicolabilidade, com início ao terceiro mês de tratamento, mantendo-se até o final do período de avaliação. Eritema e prurido no local da aplicação do adesivo foram os eventos cutâneos mais comuns, ocorrendo em 12,1% e 3,0% das pacientes, respectivamente. Discreta taxa de eventos adversos foi observada. Conclusão: A TH transdérmica, contendo estradiol e noretisterona de uso contínuo, mostrou-se efetiva no alívio sintomático em mulheres climatéricas, associando-se a uma discreta taxa de eventos adversos e boa tolerabilidade.