RESUMO
Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significant reduction in total serum cholesterol and triglycerides, and an increase in HDL-C. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect.
Assuntos
Anti-Inflamatórios/farmacologia , Dislipidemias/tratamento farmacológico , Ericales/química , Hipolipemiantes/farmacologia , Inflamação/prevenção & controle , Lipídeos/sangue , Extratos Vegetais/farmacologia , Óleos de Plantas/farmacologia , Animais , Anti-Inflamatórios/isolamento & purificação , Biomarcadores/sangue , Carragenina , Células Cultivadas , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Dislipidemias/sangue , Dislipidemias/induzido quimicamente , Frutas/química , Humanos , Hipolipemiantes/isolamento & purificação , Inflamação/induzido quimicamente , Neutrófilos/efeitos dos fármacos , Neutrófilos/metabolismo , Peroxidase/metabolismo , Fitoterapia , Extratos Vegetais/isolamento & purificação , Óleos de Plantas/isolamento & purificação , Plantas Medicinais , Polietilenoglicóis , Ratos Wistar , Fatores de TempoRESUMO
The pequi fruit (Caryocar coriaceum Wittm) has a great economic interest, regarding the use of its fruits in cooking as a source of vitamins and extraction of oils for the manufacture of cosmetics. However, are unknown studies on the thermophysical properties (specific heat, thermal diffusivity and thermal conductivity), in which properties are very important to the pulp being favored in an industrial level. The work in question was aimed at studying the physical properties of the pequi pulp with levels of total soluble solids of 6, 8, 10 and 12 °Brix. The physical properties were studied: specific heat, thermal diffusivity and thermal conductivity. The specific heat of the pulps was determined using the method of mixtures, the thermal diffusivity was determined using the method proposed by Dickerson and the thermal conductivity KD-2 equipment. Therefore, it was found that the specific heat tended to increase with the increase of temperature and total soluble solids content of the pulp. The thermal diffusivity of the pequi pulp decreased with the increase in total soluble solids; the thermal conductivity of the pulp did not show a definite increase in temperature trend in the pulps investigated.
O fruto do pequi (Caryocar coriaceum Wittm) possui um grande interesse econômico, no que se refere ao uso de seus frutos na culinária como fonte de vitaminas e na extração de óleos para a fabricação de cosméticos. Todavia, são desconhecidos estudos voltados para as propriedades termofísicas (calor específico, difusividade térmica e condutividade térmica), nas quais são propriedades de suma importância para que a polpa seja beneficiada a nível industrial. O trabalho em questão teve como objetivo estudar as propriedades físicas da polpa de pequi com teores de sólidos solúveis totais de 6, 8, 10 e 12 oBrix. As propriedades físicas estudadas foram: calor específico, difusividade térmica e condutividade térmica. O calor específico das polpas foi realizado por meio do calorímetro de mistura, a difusividade térmica utilizando-se o método do cilindro de Dickerson e a condutividade térmica no equipamento KD-2. Portanto, constatou-se que o calor específico apresentou tendência de aumento com o aumento da temperatura e do teor de sólidos solúveis totais das polpas. A difusividade térmica da polpa de pequi diminui com o aumento dos sólidos solúveis totais, a condutividade térmica das polpas não apresentou uma tendência definida com o aumento da temperatura nas polpas estudadas.
Assuntos
Condutividade Térmica , Magnoliopsida , PradariaRESUMO
The ethyl acetate extract from the fruit pulp of Caryocar coriaceum Wittm (Caryocaraceae), popularly known as pequi, has wide applications in popular medicine. Preclinical tests have demonstrated the therapeutic properties of the oil. We investigated the antinociceptive and anti-inflammatory effects of Pequi C. coriaceum Wittm ethyl acetate extract (PCCO) on zymosan-induced arthritis in rat knee joint. The animals were pretreated with PCCO for 7 consecutive days or with a single dose. Paw elevation time (PET), leukocyte infiltration, myeloperoxidase activity (MPO) and cytokine levels were assessed 4h after zymosan injection. Synovial tissue was harvested for immunohistochemical analysis, edema and vascular permeability. We observed a significant decrease in PET with PCCO pretreatment. PCCO showed a significant reduction of leukocyte migration and a decrease in MPO. Decreases were observed in cytokine release in the synovial fluid and TNF-α and cyclooxygenase-1 immunostaining in synovial tissue. Edema was inhibited by treatment with all doses of PCCO. The data suggest that PCCO exerts antinociceptive and anti-inflammatory effects on arthritis in rats.