RESUMO

The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.

Assuntos

Anti-Inflamatórios/síntese química , Chalcona/química , Administração Oral , Animais , Anti-Inflamatórios/química , Anti-Inflamatórios/uso terapêutico , Área Sob a Curva , Chalcona/síntese química , Chalcona/uso terapêutico , Modelos Animais de Doenças , Edema/induzido quimicamente , Edema/tratamento farmacológico , Curva ROC , Ratos