1.
Bioorg Med Chem Lett
; 23(20): 5519-22, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24012185
RESUMO
The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.