RESUMO

Salmonella enterica serovar Heidelberg ranks among the most prevalent causes of human salmonellosis in the United States and Canada, although it has been infrequently reported in South American and European countries. Most Salmonella infections are self-limiting; however, some invasive infections require antimicrobial therapy. In this work we characterized an oxyimino-cephalosporin resistant S. Heidelberg isolate recovered from an inpatient in a Buenos Aires hospital. CMY-2 was responsible for the ß-lactam resistance profile. S. Heidelberg contained a 97kb plasmid belonging to the Inc N group harboring blaCMY-2. ISEcp1 was located upstream blaCMY-2 driving its expression and mobilization. The isolate belonged to sequence type 15 and virotyping revealed the presence of sopE gene. In this study we identified the first CMY-2 producing isolate of S. Heidelberg in Argentina and even in South America.

Assuntos

Proteínas de Bactérias/genética , Fatores R/genética , Infecções por Salmonella/microbiologia , Salmonella enterica/genética , beta-Lactamases/genética , Adulto , Argentina , Elementos de DNA Transponíveis , Gastroenterite/complicações , Gastroenterite/microbiologia , Ordem dos Genes , Genes Bacterianos , Infecções por HIV/complicações , Humanos , Infecções por Salmonella/complicações , Infecções por Salmonella/epidemiologia , Salmonella enterica/classificação , Salmonella enterica/efeitos dos fármacos , Salmonella enterica/enzimologia , Sorotipagem , América do Sul/epidemiologia