RESUMO

The set of singular values of a digraph with respect to a vertex-degree based topological index is the set of all singular values of its general adjacency matrix. The spectral norm is the largest singular value and the energy the sum of the singular values. In this paper we characterize the digraphs which have exactly one singular value different from zero and the digraphs for which all singular values are equal. As a consequence, we deduce sharp upper and lower bounds for the spectral norm and energy of digraphs. In addition to being a natural generalization, proving the results in the general setting of digraphs allows us to deduce new results on graph energy.

RESUMO

Homicide is one of the most important mortality causes that has reduced the Mexican life expectancy. That is why the aim of this work is to identify some sociodemographic and economic factors that can help explain homicides in Mexico and measure their impact, assuming the current conditions prevail. To do that, several Machine Learning (ML) methods were evaluated. The C5.0 model is best suited for the data at hand. After fine-tuning the algorithm, we used the estimated model to identify the main factors that explain homicides. Among these factors, eleven were selected that can be influenced by direct changes in domestic public policy, laws and/or regulations. These were used as input in a two-level fractional factorial Statistical Design of Experiments (DOE) to estimate their main effects and possible interactions. Although several of these factors had statistically significant effects on homicide rate, the one that had the biggest and direct impact from a practical perspective, was the Rule of Law Index (RLI). In fact, if we assumed that all states had the median RLI of 0.37, implementing domestic policies and procedures to move them all to the best RLI level could significantly reduce homicide rates.

El homicidio es una de las principales causas de muerte que ha reducido la esperanza de vida de los mexicanos. El objetivo de este trabajo es identificar algunos factores sociodemográficos y económicos que puedan ayudar a explicar homicidios en México y medir su impacto, suponiendo que las condiciones actuales permanecen. Para lograrlo, comparamos diferentes métodos de Aprendizaje de Máquina (AM). Para tal fin, se encuentra que el modelo C5.0 es el más adecuado. Después de hacer una calibración final del modelo, lo utilizamos para determinar los veinticinco principales factores que explican el fenómeno de homicidios. Se seleccionan 11 factores que se consideran pueden ser influenciados directamente por cambios en políticas públicas, leyes y/o regulaciones. Estos predictores fueron utilizados como entrada en un diseño de experimentos factorial fraccionado con dos niveles para estimar los principales efectos principales e interacciones posibles. A pesar de que varios de estos factores tuvieron impactos estadísticamente significativos, el que mostró tener el mayor impacto directo desde una perspectiva práctica fue el Índice de Estado de Derecho (IED). De hecho, asumiendo que todos los estados tuvieran el valor de IED de 0.37, correspondiente a la mediana en todo el país, si se implementaran políticas y procedimientos para ubicar a todos los estados al nivel del mejor estado en términos de IED, se lograría una reducción altamente significativa en la incidencia de homicidios en México.

RESUMO

BACKGROUND This study aimed to produce carotenoids of two bacterial strains obtained and isolated from Caatinga soil in Northeastern Brazil and to evaluate their antioxidant and photoprotective activities. The morphological identification of bacteria was performed by Gram staining and molecularly confirmed through the 16S rRNA gene. The production of carotenoids was performed on two 23 factorial designs to analyze the influence of independent variables (temperature range, luminosity, agitation, spiral presence, and bacterial isolate type) for maximum carotenoid yield. The selected condition has been transferred to a bioreactor (10L). The identification of carotenoids was performed by liquid chromatography (HPLC) and mass spectrometry (LC-MS). Antioxidant activity was determined by inhibiting the bcarotene/linoleic acid system and the effectiveness as sunscreen was measured through its sun protection factor (SPF). RESULTS The results revealed that the isolates FT-7.22 and FT-5.12 were identified as Kocuria palustris; producers of a rare C50 carotenoid sarcinaxanthin. This is the first report on the production of carotenoids by this species from the Caatinga Domain. The pigment that was obtained from the Tryptic Soy Broth (TSB) medium in the best conditions of the factorial designs (increased agitation, aeration, and light exposure) exhibited a significant increase in the carotenoid production. The isolated FT-7.22 reached a higher sarcinaxanthin concentration (112,480 lg/L), and it exhibited promising antioxidant (76.53 ± 0.09%) and photoprotective activities (SPF = 9.36 ± 0.52). CONCLUSIUON This study demonstrated the ability of K. palustris to produce carotenoid sarcinaxanthin with antioxidant and photoprotective activities so that it can be applied in cosmetic formulations. How to cite: Mendes-Silva TCD, Vidal EE, de Souza RFR, et al. Production of carotenoid sarcinaxant

Assuntos

RESUMO

OBJECTIVE: The aim of the study was to demonstrate the clinical and economic impact of two PD-L1 IHC assays, SP142 versus 22C3, to identify the eligibility of the patients with advanced triple negative breast cancer (aTNBC) to the treatment with atezolizumab plus nab-paclitaxel in the Brazilian private healthcare system (BPHS). METHODS: The study performed a cost-effectiveness analysis based on a partitioned-survival model with three mutually exclusive health states: progression-free (PF), progression, and death. Data of progression-free survival and overall survival were extracted from a retrospective exploratory analysis of IMpassion130, an analytical harmonization of PD-L1 IHC assays. The analyses included only direct costs (drug acquisition and management of adverse events) that were based on CBHPM (Classificação Brasileira Hierarquizada de Procedimentos Médicos) and CMED PF18% (Câmara de Regulação do Mercado de Medicamentos) tables. A probabilistic sensitivity analysis was performed as a second-order Monte Carlo Simulation in order to evaluate the uncertainties of the model. RESULTS: The SP142 assay has the potential to improve PFS and generate savings to the BPHS. The incremental cost-effectiveness ratio (ICER) was -USD 4,119.43 per month of progression-free survival. CONCLUSIONS: The SP142 assay demonstrated to be a dominant alternative compared to 22C3 to guide the treatment with atezolizumab plus nab-paclitaxel in patients with aTNBC.

Assuntos

RESUMO

Cyperus difformis L. é planta daninha ocorrente em lavouras de arroz irrigado, que tem apresentado dificuldade de controle devido à resistência a herbicidas inibidores de ALS. O objetivo da pesquisa foi estimar a dose necessária para controlar 50% da população (C50) e reduzir 50% da produção de massa da parte aérea seca (GR50) em biótipo resistente e suscetível de C. difformis e avaliar o controle destes biótipos com herbicidas alternativos recomendados para a espécie. Para isso, foram conduzidos dois experimentos em casa de vegetação, em delineamento experimental completamente casualizado, com quatro repetições. O experimento I constou de biótipo resistente (CYPDI 9) e suscetível (CYPDI 8) de C. difformis e doses do herbicida pyrazosulfuron-ethyl, correspondendo a 0; 0,5; 1; 1,5; 2; 2,5; 3; 4; 6; 8; 16; 32 e 64 vezes a dose registrada (20 g ha-1). As variáveis avaliadas foram controle visual e massa da parte aérea seca (MPAS) aos 28 dias após a aplicação dos tratamentos (DAT). No experimento II os tratamentos constaram dos biótipos (CYPDI 9 e CYPDI 8), nove herbicidas: azimsulfuron (6g ha-1); bentazon (900g ha-1); bispyribac-sodium (48g ha-1); carfentrazone-ethyl (40g ha-1); ethoxysulfuron (72g ha-1); glyphosate (900g ha-1); penoxsulam (36g ha-1); propanil (3600g ha-1) e pyrazosulfuron-ethyl (20g ha-1) e testemunha que não recebeu herbicida. As variáveis avaliadas foram: controle visual aos 14, 21 e 28 DAT, área foliar (AF) e MPAS aos 28 DAT. A resistência do biótipo de C. difformis ao pyrazosulfuron-ethyl é elevada e inviabiliza seu controle pelo herbicida e, os herbicidas carfentrazone-ethyl, bentazon e propanil, detentores de mecanismos de ação alternativos ao pyrazosulfuron-ethyl, controlam o biótipo resistente de C. difformis.

Cyperus difformis L. is a weed occurrence in flooded rice, that it has been presenting control difficulty due to ALS inhibiting herbicides resistance. The objectives of this work was to determine necessary rate 50% control of the population (C50) and reduce 50% of the production the aerial dry mass (GR50) in resistant and susceptible biotypes of C. difformis and evaluate the control of these biotypes with alternative herbicides recommended for that species. For that, two experiments were performed at green house of FAEM/UFPel arranged in a completely randomized design, with four replicates. The experiment I were consisted of resistant (CYPDI 9) and susceptible of C. difformis biotype and rate of the pyrazosulfuron-ethyl herbicide, corresponding to 0, 0,5, 1, 1,5, 2, 2,5, 3, 4, 6, 8, 16, 32 and 64 times de registered rate (20g ha-1). The evaluated variables were visual control and aerial dry mass (MPAS) to the 28 days after the application of the treatments (DAT). In the experiment II the treatments were consisted of the same biotype (CYPDI 9 and CYPDI 8), nine herbicides azimsulfuron (6g ha-1); bentazon (900g ha-1); bispyribac-sodium (48g ha-1); carfentrazone-ethyl (40g ha-1); ethoxysulfuron (72g ha-1); glyphosate (900g ha-1); penoxsulam (36g ha-1); propanil (3600g ha-1) and pyrazosulfuron-ethyl (20g ha-1) and checks that didn't applied herbicide. The evaluated variables were: visual control for the herbicides to the 14, 21 and 28 DAT, foliate area and MPAS to 28 DAT. Before the results, it can be concluded that the resistance of the C. difformis biotype to pyrazosulfuron-ethyl is elevated and it makes unfeasible her control for the herbicide and the herbicides carfentrazone-ethyl, bentazon e propanil holders of alternative action mechanisms to the pyrazosulfuron-ethyl, control the resistant biotype of C. difformis.

Assuntos

RESUMO

Cyperus difformis L. is a weed occurrence in flooded rice, that it has been presenting control difficulty due to ALS inhibiting herbicides resistance. The objectives of this work was to determine necessary rate 50% control of the population (C50) and reduce 50% of the production the aerial dry mass (GR50) in resistant and susceptible biotypes of C. difformis and evaluate the control of these biotypes with alternative herbicides recommended for that species. For that, two experiments were performed at green house of FAEM/UFPel arranged in a completely randomized design, with four replicates. The experiment I were consisted of resistant (CYPDI 9) and susceptible of C. difformis biotype and rate of the pyrazosulfuron-ethyl herbicide, corresponding to 0, 0,5, 1, 1,5, 2, 2,5, 3, 4, 6, 8, 16, 32 and 64 times de registered rate (20g ha-1). The evaluated variables were visual control and aerial dry mass (MPAS) to the 28 days after the application of the treatments (DAT). In the experiment II the treatments were consisted of the same biotype (CYPDI 9 and CYPDI 8), nine herbicides azimsulfuron (6g ha-1); bentazon (900g ha-1); bispyribac-sodium (48g ha-1); carfentrazone-ethyl (40g ha-1); ethoxysulfuron (72g ha-1); glyphosate (900g ha-1); penoxsulam (36g ha-1); propanil (3600g ha-1) and pyrazosulfuron-ethyl (20g ha-1) and checks that didn"t applied herbicide. The evaluated variables were:

Cyperus difformis L. é planta daninha ocorrente em lavouras de arroz irrigado, que tem apresentado dificuldade de controle devido à resistência a herbicidas inibidores de ALS. O objetivo da pesquisa foi estimar a dose necessária para controlar 50% da população (C50) e reduzir 50% da produção de massa da parte aérea seca (GR50) em biótipo resistente e suscetível de C. difformis e avaliar o controle destes biótipos com herbicidas alternativos recomendados para a espécie. Para isso, foram conduzidos dois experimentos em casa de vegetação, em delineamento experimental completamente casualizado, com quatro repetições. O experimento I constou de biótipo resistente (CYPDI 9) e suscetível (CYPDI 8) de C. difformis e doses do herbicida pyrazosulfuron-ethyl, correspondendo a 0; 0,5; 1; 1,5; 2; 2,5; 3; 4; 6; 8; 16; 32 e 64 vezes a dose registrada (20 g ha-1). As variáveis avaliadas foram controle visual e massa da parte aérea seca (MPAS) aos 28 dias após a aplicação dos tratamentos (DAT). No experimento II os tratamentos constaram dos biótipos (CYPDI 9 e CYPDI 8), nove herbicidas: azimsulfuron (6g ha-1); bentazon (900g ha-1); bispyribac-sodium (48g ha-1); carfentrazone-ethyl (40g ha-1); ethoxysulfuron (72g ha-1); glyphosate (900g ha-1); penoxsulam (36g ha-1); propanil (3600g ha-1) e pyrazosulfuron-ethyl (20g ha-1) e testemunha que não recebeu herbicida. As variáveis avaliadas foram: contr