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SUMMARY OBJECTIVE: This study aimed to evaluate the relationship between the toxicity of cyclin-dependent kinase 4/6 inhibitors and body mass index and body surface area. METHODS: A total of 83 patients were included in the study. Patients were divided into 4 groups as 18-24.9, 25-29.9, 30-39.9, and >40 kg/m2 according to body mass index and into two groups as below and above 1.77 according to body surface area. The relationship between body mass index and body surface area and side effects was evaluated. RESULTS: No statistically significant difference was found between body mass index groups and side effects. Grade 3 neutropenia was more common in patients on palbociclib with a body surface area≤1.77. In our study, it was revealed that less hematological side effects can be encountered when body surface area is taken into account.

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ABSTRACT The assessment of the nutritional status of hospitalized patients is fundamental to the establishment of the diagnosis. For bedridden patients, however, it is not possible to determine simple measures, such as weight and height, which are the most widely used variables for nutritional assessments. Objective: Compare real and estimated anthropometric measures in hospitalized patients. Methods: A cross-sectional study was conducted with adult (>18 years of age) and senior patients (>60 years of age) admitted for clinical or surgical treatment in the general surgery infirmary of Governador Paulo Guerra Restauração Hospital. Data (sex, age, clinical diagnosis, real weight, real height, body mass index, knee height and arm circumference) were collected using nutritional follow-up charts and tabulated using Excel 2016. Statistical analyses were performed in SPSS® version 21.0. Results: One hundred and twenty patients participated in the study (median age: 55 years). Most were adults (73.3%) and women (53.3%). The mean differences in weight between the estimated and real measures were statistically significant (p=0.000), with an overestimation of this variable. Regarding height, the estimated values differed significantly from the real values in both men and women (p<0.000) and the difference was larger among the seniors (mean: -0.072). No significant difference was found between the real and estimated body mass index (p= 0.44). Conclusion: In the comparison of methods for estimating weight and height to real measures, a tendency was found to overestimate these body measures.

RESUMEN La evaluación del estado nutricional de los pacientes hospitalizados es esencial para establecer su diagnóstico. Sin embargo, para los pacientes postrados en cama, no se pueden realizar medidas sencillas como el peso y la altura, que son las más utilizadas para el diagnóstico nutricional. Objetivo: Comparar mediciones antropométricas reales y estimadas en pacientes hospitalizados. Metodología: Estudio transversal, que incluye pacientes adultos (>18 años) y personas mayores de 60 años, ingresados para tratamiento clínico o quirúrgico en la sala de cirugía general del Hospital da Restauração Governador Paulo Guerra. Los datos (sexo, edad, diagnóstico clínico, peso real, altura real, índice de masa corporal, altura de la rodilla y circunferencia del brazo) se recopilaron mediante los formularios de monitoreo nutricional y se tabularon en el software Excel 2016. Los análisis estadísticos se realizaron con SPSS®, versión 21.0. Resultados: 120 pacientes con mediana de 55 años, en su mayoría adultos (73,3%) y mujeres (53,3%). Las diferencias promedio entre las mediciones estimadas y reales fueron estadísticamente significativas, con sobreestimación del peso (p<0,0001). Con respecto a la altura, fue posible identificar que las medidas estimadas diferían significativamente (p<0,0001) de las reales para hombres y mujeres, y que esta variación era aún mayor entre los ancianos (media: -0,072). No hubo diferencias estadísticamente significativas entre el índice de masa corporal real y el estimado (p= 0,44). Conclusión: Al comparar las metodologías para estimar el peso y la altura con las mediciones reales, fue posible observar una tendencia de los métodos a sobreestimar estas mediciones corporales.

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We evaluated the live weight (LW), morphological and testicular measures and their correlations in 31 Mediterranean buffaloes at three ages. We used seven animals at 8 months of age (T1), 13 animals at the age of 10 months (T2), and 11 animals at the age of 12 months (T3) coming from a farm of the Coastal Lowlands of Rio de Janeiro. The following morphometric measurements and testes were evaluated: rump height (RH), withers height (WH), rump length (RL), round thickness (RT), scrotal circumference (SC), testicular length (TL), testicular width (TW). Testicular volume (TV) and body mass index (BMI) were also calculated. The testicular form was determined by the ratio between the TW and TL. We found the following means for the variables LW (240.57 ± 18.36; 259.38 ± 28.66; and 331.82 ± 63.23), WH (113.28 ± 2.44; 116.23 ± 4.74; and 121.45 ± 6.95cm), RH (116.07 ± 3.09; 117.54 ± 4.97; and 125.45 ± 6.92 cm), RL (34.86 ± 2.03; 36.35 ± 2.80; and 38.09 ± 3.24 cm), RT (39.07 ± 2.22; 40 ± 2.37; and 42.91 ± 3.97cm), BMI (187.37 ± 11.45; 191.69 ± 14.61; and 222.39 ± 23.57) regarding the treatments T1, T2, and T3, respectively. We found the following means for the variables SC (17.43±1.81; 19.08±1.98; and 22.11±3.25 cm), TL (8.28 ± 0.99; 9.27 ± 1.33; and 10.68 ± 1.47 cm), TW (3.25 ± 0.25; 3.90 ± 0.58; and 4.66 ± 0.80cm), and TV (109.43 ± 24.93; 198.36 ± 87.08; and 343.83 ± 183.04 cm3 ) regarding the treatments T1, T2, and T3, respectively. The predominant form in all treatments was long. There was no difference between the T1 and T2 for the studied variables. T3 had higher averages for LW, BMI, RH, SC, TV, and TW. For the variables WH, RL, TL, and RT there was no difference between T2 and T3. There was a correlation between measurements and testicular measures WH, RH, and RL and between SC and TV, TL, and TW.(AU)

Objetivou-se com este trabalho analisar o peso vivo (PV), as medidas morfométricas e testiculares e suas correlações entre si em 31 búfalos Mediterrâneo em três idades. Foram utilizados sete animais de 8 meses (T1), treze de 10 meses (T2) e onze de 12 meses (T3), de uma propriedade da Baixada Litorânea do Rio de Janeiro. As medidas morfométricas e testiculares avaliadas foram: altura da garupa (AG), altura da cernelha (AC), comprimento da garupa (CG), espessura de coxão (ECX), circunferência escrotal (CE), comprimento testicular (CT) e largura testicular (LT). Foram calculados o volume testicular (VT) e o índice de massa corpórea (IMC), e foi determinada a forma testicular pela razão entre a LT e o CT. Foram encontradas as médias para das variáveis PV (240,57 ± 18,36; 259,38±28,66 e 331,82 ± 63,23), AC (113,28 ± 2,44; 116,23 ± 4,74 e 121,45 ± 6,95 cm), AG (116,07 ± 3,09; 117,54 ± 4,97 e 125,45 ± 6,92 cm), CG (34,86 ± 2,03; 36,35 ± 2,80 e 38,09 ± 3,24 cm), ECX (39,07 ± 2,22; 40 ± 2,37 e 42,91 ± 3,97 cm), IMC (187,37 ± 11,45; 191,69 ± 14,61 e 222,39 ± 23,57) para os tratamentos T1, T2 e T3, respectivamente. Foram encontradas médias para as variáveis CE (17,43±1,81; 19,08±1,98 e 22,11 ± 3,25 cm), CT (8,28 ± 0,99; 9,27 ± 1,33 e 10,68 ± 1,47 cm), LT (3,25 ± 0,25; 3,90 ± 0,58 e 4,66 ± 0,80 cm) e VT (109,43 ± 24,93, 198,36 ± 87,08 e 343,83 ± 183,04 cm3) para os tratamentos T1, T2 e T3, respectivamente. A forma predominante para todos os tratamentos foi o Longo. Não houve diferença entre as médias dos tratamentos 1 e 2 para nenhuma das variáveis estudadas. Para as variáveis PV, AG e IMC, CE, LT e VT o tratamento3 apresentou as maiores médias. Para as variáveis AC, CG, ECX e CT não houve diferença entre os tratamentos 2 e 3. Houve correlação entre todas as medidas testiculares e as medidas de AC, AG e CG e entre CE e VT, CT, LT.(AU)

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Abstract We evaluated the live weight (LW), morphological and testicular measures and their correlations in 31 Mediterranean buffaloes at three ages. We used seven animals at 8 months of age (T1), 13 animals at the age of 10 months (T2), and 11 animals at the age of 12 months (T3) coming from a farm of the Coastal Lowlands of Rio de Janeiro. The following morphometric measurements and testes were evaluated: rump height (RH), withers height (WH), rump length (RL), round thickness (RT), scrotal circumference (SC), testicular length (TL), testicular width (TW). Testicular volume (TV) and body mass index (BMI) were also calculated. The testicular form was determined by the ratio between the TW and TL. We found the following means for the variables LW (240.57 ± 18.36; 259.38 ± 28.66; and 331.82 ± 63.23), WH (113.28 ± 2.44; 116.23 ± 4.74; and 121.45 ± 6.95cm), RH (116.07 ± 3.09; 117.54 ± 4.97; and 125.45 ± 6.92 cm), RL (34.86 ± 2.03; 36.35 ± 2.80; and 38.09 ± 3.24 cm), RT (39.07 ± 2.22; 40 ± 2.37; and 42.91 ± 3.97cm), BMI (187.37 ± 11.45; 191.69 ± 14.61; and 222.39 ± 23.57) regarding the treatments T1, T2, and T3, respectively. We found the following means for the variables SC (17.43±1.81; 19.08±1.98; and 22.11±3.25 cm), TL (8.28 ± 0.99; 9.27 ± 1.33; and 10.68 ± 1.47 cm), TW (3.25 ± 0.25; 3.90 ± 0.58; and 4.66 ± 0.80cm), and TV (109.43 ± 24.93; 198.36 ± 87.08; and 343.83 ± 183.04 cm3) regarding the treatments T1, T2, and T3, respectively. The predominant form in all treatments was long. There was no difference between the T1 and T2 for the studied variables. T3 had higher averages for LW, BMI, RH, SC, TV, and TW. For the variables WH, RL, TL, and RT there was no difference between T2 and T3. There was a correlation between measurements and testicular measures WH, RH, and RL and between SC and TV, TL, and TW.

Resumo Objetivou-se com este trabalho analisar o peso vivo (PV), as medidas morfométricas e testiculares e suas correlações entre si em 31 búfalos Mediterrâneo em três idades. Foram utilizados sete animais de 8 meses (T1), treze de 10 meses (T2) e onze de 12 meses (T3), de uma propriedade da Baixada Litorânea do Rio de Janeiro. As medidas morfométricas e testiculares avaliadas foram: altura da garupa (AG), altura da cernelha (AC), comprimento da garupa (CG), espessura de coxão (ECX), circunferência escrotal (CE), comprimento testicular (CT) e largura testicular (LT). Foram calculados o volume testicular (VT) e o índice de massa corpórea (IMC), e foi determinada a forma testicular pela razão entre a LT e o CT. Foram encontradas as médias para das variáveis PV (240,57 ± 18,36; 259,38±28,66 e 331,82±63,23), AC (113,28 ± 2,44; 116,23 ± 4,74 e 121,45 ± 6,95cm), AG (116,07 ± 3,09; 117,54 ± 4,97 e 125,45 ± 6,92 cm), CG (34,86 ± 2,03; 36,35 ± 2,80 e 38,09 ± 3,24 cm), ECX (39,07 ± 2,22; 40 ± 2,37 e 42,91 ± 3,97cm), IMC (187,37 ± 11,45; 191,69 ± 14,61 e 222,39 ± 23,57) para os tratamentos T1, T2 e T3, respectivamente. Foram encontradas médias para as variáveis CE (17,43±1,81; 19,08±1,98 e 22,11±3,25 cm), CT (8,28 ± 0,99; 9,27 ± 1,33 e 10,68 ± 1,47 cm), LT (3,25 ± 0,25; 3,90 ± 0,58 e 4,66 ± 0,80cm) e VT (109,43 ± 24,93, 198,36 ± 87,08 e 343,83 ± 183,04 cm3) para os tratamentos T1, T2 e T3, respectivamente. A forma predominante para todos os tratamentos foi o Longo. Não houve diferença entre as médias dos tratamentos 1 e 2 para nenhuma das variáveis estudadas. Para as variáveis PV, AG e IMC, CE, LT e VT o tratamento 3 apresentou as maiores médias. Para as variáveis AC, CG, ECX e CT não houve diferença entre os tratamentos 2 e 3. Houve correlação entre todas as medidas testiculares e as medidas de AC, AG e CG e entre CE e VT, CT, LT.

RESUMO

We evaluated the live weight (LW), morphological and testicular measures and their correlations in 31 Mediterranean buffaloes at three ages. We used seven animals at 8 months of age (T1), 13 animals at the age of 10 months (T2), and 11 animals at the age of 12 months (T3) coming from a farm of the Coastal Lowlands of Rio de Janeiro. The following morphometric measurements and testes were evaluated: rump height (RH), withers height (WH), rump length (RL), round thickness (RT), scrotal circumference (SC), testicular length (TL), testicular width (TW). Testicular volume (TV) and body mass index (BMI) were also calculated. The testicular form was determined by the ratio between the TW and TL. We found the following means for the variables LW (240.57 ± 18.36; 259.38 ± 28.66; and 331.82 ± 63.23), WH (113.28 ± 2.44; 116.23 ± 4.74; and 121.45 ± 6.95cm), RH (116.07 ± 3.09; 117.54 ± 4.97; and 125.45 ± 6.92 cm), RL (34.86 ± 2.03; 36.35 ± 2.80; and 38.09 ± 3.24 cm), RT (39.07 ± 2.22; 40 ± 2.37; and 42.91 ± 3.97cm), BMI (187.37 ± 11.45; 191.69 ± 14.61; and 222.39 ± 23.57) regarding the treatments T1, T2, and T3, respectively. We found the following means for the variables SC (17.43±1.81; 19.08±1.98; and 22.11±3.25 cm), TL (8.28 ± 0.99; 9.27 ± 1.33; and 10.68 ± 1.47 cm), TW (3.25 ± 0.25; 3.90 ± 0.58; and 4.66 ± 0.80cm), and TV (109.43 ± 24.93; 198.36 ± 87.08; and 343.83 ± 183.04 cm3 ) regarding the treatments T1, T2, and T3, respectively. The predominant form in all treatments was long. There was no difference between the T1 and T2 for the studied variables. T3 had higher averages for LW, BMI, RH, SC, TV, and TW. For the variables WH, RL, TL, and RT there was no difference between T2 and T3. There was a correlation between measurements and testicular measures WH, RH, and RL and between SC and TV, TL, and TW.

Objetivou-se com este trabalho analisar o peso vivo (PV), as medidas morfométricas e testiculares e suas correlações entre si em 31 búfalos Mediterrâneo em três idades. Foram utilizados sete animais de 8 meses (T1), treze de 10 meses (T2) e onze de 12 meses (T3), de uma propriedade da Baixada Litorânea do Rio de Janeiro. As medidas morfométricas e testiculares avaliadas foram: altura da garupa (AG), altura da cernelha (AC), comprimento da garupa (CG), espessura de coxão (ECX), circunferência escrotal (CE), comprimento testicular (CT) e largura testicular (LT). Foram calculados o volume testicular (VT) e o índice de massa corpórea (IMC), e foi determinada a forma testicular pela razão entre a LT e o CT. Foram encontradas as médias para das variáveis PV (240,57 ± 18,36; 259,38±28,66 e 331,82 ± 63,23), AC (113,28 ± 2,44; 116,23 ± 4,74 e 121,45 ± 6,95 cm), AG (116,07 ± 3,09; 117,54 ± 4,97 e 125,45 ± 6,92 cm), CG (34,86 ± 2,03; 36,35 ± 2,80 e 38,09 ± 3,24 cm), ECX (39,07 ± 2,22; 40 ± 2,37 e 42,91 ± 3,97 cm), IMC (187,37 ± 11,45; 191,69 ± 14,61 e 222,39 ± 23,57) para os tratamentos T1, T2 e T3, respectivamente. Foram encontradas médias para as variáveis CE (17,43±1,81; 19,08±1,98 e 22,11 ± 3,25 cm), CT (8,28 ± 0,99; 9,27 ± 1,33 e 10,68 ± 1,47 cm), LT (3,25 ± 0,25; 3,90 ± 0,58 e 4,66 ± 0,80 cm) e VT (109,43 ± 24,93, 198,36 ± 87,08 e 343,83 ± 183,04 cm3) para os tratamentos T1, T2 e T3, respectivamente. A forma predominante para todos os tratamentos foi o Longo. Não houve diferença entre as médias dos tratamentos 1 e 2 para nenhuma das variáveis estudadas. Para as variáveis PV, AG e IMC, CE, LT e VT o tratamento3 apresentou as maiores médias. Para as variáveis AC, CG, ECX e CT não houve diferença entre os tratamentos 2 e 3. Houve correlação entre todas as medidas testiculares e as medidas de AC, AG e CG e entre CE e VT, CT, LT.

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INTRODUCTION: Adiposity has been associated with atherosclerosis in clinical studies. However, few autopsy studies have investigated this association, and they had only examined the coronary artery disease. Moreover, most studies had small sample sizes and were limited to middle-aged or young adults. Our aim is to investigate the association between adiposity and systemic atherosclerosis in an autopsy study. METHODS AND ANALYSIS: A sample of 240 deceased with 30 years or more will be evaluated. The sample size was calculated using the lowest correlation coefficient found in previous studies (r=0.109), assuming a power of 90% and α=0.05. We will collect information about sociodemographics, frequency of previous contact of the deceased's next of kin and cardiovascular risk factors. We will measure neck, waist and hip circumferences, weight, height and abdominal subcutaneous tissue thickness, and then we will calculate the body mass index, waist-to-hip ratio, waist-to-height ratio and body shape index. We will also weigh the pericardial and abdominal visceral fat, the heart, and we will measure the left ventricular wall thickness. We will evaluate the presence of myocardial infarction, the degree of atherosclerosis in the aorta, carotid, coronary and cerebral arteries and plaque composition in carotid, coronary and cerebral arteries. For each individual, we will fix arterial and adipose tissue samples in 10% formalin and freeze another adipose tissue sample at -80°C for future studies. ETHICS AND DISSEMINATION: Ethical approval was granted by the Ethics Committee of University of Sao Paulo Medical School, Brazil. Results will be submitted for publication in a peer-reviewed journal.

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O objetivo deste trabalho foi caracterizar alguns aspectos morfométricos do pênis e prepúcio de touros das raças Nelore e Gir, estabelecendo as correlações destes parâmetros com outras medidas corporais. O protocolo experimental foi dividido em duas etapas, sendo que na primeira foram selecionados 40 touros, 20 da raça Nelore e 20 da raça Gir, com idade de 30 a 38 meses e peso entre 382 e 468 Kg. Após o abate dos animais em frigorífico, foram coletadas peças de pênis para dissecação e morfometria. Na segunda etapa, foram selecionados 43 touros, 23 da raça Nelore e 20 da raça Gir, com idade de 60 a 96 meses e peso entre 890 a 1120 Kg, provenientes de centrais de coleta de sêmen, para mensuração do peso e comprimento corporal, comprimento da garupa, perímetro torácico, altura anterior e posterior, menor perímetro do metacarpo esquerdo e do metatarso esquerdo, comprimento do prepúcio, menor distância do óstio prepucial à parede do abdome e perímetro do óstio prepucial. As medidas obtidas foram submetidas a teste de correlação linear. O comprimento médio do pênis e prepúcio de touros da raça Nelore foi de 71,96 cm e 52,4 cm, respectivamente e nos touros da raça Gir de 75,73 cm e 57 cm, respectivamente. Dentre as correlações efetuadas, destacam-se duas positivas; uma baixa entre o comprimento corporal e comprimento prepucial (r = 0,31, p < 0,05) e outra média entre a massa corporal e o comprimento prepucial (r = 0,66, p < 0,05). Os resultados deste estudo poderão contribuir para se estabelecer o padrão destas medidas nas raças Nelore e Gir, além de indicar as correlações com outras medidas corporais que podem ser empregadas para proceder a seleção genética de touros para a reprodução.

The aim of this study was to characterize some morphometric aspects of the penis and prepuce of Nelore and Gir bulls establishing the correlations between these parameters and other body measures. The experimental protocol was divided into two stages, being that in the first stage it was selected 40 animals, 20 Nelore and 20 Gir bulls, aged between 30 to 38 months and weighing between 382 and 486 kg. After the killing of the animals in the slaughterhouse, it was collected pieces of penis for penile dissection and morphometry. In the second stage, were selected 23 Nelore and 20 Gir bulls aged between 60 to 96 months and weighing between 890 and 1120 kg. The animals were obtained from semen collection centrals and were submitted to measurement of body mass and length, rump length, thoracic perimeter, anterior and posterior height, the lower perimeter of the left metacarpal and metatarsal, length of the prepuce, the shortest distance from preputial ostium to abdominal wall and the preputial ostium perimeter. The measures obtained were subjected to linear correlation test. The average length of the penis and prepuce of Nelore bulls were 71.96 cm and 52.4 cm respectively and in the Gir bulls were 75.73 cm and 57 cm respectively. Two positive correlations stand out among the analysis performed, the low correlation between body and preputial length (r = 0,31, p < 0,05) and mean correlation between body mass and preputial length (r = 0,66, p < 0,05). The results of this study could contribute to establish the pattern of these measures in the Nelore and Gir races and indicate the correlations with other body measures that can be considered to perform the genetic selection of bulls for breeding.

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