RESUMO
BACKGROUND: Despite previous studies have recently shown Autism Spectrum Disorders (ASD) as having a strong genetics background, over a minimum environmental background, no study up to date has investigated the interplay between genetics and environment. METHODS: We have collected data regarding Family History (FH) and Environmental Factors (EF) from 2,141 individuals with ASD and their caretakers throughout Brazil, based on an online questionnaire. Most of the ASD individuals were males (81%) and the average age was 02 years minimum for males and females, and the maximum age was 41 years for males and 54 for females. People from all states in Brazil have answered the questionnaire. Genetic inheritance was obtained based on the declared FH of Psychiatric and Neurological diagnosis. As for EF, exposure to risk factors during pregnancy was considered, like infections, diabetes, drugs/chemicals exposure, socioeconomic, and psychological factors. Respondents were invited to answer the questionnaire in lectures given throughout Brazil, and by the social networks of the NGO "The Tooth Fairy Project". A Multiple Correspondence Analysis (MCA) was conducted to search vulnerability dimensions, and a Cluster Analysis was conducted to classify and identify the subgroups. RESULTS: Regarding EF, social and psychological exposures contributed to the first two dimensions. Concerning FH, the first dimension represented psychiatric FH, while the second represented neurological FH. When analyzed together, EF and FH contributed to two new dimensions: 1. psychiatric FH, and 2. a psychosocial component. Using Cluster Analysis, it was not possible to isolate subgroups by genetic vulnerability or environmental exposure. Instead, a gradient of psychiatric FH with similar contributions of EF was observed. CONCLUSION: In this study, it was not possible to isolate groups of patients that correspond to only one component, but rather a continuum with different compositions of genetic and environmental interplay.
Assuntos
Transtorno do Espectro Autista , Masculino , Feminino , Humanos , Pré-Escolar , Adulto , Transtorno do Espectro Autista/etiologia , Transtorno do Espectro Autista/genética , Fatores de Risco , Inquéritos e Questionários , BrasilRESUMO
Las temáticas referentes a la identidad de género han ganado amplia atención en las últimas décadas. Desde las primeras descripciones clásicas del autismo, ha existido interés en el estudio del proceso identitario en dicha población. En este contexto, la comprensión del desarrollo psicosexual de niños, niñas y adolescentes (NNA) con condición del espectro autista (CEA) ha cobrado relevancia dada la evidencia sugerente de una relación entre CEA y diversidad de género incluida disforia de género (DG). Este documento pretende realizar una revisión del tema desde una perspectiva del desarrollo.
Issues related to gender identity have gained wide attention in recent decades. Since the first classical descriptions of autism, there has been interest in the study of the identity process in this population. In this context, the understanding of the psychosexual development of boys, girls and adolescents (NNA) with autism spectrum condition (ASC) has gained relevance given the suggestive evidence of a relationship between ASC and gender diversity (including gender dysphoria (GD) This document aims to carry out a review of the subject from a developmental perspective.