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Leishmaniasis may occur in three different clinical forms, namely, visceral, mucocutaneous and cutaneous, which are caused by different species of trypanosomatid protozoans of the genus Leishmania. Pentavalent antimonials are the leading treatment for cutaneous leishmaniasis despite the hepatic, renal, and cardiac toxicity. In addition, the response of some Leishmania species to pentavalent antimonials is increasingly poorer, and therefore new and more potent therapeutic alternatives are needed. Arnica montana L., Asteraceae, is a traditional medicinal plant of Europe and preparations of its flowers are commonly used externally to treat disorders of the musculoskeletal system as well as superficial inflammatory conditions. Previous studies have shown that Arnica tincture (AT), an ethanolic extract prepared from the flowerheads of Arnica montana as well as isolated Arnica sesquiterpene lactones (STLs) have antileishmanial activity in vitro against L. donovani and L. infantum, as well as in vivo against L. braziliensis. In this work, we studied the in vitro cytotoxicity and antileishmanial activity of AT and STLs against both L. braziliensis and L. tropica. The in vivo therapeutic effect of AT was studied in hamsters with cutaneous Leishmaniasis (CL) caused by experimental infection with L. braziliensis and L. tropica. Furthermore, various semisolid Arnica preparations were also evaluated against L. braziliensis. The STLs and the AT possess a very high in vitro activity against both Leishmania species with median effective concentrations (EC50) ranging from 1.9 to 5.9 µg/mL. The AT was not cytotoxic for human tissue macrophages, skin fibroblasts, and hepatic cells. The therapeutic response of hamsters infected with L. braziliensis to the topical treatment with AT was 87.5% at a dose of 19.2 µg STL/2× day/60 d, 72.7% at doses of 19.2 µg STL/1× d/60 d and 67% at a dose of 38.4 µg STL/2× d/60 d. In turn, the therapeutic response in hamsters infected with L. tropica was 100% when treated at a dose of 19.2 µg STL/2× day/60 d and 71% at a dose of 38.4 µg STL/2× d/60 d. On the other hand, the effectiveness of treatment with glucantime administered intralesionally at a dose of 200 mg/every three days for 30 days was 62.5% for L. braziliensis and 37.5% for L. tropica infection. These results are promising and encourage the implementation of clinical trials with AT in CL patients as a first step to using AT as a drug against CL.

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Arnica montana 6CH is a medicine indicated for inflammatory and painful conditions, especially in muscle structures. The RDC / TMD Axis II questionnaire is a validated tool for the diagnosis of Temporomandibular Muscle Dysfunction. Objective: This multicenter, randomized and controlled study, approved by Human or Animal Research Ethics Committee UniFOA -CAAE: 48680015.3.0000.5237 aimed to verify the clinical performance of Arnica montana 6CH in contractures and muscle pain triggered by isometric stress. Materials and Methods: 70 patients underwent prolongeddental treatment sessions, and they were selected after clinical examination and positive responses to the RDC / TMD questionnaire to confirm signs and symptoms of Temporomandibular Muscle Dysfunction at the first consultation. Randomly, Arnica montana 6CH was prescribed for 35 patients called group I, and placebo for 35 patients called group II, at a dose of 5 globules, 03 times a day, for 1 week. In the second endodontic consultation, after 15 days, a new clinical examination was performed at the beginning and end of the prolonged dental consultation with crossing of data from the RDC questionnaire, to monitor the prevalence of TMD muscle signs and symptoms. The data were tabulated and analyzed. Statistical analysis: The test t de Student was used for paired samples, significant at the level ≤ 0.05%. Results:Anamnetic data from the RDC questionnaire, 86% of the individuals in the GI had lower pain and muscle contracture rates in the second consultation, compared with 22% in the GII. Conclusion:The drug Arnica montana 6CH proved to be effective in preventing muscle changes and clinical symptoms resulting from isometric efforts with a statistically significant difference (p ≤ 0.05).

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This study evaluated the effect of adding ultra-diluted and dynamized Arnica montana 6 cH, and its vehicle (0.3% ethanol) to the in vitro maturation (IVM) medium, in the absence (experiment 1) or presence (experiment 2) of heat stress (HS), on bovine oocyte maturation and in vitro embryo production (IVEP). In experiment 1 (n = 902 cumulus oocyte complexes, COCs), the treatments were 1) IVM medium (Control treatment), 2) IVM medium + 0.3% ethanol, and 3) IVM medium + Arnica montana 6 cH. In experiment 2 (n = 1064 COCs), the treatments were 1) IVM medium without HS, 2) IVM medium under HS, 3) IVM medium + ethanol under HS, and 4) IVM medium + Arnica montana under HS. In the absence of HS (experiment 1), the addition of Arnica montana to the IVM medium had a deleterious effect on the IVEP (cleavage and blastocyst rates) and the total cell number/blastocysts. On the other hand, ethanol (0.3%) increased IVEP in relation to the Control and Arnica montana treatments. However, in the presence of HS during IVM (experiment 2), the addition of ethanol or Arnica montana increased IVEP when compared to the HS treatment alone, and the Arnica montana treatment resulted in greater total cell number/blastocysts compared to the other treatments. In conclusion, this study showed for the first time that the negative or positive effect of Arnica montana 6 cH on IVEP depends on the culture condition (i.e., absence or presence of HS during IVM). On the other hand, ethanol showed beneficial and consistent results on IVEP regardless of exposure to HS.

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Background: ultraviolet radiation types A and B (UV) (400-315nm and 315-280nm respectively) are the main components present in sunlight known to cause skin injuries. Arnica montana is a plant that has been widely studied for containing anti-inflammatory, healing and analgesic properties capable of preventing or ameliorating lesions. Here, we investigated the therapeutic effect of topical application of Arnica montana after UVB-induced cutaneous injuries in mice.Methods: mice were exposed to UVB radiation (Philips TL40W/12 RS lamp) in a period of 3 hours. After one hour of radiation exposure, the animals were treated with topical application of Arnica montana ointment (250 mg/g) in the ear. At the time of 16 hours after treatment, the parameters of edema, oxidative stress and inflammatory reaction were measured in the ear of mice.Results: our results demonstrated that topical treatment with Arnica montana reduced the UVB-induced inflammatory response as demonstrated by the reduction of ear edema, inhibition of myeloperoxidase activation, decrease of nuclear factor kappa B levels and reduction of proinflammatory cytokines levels, such as interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma. In addition, Arnica montana ameliorated oxidative damage mediated by UVB radiation, as demonstrated by the reduction of lipid peroxidation, protein oxidation and increase of tissue antioxidant capacity and glutathione levels in the ear.Conclusion: we concluded that Arnica montana ointment is effective in alleviating the auricular inflammatory process and oxidative damage induced by acute UVB radiation, sustaining the traditional use of Arnica montana for the treatment of skin disorders.

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In search for potential therapeutic alternatives to existing treatments for cutaneous Leishmaniasis, we have investigated the effect of Arnica tincture Ph. Eur. (a 70% hydroethanolic tincture prepared from flowerheads of Arnica montana L.) on the lesions caused by infection with Leishmania braziliensis in a model with golden hamsters. The animals were treated topically with a daily single dose of the preparation for 28 days. Subsequently, the healing process was monitored by recording the lesion size in intervals of 15 days up to day 90. As a result, Arnica tincture fully cured three out of five hamsters while one animal showed an improvement and another one suffered from a relapse. This result was slightly better than that obtained with the positive control, meglumine antimonate, which cured two of five hamsters while the other three showed a relapse after 90 days. This result encourages us to further investigate the potential of Arnica tincture in the treatment of cutaneous Leishmaniasis.

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Se presenta un caso de trauma dentoalveolar en un paciente masculino de 22 años de edad, al sufrir un asalto en la Ciudad de México. El paciente acude al consultorio dental 29 horas posteriores al incidente; durante la exploración se identifican edema y laceraciones en los labios; movilidad de los dientes centrales superiores y fractura del ángulo mesio-incisal del lateral superior derecho. El estudio radiográfico muestra fractura de las coronas en los centrales superiores. El abordaje terapéutico combinó Homeopatía, tratamiento endodóntico, periodontal y prótesis. Los medicamentos que se administraron fueron: Arnica montana, Hypericum perforatum, Calendula officinalis y Echinacea angustifolia (nombre de marca: Gavosim); se prescindió de antibióticos y antiinflamatorios. A las cuatro semanas del tratamiento endodóntico se remitió al paciente con el periodoncista, y cuatro semanas después, con el protesista. Al final, se logró la rehabilitación total. Se concluye que los medicamentos prescritos facilitaron la recuperación de los tejidos periodontales.

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Objetivo: Dados estatísticos nacionais e mundiais demonstram que o número de indivíduos idosos tende a crescer de maneira exponencial nos próximos anos, tornando-se uma população significativamente e proporcionalmente maior que as demais. Entre as doenças mais comuns nessa faixa estaria encontra-se a osteoporose, doença que reduz a massa esquelética e deteriora a microarquitetura do osso causando fragilidade e aumentando o risco de fraturas. Material e Métodos: Este estudo teve como proposta avaliar o efeito da Arnica montana fitoterápica e homeopática no reparo de lesões ósseas, visando uma possível forma de tratamento de fraturas na vigência da osteoporose. Os ensaios experimentais foram realizados em ratas Wistar adultas, divididas em quatro grupos: ovariectomizado tratado com Arnica montana 6CH homeopática (OVZ 6CH); ovariectomizado tratado com extrato fitoterápico de Arnica montana (OVZ TM); ovariectomizada tratado com placebo (OVZ PL) falsa cirurgia de ovariectomia e tratado com placebo (Sham PL). Após 45 dias da cirurgia sham ou de ovariectomia, foi realizada uma lesão óssea monocortical. Os animais foram eutanasiados após 6, 12, 18 e 28 dias e as tíbias retiradas para avaliação das suas dimensões e analise do reparo ósseo através de densidade óssea radiográfica, ensaios biomecânicos e microscopia eletrônica de varredura (MEV). Os dados do teste de flexão foram submetidos à analise estatística pelos testes de ANOVA e Tukey (p< 5%). Resultados: Conclui-se que o tratamento com arnica 6CH foi melhor que o com arnica TM quanto à resistência e à qualidade de regeneração óssea, enquanto a TM mostrou melhor valor de densidade óptica. Conclusão: Esse estudo concluiu que o tratamento com Arnica montana homeopática foi mais eficiente que com Arnica fitoterápica na regeneração óssea de ratas com osteoporose (AU)

Objective: National and international data show that in the next years the elder population tends to have an exponential increase becoming to be significantly higher than other ages. Among the frequent diseases in the elderly, osteoporosis is a disease that decreases bone mass and deteriorates bone structure causing fragility and a high risk of fracture. This study aimed to evaluate the effect of phytotherapic and homeopathic Arnica montana on bone repair quality and its possible use in the treatment of bone fracture in patients with osteoporosis. Material and Methods: This experimental study was performed in Wistar adult female rats divided in 4 groups according to the following treatments: ovariectomized treated with homeopathic A. montana 6CH (OVZ 6CH); ovariectomized treated with phytotherapic A. montana (OVZ TM); ovariectomized with placebo (OVZ PL) and rats with sham surgery and placebo (Sham PL). In a period of 45 days after ovariectomy or sham surgery, all animals got a monocortical lesion. They were euthanized after 6, 12, 18 and 28 days and had the tibiae removed to evaluate dimensions and bone repair by radiographic density, biomechanical test and scanning electronic microscopy (SEM). Data were analyzed by ANOVA and TUKEY tests (p < 0.05). Results: Results showed that treatment with Arnica 6CH was better than Arnica TM considering bone resistance and bone repair quality. Conclusion: This study concluded that treatment with homeopathic A. montana was more efficient than with phytotherapic Arnica in bone regeneration in rats with osteoporosis.(AU)

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BACKGROUND: Studies have shown that Arnica montana shows anti-inflammatory and antioxidant activities. It has been used in traditional medicine for the treatment of several disorders. The aim of this study was to investigate the effect of Arnica montana on mast cells during the wound healing of oral ulcers. METHOD: An ulcerated lesion was chemically induced on the tongue of 75 male albino rats and, then, treated topically for seven days using saline solution (control), Arnica montana gel or tincture. The animals were killed after 2nd, 7th, 14th, 21th and 42th day of treatment. The tongues were removed and subjected to routine laboratory (0.2% toluidine blue staining). The numbers of mast cell were determined in two regions: superficial and submucosa. RESULTS: The numbers of mast cells were significantly increased for all groups in the region of the deeper tissue when compared to the superficial region. No statistical difference was observed in mast cell numbers for each group. CONCLUSION: This study revealed that Arnica montana tincture and gel were unable to change mast cell population during wound healing of oral ulcer of rats. According to these results, the anti-inflammatory effects of Arnica montana were not related to inhibition of mast cell degranulation.

OBJETIVO: Sabe-se que a Arnica montana mostra atividade anti-inflamatória e anti-oxidante e tem sido usada em medicina tradicional para o tratamento de vários distúrbios. O objetivo deste estudo foi investigar o efeito da Arnica montana em mastócitos durante a cicatrização de feridas de úlceras orais. MÉTODO: Uma úlcera foi quimicamente induzida na língua de 75 ratos albinos machos e, em seguida, tratada topicamente durante sete dias, utilizando solução salina (controle), gel ou tintura de Arnica montana. Os animais foram sacrificados após 2, 7, 14, 21 e 42º dia de tratamento. As línguas foram removidas e submetidas a rotina de laboratório (coloração com 0,2% de azul de toluidina). A densidade de mastócitos foi determinada em duas regiões: superficial e submucosa. RESULTADOS: O número de mastócitos aumentou nitidamente para todos os grupos na região mais profunda do tecido peri-ulceroso, quando comparada à região superficial. Nenhuma diferença estatística foi observada no número de mastócitos entre os grupos. CONCLUSÃO: Este estudo revelou que a tintura ou o gel de Arnica montana foram incapazes de interferir na população de mastócitos durante a cicatrização da úlcera oral de ratos. De acordo com estes resultados, os efeitos anti-inflamatórios de Arnica montana não foram relacionados à inibição da degranulação dos mastócitos.

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Se realizó un estudio de intervención terapéutica en 80 pacientes con dolor luego de la extracción de terceros molares retenidos, en el Hospital Provincial Docente Clinicoquirúrgico "José Ramón López Tabrane" de la provincia de Matanzas, desde enero del 2012 hasta igual mes del 2013, con vistas a evaluar la evolución de estos. Para ello se formaron 2 grupos de 40 integrantes cada uno; a uno se le indicó tratamiento convencional con dipirona de 300 mg (grupo de control) y al otro, homeopatía con Arnica montana en 30 ch (grupo experimental). Los resultados demostraron la existencia de una terapia alternativa que podría ser utilizada cuando los medicamentos de primera elección hayan fallado, ya sea por su baja eficacia o por la aparición de reacciones adversas. En los pacientes tratados con Arnica montana, el efecto fue satisfactorio; además, este remedio homeopático es seguro y menos costoso para el Sistema Nacional de Salud cubano.

A therapeutic intervention study was carried out in 80 patients with pain after the extraction of third retained molars, in "José Ramón López Tabrane" Teaching Provincial Clinical-Surgical Hospital in Matanzas province, from January, 2012 to the same month of 2013, with the objective of evaluating their clinical course. For this purpose, 2 groups of 40 members each were formed; conventional treatment with dipyrone of 300 mg (control group) was indicated to one of them, and to the other homeopathy with Arnica montana in 30 ch (experimental group). The results demonstrated the existence of an alternative therapy that could be used when first election drugs have failed, either for their low effectiveness or for the emergence of adverse reactions. In the patients treated with Arnica montana, the effect was satisfactory; also, it can be said that this homeopathic remedy is safe and less expensive for the Cuban National Health System.

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Trata-se de estudo comparativo para avaliar a atividade dos medicamentos nimesulida, Arnica TM, Arnica 6CH comparados com H2O no tratamento da Doença Periodontal experimental induzida por ligadura em ratos. Esta doença se caracteriza por processo inflamatório que pode evoluir até ao ligamento periodontal e tecido ósseo provocando perda óssea. Mediadores produzidos pelo hospedeiro e substâncias do biofilme são responsáveis pelos danos que podem levar até a perda do elemento dentário. O objetivo deste trabalho foi desenvolver estudo exploratório descritivo para analisar, aprofundar e comparar os efeitos das medicações citadas, investigando possíveis inovações no tratamento da doença periodontal. A metodologia consistiu em: 1) colocação, sob anestesia, da ligadura no primeiro molar inferior esquerdo. 2) administração diária por gavagem de H2O (controle) (1μl/g), nimesulida (1μl/g, de uma suspensão com 5mg/ml), Arnica TM (8μl/300g) ou Arnica 6CH (3,21μl/300g) durante 14, 21 e 28 dias a quatro grupos de ratos Wistar (n=30/ grupo); 3) eutanásia e coleta de material para análises histológica, da perda óssea e RT-PCR (alvos: TNF-α, COX-2, IL-6, OPG e RANKL); 4) análise estatística paramétrica realizada por ANOVA a um ou dois critérios, seguida do teste de Tukey, ou por análise não paramétrica por Kruskal-Wallis, seguido do método de Dunns, nível de significância de 5%. Quanto à perda óssea, não houve diferença estatística entre os grupos e nenhum dos tratamentos foi capaz de contê-la. Os escores para o infiltrado inflamatório não mostraram diferença significativa entre os grupos nos períodos estudados. Quanto ao escore geral, que envolve intensidade do infiltrado inflamatório, migração do epitélio juncional, integridade do cemento e da crista óssea alveolar, não houve diferença significativa entre os grupos nos períodos. Na expressão do RNAm para as citocinas vimos para o TNF-α não haver diferença significativa entre os grupos, quando se analisou isoladamente...

This is a comparative study to evaluate the activity of nimesulide medicines, Arnica TM, Arnica 6CH compared with H2O in the treatment of experimental periodontal disease induced by ligation in rats. This disease is characterized by an inflammatory process that may progress to the periodontal ligament and bone tissue leading to bone loss. Mediators produced by the host and biofilm substances are responsible for the damage that can lead to tooth loss. The aim of this exploratory and descriptive study was to analyze, deepen and compare the effects of the mentioned medications, investigating possible innovations in the treatment of periodontal disease. The methodology consisted of: 1) placing under anesthesia ligature in the first lower left molar. 2) daily administration by gavage H2O (control) (1μl/g), nimesulide (1μl/g, a suspension of 5 mg / ml), Arnica TM (8μl/300g) or Arnica 6CH (3,21μl/300g) for 14, 21 and 28 days to four groups of Wistar rats (n = 30 / group); 3) euthanasia and collection of material for histological, bone loss and RTPCRanalysis (targets: TNF-α, COX-2, IL-6, OPG and RANKL); 4) parametric statistical analysis performed by ANOVA to one or two criteria, followed by Tukey test, or nonparametric analysis by Kruskal-Wallis, followed by Dunns method, 5% significance level. Regarding the bone loss, there was no statistical difference between the groups and none of the treatments was able to contain it. The scores for the inflammatory infiltrate showed no significant difference between the groups in the study periods. Regarding the general score, which involves intensity of the inflammatory infiltrate, migration of the junctional epithelium integrity of the cement and the alveolar bone crest, there was no significant difference between groups in the periods. At the mRNA expression for the cytokines we saw for TNF-α no significant difference between groups when analyzed separately periods of 14 and 28 days. However, in the 21day...

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Se realizó un estudio de intervención terapéutica en el módulo de San Benito de Mayarí, provincia de Santiago de Cuba, en el primer cuatrimestre de 2010, a fin de evaluar la evolución de 72 pacientes con estomatitis subprótesis de grados I y II, distribuidos de forma alterna en 2 grupos: en el A se incluyeron los números impares, con terapéutica convencional; y en el B los pares, con tratamiento homeopático. En ambos grupos predominaron los integrantes de 45-54 años y del sexo femenino, así como los curados al tercer día (72,2 y 80,6 %, respectivamente). El tratamiento homeopático con árnica montana en pacientes con estomatitis subprótesis de grados I y II, fue tan beneficioso como la terapéutica convencional en igual tiempo de evolución y estuvo exento de reacciones adversas, lo cual justificó el uso de esta modalidad terapéutica, que al igual que otras de la medicina natural y tradicional, es inocua, económica y de fácil acceso.

A study of therapeutic intervention in the module of San Benito, from Mayarí, II Frente municipality, Santiago de Cuba province was carried out in the first quarter of 2010, in order to evaluate the clinical course of 72 patients with denture stomatitis of grades I and II, alternatively distributed in 2 groups: in group A the odd numbers were included, with conventional therapy; and in group B the pairs, with treatment. In both groups the members of 45-54 years and female sex prevailed, as well as those cured at the third day (72.2 and 80.6%, respectively). The homeopathic treatment with arnica montana was as beneficial as the conventional therapy in same time for the clinical course and it had no adverse reactions, what justifies the use of this therapeutic modality which as others modalities of the natural and traditional medicine, it is innocuous, economic and of easy access.

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Comunicamos un caso de dermatitis por contacto severa debida al Árnica montana, en una paciente con antecedentes de hipertensión arterial tratada regularmente y controlada; se enfatiza la importancia de un control evolutivo, examen físico semiológico completo y los diagnósticos diferenciales, de estas variantes severas e infrecuentes.

The presentation of a case of irritant contact dermatitis in a patient with a history of high blood pressure regularly treated and controlled, who starts on 19.04.13 with fever of 39º5 which ceded with use of current antipyretic; accompanied by myalgia, retro-ocular pain, arthralgias, headache of strong intensity, complete haematology reports thrombocytopenia and leukocytosis at the expense of segmented, picture that remained for 48 hours; later is associated with stabbing pain and right lower limb rigidity. 22.04.13 presents increase in volume and signs of phlogosis of elevated erythematous edges that extends to the sural region, with blister on right twin region of approximately 10x10 cm with functional limitation of that member. The patient is hospitalized under the diagnosis of Bullous erysipelas, receives broad spectrum antibiotics to Gram +, Gram - and anaerobic. 29.04.13 blister hatches draining not foul-smelling yellowish secretion; it is cultivated and Gram, reporting no bacterial growth. Refers to Central Hospital of Maracay entering it with the diagnosis of cellulitis blistering, where it performed second Gram and cultivation reported without bacterial growth; they perform a biopsy which reports epidermal necrotic dermatitis superficial and deep compatible with dermatitis irritant contact. The case is reevaluated, interrogating again to the patient and the dermal symptoms coincide with the use of Árnica montana product (this data was not reported or questioned in the initial history). Update about the product reported that exists extensive reference on cases of dermatitis contact, mainly by the use of Árnica montana and one of its components; methylparaben, these cases have been reported by prolonged use of the product described as excited skin syndrome or angry back. The patient after to the second questioned referred the use of this product frequently for several years topically and even concerned using infusions of the flower of Árnica montana orally. It was decided to deal with steroids intravenously, resulting in evident improvement with egress to the fifth day and outpatient follow-up, which reported complete remission of picture.

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Comunicamos un caso de dermatitis por contacto severa debida al Arnica montana, en una paciente con antecedentes de hipertensión arterial tratada regularmente y controlada; se enfatiza la importancia de un control evolutivo, examen físico semiológico completo y los diagnósticos diferenciales, de estas variantes severas e infrecuentes.(AU)

The presentation of a case of irritant contact dermatitis in a patient with a history of high blood pressure regularly treated and controlled, who starts on 19.04.13 with fever of 39º5 which ceded with use of current antipyretic; accompanied by myalgia, retro-ocular pain, arthralgias, headache of strong intensity, complete haematology reports thrombocytopenia and leukocytosis at the expense of segmented, picture that remained for 48 hours; later is associated with stabbing pain and right lower limb rigidity. 22.04.13 presents increase in volume and signs of phlogosis of elevated erythematous edges that extends to the sural region, with blister on right twin region of approximately 10x10 cm with functional limitation of that member. The patient is hospitalized under the diagnosis of Bullous erysipelas, receives broad spectrum antibiotics to Gram +, Gram - and anaerobic. 29.04.13 blister hatches draining not foul-smelling yellowish secretion; it is cultivated and Gram, reporting no bacterial growth. Refers to Central Hospital of Maracay entering it with the diagnosis of cellulitis blistering, where it performed second Gram and cultivation reported without bacterial growth; they perform a biopsy which reports epidermal necrotic dermatitis superficial and deep compatible with dermatitis irritant contact. The case is reevaluated, interrogating again to the patient and the dermal symptoms coincide with the use of Arnica montana product (this data was not reported or questioned in the initial history). Update about the product reported that exists extensive reference on cases of dermatitis contact, mainly by the use of Arnica montana and one of its components; methylparaben, these cases have been reported by prolonged use of the product described as excited skin syndrome or angry back. The patient after to the second questioned referred the use of this product frequently for several years topically and even concerned using infusions of the flower of Arnica montana orally. It was decided to deal with steroids intravenously, resulting in evident improvement with egress to the fifth day and outpatient follow-up, which reported complete remission of picture.(AU)

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El Arnica montana es uno de los medicamentos que se emplean con mayor frecuencia en la práctica homeopática. Comúnmente, es la primera elección en la atención de traumatismos, contusiones y golpes, especialmente de partes blandas. También se emplea en torceduras, fracturas, esfuerzos exagerados, enfermedades reumáticas, traumas emocionales y para mejorar la recuperación de los pacientes que se someten a intervenciones quirúrgicas. Debido al interés que genera, el Arnica montana ha sido objeto de numerosos estudios en diferentes áreas para comprobar su alcance y determinar sus mecanismos de acción. A continuación se presenta una revisión de algunos artículos publicados sobre este medicamento; unos versan sobre sus principios activos y otros analizan diversos experimentos que se han efectuado.

Arnica montana is one of the most often used drugs in homeopathic practice. Commonly, it is the first choice in the trauma care, bruises and bumps, especially soft tissue. Also used in sprains, fractures, exaggerated efforts, rheumatic diseases and emotional trauma to improve recovery of patients who undergo surgery. Due to the interest generated, Arnica montana has been the subject of numerous studies in different areas to check their range and determine their mechanisms of action. Below is a review of some articles published on this medication, some deal with other active principles and discusses various experiments that have been conducted.

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El Arnica montana es uno de los medicamentos que se emplean con mayor frecuencia en la práctica homeopática. Comúnmente, es la primera elección en la atención de traumatismos, contusiones y golpes, especialmente de partes blandas. También se emplea en torceduras, fracturas, esfuerzos exagerados, enfermedades reumáticas, traumas emocionales y para mejorar la recuperación de los pacientes que se someten a intervenciones quirúrgicas. Debido al interés que genera, el Arnica montana ha sido objeto de numerosos estudios en diferentes áreas para comprobar su alcance y determinar sus mecanismos de acción. A continuación se presenta una revisión de algunos artículos publicados sobre este medicamento; unos versan sobre sus principios activos y otros analizan diversos experimentos que se han efectuado. (AU)

Arnica montana is one of the most often used drugs in homeopathic practice. Commonly, it is the first choice in the trauma care, bruises and bumps, especially soft tissue. Also used in sprains, fractures, exaggerated efforts, rheumatic diseases and emotional trauma to improve recovery of patients who undergo surgery. Due to the interest generated, Arnica montana has been the subject of numerous studies in different areas to check their range and determine their mechanisms of action. Below is a review of some articles published on this medication, some deal with other active principles and discusses various experiments that have been conducted.(AU)

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La homeopatía es considerado un sistema médico complejo estructurado en términos teóricos y simbólicos configurando una racionalidad médica de la morfología humana basada en la doctrina del vitalismo que se rige por los principios de la individualidad la similitud y la experimentación pura y las dosis infinitesimales. El Árnica Montana una planta denominada así primariamente por ser encontrada en las montañas y sus hábitat natural es en la península escandinava, sur de Europa, Norteamérica entre otros. Ha sido utilizada por propiedades farmacológicas básicas como analgésico y antiinflamatorio. El objetivo de este trabajo es determinar el efecto del árnica montana en su forma homeopática en la viabilidad celular y la regulación de IL6 sobre las células mononucleares de personas sanas in vitro. Esto en diluciones homeopáticas (6CH, 15CH, 30CH, 60CH, 200CH, y 1000CH). Los resultados mostraron que el árnica montana tiene un efecto proliferativo sobre las células mononucleares de pacientes sanos en las diferentes diluciones a las 48 y 72 horas es de anota que en la 200CH y 1000 CH son estadísticamente significativas. En cuanto a la cuantificación de IL6 se observa que responden de una manera diferente a cada una de las diluciones pero se conserva que a la dilución 200CH y 1000CH son las que producen mayor cantidad de IL6. Vemos claramente que las diferentes diluciones tienen diferentes respuestas en los diferentes individuos confirmando el principio de la individualidad premisa fundamental y básica de la homeopatía.

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Dados estatísticos nacionais e mundiais demonstram que o número de indivíduos idosos tende a crescer de maneira exponencial nos próximos anos, tornando-se uma população significantemente e proporcionalmente maior que as demais. Entre as doenças mais comuns nesta faixa etária encontra-se a osteoporose, doença que reduz a massa esquelética e deteriora a microarquitetura do osso causando fragilidade e aumentando o risco de fraturas. Este estudo teve como proposta avaliar o efeito da Arnica montana fitoterápica e homeopática no reparo de lesões ósseas, visando uma possível forma de tratamento de fraturas na vigência de osteoporose. Os ensaios experimentais foram realizados em ratas Wistar adultas, divididas em quatro grupos: ovariectomizado tratado com Arnica montana 6CH (OVZ 6CH); ovariectomizado tratado com Arnica montana tintura mãe (OVZ TM); ovariectomizado tratado com placebo (OVZ PL) e animais com falsa cirurgia de ovariectomia e tratado com placebo (Sham PL). Após 45 dias da cirurgia sham ou de ovariectomia, foi realizada uma lesão óssea monocortical na tíbia de todos os animais e iniciados os respectivos tratamentos. Os animais foram eutanasiados após, 6, 12, 18 e 28 dias e as tíbias retiradas para avaliação das suas dimensões e análise do reparo ósseo através de densidade óssea radiográfica, ensaios biomecânicos e microscopia eletrônica de varredura (MEV). Os dados foram submetidos à análise estatística pelos testes de ANOVA e Tukey (p<5%). Demonstraram que o tratamento com arnica 6CH foi melhor que o com arnica TM quanto à resistência e à qualidade da regeneração óssea, enquanto a TM mostrou melhor valor de densidade óptica

National and international data show that in the next years the elder population tends to have an exponential increase becoming to be significantly higher than the other age population. Among the frequent diseases in the elderly is osteoporosis, a disease that decreases bone mass and deteriorates bone structure causing fragility and a high risk of fracture. The aim of this study was to evaluate the effect of phytotherapic and homeopathic Arnica montana on bone repair quality, aiming its possible use in the treatment of bone fracture in patients with osteoporosis. This experimental study was realized in Wistar adult female rats divided in 4 groups according to the following treatments: ovariectomized treated with Arnica montana 6CH (OVZ 6CH); ovariectomized treated with extract of Arnica montana (OVZ TM); ovariectomized with false treatment with placebo (OVZ PL) and rats with sham surgery and false treatment with placebo (Sham PL). In a period of 45 days after ovariectomy or sham surgery all animals were drilled a monocortical lesion in their tibiae and began the proposed treatments. They were euthanized after 6, 12, 18 e 28 days and had the tibiae removed to evaluation of tibiae dimensions and bone repair by radiographic density, biomechanical test and electronic scan microscopy (MEV). Data were analyzed by ANOVA e Tukey tests (p<5%). The results showed that treatment with arnica 6CH was better than with arnica TM considering bone resistance to biomechanical flection and bone repair quality, while arnica TM showed better bone density values

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As desordens musculares geralmente estão presentes na Disfunção Temporomandibular (DTM). Sua principal sintomatologia é dor, edema, proveniente de injúria tecidual e inflamação. O tratamento das DTMs consiste em tratamento suporte para alívio da sintomatologia e “definitivo” para eliminar as causas e fatores que são perpetuantes. O uso de antiinflamatórios (AINEs), relaxantes musculares, placas oclusais, fitoterápicos com ação antiinflamatória como Arnica Montana são indicados como tratamento suporte. A Arnica montana tem sido usada para redução de inflamação e dor causada por entorse, contusões e ferimentos. Sua principal ação é inibição da ativaçãodo fator de transcrição celular NF- қB.

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RESUMO

Objetivo: Avaliar a ação do medicamento homeopático Arnica montana 6 cH comparada ao Diclofenaco Sódico 50mg no controle do edema após remoção de terceiros molares inclusos. Métodos: O trabalho tratou-se de uma pesquisa experimental, cruzada, randomizada, duplo-cega, realizada em 30 alunos voluntários do curso de Odontologia da Universidade Federal de Sergipe, com presença de dentes inclusos em bilaterais, perfazendo um total de 120 dentes, com indicação da mesma técnica cirúrgica exodôntica. Os grupos foram divididos em Grupo A: os que usaram a Arnica Montana 6cH e Grupo D: os que usaram Diclofenaco de Sódio 50mg. Para a mensuração do edema, foi utilizada uma fita métrica com a qual foram tomadas três medidas como referência: 1) canto de olho ao tragus (CO-T); 2) canto de olho ao ângulo da mandíbula (CO-AM); 3) comissura labial ao tragus (CL-T). Estas foram realizadas quatro vezes sendo a primeira logo após o fim do procedimento cirúrgico, e as demais após 24h, 48h e 72h da cirurgia. O teste de Shapiro-Wilk foi usado para verificação da distribuição normal das variáveis. Nas variáveis que apresentaram dados paramétricos foi usado o teste de comparação de Student. Os dados foram considerados estatisticamente significantes quando p menor que 0,05. Resultados: No período de 48h pós-cirurgia, o edema foi mais marcante para ambos os grupos nos segmentos CO-AM e CL-T. Após 72h ocorreu uma regressão do edema para ambas as medicações testadas. O segmento que menos apresentou edema foi o CO-T para as duas medicações. O teste de Student mostrou que as medicações se equivalem na efetividade anti-edematosa (p maior que 0,05). Conclusão: O medicamento homeopático Arnica montana 6 cH possui eficácia no controle do edema pós-extração de terceiros molares inclusos. A Arnica montana 6cH quando comparada ao Diclofenaco de Sódio 50mg se mostrou equivalente no controle do edema pós-cirúrgico.

Objective: To evaluate the Arnica montana 6 cH homeopathic efficacy compared to 50mg Diclofenac Sodium in the control of edema after removal of third molars. Methods: This work was an experimental, cross, randomized, double-blind study held on 30 volunteers student from the Dental School at the Sergipe Federal University, with the presence of impacted teeth on both sides, making a total of 120 teeth, indicating the same surgical technique. The groups were divided as follows: GROUP A: those who used the Arnica Montana 6cH and GROUP D: those who used 50mg Diclofenac Sodium. For edema measurement, we used a measure tape with which three measures were taken as reference: 1) eye corner to the tragus (EC-T); 2) eye corner to the jaw angle (EC-JA); 3) labial commissure to the tragus (LC-T). These were four times the first being shortly after the end of surgery and the remaining after 24h, 48h and 72h the end of surgery. Shapiro-Wilk test was used to verify the normal distribution of the studied variables. For normal distribution, Student test was used. The data were considered statistically significant when p less than 0.05. Results: In 48h post-surgery, the edema was notable for both groups in the segments EC-JA and LC-T. After 72h there was decrease of the edema for both drugs tested. The segment EC-T showed less edema for two medications. Student test showed that medications were similar anti-edematous efficacy (p greater than 0.05). Conclusions: The homeopathic remedy Arnica montana 6 cH has efficacy in controlling post-extraction edema of third molars. The Arnica montana 6cH compared to 50mg Diclofenac Sodium was equivalent to control postoperative edema.

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Son el resultado de la acción de determinados agentes externos capaces de actuar rápida e instantáneamente sobre el organismo, superando la resistencia de aquellos tejidos u órganos en los que directa o indirectamente recae su acción. Siendo una patología muy frecuente debido a la actual situación social y laboral (transporte, industria, deportes, etc).

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