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1.
Clin Transl Oncol ; 2023 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-38070049

RESUMO

Appendiceal mucinous lesions' classification and nomenclature has been modified several times along the last decades, reflecting their great heterogeneity and making difficult to compare results and draw conclusions. Despite its nearby origin, appendiceal mucinous lesions have a distinctive behaviour compared to colorectal cancer, including their molecular and genetic markers. Due to their low frequency, their management is not well standardised. However, surgery is considered the cornerstone of treatment. Their indolent behaviour has encouraged surgeons to apply more aggressive treatments, such as cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), that may extend overall survival. Chemotherapy is reserved for unresectable and/or disseminated disease and could play a role in the adjuvant and neoadjuvant setting. Pressurised intraperitoneal aerosol chemotherapy (PIPAC) is recently emerging as a possible alternative for treatment in advanced disease although its results in long-term survival are lacking Hereby, we review the available evidence in the management of appendiceal mucinous lesions, including localised and disseminated disease, with a special emphasis on the oncological perspective, focusing on the lights and shadows of the systemic treatments.

2.
Rev. argent. coloproctología ; 34(3): 22-26, sept. 2023. ilus
Artigo em Espanhol | LILACS | ID: biblio-1552478

RESUMO

Un plastrón apendicular es una masa apendicular palpable que contiene el apéndice inflamado, vísceras adyacentes y el omento mayor, asociado a o no a la presencia de pus. El manejo del plastrón apendicular abscedado es controvertido. Cuando hay signos de sepsis asociados, la indicación es una intervención quirúrgica de urgencia, de lo contrario puede optarse por un tratamiento conservador. La utilización de drenaje percutáneo tiene una alta tasa de efectividad, aunque la tasa de neoplasias no detectadas presenta un porcentaje no despreciable, especialmente en los pacientes mayores de 40 años. El objetivo de esta presentación es comunicar una paciente de 65 años con diagnóstico presuntivo de plastrón apendicular abscedado quien luego del fracaso de los drenajes percutáneos fue sometida a una laparotomía exploratoria y hemicolectomía derecha. El diagnóstico histopatológico fue de adenocarcinoma mucinoso del apéndice. (AU)


A palpable inflammatory appendiceal mass may contain the inflamed appendix, adjacent viscera, and the greater omentum, associated or not with the presence of pus. The management of an inflammatory appendiceal mass is controversial. When there are associated signs of sepsis, the indication is emergency surgery, otherwise, you can opt for a conservative treatment. The use of percutaneous drainage has a high rate of effectiveness, although the rate of undetected neoplasia is not negligible, especially in patients older than 40 years. We present the case of a 65-year-old female patient with a presumptive diagnosis of an appendiceal mass with abscess, who underwent exploratory laparotomy and right hemicolectomy after percutaneous drainage failure. The histopathological diagnosis was mucinous adenocarcinoma of the appendix. (AU)


Assuntos
Humanos , Feminino , Idoso , Neoplasias do Apêndice/patologia , Apendicite/cirurgia , Apendicite/diagnóstico , Apendicectomia , Diagnóstico por Imagem , Colectomia , Adenocarcinoma Mucinoso , Abscesso Abdominal
3.
Rev. colomb. gastroenterol ; 36(2): 275-279, abr.-jun. 2021. graf
Artigo em Inglês, Espanhol | LILACS | ID: biblio-1289309

RESUMO

Resumen Se presenta el caso de una mujer joven con hallazgo endoscópico incidental en una colonoscopia de seguimiento, que consistía en una lesión en el ciego con histología benigna. Se describe el proceso diagnóstico y el tratamiento quirúrgico. Se revisa la literatura existente y se discuten la incidencia, el cuadro clínico y las indicaciones de tratamiento quirúrgico de una patología rara de baja aparición.


Abstract This is the case of a young patient with an incidental endoscopic finding of a lesion in the cecum during follow-up colonoscopy with benign histology. The diagnostic process and surgical treatment are described. The existing literature was reviewed and the incidence, symptoms and indications of surgical treatment of this rare condition are discussed.


Assuntos
Humanos , Feminino , Adulto , Colonoscopia , Endometriose , Intussuscepção , Pacientes , Mulheres , Diagnóstico
4.
J Med Case Rep ; 14(1): 152, 2020 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-32921300

RESUMO

INTRODUCTION: Endometriosis of the appendix is very uncommon, accounting for only about 1% of all cases of endometriosis. However, endometriosis is found in the appendix in approximately 8-13% of patients with deep infiltrating endometriosis and is particularly common in patients with severe forms of deep infiltrating endometriosis. Neuroendocrine tumors are the most common neoplasms of the appendix and may be misdiagnosed when there are multiple endometriosis lesions in the pelvis. CASE PRESENTATION: We describe a case of a Caucasian patient with deep infiltrating endometriosis with rectal involvement, retrocervical lesions, and a right ovarian endometrioma with no suspected lesions in the appendix. She underwent laparoscopy and, after a systematic intraoperative evaluation, suspected involvement of the appendix was observed. The patient underwent ovarian cystectomy, excision of the pelvic endometriosis lesions, appendectomy, and anterior stapler discoid resection. Histopathological analysis of the appendix revealed endometriosis and a well-differentiated neuroendocrine carcinoma at the appendix tip. DISCUSSION: Our patient's case emphasizes the need to approach these lesions carefully and strengthens the indication for appendectomy when the appendix is affected in the setting of endometriosis. Despite the more likely diagnosis of appendiceal endometriosis, neuroendocrine tumors cannot be ruled out by imaging examinations, and both conditions can occur in the same patient.


Assuntos
Neoplasias do Apêndice , Apêndice , Endometriose , Tumores Neuroendócrinos , Apendicectomia , Neoplasias do Apêndice/diagnóstico , Neoplasias do Apêndice/cirurgia , Apêndice/diagnóstico por imagem , Apêndice/cirurgia , Endometriose/diagnóstico , Endometriose/cirurgia , Feminino , Humanos , Tumores Neuroendócrinos/diagnóstico por imagem , Tumores Neuroendócrinos/cirurgia
5.
Rev Fac Cien Med Univ Nac Cordoba ; 77(2): 113-116, 2020 04 07.
Artigo em Espanhol | MEDLINE | ID: mdl-32558515

RESUMO

Introduction: An appendiceal collision tumor is defined as the presence of histologically distinct types of tumors in the appendix without transition between them. Appendiceal tumors are rare, with epithelial neoplasms and neuroendocrine tumors being the most common. Objective: Report the case of woman with acute appendicitis and diagnosis of an appendiceal collision tumor. Case presentation: A 35 years old woman, who consulted for a 24 hours of continuous epigastric pain with migration to the right iliac fossa; the routine blood test showed leukocytosis with neutrophilia and an ultrasound scan abdomen demonstratedsigns in favor of acute appendicitis; a diagnosis of acute appendicitis and surgical treatment. The anatomopathological study and immunostaining revealed well-differentiated neuroendocrine neoplasia and low-grade mucinous epithelial neoplasia. A follow-up with postsurgical tumor markers was performed with normal results, in addition to computed tomography and postoperative colonoscopy without alterations. Discussion: Appendiceal collision tumor is infrequently. Generally the diagnosis is made with anatomopathological study and supposes great challenges for postoperative control because there are no guidelines to follow up. Conclusion: More research should be done in order to have recommendations for this disease. Conclusion: More research should be done in order to have recommendations for this disease.


Introducción: Se define a un tumor de colisión apendicular, como la presencia de dos tipos de tumores histológicamente distintos, dentro del apéndice sin transición entre ellos. Los tumores apendiculares son poco frecuentes, siendo las neoplasias epiteliales y los tumores neuroendocrinos los más comunes. Objetivo: Presentar el caso de una paciente con diagnóstico de tumor de colisión apendicular que se presentó como apendicitis aguda. Caso clínico: Mujer de 35 años de edad sin antecedentes patológicos que consultó por dolor epigástrico de 24 horas de evolución, con migración a fosa ilíaca derecha, de tipo continuo. El examen físico reveló un abdomen blando con defensa en fosa ilíaca derecha; el análisis de sangre mostró leucocitosis con neutrofilia y una ecografía en favor de apendicitis aguda. Se realizó apendicectomía mediante incisión de Mc Burney. El estudio anatomopatológico e inmunomarcación informó neoplasia neuroendocrina bien diferenciada y neoplasia epitelial mucinosa de bajo grado. Se realizó seguimiento con marcadores tumorales postquirúrgicos con resultados normales, además de tomografía computada y colonoscopia postquirúrgicos normales. Dsicusión: El tumor de colisión apendicular es muy poco frecuente. Generalmente el diagnóstico se realiza con el estudio anatomopatológico y plantea grandes desafíos para el control, ya que no existe consenso de cómo realizar el seguimiento postquirúrgico . Conclusión: Se debe investigar más al respecto para contar con recomendaciones de vigilancia para dicha enfermedad


Assuntos
Adenocarcinoma Mucinoso/diagnóstico , Neoplasias do Apêndice/diagnóstico , Apendicite/diagnóstico , Tumores Neuroendócrinos/diagnóstico , Doença Aguda , Adenocarcinoma Mucinoso/patologia , Adenocarcinoma Mucinoso/cirurgia , Adulto , Apendicectomia , Neoplasias do Apêndice/patologia , Neoplasias do Apêndice/cirurgia , Apendicite/patologia , Apendicite/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Tumores Neuroendócrinos/patologia , Tumores Neuroendócrinos/cirurgia
6.
Clin Transl Oncol ; 18(5): 437-48, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26489426

RESUMO

The epithelial appendiceal neoplasms are uncommon and are usually detected as an unexpected surgical finding. The general surgeon should be aware of the diversity of its clinical manifestations and biological behaviors along with the significance of the surgical treatment on the progression of the illness and the prognosis of the patients. The operative findings and, especially, tumor histology, determine the type of surgery. Intestinal histologic subtype behaves and should be treated similarly to the right colon neoplasms; while mucinous tumors, often discordant between histology and its aggressiveness, can be treated with a simple appendectomy or require complex oncological surgeries. Mucinous tumors are often associated with the presence of mucin or tumor implants in the abdominal cavity, being the clinical syndrome known as pseudomyxoma peritonei (PMP). PMP tends to present an indolent but deadly evolution and requires a multimodal approach as a single treatment with curative potential: complete cytoreductive surgery plus hyperthermic Intra-peritoneal chemotherapy (CCRS + HIPEC) now considered the standard of care in this pathology. The general surgeon should be aware of the governing principles of the treatment of appendiceal neoplasms with or without peritoneal dissemination, know the therapeutic frontiers in every situation (avoiding unnecessary or counterproductive surgeries) and sending early these patients to specialised centres in the radical management of malignant diseases of the peritoneum in the conditions and with the necessary information to facilitate a possible radical treatment.


Assuntos
Adenocarcinoma Mucinoso/terapia , Neoplasias do Apêndice/terapia , Neoplasias Epiteliais e Glandulares/terapia , Neoplasias Peritoneais/terapia , Guias de Prática Clínica como Assunto , Adenocarcinoma Mucinoso/patologia , Neoplasias do Apêndice/secundário , Humanos , Neoplasias Epiteliais e Glandulares/secundário , Neoplasias Peritoneais/secundário , Pseudomixoma Peritoneal
7.
JSLS ; 19(3)2015.
Artigo em Inglês | MEDLINE | ID: mdl-26175555

RESUMO

INTRODUCTION: Endometriosis is occasionally found in the appendix, particularly in severe forms of deep infiltrating disease. Carcinoid tumor is the most common neoplasm of the appendix and may be overlooked or misdiagnosed when there are multiple endometriosis lesions in the pelvis. CASE DESCRIPTION: We describe two cases of carcinoid tumor diagnosed in patients who underwent surgery to treat endometriosis, in whom the diagnosis of appendiceal endometriosis was presumed. DISCUSSION: In the context of endometriosis, surgery is indicated when the appendix is affected. Despite the more likely diagnosis of appendiceal endometriosis, carcinoid tumors cannot be ruled out by imaging examinations.


Assuntos
Neoplasias do Apêndice/diagnóstico , Apêndice/patologia , Tumor Carcinoide/diagnóstico , Diagnóstico por Imagem/métodos , Endometriose/diagnóstico , Adulto , Feminino , Humanos , Masculino
8.
Cir Cir ; 82(2): 206-11, 2014.
Artigo em Espanhol | MEDLINE | ID: mdl-25312322

RESUMO

BACKGROUND: Pseudomyxoma peritonei is a disease characterized by an intraperitoneal adenomucinous tumor cell disemination, being cecal appendix the most common etiology. OBJECTIVE: To report a surgeon's group experience and a detailed up to date literature review. CLINICAL CASES: 1. A 74 year old woman with a history of four days with mesogastrium and right lower quadrant abdominal pain associated with diarrhea and fever was admitted to our institution. Upon admission she presented with signs of peritoneal irritation and muscular rigidity, leukocytosis of 14,500 cels/mm(3), 89% neutrophils and 1% bands. An acute appendicitis diagnosis was established, being scheduled for diagnostic laparoscopy, during procedure, significant bowel distention was found, so conversion to laparotomy was required. Case 2. A 73 year old male with a history of one year with intermittent abdominal pain at right iliac fossa and hypogastrium was admitted to our institution. Dyspnea, constipation alternating with periods of diarrhea, gastric fullness and heartburn occurred. On physical examination only a palpable tumor occupying mesogastrium and both iliac fossae was noticed, therefore, a laparotomy was performed. In both cases diagnoses were made during procedure, finding multiple scattered multilobulated mucinous tumor implants within the peritoneal cavity. Histopathological studies confirmed a pseudomyxoma peritonei diagnoses. CONCLUSIONS: Peritoneal pseudomyxoma is a rare malignant tumor with a difficult diagnosis characterized by copious production of mucinous ascites and multiple tumors implants on serosa of intracavitary viscera. The gold standard treatment consists of cytoreductive surgery and perioperative intraperitoneal chemotherapy and/or adjuvant chemotherapy.


Antecedentes: el pseudomixoma peritoneal se caracteriza por la diseminación celular intraperitoneal de un tumor adenomucinoso; el apéndice cecal es la etiología más frecuente. Objetivo: reportar la experiencia de un grupo de Cirugía General y revisar la bibliografía. Casos clínicos: 1: paciente femenina de 74 años de edad, que cuatro días previos inició con dolor abdominal tipo cólico en el mesogastrio y fosa iliaca derecha, evacuaciones diarreicas y fiebre. A su ingreso al hospital se la encontró con datos de irritacion peritoneal y resistencia muscular, leucocitosis de 14,500 células por mm3, neutrófilos 89%, bandas 1%. Se diagnosticó: apendicitis aguda y se programó para laparoscopia diagnóstica, con distensión importante de asas, por lo que se decidió convertir a laparotomía. Caso 2: paciente masculino de 73 años de edad; el padecimiento actual se inició con dolor intermitente en la fosa iliaca derecha e hipogastrio, de un año de evolución. Al cuadro se agregaron: disnea, estreñimiento alternado con periodos de diarrea, plenitud gástrica, y pirosis. A la exploración física se encontró un tumor palpable en el mesogastrio y ambas fosas iliacas. Por eso se le realizó la laparotomía exploradora. En ambos casos el diagnóstico se estableció en el transoperatorio con el hallazgo de múltiples implantes tumorales mucinosos multilobulados diseminados en la cavidad peritoneal, el diagnóstico se confirmó con el reporte histopatológico de pseudomixoma peritoneal. Conclusiones: el pseudomixoma peritoneal es una neoplasia poco frecuente y de difícil diagnóstico, caracterizada por producción copiosa de ascitis mucinosa y de múltiples implantes tumorales en la serosa de las vísceras intracavitarias. El tratamiento ideal es la cirugía citorreductiva y la quimioterapia intraperitoneal perioperatoria o la quimioterapia postoperatoria, o ambas.


Assuntos
Adenocarcinoma Mucinoso/patologia , Neoplasias do Apêndice/complicações , Apêndice/patologia , Neoplasias Peritoneais/secundário , Pseudomixoma Peritoneal/diagnóstico , Dor Abdominal/etiologia , Adenocarcinoma Mucinoso/cirurgia , Idoso , Neoplasias do Apêndice/diagnóstico , Apendicite/diagnóstico , Diagnóstico Diferencial , Diarreia/etiologia , Feminino , Humanos , Laparotomia , Masculino , Neoplasias Peritoneais/patologia , Neoplasias Peritoneais/cirurgia , Pseudomixoma Peritoneal/etiologia , Pseudomixoma Peritoneal/cirurgia , Ruptura Espontânea
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