RESUMO
BACKGROUND: Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA), an operationalized definition of successful cognitive aging. SA showed increased thickness and altered functional connectivity in the anterior cingulate cortex as a neurobiological signature. However, their metabolic alterations are yet to be uncovered. OBJECTIVE: Herein, a metabolic (FDG-PET), amyloid (PIB-PET), and functional (fMRI) analysis of SA were conducted. METHODS: Ten SA, ten age-matched older adults (C80), and ten cognitively normal middle-aged (C50) adults underwent cognitive testing and multimodal neuroimaging examinations. Anterior and posterior regions of the cingulate cortex and hippocampal areas were primarily examined, then subregions of anterior cingulate were segregated. RESULTS: The SA group showed increased metabolic activity in the left and right subgenual anterior cingulate cortex (sACC, pâ<â0.005 corrected, bilateral) and bilateral hippocampi (right: pâ<â0.0005 and left: pâ<â0.005, both corrected) as compared to that in the C80 group. Amyloid deposition was above threshold in 30% of SA and C80 (pâ>â0.05). The SA group also presented decreased connectivity between right sACC and posterior cingulate (pâ<â0.005, corrected) as compared to that of the C80 group. CONCLUSION: These results support the key role of sACC and hippocampus in SA, even in the presence of amyloid deposition. It also suggests that sACC may be used as a potential biomarker in older adults for exceptional memory ability. Further longitudinal studies measuring metabolic biomarkers may help elucidate the interaction between these areas in the cognitive aging process.
Assuntos
Peptídeos beta-Amiloides/metabolismo , Envelhecimento Cognitivo/psicologia , Glucose/metabolismo , Giro do Cíngulo/metabolismo , Hipocampo/metabolismo , Idoso , Idoso de 80 Anos ou mais , Feminino , Giro do Cíngulo/diagnóstico por imagem , Hipocampo/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Testes Neuropsicológicos , Tomografia por Emissão de PósitronsRESUMO
Amyloid goiter is an atypical manifestation of amyloidosis. A case of a patient with rheumatoid arthritis history and sub-acute thyroid gland volume significantly increased is presented. Ultrasonographic and computed tomography findings were compatible with amyloid goiter. The aim of this study is to describe its radiologic features.
El bocio amiloide es una manifestación atípica de la amiloidosis. Se presenta el caso de una paciente con antecedentes de artritis reumatoide y aumento de volumen subagudo de la glándula tiroidea con hallazgos ultrasonográficos y por tomografía computada compatible con bocio amiloide. Se exponen sus características radiológicas, objeto de la presente comunicación.